• Journal of The Korean Ophthalmological Society
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• v.60 no.2
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• pp.144-151
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• 2019

Purpose: Intravitreal aflibercept, ranibizumab, bevacizumab, and dexamethasone are the most widely used drugs in the treatment of diabetic macular edema (DME). The aim of this study was to compare the efficacy and safety of anti-vascular endothelial growth factors and dexamethasone for the treatment of DME. Methods: There were nine previous systematic reviews on this topic; we updated these high-quality reviews. Seven studies were added to two studies following a literature search. Efficacy outcomes were 1) average improvement in visual acuity, 2) proportion of patients who experienced an improvement in vision (an increase in best-corrected visual acuity (BCVA) of ${\geq}15$ in the Early Treatment Diabetic Retinopathy Study [ETDRS]), and 3) proportion of patients who experienced worsening vision (a decrease in BCVA of ${\geq}15$ in the ETDRS). Safety outcomes included systemic adverse events and ocular-related adverse events. Results: The mean difference in the BCVA for ranibizumab versus bevacizumab treatment was 0.16 (95% confidence interval [CI]: -0.02, 0.34), and that for ranibizumab versus aflibercept was -0.08 (95% CI: -0.26, 0.10). The mean difference in the change of BCVA for aflibercept versus ranibizumab was -0.20 (95% CI: -0.40, -0.01), and that for aflibercept versus bevacizumab was -0.34 (95% CI: -0.53, -0.14). Other efficacy outcomes showed similar trends, and there was no significant difference between treatments. There was also no significant difference in both systemic and ocular adverse events rates between the treatments. Conclusions: In DME patients, the efficacy of aflibercept was found to be higher with respect to BCVA changes compared with ranibizumab or bevacizumab. However, there were no significant difference in terms of visual acuity improvement or visual acuity of more than 15 letters, nor in terms of anti-vascular endothelial growth factors (as a safety outcome).

• Journal of agriculture & life science
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• v.46 no.6
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• pp.17-24
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• 2012

Soil types for cultivated crops are approximately compose of volcanic ash soils for black(21%) and dark brown soils(41%), and non-volcanic ash soil of red-yellow soil(17%) in Jeju Island. The effects of these soils on fruit qualities of kiwifruit 'Jecy Gold'(Actinidia chinensis cv. Jecy Gold) were investigated in non-heating plastic house. Soil moisture potential was the lowest in the red-yellow soil during fruit growth. However, transverse diameter of fruit in the red-yellow soil was tends to be smaller than in volcanic ash soils, but longitudinal length of fruit was not shown difference by soil types during fruit maturation. Soluble solids in fruit was not differed by soil types until 140 days after of anthesis, after that the red-yellow soil was the highest. No difference on acid contents and hardness of fruit by soil types. Fructose, glucose and sucrose contents in harvested fruit were $4.45{\pm}2.08$, $5.43{\pm}1.13$, and $2.40{\pm}0.40%$ for the red-yellow soil, $2.51{\pm}0.55$, $3.52{\pm}0.86$, and $0.79{\pm}0.33%$ for the black soil and $2.54{\pm}0.47$, $3.52{\pm}0.73$, and $0.73{\pm}0.38%$ for the dark brown soil, respectively. These results show that soluble solid and free sugars in fruit were affected by soil types. It is estimated that soil moisture was rapidly drought in the red-yellow soil of non-volcanic ash soil than in the black and dark brown soils of volcanic ash soil.

• Korean Journal of Breeding Science
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• v.43 no.1
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• pp.42-49
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• 2011

QTL analysis for blast resistance was carried out using 140 $BC_3F_3$ lines derived from a cross between Ilpum as a recurrent parent and Moroberekan as a donor parent. 140 $BC_3F_3$ lines with the parents were inoculated with nine blast isolates. To identify QTLs for resistance to nine blast isolates, 134 SSR markers showing polymorphisms between the parents were genotyped for the 140 $BC_3F_3$ lines. A total of 17 resistance QTLs to nine isolates were detected on chromosomes 2, 3, 4, 6, 7, 9 and 10. The phenotypic variance explained by each QTL ranged from 8.2% to 26.4%. The Moroberekan alleles contributed the positive effect at these 17 QTL loci. In a previous study, the QTL, Pi45(t) for durable resistance to blast was identified using a sequential planting method. To know the relationship between Pi45(t) and the isolate-specific resistance gene, an $F_2$ population was developed from a cross between Ilpum and an introgression line harboring Pi45(t). $F_3$ lines segregating for the Pi45(t) were inoculated to three isolates. $F_3$ lines from the $F_2$ plants with the Moroberekan segment at the target region showed resistance to two isolates. This result seems to indicate that the Pi45(t) and the isolate-specific resistance gene are tightly linked or the resistance is controlled by the same gene(s). The markers linked to genes controlling blast resistance would be useful in developing blast resistance lines in the breeding program.

