• Molecules and Cells
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• 제23권1호
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• pp.88-93
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• 2007

Neuropeptide Y (NPY) is an orexigenic and hypothermic peptide. To understand its role in hypothermic conditions, male rats were placed in a $24^{\circ}C$ or $4^{\circ}C$ air chamber for 1.5 h. The expression of c-Fos protein, and NPY mRNA and protein, was analyzed in the hypothalamus 1 h-2 h later. The cold treatment increased the number of c-Fos-immunoreactive cells in the paraventricular hypothalamic nucleus (PVN) and arcuate nucleus (ARC). At the same time it decreased the density of NPY-immunoreactive components in the PVN, dorsomedial hypothalamic nucleus and ARC, as well as of NPY transcripts in the PVN and ARC. No colocalization of c-Fos with NPY was detected. These results suggest that short-term cold exposure should reduce indirectly NPY production in some hypothalamic nuclei to facilitate thermogenesis without inducing feeding behavior.

• 전기학회논문지P
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• 제67권2호
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• pp.106-111
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• 2018

Recently, due to the effect of global warming, the high temperature phenomenon continues, and the time for workers exposed to high temperature, cold and infrared is increasing and then safety is threatened. Due to the nature of on-site work, the work is being carried out in an unreasonable manner due to the process, which is exposed to disasters due to high temperature and cold. Even though the injured skin may be damaged, the worker may not be aware of it and may be injured. By understanding the working environment of the worker and calculating the risk index and expressing it on the helmet, the surrounding colleagues inform the worker of the risk and take appropriate measures so that the accident can be prevented in advance. This study was conducted to investigate the effect of exposure duration on the workers' by measuring the exposure time, the risk index is displayed in the form of a traffic light to the helm, informing neighboring workers and managers, and transmitting to the workers by voice.

• Nuclear Engineering and Technology
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• 제55권11호
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• pp.4181-4190
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• 2023

Nuclear power plants are subjected to various processes during decommissioning, including cutting, decontamination, disposal, and treatment. The cutting of massive bio-shields is a significant step in the decommissioning process. Cutting is performed near the target structure, and during this process, workers are exposed to potential radioactive elements. However, studies considering worker exposure management during such cutting operations are limited. Furthermore, dismantling a nuclear power plant under certain circumstances may result in the unnecessary radiation exposure of workers and an increase in secondary waste generation. In this study, a cutting scenario was formulated considering the bio-shield as a representative structure. The specifications of a standard South Korean radioactive waste disposal drum were used as the basic conditions. Additionally, we explored the hot-to-cold and cold-to-hot methods, with and without the application of polishing during decontamination. For evaluating various scenarios, different cutting time points up to 30 years after permanent shutdown were considered, and cutting speeds of 1-10nullm²/h were applied to account for the variability and uncertainty attributable to the design output and specifications. The obtained results provide fundamental guidelines for establishing cutting methods suitable for large structures.

• Pediatric Infection and Vaccine
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• 제5권2호
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• pp.302-307
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• 1998

Hemolytic anemia due to cold agglutinin disease is a known complication of Mycoplasma pneumoniae infection but is rarely observed, particularly in children. A case of Mycoplasma pneumonia complicated with hemolytic anemia is presented. A 7 year-old girl was adimitted because of fever, cough, sputum and pale appearance. Chest X-ray showed pneumonic consolidation of Rt. upper lobe, lingular division. Laboratory studies disclosed the following values : Hb 5.3g/dL, Hct 11.1%, reticulocyte 2.9%, indirect Coombs test negative, direct Coombs test(monovalent) Anti-C3d positive, Anti-IgG negative, Anti-IgM negative, cold agglutinin titer 1 : 256, mycoplasma antibody titer 1 : 640, total bilirubin 1.0mg/dL. Initial PBS before wanning showed agglutination of red blood cells. The diagnosis of cold agglutinin hemolytic anemia complicating mycoplasma pneumonia was made. And treatment with roxithromycin, prednisolone and avoiding cold exposure was initiated, and complete recovery ensued. We report a case of cold agglutinin hemolytic anemia complicating mycoplasma pneumonia in children.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.259-259
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• 1994

Protein kinase C (PKC) participates in many cellular signal transduction. Previously we found that PKC activity of whole rat brain was altered after an exposure to cold temperature of 4 $^{\circ}C$ (Lee and Choi, Exp. Neurobiol., 2, 6, 1993). In this time PKC activity in each region of rat brain was investigated in order to know each regions is affected mostly by the stress.

