• 한국과학교육학회지
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• 제18권3호
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• pp.427-441
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• 1998

청소년들의 과학적 추론이나 과학개념 변화에 영향을 미치는 변인들에 대한 교육학적 또는 심리학적 접근에서 수행 된 연구들은 많지만, 아직 두뇌기능의 성숙적 측면에서 이들 변인에 대한 접근은 국내외적으로 거의 이루어지질 않았다. 이 연구는 청소년들의 과학객 추론 능력과 개념획득 능력이 그들의 전두엽연합령(prefrontal lobes)의 인지적 기능, 예를 들면 설계기능(planning function) 또는 억제기능(inhibiting function)의 성숙에 의해서 주로 매개된다는 가설을 테스트하였다. 이 가설을 테스트하기 위하여 한국의 중등학생들의 과학척 추론 능력, 수업을 통한 개념 변화 능력, 추론능력과 개념변화에 영향을 미치는 것으로 알려져 온 탈잠입능력과 작동기억용량, 그리고 설계능력과 억제능력을 조사하여 그들 사이의 상관성과 회귀계수를 알아보았다. 이 연구의 결과는 전두엽연합령의 셜계능력과 억제능력이 과학적 추론 및 개념변화와 통계적으로 유의하게 관련되어 있음을 보여주었을 뿐만아니라, 더 나아가 과학적 추론과 개념변화에 이미 유의미한 인지변인으로 지지되어온 탈잡입능력과 작동기억용량보다 높은 지수로 관련되어 있음을 보여주었다. 이 연구는 또한 전두엽연합령의 인지적 기능들이 크게 활성과정(representing process)과 억제과정 (inhibiting process)으로 수행되어짐올 보여주었고, 이들 두 인지과정은 과학적 추론과 개념변화과정은 물론 다른 인지활동에도 적용되어질 수 있음을 본 연구는 제시하고 있다.

• 한국산학기술학회논문지
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• 제21권8호
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• pp.537-545
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• 2020

본 연구는 회복기 단계에 있는 뇌혈관 질환자를 대상으로 가상현실 콘텐츠를 활용한 인지재활프로그램의 임상적 적용 효과를 알아보았다. 연구방법은 회복기 단계의 뇌혈관 질환자 34명을 대상으로 대조군(16명)과 실험군(18명)으로 나눈 후에 가상현실 콘텐츠 기반의 인지재활프로그램을 적용한 후, 인지기능과 일상생활활동 능력, 상지기능에서의 효과를 비교하고자 하였다. 대조군에는 보편적인 재활치료 프로그램을 실시하고, 실험군에서는 보편적인 재활치료 프로그램과 가상현실 콘텐츠 기반의 인지재활프로그램을 제공하였다. 두 집단 모두 하루 2회(1회 30분씩)씩, 주 5회, 4주간(총 20회기) 실시하였다. 중재 결과, 두 집단 모두 일상생활활동 능력이 모두 유의미하게 향상되었지만(p<.05), 실험군에서의 변화량이 대조군보다 5점정도 더 향상되었다(p<.05). 인지기능에서도 실험군과 대조군이 유의미한 차이를 보였고(p<.05), 변화량에서 실험군이 대조군보다 2점정도의 변화 수치를 보였다(p<.05). 상지기능에서는 대조군과 실험군 간의 유의마한 차이는 없었고(p>.05), 전후 변화량을 비교한 결과 실험군이 대조군보다 0.7점정도 유의미한 변화폭을 보였다(p<.05). 가상현실 콘텐츠를 활용한 인지재활프로그램이 일반적인 재활치료 프로그램에 비해서 일상생활활동 능력과 인지기능에서의 유의미한 향상 폭의 차이가 있다는 것을 확인하는 연구였다.

• 한국식품과학회지
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• 제52권3호
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• pp.263-273
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• 2020