• Korean Journal of Breeding Science
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• v.41 no.3
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• pp.228-235
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• 2009

Growth and branch characteristics of 35 half-sib families were surveyed in a seedling seed orchard of Quercus acutissima at ages 10 and 12. The averages of height, DBH (diameter at breast height), branch height, crown width, branch angle and stem straightness at age 12 were 9.96 m, 14.50 cm, 1.04 m, 6.80 m, $18.82^{\circ}$ and 2.58, respectively. Families of 075 and 052 showed superior height growth and 0511 and 0517 were inferior ones. For DBH growth, 075 and 0413 were best families and 0725 and 0511 were inferior families. Pearson's product moment and Spearman's rank correlation coefficients were all positive for all growth traits except branch angle at ages 10 and 12. This result showed that the families with good height and DBH growth were also superior in stem straightness. In ANOVA, there was a highly significant difference among families in height, DBH, cylindric volume and stem straightness. Branch height, crown width and branch angle were also significantly different among families. Family heritability was higher than individual heritability at ages 10 and 12. Height, DBH and stem straightness were under strong genetic control, showing high family heritability. This implies that high genetic gain could be expected by family selection. Expected genetic gain for each trait was estimated based on the family selection. The highest genetic gain was expected for the traits of branch angle, height and DBH because of the large phenotypic standard deviation and the high family heritability. The growth performance and branch characteristics were weighted by the magnitude of genetic variation and heritability. The weighted values were then subjected to estimate family breeding values. This family breeding value would be applied as a criterion in the genetic thinning of the seed orchard.

• Journal of Energy Engineering
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• v.28 no.3
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• pp.65-79
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• 2019

The study attempted to estimate the optimal facility capacity by combining renewable energy sources that can be connected with gas CHP in industrial complexes. In particular, we reviewed industrial complexes subject to energy use plan from 2013 to 2016. Although the regional designation was excluded, Sejong industrial complex, which has a fuel usage of 38 thousand TOE annually and a high heat density of $92.6Gcal/km^2{\cdot}h$, was selected for research. And we analyzed the optimal operation model of CHP Hybrid System linking fuel cell and photovoltaic power generation using HOMER Pro, a renewable energy hybrid system economic analysis program. In addition, in order to improve the reliability of the research by analyzing not only the heat demand but also the heat demand patterns for the dominant sectors in the thermal energy, the main supply energy source of CHP, the economic benefits were added to compare the relative benefits. As a result, the total indirect heat demand of Sejong industrial complex under construction was 378,282 Gcal per year, of which paper industry accounted for 77.7%, which is 293,754 Gcal per year. For the entire industrial complex indirect heat demand, a single CHP has an optimal capacity of 30,000 kW. In this case, CHP shares 275,707 Gcal and 72.8% of heat production, while peak load boiler PLB shares 103,240 Gcal and 27.2%. In the CHP, fuel cell, and photovoltaic combinations, the optimum capacity is 30,000 kW, 5,000 kW, and 1,980 kW, respectively. At this time, CHP shared 275,940 Gcal, 72.8%, fuel cell 12,390 Gcal, 3.3%, and PLB 90,620 Gcal, 23.9%. The CHP capacity was not reduced because an uneconomical alternative was found that required excessive operation of the PLB for insufficient heat production resulting from the CHP capacity reduction. On the other hand, in terms of indirect heat demand for the paper industry, which is the dominant industry, the optimal capacity of CHP, fuel cell, and photovoltaic combination is 25,000 kW, 5,000 kW, and 2,000 kW. The heat production was analyzed to be CHP 225,053 Gcal, 76.5%, fuel cell 11,215 Gcal, 3.8%, PLB 58,012 Gcal, 19.7%. However, the economic analysis results of the current electricity market and gas market confirm that the return on investment is impossible. However, we confirmed that the CHP Hybrid System, which combines CHP, fuel cell, and solar power, can improve management conditions of about KRW 9.3 billion annually for a single CHP system.