• 원예과학기술지
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• 제32권5호
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• pp.607-613
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• 2014

Calcium has been associated with improved cold tolerance in many crops. The aim of this study was to investigate the changes in leaf cell $Ca^{2+}$ distribution and cell organelle ultrastructure of loquat (Eriobotrya japonica Lindl.) plants in response to cold stress at $-3^{\circ}C$, using transmission electron microscopy (TEM). Two loquat accessions, Zaozhong 6 (a commercial cultivar) and oakleaf loquat (a wild relative) were used. Cold tolerance, as measured by leaf browning rate, was higher in oakleaf plants, and calcium treatment improved cold tolerance in both species. Cold stress first induced inward transport of $Ca^{2+}$ from the intracellular space. Then, the imported $Ca^{2+}$ was aggregated around the chloroplast membrane, finally entering the chloroplast. This pattern of $Ca^{2+}$ distribution in leaf cells occurred earlier in Zaozhong 6 than in the wild loquat. With increasing time of cold exposure, the chloroplast membranes of Zaozhong 6 leaves were damaged, blurred and even disappeared, while those of wild oakleaf loquat leaves maintained their structure longer. In Zaozhong 6, cold stress induced a clear cavity between poorly structured granal thylakoids and vesicles appearing inside the chloroplast, while in oakleaf leaves cold stress had little effect on the ultrastructure of chloroplasts (although chloroplast membranes looked blurred). Loquat leaves accumulated free calcium ions around chloroplasts in response to cold stress, with earlier calcium accumulation occurring in the cold-sensitive cultivar Zaozhong 6 than in wild oakleaf loquat. These results demonstrate that these two loquat species have differences in both cold tolerance and calcium accumulation dynamics.

• 한국농림기상학회지
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• 제18권3호
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• pp.99-108
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• 2016

최근 겨울 기온이 상승하면서 밀의 파종시기가 변화되고 있다. 겨울 밀의 경우, 파성 소거에 필요한 저온 노출지속기간이 충족되지 않으면 출수뿐만 아니라 생육이 불안정해질 수 있다. 한국의 농촌진흥청 국립식량과학원은 국제옥수수밀 연구소의 멕시코 톨루카에서 한국의 기후에 맞는 밀 육종을 위해 1996년 이후 지속적으로 밀 적응시험을 수행해 왔다. 그러나 톨루카의 최근 겨울기후가 상승하는 등 이상기후 발생에 의해 밀 파종시기 및 생육에 변화가 발생하였고 이에 따라 우리나라 겨울 밀의 육종 및 적응시험 전략의 변화가 필요하여 이를 위한 기초자료를 제공하고자 본 연구를 수행하였다. 2013년과 2014년에 파종된 CIMMYT 교배 품종과 우리나라 겨울 밀 교배 품종의 출수생태를 그룹별(II and III) 저온 노출지속기간의 변화와 결합하여 파종시기의 변화에 따른 저온 노출지속기간과 출수율에 미치는 영향을 분석하였다. 2013년 11월 6일, 22일, 12월 6일로 3회 파종시기에서 11월 6일에 파종한 것은 저온 노출지속기간은 충분히 충족되지 않았고, 14일 이후인 11월 22일과 12월 6일에는 저온 노출지속기간이 충족되었다. 그러나 2014년 11월 5일과 20일에 파종한 경우는 저온 노출지속기간이 충족되었고, 오히려 12월 5일에 파종한 것에서 저온 노출지속기간이 충족되지 않았다. 이것은 2012년 이후 11월에 빈번한 고온 발생에 의해 11월 파종 후 저온 노출지속기간을 충족시키지 못했던 반면, 2014년 11월 일별 최저기온은 $3.0^{\circ}C$ 미만으로, 11월 파종 후에도 저온 노출지속기간을 충족할 수 있는 기후환경이 유지되었기 때문인 것으로 판단된다. 또한, 우리나라 겨울 밀의 품종 개량 및 적응시험에서 춘파성인 그룹 II는 3회 파종시기 변경에 따라 출수율의 증감 차이가 확실하지 않았는데, 추파성인 그룹 III는 파종시기별 출수율이 뚜렷하게 나타나서 추파성인 그룹 III가 파종시기 이동에 더 민감할 것으로 판단되어 shuttle breeding의 효과가 더 클 것으로 보인다. 또한, 가까운 미래 기후변화 시나리오 전망에 적용한 결과, 톨루카에서 그룹 II의 미래 적정 파종시기는 예측되었지만, 그룹 III에서는 미래 적정 파종시기를 아예 예측할 수 없었기 때문에 추파성인 그룹 III에 대한 shuttle breeding 에는 이러한 점이 고려되어야 할 것으로 판단된다.

