• 제목/요약/키워드: Cohort study

검색결과 1,742건 처리시간 0.034초

ZNF492 and GPR149 methylation patterns as prognostic markers for clear cell renal cell carcinoma: Array-based DNA methylation profiling

  • Yong‑June Kim;Wooyeong Jang;Xuan‑Mei Piao;Hyung‑Yoon Yoon;Young Joon Byun;Ji Sang Kim;Sung Min Kim;Sang Keun Lee;Sung Pil Seo;Ho Won Kang;Won Tae Kim;Seok Joong Yun;Ho Sun Shon;Keun Ho Ryu;Sang Won Kim;Yun‑Sok Ha;Ghil Suk Yoon;Sang‑Cheol Lee;Tae Gyun Kwon;Wun‑Jae Kim
    • Oncology Letters
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    • 제42권1호
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    • pp.453-460
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    • 2019
  • The present study aimed to identify novel methylation markers of clear cell renal cell carcinoma (ccRCC) using microarray methylation analysis and evaluate their prognostic relevance in patient samples. To identify cancer-specific methylated biomarkers, microarray profiling of ccRCC samples from our institute (n=12) and The Cancer Genome Atlas (TCGA) database (n=160) were utilized, and the prognostic relevance of candidate genes were investigated in another TCGA dataset (n=153). For validation, pyrosequencing analyses with ccRCC samples from our institute (n=164) and another (n=117) were performed and the potential clinical application of selected biomarkers was examined. We identified 22 CpG island loci that were commonly hypermethylated in ccRCC. Kaplan-Meier analysis of TCGA data indicated that only 4/22 loci were significantly associated with disease progression. In the internal validation set, Kaplan-Meier analysis revealed that hypermethylation of two loci, zinc finger protein 492 (ZNF492) and G protein-coupled receptor 149 (GPR149), was significantly associated with shorter time-to-progression. Multivariate Cox regression models revealed that hypermethylation of ZNF492 [hazard ratio (HR), 5.44; P=0.001] and GPR149 (HR, 7.07; P<0.001) may be independent predictors of tumor progression. Similarly, the methylation status of these two genes was significantly associated with poor outcomes in the independent external validation cohort. Collectively, the present study proposed that the novel methylation markers ZNF492 and GPR149 could be independent prognostic indicators in patients with ccRCC.

Korean Multicenter Registry of ELUVIA Stent for Femoropopliteal Artery Disease: K-ELUVIA Registry

  • Joongmin Kim;Young-Guk Ko;Seung-Jun Lee;Chul-Min Ahn;Seung-Woon Rha;Cheol Ung Choi;Pil-Ki Min;Jong Kwan Park;Ji-Yong Jang;Young Jin Youn;Tae-Soo Kang;Chang-Hwan Yoon;Donghoon Choi
    • Korean Circulation Journal
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    • 제54권9호
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    • pp.565-576
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    • 2024
  • Background and Objectives: The K-ELUVIA study aimed to investigate the clinical effectiveness and safety of EluviaTM, a polymer-coated, paclitaxel-eluting stent, for femoropopliteal artery disease using data from a prospective Korean multicenter registry. Methods: A total of 105 patients with femoropopliteal artery disease who received endovascular treatment (EVT) with EluviaTM stents at 7 Korean sites were enrolled in a prospective cohort and followed for 2 years. The primary endpoint was the 2-year clinical patency. The secondary endpoint was 2-year freedom from clinically driven target lesion revascularization (TLR). Results: Mean patient age was 68.2±10.4 years, and most patients (82.7%) were male. Mean lesion length was 168.3±117.6 mm. Chronic total occlusion was found in 57.7% of patients. Trans-Atlantic Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II) type C or D lesions were present in 46.1% of patients. Procedural success was achieved in 99.0% of patients. The clinical patency rate was 84.4% at 1 year after EVT and 76.3% at 2 years post-EVT. The freedom from TLR rate was 89.1% at 1 year after EVT and 79.1% at 2 years post-EVT. Chronic total occlusion (hazard ratio [HR], 3.53; 95% confidence interval [CI], 1.08-11.67; p=0.039) and smaller mean stent diameter (HR, 0.40; 95% CI, 0.16-0.98; p=0.044) were identified as independent predictors of loss of clinical patency at 2 years. Conclusions: The K-ELUVIA study demonstrated favorable 2-year clinical effectiveness and safety outcomes of Eluvia stent for femoropopliteal artery lesions in real-world practice.