• Asian Journal of Turfgrass Science
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• v.23 no.2
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• pp.317-330
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• 2009

Research was initiated to investigate germination vigor, number of leaves, plant height and turfgrass density. A total of 18 treatment combinations were used in the study. Treatments were made of soil organic amendment(SOA), sand, and water-absorbing polymer. Germination vigor, leaf number, plant height and turfgrass density were evaluated in Kentucky bluegrass(KB) grown under greenhouse conditions. Significant differences were observed in germination vigor, leaf number, plant height and turfgrass density among 18 mixtures of SOA and polymer. Highest germination rate was associated with mixture of SOA 20% + sand 80% + polymer 0%, resulting in 56.3% for KB. Number of leaves at 60 DAS(days after seeding) were greater with KB over PR, while plant height higher with PR over KB. Leaf number increased with SOA, being SOA 20% > SOA 100% > SOA 10% and with polymer from 0 to 12%. Plant height was greatest with SOA 20% and lowest with SOA 100%. Greater density was observed with PR rather than KB due to longer plant height. Turf density was best under SOA 10% and poorest under SOA 100% in KB. A further research would be required for investigating the individual effect of K-SAM, Ca, perlite on the turf growth characteristics.

• Food Science and Preservation
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• v.24 no.3
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• pp.351-360
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• 2017

We have studied the technology to extend the storage period of 'Seolhyang' strawberries using modified atmosphere package (MAP) and ethyl pyruvate (EP) treatment for domestic distribution and export. The selected ripe strawberries harvested on December 28, 2016 at the Sancheong farmhouse were transported to the laboratory for 2 h and tested. After a day's precooling at $4^{\circ}C$, the strawberries were divided into seven experimental groups. These groups were control, active MAP using low density polyethylene (LDPE), active MAP using polyamide (PA), active MAP using PA with EP treatment, passive MAP using LDPE, passive MAP using PA and passive MAP using PA with EP treatment. Quality analysis was carried out every 4 days during the storage period of 16 days. During the storage period of 16 days, MAP decreased from 3.5% to less than 1.1% in weight loss ratio compared with control, and decreased from 36% to less than 7% in fungal incidence. In the case of fungi in the EP treatment group, hyphae did not grow on the outside of the strawberry but grew to the inside. This tendency was similar to that in the low oxygen and high carbon dioxide environment of the MAP, the mycelium of the fungus did not grow outside of the strawberry. Fungi are the biggest problem in the distribution and export of strawberries, and these results suggest that MAP alone could inhibit mold and increase shelf life.

• Korean Journal of Soil Science and Fertilizer
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• v.22 no.4
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• pp.290-295
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• 1989

An incubation study was conducted to examine the effect of soil pH and temperature on nitrification potential of 8 different soil series applied with no-N and 200 ugN/g soil as a compound fertilizer at 60 % moisture content of maximum water holding capacity for 8 weeks, whose series were ranged from acid to mild alkali as Gopyeong(Jincheon, pH 4.51), Yesan(Jincheon, pH 4.54), Jigog(Eumseong, pH 4.71), Songsan(Goesan, pH 5.01), Angye(Seongju, pH 5.34), Banho(Seongju, pH 5.73), Weongog(Jincheon, pH 5.93), and Banho(Seongju, pH 7.70), respectively. Interrelationship between the nitrifiable and the net $NO_3-N$(N added plot-no-N plot) accumulated in the soil and tobacco yield in the no fertilizer plot were investigated as well. 1. Nitrification response was various according to soil characteristics at each temperature condition showing that nitrifiable $NO_3-N$ values of the soils were much higher at $25^{\circ}C$ than $15^{\circ}C$. And difference of nitrification potential affected by temperature was markedly distinguishable from 2 weeks after incubation and was showing a tendency to reduce with increasing of soil pH. 2. At each temperature condition, net $NO_3-N$ accumulated at 2 and 4 weeks after incubation was positively correlated with soil pH. 3. Tobacco yield in the no fertilizer plot was more highly correlated with the values of nitrifiable and net $NO_3-N$ accumulated at $15^{\circ}C$ similar to soil temperature in rhizosphere of early stage of tobacco growth than those at optimum temperature($25^{\circ}C$).

