• 한국음향학회지
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• 제19권5호
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• pp.20-26
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• 2000

화자 확인시스템에서 화자의 장기간 음성 변동에 대처하기 위해서는 작은 양의 데이터로써 화자 확인을 위한 HMM(hidden Markov model) 파라미터 갱신과 사전 문턱치 결정이 중요한 요소이다. 본 연구에서는 화자내 변이(mea-speaker variation)에 적응하는 모델 갱신방법과 이에 따른 문턱치 적응에 관한 방법을 제안한다. 제안하는 방법은 분기간 화자내 변이로 발생할 수 있는 오인식율을 Baum-Welch re-estimation을 통해 현재 화자 모델 파라미터에 새로운 음성 데이터를 적응시킴으로써 감소시킨다. 본 논문에서 제안하는 사전 문턱치 결정 방법은 기존의 월드 모델(world model) 방법과 군중 모델(cohort model) 방법의 하이브리드 형태로써 실험적으로 결정된다. 실험에 의해 모델 갱신을 하지 않은 경우보다 제안하는 모델 갱신방법의 화자 인식율이 우수함을 확인하였다. 또한, 사후 문턱치 결정에 의한 인식율과 제안한 사전 문턱치 결정에 의한 인식율의 차이가 근소함을 확인하였다.

• Korean Journal of Radiology
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• 제23권4호
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• pp.466-478
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• 2022

Objective: ¹⁸F-fluorodeoxyglucose (FDG) PET/CT is often used for detecting malignancy in patients with newly diagnosed hemophagocytic lymphohistiocytosis (HLH), with acceptable sensitivity but relatively low specificity. The aim of this study was to improve the diagnostic ability of ¹⁸F-FDG PET/CT in identifying malignancy in patients with HLH by combining ¹⁸F-FDG PET/CT and clinical parameters. Materials and Methods: Ninety-seven patients (age ≥ 14 years) with secondary HLH were retrospectively reviewed and divided into the derivation (n = 71) and validation (n = 26) cohorts according to admission time. In the derivation cohort, 22 patients had malignancy-associated HLH (M-HLH) and 49 patients had non-malignancy-associated HLH (NM-HLH). Data on pretreatment ¹⁸F-FDG PET/CT and laboratory results were collected. The variables were analyzed using the Mann-Whitney U test or Pearson's chi-square test, and a nomogram for predicting M-HLH was constructed using multivariable binary logistic regression. The predictors were also ranked using decision-tree analysis. The nomogram and decision tree were validated in the validation cohort (10 patients with M-HLH and 16 patients with NM-HLH). Results: The ratio of the maximal standardized uptake value (SUVmax) of the lymph nodes to that of the mediastinum, the ratio of the SUVmax of bone lesions or bone marrow to that of the mediastinum, and age were selected for constructing the model. The nomogram showed good performance in predicting M-HLH in the validation cohort, with an area under the receiver operating characteristic curve of 0.875 (95% confidence interval, 0.686-0.971). At an appropriate cutoff value, the sensitivity and specificity for identifying M-HLH were 90% (9/10) and 68.8% (11/16), respectively. The decision tree integrating the same variables showed 70% (7/10) sensitivity and 93.8% (15/16) specificity for identifying M-HLH. In comparison, visual analysis of ¹⁸F-FDG PET/CT images demonstrated 100% (10/10) sensitivity and 12.5% (2/16) specificity. Conclusion: ¹⁸F-FDG PET/CT may be a practical technique for identifying M-HLH. The model constructed using ¹⁸F-FDG PET/CT features and age was able to detect malignancy with better accuracy than visual analysis of ¹⁸F-FDG PET/CT images.