The Third Nationwide Korean Heart Failure III Registry (KorHF III): The Study Design Paper

  • Minjae Yoon;Eung Ju Kim;Seong Woo Han;Seong-Mi Park;In-Cheol Kim;Myeong-Chan Cho;Hyo-Suk Ahn;Mi-Seung Shin;Seok Jae Hwang;Jin-Ok Jeong;Dong Heon Yang;Jae-Joong Kim;Jin Oh Choi;Hyun-Jai Cho;Byung-Su Yoo;Seok-Min Kang;Dong-Ju Choi
    • International Journal of Heart Failure
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    • 제6권2호
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    • pp.70-75
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    • 2024
  • With advancements in both pharmacologic and non-pharmacologic treatments, significant changes have occurred in heart failure (HF) management. The previous Korean HF registries, namely the Korea Heart Failure Registry (KorHF-registry) and Korean Acute Heart Failure Registry (KorAHF-registry), no longer accurately reflect contemporary acute heart failure (AHF) patients. Our objective is to assess contemporary AHF patients through a nationwide registry encompassing various aspects, such as clinical characteristics, management approaches, hospital course, and long-term outcomes of individuals hospitalized for AHF in Korea. This prospective observational multicenter cohort study (KorHF III) is organized by the Korean Society of Heart Failure. We aim to prospectively enroll 7,000 or more patients hospitalized for AHF at 47 tertiary hospitals in Korea starting from March 2018. Eligible patients exhibit signs and symptoms of HF and demonstrate either lung congestion or objective evidence of structural or functional cardiac abnormalities in echocardiography, or isolated right-sided HF. Patients will be followed up for up to 5 years after enrollment in the registry to evaluate long-term clinical outcomes. KorHF III represents the nationwide AHF registry that will elucidate the clinical characteristics, management strategies, and outcomes of contemporary AHF patients in Korea.

가족계획과 모자보건 통합을 위한 조산원의 투입효과 분석 -서산지역의 개입연구 평가보고- (An Intervention Study on Integration of Family Planning and Maternal/Infant Care Services in Rural Korea)