본 연구에서는 양파(Allium Cepa L.) 과육과 과피를 이용하여 in vitro 신경세포 보호효과 및 Aβ로 유도된 인지기능 장애 마우스 모델에서의 개선효과를 검증하고자 하였다. 양파 과육 분획물(EOF)과 과피 분획물(EOP) 모두 PC-12 세포에서 Aβ로 유도된 세포 독성에 대하여 신경세포 보호효과(세포 내 산화적 스트레스 억제, 세포 생존율 및 세포막 보호효과)를 나타냈다. Aβ로 유도된 인지장애 마우스 모델에서의 행동실험(Y-미로, 수동회피 및 Morris 수중 미로 시험) 결과 또한 양파 과육 분획물(EOF)과 과피 분획물(EOP) 모두 효과적인으로 학습 및 기억능력을 개선시키는 것으로 나타났다. 행동실험 후 마우스 뇌조직에서의 산화적 스트레스에 대한 생체 방어 기작의 일종인 SOD 함량의 증가, oxidized GSH/총 GSH 및 MDA 함량 감소를 나타냄에 따라 산화적 스트레스에 대한 우수한 항산화효과가 긍정적인 영향을 미친 것으로 판단된다. 또한, 뇌조직으로부터 분리한 미토콘드리아에 대하여 막 전위(MMP) 보호 및 ATP 함량 증가를 나타냈으며, 미토콘드리아와 관련된 apoptosis 경로에서 BAX의 감소 및 cytochrome c 방출 억제를 통해 caspase 3/7의 활성을 억제하는 것으로도 나타났다. 결국, 양파 과육 분획물(EOF)과 과피 분획물(EOP)은 AChE의 활성 억제 및 ACh의 함량을 증가시킴으로써 효과적인 콜린성 시스템 보호효과를 나타냄에 따라, Aβ로 유도된 인지기능 장애를 예방할 수 있는 고부가가치 건강기능식품 소재로의 활용 가능성이 기대된다.

• 생물정신의학
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• 제12권2호
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• pp.98-106
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• 2005

Objectives:Donepezil is a widely used drug for the treatment of patients with Alzheimer's disease(AD). The aim of the present study was to clarify the efficacy and the characteristics of responders to donepezil. Methods:Patients with probable AD(n=80;75.7 years) and small vessel dementia(SVD)(n=18;77.8 years) who received donepezil were retrospectively analyzed using Alzheimer's registry, and three questions were asked:1) Does donepezil therapy improves cognitive symptoms in patients with dementia? 2) If donepezil improves cognitive symptoms, which items of the K-MMSE are improved? 3) What are the characteristics of responder to donepezil medication? Results:1) After donepezil medication, cognitive function measured by the K-MMSE was significantly improved in both types of dementia(AD and SVD), However, statistical differences were not found between these groups. 2) In a clinical trial of donepezil, the patients performed better than before mediation on K-MMSE items assessing orientation, recall, construction, concentration, calculation. 3) In AD, the K-MMSE score before medication was closely related with response of donepezil. Conclusion:This study suggests that donepezil improves various cognitive functions in both types of dementia, and the responsive group had significantly lower K-MMSE scores than the non-responsive group before medication.

• Journal of Korean Biological Nursing Science
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• 제22권2호
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• pp.111-118
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• 2020

Purpose: The purpose of this study was to understand the impact of long- and short-term energy drinks on anxiety-like, depressionlike, and cognitive behavior in adolescent rats. Methods: Adolescent rats (age six weeks) were randomly classified into a control group (CON), a long-term administration group (LT), and a short-term administration group (ST). The LT group was orally administered 1.5 mL/100 g (body weight) of energy drink twice daily for 14 days, the ST group was orally administered for one day, and the control group applied the same amount of normal saline. Later, an open-field test, a forced swim test, novel object recognition test, and an 8-arm radial maze test was conducted to assess the rats' anxiety, depression, and cognitive function. Results: There were different effects in the long- and short-term groups of energy drink administration. In the LT group, anxiety- and depressive-like behavior increased because of increased movement in the side corner and decrease of immobility time. Also, the time to explore novel objects decreased, and the number of correct responses was reduced, indicating a learning and memory function disorder. However, the ST group was not different from the control group. Conclusion: These results indicate that long-term consumption of energy drinks can increase anxiety-like, depression-like behavior, and this can lead to decrease in learning and memory functions. Thus, nurse and health care providers should understand the impact of energy drink consumption in adolescence to provide appropriate practices and education.

• Journal of Korean Neurosurgical Society
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• 제58권1호
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• pp.22-29
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• 2015