• Korean Journal of Soil Science and Fertilizer
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• v.20 no.2
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• pp.115-121
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• 1987

A pot experiment was conducted to investigate the influence of Ca and Mg saturation ratios of soil on the uptake of Ca, Mg and K by rice plant. A silty loam soil was treated with $CaCl_2$ and $MgCl_2$ to obtain different degrees of Ca and Mg saturation. The studied ranges of Ca and Mg saturation ratios were 81:19, 70:30, 52:48, 55:45, and 31:69 in terms of the ratio of exchangeable Ca and Mg. Two levels of K application (90kg/ha, and 180kg/10a as $K_2O$) were also included in this study. The significant observation were summarized as follows. 1. When the Ca saturation of soil was dominant over Mg, the soil solution contained more Ca than Mg and vice versa. These led to the higher uptake of Ca by rice plant in Ca dominant soils and higher uptake of Mg in Mg dominant soils. 2. When the Ca and Mg saturation ratio was about equal, more Mg was released to soil solution leading to higher concentration of Mg in rice plant compare to that of Ca. 3. A trend was observed that the concentration of K in soil solution was lower in Mg dominant soils than in Ca dominant soils. This also resulted in the depressed uptake of K by rice plant under Mg dominant system when compare to Ca dominant system. 4. The increase application of K led to the increase in relative concentration of K to (Ca+Mg+K), and to the depression of divalent uptake by rice plant. However, it was observed that the degree of depression in uptake divalent by K application was more sensitive in case of Mg than that of Ca. 5. When viewed from grain yield of rice, it is pointed out that the optimum range of Ca to Mg ratio in soil may fall in the vicinity of 7:3. 6. Although K uptake by rice plant was influenced by the term of $AK^+/{\sqrt{A(Ca^{{+}{+}}+Mg^{{+}{+}})$ in soil solution, $AK^+$ itself was affected by the ratios of Ca:Mg in soil, as it were $AK^+$ value was decreased in Mg dominant soil than in Ca.

• Korean Journal of Soil Science and Fertilizer
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• v.22 no.4
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• pp.257-264
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• 1989

In order to study spatial variability of soil chemical properties across the land-partitioned boundary on Hwadong silt clay loam soil (Fine clayey, mixed, mesic family of Aquic Hapludalfs) in the experimental fie ld of the wheat and Barley Research Institute in Suwon, all measured data were analyzed by means of kriging, fractile diagram, smooth frequency distribution, and autocorrelation. Sampling for soil chemical property analysis was made at 225 intersections of 15x 15 grid with 10m interval from three soil depths (0-10cm, 25-35cm, 50-60cm) in the seven patitioned fields. 1. The coefficient of variance (CV) of various chemical properties varied from 5.4 to 72.7%. Soil pH was classified into the low variation group with CV smaller than 10%, while the other chemical properties belonged to the medium variation group with C.V. between 10 and 100% 2. The approximate number of soil samples for the determination of various chemical properties with error smaller than 10% were two for pH, ten for CEC, 15 for exchangeable Ca, 32 for total nitrogen content, 39 for exchangeable Mg, 40 for exchangeable K, 61 for exchangeable Na, 82 for organic matter content, 212 for available phosphate,. 3. Smooth frequency distribution and fractile diagram showed that available phosphate was in log-normal distribution while others were in normal distribution. 4. Serial correlation analysis revaled that the soil chemical properties had spatial dependence between two nearest neighbouring grid points. Autocorrelation analysis of chemcial properties measured between the serial grid points in the direction of south to north following land-partitioned boundary showed that the zone of influence showing stationarity ranged from 20 to 50m. In the direction of east to west accross land-partitioned boundary, the autocorrelogram of many chemical properies showed peaks with the periodic interval of 30m, which were similar to the partitioned land width. This reveals that the land-partitioned boundary causes soil variability.