• Journal of Nutrition and Health
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• 제53권4호
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• pp.406-415
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• 2020

본 연구는 2013-2017년 국민건강영양조사 자료를 이용하여 만 19-64세 성인 남녀를 대상으로 채소·과일 섭취에 따른 일반적 사항과 식품 및 영양소 섭취 상태를 파악하고 채소·과일의 섭취와 천식 유병률의 관련성을 알아보고자 시행되었다. 전체 대상자의 천식 유병률은 2.6% 이었고, 채소·과일의 섭취량에 따라 1.8%-3.1%로 나타났다. 채소·과일 섭취량이 많을수록 평균 연령과 가구소득은 높았고 교육수준은 낮았으며, 흡연자의 비율과 알코올 섭취 빈도도 낮았다. 채소·과일의 섭취량이 많은 군이 우유 및 유제품을 제외한 모든 식품군의 섭취량이 많았고, 에너지를 포함한 영양소의 섭취량도 많았다. 열량영양소의 섭취비율의 경우, 채소·과일의 섭취량이 많은 군이 적은 군에 비해 탄수화물과 단백질의 섭취비율은 높고, 지방의 섭취비율은 낮았다. 채소와 과일 섭취량에 따른 3사분위군의 천식에 대한 위험도는 최하위 사분위군 대비 각각 35%, 40%까지 감소하였다. 그러나 최상위 사분위군의 경우, 최하위 사분위군과 비교하여 천식에 대한 위험도가 유의하게 감소하지 않았다. 이러한 결과를 통하여 권장량 수준의 적절한 채소·과일의 섭취가 천식을 예방 및 관리하는데 도움이 될 것이라 생각된다. 또한 채소·과일의 섭취가 천식의 발생과 치료효과에 미치는 영향을 파악하기 위해 장기간의 코호트 연구와 임상시험 연구가 필요할 것으로 생각된다.

• 한국인구학
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• 제19권1호
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• pp.5-44
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• 1996

여성, 특히 기혼여성의 사회적 참여는 해마다 증가하는 추세를 보이고 있으며, 이들을 좀 더 적극적으로 활용하려는 정책적 관심도 증대되고 있다. 그러나 기혼여성 노동력의 노동시장 참여를 걸정짓는 요인에 대한 분석은 매우 부진했으며, 특히 가사분담과 생애주기에 따른 가족내 재생산노동의 수요변화 등에 동태적인 변화에 대한 경험적 분석은 매우 미미하였다. 이 연구는 여성의 노동시장 참여에 관한 개인사적 자료를 활용하여 여성의 재생산노동과 생산노동간의 연관성, 그리고 생애주기에 따른 가족내 여성의 변화 등이 여성의 노동시장 참여에 미치는 영향에 관하여 사건사분석의 방법론을 활용하여 경험적인 분석을 행하였다. 한국여성개발원이 1991년도에 수집한 '제2차 여성취업실태 조사' 자료를 토대로 도시지역에 거주하는 여성들만을 대상으로 분석하였고, 분석방법으로는 횡단면자료를 중심으로는 로짓분석을, 취업과 비취업간의 전환에 대해서는 전환율을 종속변수로 하는 콕스회귀 분석을 시행하였다. 그 결과 여성의 노동시장 참여가 전반적인 증대에도 불구하고 나이, 코호트, 가족형성의 주기 등에 따라 상당한 편차를 나타내고 있다. 특히 결혼과 출산은 고용의 지속성에 강한 부정적 영향을 미치며, 가사노동과 육아 책임의 대부분을 여성이 부담하는 상황에서 가족내 재생산과 노동시장내 생산노동간의 상호교환관계(trade-off)가 존재함을 보여준다. 여성의 취업주기는 개인의 인적 특성과 가족형성기의 특징 이외에 전반적인 노동시장구조의 영향을 받고 있는 것으로 나타내는데, 특히 하층 저학력 여성의 전환과정은 신경제학적 개념이, 고학력 여성의 비취업으로의 강한 회귀현상은 신구조주의적 관점에서 이해되어야 할 사항이다. 이 연구의 결과는 여성의 노동시장 참여를 제고하고 취업의 질을 높이기 위해서는 가족형성주기와 연관된 여성들의 기회비용를 낮추는 방법, 예를 들면 다양한 탁아 및 보육시설의 설치, 차별적 고용관행의 폐지, 유연한 시간근무를 가능케 하는 다양한 파트타임제의 확대 등과 같은 정책이 필요함을 시사하고 있다.