• 한국산학기술학회논문지
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• 제21권8호
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• pp.60-66
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• 2020

본 연구에서는 화학사고 및 화학테러 대응 시 화학물질로부터 인명 및 환경을 보호하기 위한 경계구역 설정에 관하여 국·내외 사례 조사를 바탕으로 우리나라 실정에 적합한 경계구역 선정 개선방안을 제시하고자 하였다. 현재 다양한 관계부처에서는 공통적으로 hot zone, warm zone, cold zone으로 구분하여 사용 중이나 특정 지역에 대해서는 용어 활용 측면에서 상이한 의미로 혼용되고 있다. 따라서 경계구역을 기존 3개 지역에서 hot zone, warm zone, cold zone, safety zone 4개 지역으로 구분하여 활용할 것을 제시하였다. 그리고 warm zone을 관심지역, safety zone을 안전지역으로 용어를 정립하도록 한다. 기존에 적용하던 ERPG 급성노출기준은 다양한 노출시간을 고려하지 않기 때문에 장시간 노출상황 적용에 적합하지 않으므로 적용 우선순위를 AEGL, ERPG, PAC, IDLHs 순으로 하도록 한다. CARIS 정보제공 방안은 확산평가가 가능한 물질 또는 불가능한 물질이거나 실내누출 상황으로 구분하고 풍향신뢰선과 ERG의 초기이격거리 및 방호활동거리를 함께 표현하여 현장대응 및 주민대피 결정 정보자료로 활용될 수 있도록 한다.

• 동의생리병리학회지
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• 제21권6호
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• pp.1407-1410
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• 2007

We designed to investigate the relationship the cold-hot theory of herbology and body temperature in experimental model. we prepared four kinds of oriental medicine, which consisted of two cold herbs, Daehwang and Seokgo, and two hot herbs, Buja and Padu. Decrease of body temperature by cold exposure for 12 hour was not inhibited by four herbs oral administration for two weeks. Thermogenesis in mammals is an essential physiological function to maintain the body temperature. Mitochondrial uncoupling proteins(UCPs), which have a potential to generate heat by uncoupling oxidative phosphorylation, apper to play a crucial role in thermogenesis. Therefore UCP is commonly recognized as a key molecule in metabolic thermogenesis and its dysfunction contributes to the development of obesity. In these experiments, Daehwang water extracts inhibited the UCP1 mRNA expression increase by cold exposure in brown adipose tissue. But other herbs did not significantly influence on UCPs mRNA expression in white adipose tissue and seleus muscle tissue. Based on this experiment, we will try to clarify the effects of Daehwang water extracts on UCP1 expression and function.

• 한국양식학회지
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• 제10권2호
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• pp.189-197
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• 1997

A series of short (8 hours) and long term (96 hours) exposure studies was conducted on a laboratory scale to evaluation (1) the threshold concentrations of petroleum hydrocarbon in seawater which can lead to tainting problems in yellow tail (Seriola quinqueradiata) and (2) the time to recover (depuration period) once the tainting has occurred. The water-soluble fraction (WSF) of crude oil was prepared by stirring the oil with cold seawater. The main component of the WSF were low-boiling aromatics, although these were only al small proportion of the starting oil. From the sencory evaluation it was concluded that the threshold hydrocarbon levels in seawater which will impart a taint in yellow tail fillets within a 8-hour exposure period (short exposure period) are in the range of 0.4 to 1.0 ppm and within a 96-hour exposure period (long exposure period) are in the range of 0.2 to 0.5 ppm. Depuration trials were carried out with WSF from crude oil. The fish were exposed for 48 hours to concentration of 2.5 ppm hydrocarbons. After 48-hour exposure period, the fish were allowed to depurate in fresh, uncontaminated seawater. Depuration time for these fish was 10 days. The taste panelists were able to detect the contaminated fillets very easily while the depurated fish could not be distiguished from the control.