• Archives of Pharmacal Research
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• v.10 no.2
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• pp.100-102
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• 1987

Inhibition of platelet aggregation by colchicine, thiocolchicine, O-demethylated and 3-glucosidic congeners was measured in vitro. 2-And 3-demethylated analogs of colchicine and thiocolchicine were found tobe as potent as colchicine and thiocolchicine, respectively, whereas 1-demethylated compounds were found to be considerably less active. Both glucosides, colchicoside and thiocolchicoside, were not very active in this assay. 2, 3-Didemethylcolchicine, which is much less toxic than colchicine, showed similar inhibitory effects on platelet aggregation as colchicine.