  • 방숙;한성현;이정자;안문영;이인숙;김은실;김종호
    • Journal of Preventive Medicine and Public Health
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    • 제20권1호
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    • pp.165-203
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    • 1987
  • This project was a service-cum-research effort with a quasi-experimental study design to examine the health benefits of an integrated Family Planning (FP)/Maternal & Child health (MCH) Service approach that provides crucial factors missing in the present on-going programs. The specific objectives were: 1) To test the effectiveness of trained nurse/midwives (MW) assigned as change agents in the Health Sub-Center (HSC) to bring about the changes in the eight FP/MCH indicators, namely; (i)FP/MCH contacts between field workers and their clients (ii) the use of effective FP methods, (iii) the inter-birth interval and/or open interval, (iv) prenatal care by medically qualified personnel, (v) medically supervised deliveries, (vi) the rate of induced abortion, (vii) maternal and infant morbidity, and (viii) preinatal & infant mortality. 2) To measure the integrative linkage (contacts) between MW & HSC workers and between HSC and clients. 3) To examine the organizational or administrative factors influencing integrative linkage between health workers. Study design; The above objectives called for quasi-experimental design setting up a study and control area with and without a midwife. An active intervention program (FP/MCH minimum 'package' program) was conducted for a 2 year period from June 1982-July 1984 in Seosan County and 'before and after' surveys were conducted to measure the change. Service input; This study was undertaken by the Soonchunhyang University in collaboration with WHO. After a baseline survery in 1981, trained nurses/midwives were introduced into two health sub-centers in a rural setting (Seosan county) for a 2 year period from 1982 to 1984. A major service input was the establishment of midwifery services in the existing health delivery system with emphasis on nurse/midwife's role as the link between health workers (nurse aids) and village health workers, and the referral of risk patients to the private physician (OBGY specialist). An evaluation survey was made in August 1984 to assess the effectiveness of this alternative integrated approach in the study areas in comparison with the control area which had normal government services. Method of evaluation; a. In this study, the primary objective was first to examine to what extent the FP/MCH package program brought about changes in the pre-determined eight indicators (outcome and impact measures) and the following relationship was first analyzed; b. Nevertheless, this project did not automatically accept the assumption that if two or more activities were integrated, the results would automatically be better than a non-integrated or categorical program. There is a need to assess the 'integration process' itself within the package program. The process of integration was measured in terms of interactive linkages, or the quantity & quality of contacts between workers & clients and among workers. Intergrative linkages were hypothesized to be influenced by organizational factors at the HSC clinic level including HSC goals, sltrurture, authority, leadership style, resources, and personal characteristics of HSC staff. The extent or degree of integration, as measured by the intensity of integrative linkages, was in turn presumed to influence programme performance. Thus as indicated diagrammatically below, organizational factors constituted the independent variables, integration as the intervening variable and programme performance with respect to family planning and health services as the dependent variable: Concerning organizational factors, however, due to the limited number of HSCs (2 in the study area and 3 in the control area), they were studied by participatory observation of an anthropologist who was independent of the project. In this observation, we examined whether the assumed integration process actually occurred or not. If not, what were the constraints in producing an effective integration process. Summary of Findings; A) Program effects and impact 1. Effects on FP use: During this 2 year action period, FP acceptance increased from 58% in 1981 to 78% in 1984 in both the study and control areas. This increase in both areas was mainly due to the new family planning campaign driven by the Government for the same study period. Therefore, there was no increment of FP acceptance rate due to additional input of MW to the on-going FP program. But in the study area, quality aspects of FP were somewhat improved, having a better continuation rate of IUDs & pills and more use of effective Contraceptive methods in comparison with the control area. 2. Effects of use of MCH services: Between the study and control areas, however, there was a significant difference in maternal and child health care. For example, the coverage of prenatal care was increased from 53% for 1981 birth cohort to 75% for 1984 birth cohort in the study area. In the control area, the same increased from 41% (1981) to 65% (1984). It is noteworthy that almost two thirds of the recent birth cohort received prenatal care even in the control area, indicating that there is a growing demand of MCH care as the size of family norm becomes smaller 3. There has been a substantive increase in delivery care by medical professions in the study area, with an annual increase rate of 10% due to midwives input in the study areas. The project had about two times greater effect on postnatal care (68% vs. 33%) at delivery care(45.2% vs. 26.1%). 4. The study area had better reproductive efficiency (wanted pregancies with FP practice & healthy live births survived by one year old) than the control area, especially among women under 30 (14.1% vs. 9.6%). The proportion of women who preferred the 1st trimester for their first prenatal care rose significantly in the study area as compared to the control area (24% vs 13%). B) Effects on Interactive Linkage 1. This project made a contribution in making several useful steps in the direction of service integration, namely; i) The health workers have become familiar with procedures on how to work together with each other (especially with a midwife) in carrying out their work in FP/MCH and, ii) The health workers have gotten a feeling of the usefulness of family health records (statistical integration) in identifying targets in their own work and their usefulness in caring for family health. 2. On the other hand, because of a lack of required organizational factors, complete linkage was not obtained as the project intended. i) In regards to the government health worker's activities in terms of home visiting there was not much difference between the study & control areas though the MW did more home visiting than Government health workers. ii) In assessing the service performance of MW & health workers, the midwives balanced their workload between 40% FP, 40% MCH & 20% other activities (mainly immunization). However, $85{\sim}90%$ of the services provided by the health workers were other than FP/MCH, mainly for immunizations such as the encephalitis campaign. In the control area, a similar pattern was observed. Over 75% of their service was other than FP/MCH. Therefore, the pattern shows the health workers are a long way from becoming multipurpose workers even though the government is pushing in this direction. 3. Villagers were much more likely to visit the health sub-center clinic in the study area than in the control area (58% vs.31%) and for more combined care (45% vs.23%). C) Organization factors (admistrative integrative issues) 1. When MW (new workers with higher qualification) were introduced to HSC, it was noted that there were conflicts between the existing HSC workers (Nurse aids with less qualification than MW) and the MW for the beginning period of the project. The cause of the conflict was studied by an anthropologist and it was pointed out that these functional integration problems stemmed from the structural inadequacies of the health subcenter organization as indicated below; i) There is still no general consensus about the objectives and goals of the project between the project staff and the existing health workers. ii) There is no formal linkage between the responsibility of each member's job in the health sub-center. iii) There is still little chance for midwives to play a catalytic role or to establish communicative networks between workers in order to link various knowledge and skills to provide better FP/MCH services in the health sub-center. 2. Based on the above findings the project recommended to the County Chief (who has power to control the administrative staff and the technical staff in his county) the following ; i) In order to solve the conflicts between the individual roles and functions in performing health care activities, there must be goals agreed upon by both. ii) The health sub·center must function as an autonomous organization to undertake the integration health project. In order to do that, it is necessary to support administrative considerations, and to establish a communication system for supervision and to control of the health sub-centers. iii) The administrative organization, tentatively, must be organized to bind the health worker's midwive's and director's jobs by an organic relationship in order to achieve the integrative system under the leadership of health sub-center director. After submitting this observation report, there has been better understanding from frequent meetings & communication between HW/MW in FP/MCH work as the program developed. Lessons learned from the Seosan Project (on issues of FP/MCH integration in Korea); 1) A majority or about 80% of the couples are now practicing FP. As indicated by the study, there is a growing demand from clients for the health system to provide more MCH services than FP in order to maintain the achieved small size of family through FP practice. It is fortunate to see that the government is now formulating a MCH policy for the year 2,000 and revising MCH laws and regulations to emphasize more MCH care for achieving a small size family through family planning practice. 2) Goal consensus in FP/MCH shouBd be made among the health workers It administrators, especially to emphasize the need of care of 'wanted' child. But there is a long way to go to realize the 'real' integration of FP into MCH in Korea, unless there is a structural integration FP/MCH because a categorical FP is still first priority to reduce the rate of population growth for economic reasons but not yet for health/welfare reasons in practice. 3) There should be more financial allocation: (i) a midwife should be made available to help to promote the MCH program and coordinate services, (in) there should be a health sub·center director who can provide leadership training for managing the integrated program. There is a need for 'organizational support', if the decision of integration is made to obtain benefit from both FP & MCH. In other words, costs should be paid equally to both FP/MCH. The integration slogan itself, without the commitment of paying such costs, is powerless to advocate it. 4) Need of management training for middle level health personnel is more acute as the Government has already constructed 90 MCH centers attached to the County Health Center but without adequate manpower, facilities, and guidelines for integrating the work of both FP and MCH. 5) The local government still considers these MCH centers only as delivery centers to take care only of those visiting maternity cases. The MCH center should be a center for the managment of all pregnancies occurring in the community and the promotion of FP with a systematic and effective linkage of resources available in the county such as i.e. Village Health Worker, Community Health Practitioner, Health Sub-center Physicians & Health workers, Doctors and Midwives in MCH center, OBGY Specialists in clinics & hospitals as practiced by the Seosan project at primary health care level.

