• Journal of Animal Science and Technology
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• 제52권6호
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• pp.467-473
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• 2010

A total of 4,323,781 records for informal 16 primary linear descriptive traits of dairy cows in Holstein breed from 1988 to 2007 in USA were analyzed to estimate adjustment factors for lactation number and stage. While all factors in the model were highly significant (P < 0.01), major influences on linear type traits were due to lactation number and stage. The frequencies of lactation number 1 through 6 were 58.6, 22.0, 11.8, 4.8, 2.1, and 0.8%, respectively. Further, the frequencies of lactation stage were 0.7, 76.9, 15.3, 4.9, and 2.1%, respectively, for springing, early, medium, late, and dry. To adjust 16 linear traits (stature, dairy form, strength, body depth, rump width, rump angle, legs rear view, leg set, foot angle, fore udder, rear udder height, rear udder width, udder support, udder depth, and front teat placement), additive and multiplicative adjustment factors of lactation number (lactations 2 to 4) and stage (springing, medium, late and dry) were estimated with the solutions in the generalized linear model, assigning lactation 1 and stage early as base class. Additive adjustment factors of lactation number ranged from -1.23 to 2.908, while multiplicative factors ranged from 0.853 to 2.207. Further, additive and multiplicative adjustment factors for lactation stage ranged from -0.668 to 0.785, and from 0.891 to 1.154. Application of adjustment factors to 20 randomly sampled sub-data sets produced the results that additive adjustment factors for both lactation number and stage reduced more mean square of lactation number and stage over 16 linear traits than any combination of adjustments, and leaded additive adjustment factors for both lactation number and stage as a choice of methods for adjustment of informal 16 primary linear type traits collected by classifiers of AI studs.

• 한국직업건강간호학회지
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• 제25권3호
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• pp.238-248
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• 2016

Purpose: The purpose of this empirical research was to describe the contents what had happened to nurses experiencing taeoom. Methods: This study explored the phenomenological ways to understand lived experiences in nurses' 'Taeoom' and investigated the 'Taeoom' through the deductive content analysis. For the this study, the data was collected through individual interviews with 11 nurses who worked over 12months in 1 hospital, lived in 5 areas, working 7 nursing unit of 10 hospitals. The interviews conducted by semi structured questions about participants' lived experiences in 'Taeoom'. Results: Inductive contents analysis identified 5 categories and 15 subcategories. Main themes in this study included a failed membership, difficult of practical field adaptation, feared with nursing unit life, self-centered peer relationships and rite of passage. Conclusion: This study results have been illuminated with edged sword which has a dark side and a light side to experienced in 'Taeoom'. Newly employed nurses have suffering from 'Taeoom' as well as retained nurse. Therefore, policy and practice programs for a diminution of suffering and management for nurses 'Taeoom' should be developed and implemented.

• 한국임상약학회지
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• 제22권3호
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• pp.202-210
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• 2012

Methoxy polyethylene glycol-epoetin beta (MPG-EPO), a continuous erythropoietin receptor activator, is a new erythropoiesis-stimulating agent with a long half-life. The purpose of this prospective study is to assess the effects of once-monthly subcutaneous MPG-EPO on hematological responses and nutritional status in peritoneal dialysis patients. Forty four patients undergoing stable peritoneal dialysis were enrolled into the study. Darbepoetin alfa therapy, in peritoneal dialysis patients, was converted to the monthly administration of subcutaneous MPG-EPO for 6 months. The starting dose of MPG-EPO was based on the previous weekly dose of darbepoetin alfa. The dose adjustments were performed to maintain the hemoglobin (Hb) levels in a target range of 10.5-11.0 g/dL. If the Hb levels exceeded 11.0 g/dL, MPG-EPO was temporarily interrupted for 1 month. The mean Hb levels were stable with the values of $9.5{\pm}1.1$ g/dL at baseline, and $10.4{\pm}0.9$ g/dL at the 6th month after conversion. The mean differences in the changes of Hb levels between the baseline and the 6th month were $0.9{\pm}1.4$ g/dL, which was statistically significant. However, the mean differences of iron, transferrin saturation and ferritin concentrations were not significant. It did not show significant differences in the changes of the nutritional parameters. These results suggest that the once-monthly subcutaneous administration of MPG-EPO for 6 months effectively maintains the Hb levels and nutritional status in peritoneal dialysis patients. Taken together, the once-monthly subcutaneous administration of MPG-EPO was practical and might improve the clinical compliance for the management of renal anemia in peritoneal dialysis patients.

• The Korean Journal of Pain
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• 제29권4호
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• pp.239-248
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• 2016

Background: The present study was undertaken to evaluate the incidence of chronic persistent post-surgical pain (CPPP) and the role of signal transduction genes in patients undergoing staging laparotomy for carcinoma ovary. Methods: The present observational study was undertaken following institutional ethical committee approval and informed consent from all the participants. A total 21 patients of ASA grade I to III with age 20-70 years, scheduled for elective staging laparotomy for carcinoma ovary were included. Patients were excluded if had other causes of pain, cognitive dysfunction or chronic neurological disorders. Statistical analysis of pool data was done using SPSS version-17. For various scales like GPE, PDQ, NPSI, the visual analogue scale (VAS), global perceived effect (GPE), the pain DETECT questionnaire (PDQ), and neuropathic pain symptoms inventory (NPSI), one factor repaeted measure ANOVA applied with simple contrast with baseline as on post-operative day 1 (considered as reference and compared with subsequent time-interval), and the P values were adjusted according to "Bonferroni adjustments". In patients with CPPP, the ${\Delta}ct$ values of mRNA expressions of genes at the end of postoperative day 90 were compared with the baseline control values by one factor repeated ANOVA. P value < 0.005 significant. Results: The present study demonstrates 38.1% (8 out of 21 patients) incidence of CPPP. The functional status and quality of life as were observed to be significantly diminished in all patients with chronic pain. An up-regulation in the mRNA expression of signal transduction and a positive correlation was noted between the mRNA expression of signal transduction genes and VAS score in all patients with CPPP at the end of postoperative day 90. Conclusions: The reported incidence of CPPP in patients with carcinoma ovary was 38.1%. An up-regulation and positive correlation between mRNA expression of signal transduction genes and VAS score depicts its potential role in the pathogenesis of CPPP.