• 한국인구학
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• 제24권1호
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• pp.67-90
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• 2001

통계청에서는 출생 및 사망 신고가 동시에 누락되는 영아사망 미신고분을 감안하여 기간 출생률 및 사망률, 생명표상의 기간 영아사망확률을 추정하여 왔다. 보건복지부의 93년 및 96년 출생 코호트 영아사망조사 결과가 발표됨에 따라 통계청이 1971년-1997년 영아사망확률을 재추정하였다. 자료원은 사망신고 자료, 보건복지부 조사. 선진국의 사망신고 자료, 모델생명표 및 일본생명표이었으며, 17가지 방법으로 시산하였다. 최종 방법은 1993년 보건복지부 조사의 사망확률과 사망신고 자료의 1∼4세 사망 확률 관계에 의존하여 1971-1991년 영아사망확률을 추정하였고, 93년은 93년 보건 복지부 조사의 영아사망확률을 사용하였으며, 95년과 97년에 대해서는 93년과 96년 보건복지부 조사에 나타난 영아사망확률 감소율을 적용하였다. 영아사망확률은 Coale-Demeny North Model 을 활용하여 영아사망률로 전환하였다. 통계청이 수집한 98년 화장장 자료로 영아사망 미신고를 보완하여 영아사망률을 추정해 본 결과 화장장 자료는 영아사망수준 추정을 위한 중요한 자료원이 될 뿐만 아니라 신생아사망을 크게 보완하고, 태아사망 및 주산기사망 통계 생산도 가능한 것으로 나타났다.

• Journal of Preventive Medicine and Public Health
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• 제25권2호
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• pp.148-156
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• 1992

혈중 카드뮴, 아연 및 아연에 대한 카드뮴의 비와 혈압 간의 관련성을 보기 위하여 울산 및 그 인근지역에서 직업적으로 카드뮴에 폭로된 경력이 없는 근로자중 고혈압군 83명과 대조군 77명을 성과 연령에 대해 빈도수 짝짓기로 선택하여 얻은 결과는 다음과 같다. 평균 혈중 카드뮴치는 고혈압군이 $2.90{\eta}g/ml$로, 대조군의 $1.99{\eta}g/ml$보다 유의하게 높았으며(P<0.01), 흡연 정도와 연령에 대해 층화분석을 한 후에도 모든 층에서 고혈압군이 유의하게 놀았다. 혈중 아연에 대한 카드뮴의 비도 고혈압군이 2.46. 대조군의 1.65로 유의하게 높았으며(P<0.01), 흡연정도와 연령에 대해 층화분석을 한 후에도 모든 층에서 고혈압군이 유의하게 높았다. 혈중 아연치는 두 군 사이에 유의한 차이를 볼 수 없었다. 홉연, 연령, 음주, 크레아티닌 및 ${\beta}2$-마이크로글로블린 등의 혼란변수를 고려한 다변량 분적상 혈중 아연에 대한 카드뮴의 비가 가장 유의한 변수로 나타났다. 본 연구를 통하여 볼 때 정상치 범위 이내의 혈중 카드뮴치도 고혈압과 관련성이 있을 것으로 생각되며, 특히 아연치에 대한 상대적인 카드뮴치의 상승이 카드뮴의 절대치보다 더욱 중요한 인자일 것으로 생각된다. 그러나 명확한 인과관계를 밝히기 위하여서는 코호트 연구가 필요할 것으로 생각된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7917-7922
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• 2015

DNA ploidy is an important prognostic parameter in paediatric B-ALL, but the significance of the S-phase fraction is unclear. In present study, DNA ploidy was assessed in 40 pediatric B-ALL cases by flow cytometry. The DI (DNA index) and percentage of cells in S-phase were calculated using Modfit software. Aneuploidy was noted in 26/40 (65%) cases. A DI of 1.10-1.6 (hyperdiploidy B) was noted in 20/40 (50%) and 6/40 (15%) had a DI>1.60 (triploid and tetraploid range). Some 14/40 (35%) cases had a diploid DI between 0.90-1.05. None of the cases had a DI <0.90 (hypodiploid) or in the 1.06-1.09 (hyperdiploid A) range. The mean S-phase fraction was 2.6%, with 24/40 (60%) having low and 16/40 (40%) high S-phase fractions. No correlation was noted with standard ALL risk and treatment response factors with DI values or S-phase data, except for a positive correlation of low S-phase with high NCI risk category (p=0.032). Overall frequency of hyperdiploidy in our cohort of B-ALL patients was very high (65%). No correlation between hyperdiploidy B and low TLC or common B-phenotype was observed in our study as 42% cases with DI 1.10-1.6 had TLC> $50{\times}10^9$ and 57.1% CD 10 negativity. The study also highlighted that S-phase fraction analysis does not add any prognostic information and is not a useful parameter for assessment in ALL cases. However, larger studies with long term outcome analysis are needed to derive definitive conclusions.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1603-1609
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• 2014