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고려인삼으로 제조된 홍삼중의 화학적 암 예방성분 (Cancer Chemopreventive Compounds of Red Ginseng Produced from panax ginseng C.A. Meyer)

  • Yun, Taik-Koo;Lee, Yun-Sil;Lee, You-Hui;Yun, Hyo-Yung
    • Journal of Ginseng Research
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    • 제25권3호
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    • pp.107-111
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    • 2001
  • 발암물질을 투여하여 발생하는 마우스 폐선종은 홍삼추출믈의 투여에 의하여 그 발생율이 억제되나 수삼을 투여하면 발생율이 억제되지 않는다. 또한 암환자-대조군연구 결과에 있어서도 수삼즙 또는 수삼절편을 복용한 사람에서는 암의 위험비가 감소되지 않으나 수삼열탕 또는 홍삼을 복용하면 현저한 위험비의 감소를 볼 수 있었다. 이와 같은 결과는 열로 처리된 홍삼중에 암예방 유효성분이 있을 것이라고 추정되어 왔다. 저자들은 4종의 홍삼중의 진세노사이드 즉 Rh$_1$, Rh$_2$, Rg$_3$ 및 Rg$_{5}$ 를 고려홍삼으로부터 분리합성하여 윤의 9주 중기 항발암실험법에 의하여 항발암성을 관찰한바 진세노사이드 Rg$_3$와 Rg$_{5}$의 투여시에는 통계학적으루 유의한 폐선종 발생율이 감소되었으나 Rh$_2$에서는 폐선종발생율이 약간 감소되는 경향을 보였고 Rh$_1$에서는 전혀 영향을 주지 않았다. 이와 같은 소견으로 홍삼에 의한 항발암작용 또는 암예방작용은 홍삼중의 진세노사이드 Rg$_3$및 Rg$_{5}$가 유효성분임을 파악하였으며 이들 진세노사이드 Rg$_3$ Rg$_{5}$ 및 Rh$_2$가 단독 또는 복합적으로 작용할 것으로 추정된다.