• 생명과학회지
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• 제33권12호
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• pp.1046-1051
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• 2023

본 연구의 목적은 개인의 흡연여부와 다양한 사회경제적 변수 간 영향관계가 성별과 장애여부에 따라 구분된 하위집단에서 차별적으로 나타나는지를 확인하는데 있다. 특히 본 연구는 일반인의 흡연 여부가 아니라 장애인을 대상으로 흡연의 여부가 장애인의 건강에 미치는 영향을 분석한 연구로 연구의 의의가 있다고 볼 수 있다. 본 연구에서는 장애인의 흡연율과 흡연 요인을 분석하는데 목적이 있다. WHO에 따르면 담배로 인한 사망자는 매년 600만명에 이른다. 담배는 심혈관질환, 폐질환, 암 등 비전염성질환과 조기 사망에 매우 강한 인과관계를 갖는 것으로 알려져 있다. UN이 제시한 지속가능 발전목표(Sustainable Development Goals, 이하 SDGs)는 건강한 삶의 보장과 모든 세대의 복지 증진(Ensure healthy lives and promote well-being for all at all ages)을 위해 WHO의 담배규제기본협약(Framework Convention on Tobacco Control)을 이행할 것을 요구하고 있다. 이것은 흡연의 모든 과정에서 발생하는 다양한 위협요인이 흡연자뿐만 아니라 경제, 사회, 환경 등 다양한 영역에서 다차원적으로 작용하는 위협하기 때문이다. 본 연구목적의 달성을 위해 본 연구는 2013년 국민건강영양조사를 활용하여 흡연과 선행연구에서 확인된 흡연 영향요인 간 인과관계를 확인하였다. 본 연구를 위하여 특히 성별과 장애여부에 따라 구분된 4개의 하위집단을 독립적 모형으로 하여 분석하였으며 흡연여부를 종속변수로 하는 로지스틱회귀분석을 활용하였다. 본 연구 분석결과 독립변수의 영향력 여부는 성별과 장애유무에 따라 구분된 각 집단별로 뚜렷한 차이를 나타내는 것이 확인되었다. 상대적으로 비장애집단에서 독립변수의 영향이 유의한 반면 장애집단에서는 유의성이 상실되는 경향을 보였으며 이 같은 경향은 특히 장애여성집단에서 더욱 명백하게 확인되었다. 분석결과를 기반으로 장애집단의 특성을 고려하지 않은 기존의 선행연구가 가진 설명의 한계를 확인하였으며 장애의 물리적·심리적 특수성을 충분히 고려한 연구모형을 통해 흡연과의 상관관계를 재분석해야 함을 함의로 제시하였다. 추후 장애인의 건강한 삶의 질을 개선하기 위하여 건강증진 영향들을 분석한 이후 건강증진에 기여할 수 있는 대표적인 변인들을 고려하여 적용하는 다양한 연구들이 수행되어져야 할 것으로 여겨진다.

• 생명과학회지
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• 제29권2호
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• pp.265-271
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• 2019

일반적으로 요중 카드뮴 농도는 요비중 또는 요중 크레아티닌 농도로 보정한 값을 사용해왔다. 그러나 어떤 보정방법이 더 타당한지에 대한 논란은 계속되고 있다. 본 연구에서는 비교적 큰 규모의 일반인구집단을 대상으로 요중 카드뮴농도와 각종 신장손상지표들과의 관련성을 평가함에 있어 요비중 보정 방법과 요중 크레아티닌 보정 방법 중 어느 방법이 더 타당한지 비교 평가하였다. 1,086명의 자원자 중 신장질환의 질병력이 있는 사람을 제외한 862명이 최종적으로 연구대상에 포함되었다. 대상자들로부터 측정한 요중 카드뮴 농도 및 malondialdehyde (MDA), N-acetyl-${\beta}$-D-glucosaminidase 농도, 혈중 크레아티닌을 이용하여 산출한 사구체여과율 등의 신장손상지표들간의 관련성을 평가하였다. 연구 결과, 요중 크레아티닌 농도보다는 요비중으로 보정한 카드뮴 농도가 각종 신장손상지표와 높은 상관성이 있음을 보여주었다. 특히, 요비중 보정 카드뮴 농도는 요중 MDA 농도와 양의 상관관계를, 사구체여과율과는 음의 상관관계를 보여주었다. 이러한 결과는 일반인구집단에서 카드뮴 노출이 많아질수록 사구체여과율이 감소함을 의미하며 이러한 기전에서 산화적스트레스가 관여하고 있음을 보여준다. 또한, 사구체여과율이 카드뮴 노출에 의한 유용한 신장손상지표 중 하나로 사용될 수 있음을 의미한다.