Background: The response to treatment and overall survival (OS) of patients with acute myeloid leukemia (AML) is variable, with a median ranging from 6 months to 11.5 years. TP53 is associated with old age, chemotherapy resistance, and worse OS. Using genetic sequencing, we set out to look at our own experience with AML, and hypothesized that both TP53 mutations and SNPs at codon 72 would mimic the literature by occurring in a minority of patients, and conferring a worse OS. Materials and Methods: We performed a pilot study of randomly selected, newly diagnosed AML patients at Mount Sinai Medical Center, diagnosed from 2005-2008 (n=10). TP53 PCR sequencing was performed using DNA from bone marrow smears. Analysis was accomplished using Mutation Surveyor software with confirmation of the variants using the COSMIC and dbSNP databases. Results: Fewer than half of the patients harbored TP53 mutations (40%). There was no significant difference in OS based on gender, AML history, risk-stratified karyotype, or TP53 mutation. There were possible trends toward improved survival among patients less than 60 (11 vs 4 months, p=0.09), Hispanics (8 vs 1 months, p=0.11), and those not harboring SNP P72R (8 vs 2 months, p=0.10). There was a significant improvement in survival among patients with better performance status (28 vs 4 months, p=0.01) and those who did not have a complex karyotype (8 vs 1 months, p=0.03). The most commonly observed TP53 mutation was a missense N310K (40%) and the most commonly observed SNP was P72R (100.0%). Conclusions: Our study confirms previous reports that poor PS and the presence of a complex karyotype are associated with a decreased OS. In our cohort, TP53 mutations were relatively common, occurring more frequently in male patients with an adverse karyotype. Although there was no significant difference in survival between TP53 mutated and un-mutated patients, there was a possible trend toward worse OS among patients with SNP P72R. Larger studies are needed to validate these findings.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6227-6231
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• 2013

In the past, hepatitis B virus (HBV) infection was endemic in the general Korean population. The association of HBV infection with the occurrence of liver cancer has been well demonstrated in several epidemiologic studies. While the mortality rates of liver cancer in Korea have decreased steadily over the last decade, the presence of hepatitis B surface antigen (HBsAg) in mothers remains high at 3-4%, and 25.5% of these HBsAg positive mothers are positive for hepatitis B e antigen (HBeAg). HBV infection caused almost a quarter of hepatocellular carcinoma (HCC) cases and one-third of deaths from HCC. These aspects of HBV infection prompted the Korean government to create a vaccination program against HBV in the early 1980s. In 1995, the Communicable Disease Prevention Act (CDPA) was reformed, and the government increased the number of HBV vaccines in the National Immunization Program (NIP), driving the vaccination rate up to 95%. In 2000, the National Health Insurance Act (NHIA) was enacted, which provided increased resources for the prevention of perinatal HBV infection. Then in 2002, the Korean government, in conjunction with the Korean Medical Association (KMA), launched an HBV perinatal transmission prevention program. The prevalence of HBsAg in children had been high (4-5%) in the early 1980s, but had dropped to below 1% in 1995, and finally reached 0.2% in 2006 after the NIP had been implemented. After the success of the NIP, Korea finally obtained its first certification of achievement from the Western Pacific Regional Office of the World Health Organization (WPRO-WHO) for reaching its goal for HBV control. An age-period-cohort analysis showed a significant reduction in the liver cancer mortality rate in children and adolescents after the NIP had been implemented. In addition to its vaccination efforts, Korea launched the National Cancer Screening Program (NCSP) for 5 leading sites of cancer, including the liver, in 1999. As a consequence of this program, the 5-year liver cancer survival rate increased from 13.2% (1996-2000) to 23.3% (2003-2008). The development of both the primary and secondary prevention for liver cancer including HBV immunization and cancer screening has been of critical importance.