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Implications of Emphysema and Lung Function for the Development of Pneumonia in Patients with Chronic Obstructive Pulmonary Disease

  • Hong, Yoonki;Lee, Jae Seung;Yoo, Kwang Ha;Lee, Ji-Hyun;Kim, Woo Jin;Lim, Seong Yong;Rhee, Chin Kook;Lee, Sang-Do;Oh, Yeon-Mok
    • Tuberculosis and Respiratory Diseases
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    • 제79권2호
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    • pp.91-97
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    • 2016
  • Background: Chronic obstructive pulmonary disease (COPD) is sometimes complicated with pneumonia, but little is known about the risk factors that promote the development of pneumonia in COPD. These risk factors were evaluated in the present study. Methods: The data of 324 patients with COPD from a prospective multi-center observational cohort with obstructive lung disease were evaluated retrospectively. To identify risk factors for the development of pneumonia in COPD, the clinical and radiological data at enrollment and the time to the first episode of pneumonia were analyzed by Cox proportional hazard analysis. Results: The median follow-up time was 1,099 days and 28 patients (8.6%) developed pneumonia. The Cox analysis showed that post-bronchodilator forced expiratory volume in one second ($FEV_1$, % of predicted) and the computed tomography (CT) emphysema extent (inspiratory V950) were independent risk factors for the development of pneumonia (post-bronchodilator $FEV_1$: hazard ratio [HR], 0.97; 95% confidence interval [CI], 0.94-1.00; p=0.048 and inspiratory V950: HR, 1.04; 95% CI, 1.01-1.07; p=0.01). Conclusion: Emphysema severity measured by CT and post-bronchodilator $FEV_1$ are important risk factors for the development of pneumonia in COPD.

미세 치근단 수술의 성공과 실패 (Success and failure of endodontic microsurgery)

  • 송민주;김의성
    • Restorative Dentistry and Endodontics
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    • 제36권6호
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    • pp.465-476
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    • 2011
  • 최근의 근관치료학 분야에서 외과적 재치료는 수술현미경, 초음파기구, 미세수술기구 등의 도입으로 많은 변화가 있어 왔다. 본 논문에서는 기존의 전통적인 치근단 수술법과 비교하여 미세 치근단 수술의 주요 술식을 알아보고 이미 출간된 논문에 근거하여 미세 치근단 수술의 성공과 실패 그리고 성공과 실패에 영향을 미치는 요소들을 고찰하고자 하였다. 수술현미경은 수술부위를 밝게 확대해서 봄으로써 치근단 부위의 미세한 형태를 조명할 수 있게 되었으며 이는 술식의 성공을 위해서 필수적인 요소가 되었다. 초음파 기구 또한 치근단 역충전을 위한 정확한 와동형성을 가능하게 해 주었다. 따라서 미세 치근단 수술은 기존방식의 문제점이었던 많은 골삭제, 경사진 치근절제, 부정확한 역충전 와동 형성, 치근단 미세구조 관찰의 어려움 등을 극복함으로써 술식이 더욱 정확해지고, 성공가능성이 더 높아졌다고 볼 수 있다. 미세 치근단 수술에 영향을 미치는 요소에는 다양한 요인들이 존재할 수 있으나 전통방식의 치근단 수술보다 술식이 표준화 됨으로써 술식에 의한 영향을 줄일 수 있다. 환자와 치아에 관계되는 요소 중에서는 치주질환의 이환 여부와 치아위치(tooth position)가 예후에 영향을 미치는 것으로 알려져 있으나 이에 대한 연구는 아직까지 그 수가 부족한 상태로 앞으로 검증수준 (evidence level)이 높은 Randomized clinical trial 혹은 전향적 코호트 연구가 많이 이루어져야 할 것이다.

Diabetes Mellitus and Site-specific Colorectal Cancer Risk in Korea: A Case-control Study

  • Woo, Hyeongtaek;Lee, Jeeyoo;Lee, Jeonghee;Park, Ji Won;Park, Sungchan;Kim, Jeongseon;Oh, Jae Hwan;Shin, Aesun
    • Journal of Preventive Medicine and Public Health
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    • 제49권1호
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    • pp.45-52
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    • 2016
  • Objectives: Previous large-scale cohort studies conducted in Korea have found a positive association between diabetes mellitus (DM) and colorectal cancer (CRC) in men only, in contrast to studies of other populations that have found significant associations in both men and women. Methods: A total of 1070 CRC cases and 2775 controls were recruited from the National Cancer Center, Korea between August 2010 and June 2013. Self-reported DM history and the duration of DM were compared between cases and controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by binary and polytomous logistic regression models. Results: DM was associated with an elevated risk of CRC in both men (OR, 1.47; 95% CI, 1.13 to 1.90) and women (OR, 1.92; 95% CI, 1.24 to 2.98). This association remained when we controlled for age, body mass index, alcohol consumption, and physical activity level. In sub-site analyses, DM was associated with distal colon cancer risk in both men (multivariate OR, 2.04; 95% CI, 1.39 to 3.00) and women (multivariate ORs, 1.99; 95% CI, 1.05 to 3.79), while DM was only associated with rectal cancer risk in women (multivariate OR, 2.05; 95% CI, 1.10 to 3.82). No significant association was found between DM and proximal colon cancer risk in either men (multivariate OR, 1.45; 95% CI, 0.88 to 2.41) or women (multivariate OR, 1.79; 95% CI, 0.78 to 4.08). Conclusions: Overall, DM was associated with an increased risk of CRC in Koreans. However, potential over-estimation of the ORs should be considered due to potential biases from the case-control design.

유기인계 살충제 중독환자에서 30일 사망률에 대한 예후 예측인자로서의 저알부민혈증의 유용성 (Hypoalbuminemia as a Predictor of 30-day Mortality in Patients with Acute Organophosphate Insecticide Poisoning)

  • 김소연;이륜경;김태후;김동훈;김태윤;이수훈;정진희;이상봉;강창우
    • 대한임상독성학회지
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    • 제15권1호
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    • pp.11-16
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    • 2017
  • Purpose: The association of hypoalbuminemia with 30-day in-hospital mortality in patients with organophosphate insecticide poisoning (OPI) was studied. Methods: This retrospective cohort study was conducted between January 2006 and November 2013 in the emergency department (ED) after OPI poisoning. A Kaplan-Meier 30-day survival curve and the log-rank test were used to analyze patients stratified according to serum albumin levels on ED admission (hypoalbuminemia or normo-albuminemia). Independent risk factors including hypoalbuminemia for 30-day mortality were determined by multivariate Cox regression analysis. Results: A total of 135 patients were included. Eighty-eight (65%) patients were male and the mean age was $57.3{\pm}17.0$ years. Serum albumin, mean arterial pressure, and Glasgow coma scale score were significantly higher in the survival group than the non-survival group. APACHE II score was significantly lower in the non-survival group than the survival group. The mortality of the hypoalbuminemia group (serum albumin <3.5 g/dl) was 68.8%, while that of the normo-albuminemia group (serum albumin ${\geq}3.5g/dl$) was 15.1%. The area under the ROC curve of the serum albumin level was 0.786 (95% CI, 0.690-0.881) and the APACHE II score was 0.840 (95% CI, 0.770-0.910). Conclusion: Hypoalbuminemia is associated with 30-day mortality in patients with OPI poisoning.

우리나라 중학교 2학년 학생들의 과학에 대한 정의적 태도 특성 탐색 (Exploration of Features of Korean Eighth Grade Students' Attitudes Toward Science)

  • 곽영순
    • 한국과학교육학회지
    • /
    • 제37권1호
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    • pp.135-142
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    • 2017
  • 4년 주기로 반복되는 TIMSS 연구에서는 2016년 말에 TIMSS 2015 결과를 발표하였다. 본 연구에서는 TIMSS 2015 결과 중에서, 학생들의 설문 응답 결과를 토대로 우리나라 학생들의 과학에 대한 태도와 성취도의 관계를 살펴보고, TIMSS 평가주기별 공통문항을 중심으로 학생들의 응답 변화추이와, 학교급 변화에 따른 학생들의 태도 변화추이를 살펴보았다. 연구결과에 따르면 우리나라 중학교 2학년 학생들은 과학 성취도 상위 15개국은 물론 전체 참여국 중 과학에 대한 자신감, 과학 학습에 대한 흥미, 과학에 대한 가치인식 등에서 최하위 수준을 나타내었다. 또한, TIMSS 평가주기별 공통문항을 중심으로 과학에 대한 태도를 분석한 결과, 우리나라 학생들은 과학에 대한 자신감과 과학 학습에 대한 흥미는 TIMSS 2011에 비해 TIMSS 2015에서 모두 낮아졌다. 반면에 과학에 대한 도구적 가치인식의 경우 TIMSS 2011에 비해 TIMSS 2015에서 모두 상승하였다. 또한, 우리나라 학생들은 초등학교 4학년에서 중학교 2학년으로 진학함에 따라 과학에 대한 자신감과 흥미가 감소하는 것으로 나타났다. 연구결과를 토대로, 우리나라 중학생들의 과학에 대한 정의적 태도 개선을 위한 후속연구와 과학과 교수학습 개선 방안을 제안하였다.