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4335-4340
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• 2016

Background: Bone metastasis is a single condition but presents with various patterns and severities. Skeletal-related events (SREs) deteriorate overall performance status and reduce quality of life. However, guidelines for early detection and management are limited. This study includes a survey of the prevalence of bone metastasis in cases with common cancers in Thailand as well as a focus on survival patterns and SREs. Materials and Methods: A retrospective cohort analysis was conducted using a database of the Chiang Mai Cancer Registry and the Musculoskeletal Tumor Registry of the OLARN Center, Chiang Mai University. The prevalence of bone metastasis from each type of primary cancer was noted and time-to-event analysis was performed to estimate cancer survival rates after bone metastasis. Results: There were 29,447 cases of the ten most common cancers in Thailand, accounting for 82.2% of the entire cancer registry entries during the study period. Among those cases, there were 2,263 with bone metastases, accounting for 7.68% of entries. Bone metastasis from lung, liver, breast, cervix and prostate are common in the Thai population, accounting for 83.4% of all positive cases. The median survival time of all was 6 months. Of the bone metastases, 48.9% required therapeutic intervention, including treatment of spinal cord and nerve root compression, pathological fractures, and bone pain. Conclusions: The frequency of the top five types of bone metastasis in Thailand were different from the frequencies in other countries, but corresponded to the relative prevalence of the cancers in Thailand and osteophilic properties of each cancer. The results of this study support the establishment of country specific guidelines for primary cancer identification with skeletal lesions of unknown origin. In addition, further clinical studies of the top five bone metastases should be performed to develop guidelines for optimal patient management during palliative care.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.413-418
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• 2016

Objective: To assess the safety and effectiveness of a mouth-rinse with G-CSF (JiSaiXin, produced by NCPC Biotechnology Co., Ltd) in treating patients with chemotherapy-induced oral mucositis (CIM). Method: A consecutive cohort of patients with advanced cancers and CIM were treated with mouth-rinse G-CSF. All chemotherapy for patients with advanced cancers was adopted from regimens suggested by NCCN guidelines. The mouth-rinse with G-CSF at a dose of 150-300ug plus 100ml-500ml normal saline was started from the time of oral mucositis was confirmed and continuously used for at least 7 days as one course. After at least two courses of treatment, safety and efficacy were evaluated. Results: There were 7 female and 7 male patients with advanced cancer and CIM recruited into this study, including 5 with colorectal, 2 with lung, 1 patient with gastric, 1 with cervical and 1 with pancreatic cancer, as well as 2 patients with diffuse large B cell lymphomas, 1 with nasopharyngeal and 1 with gastric cancer. The median age was 57 (41-79) years. Grade 1 to 2 myelosuppression was observed in 3/14 patients, and Grade 4 myelosuppression in 1/14. Adverse effects on the gastrointestinal tract were documented in 5/14 patients, and were Grade 1 to Grade 3. No treatment related death was documented. Regarding CIM, the median response time to mouth rinse of G-CSF was 2 (1-5) days, and all patients with CIM demonstrated a positive response. Conclusions: Mouth-rinse with G-CSF proved to be safe and effective in treating patients with advanced cancers and CIM. However, further randomized controlled studies should be conducted to clarify the effectiveness of this treatment with other lesions.

• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.283-290
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• 2015

Purpose: The aims of this case-control study were to assess the correlation between some food habits in the last two decades and gastric cancer in East Azerbaijan of Iran. Materials and Methods: In this hospital based case control study, 616 patients (212 gastric cancer patients, 404 cancer free patients) were recruited. Food habits of patients over the past two decades were assessed with a structured questionnaire. We used conditional logistic regression analysis for estimating crude and adjusted odds ratios (OR) and their respective 95% confidence intervals (95%CI). Results: In this study, over-eating, consumption of high fat milk and yogurt and especial types of cheese increased the risk of gastric cancer (All<0.05). Consumption of such especial cheeses such as Koze and Khiki increased the risk of gastric cancer by 12.6 fold (95% CI:1.99-79.36) and 7.36 fold (95% CI:1.33-40.54), respectively. In addition, high fat food, moldy food, and pickled vegetables consumption as well as reuse of cooking oil for frying were significantly associated with gastric cancer risk. Furthermore, intake of Ghorme (deep fried meat) was positively correlated with gastric cancer risk (OR:1.31;95%CI: 0.91-1.87). Conclusions: It can be confirmed that particular food habits which have been very common in East-Azerbaijan in the last two past decades increase risk of gastric cancer. According to our results and taking into account the long latency period of gastric cancer it can be concluded that nutrition education for a healthy diet should be performed from early childhood. However, further well designed cohort studies are needed to achieve more clear results.