Objective : Perinatal hypoxic-ischemic encephalopathy (HIE) and prolonged febrile seizures (pFS) are common neurologic problems that occur during childhood. However, there is insufficient evidence from experimental studies to conclude that pFS directly induces hippocampal injury. We studied cognitive function and histological changes in a rat model and investigated which among pFS, HIE, or a dual pathologic effect is most detrimental to the health of children. Methods : A rat model of HIE at postnatal day (PD) 7 and a pFS model at PD10 were used. Behavioral and cognitive functions were investigated by means of weekly open field tests from postnatal week (PW) 3 to PW7, and by daily testing with the Morris water maze test at PW8. Pathological changes in the hippocampus were observed in the control, pFS, HIE, and HIE+pFS groups at PW9. Results : The HIE priming group showed a seizure-prone state. The Morris water maze test revealed a decline in cognitive function in the HIE and HIE+pFS groups compared with the pFS and control groups. Additionally, the HIE and HIE+pFS groups showed significant hippocampal neuronal damage, astrogliosis, and volume loss, after maturation. The pFS alone induced minimal hippocampal neuronal damage without astrogliosis or volume loss. Conclusion : Our findings suggest that pFS alone causes no considerable memory or behavioral impairment, or cellular change. In contrast, HIE results in lasting memory impairment and neuronal damage, gliosis, and tissue loss. These findings may contribute to the understanding of the developing brain concerning conditions caused by HIE or pFS.

• 한국콘텐츠학회논문지
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• 제11권12호
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• pp.986-997
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• 2011

본 연구는 학습을 위한 멀티미디어 활용에 대한 설계 원리 중 멀티미디어 원리와 개인차 원리가 스마트패드 기반 콘텐츠에서도 적용되는지 살펴보았다. 이를 위해 텍스트 기반 콘텐츠와 멀티미디어 원리(텍스트+이미지)를 적용한 콘텐츠를 각각 개발하고, 학습자들을 사전지식이 높은 집단과 낮은 집단으로 분류한 다음, 각 집단을 양분하여 두 종류의 스마트 패드용 콘텐츠를 학습하게 하였다. 각 집단의 인지부하 정도와 학업성취도를 측정한 결과, 멀티미디어 원리와 개인차 원리는 인지부하에 유의한 효과를 가져오지 못하였으나, 학업성취도 차원에서는 모두 유의한 효과를 가져왔다. 이러한 연구결과는 PC 모니터보다 제한된 스마트 패드의 화면 크기, 이미지의 성격, 그리고 학습목표의 성격 등에 기인한 것으로 보여지며, 향후 스마트 패드용 콘텐츠 개발에 있어 시사점을 제공할 수 있다.

• 생물정신의학
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• 제11권2호
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• pp.155-164
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• 2004

Objective:The present study examined the association between basic neurocognitive functions and emotional recognition in chronic schizophrenia. Furthermore, to Investigate cognitive variable related to emotion recognition in Schizophrenia. Methods:Forty eight patients from the Yongin Psychiatric Rehabilitation Center were evaluated for neurocognitive function, and Emotional Recognition Test which has four subscales finding emotional clue, discriminating emotions, understanding emotional context and emotional capacity. Measures of neurocognitive functioning were selected based on hypothesized relationships to perception of emotion. These measures included:1) Letter Number Sequencing Test, a measure of working memory;2) Word Fluency and Block Design, a measure of executive function;3) Hopkins Verbal Learning Test-Korean version, a measure of verbal memory;4) Digit Span, a measure of immediate memory;5) Span of Apprehension Task, a measure of early visual processing, visual scanning;6) Continuous Performance Test, a measure of sustained attention functioning. Correlation analyses between specific neurocognitive measures and emotional recognition test were made. To examine the degree to which neurocognitive performance predicting emotional recognition, hierarchical regression analyses were also made. Results:Working memory, and verbal memory were closely related with emotional discrimination. Working memory, Span of Apprehension and Digit Span were closely related with contextual recognition. Among cognitive measures, Span of Apprehension, Working memory, Digit Span were most important variables in predicting emotional capacity. Conclusion:These results are relevant considering that emotional information processing depends, in part, on the abilities to scan the context and to use immediate working memory. These results indicated that mul- tifaceted cognitive training program added with Emotional Recognition Task(Cognitive Behavioral Rehabilitation Therapy added with Emotional Management Program) are promising.

• Biomolecules & Therapeutics
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• 제19권2호
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• pp.224-230
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• 2011

In order to develop silk peptide (SP) preparations possessing cognition-enhancing effect, several candidates were screened through in vitro assays, and their effectiveness was investigated in facilitated brain aging model rats. Incubation of brain acetyl-cholinesterase with SP-PN (1-1,000 ${\mu}g/ml$) led to inhibition of the enzyme activity up to 35%, in contrast to a negligible effect of SP-NN. The expression of choline acetyltransferase (ChAT) mRNA of neural stem cells expressing ChAT gene (F3.ChAT) was increased by 24-hour treatment with 10 and 100 ${\mu}g/ml$ SP-NN (1.35 and 2.20 folds) and SP-PN (2.40 and 1.34 folds). Four-week subcutaneous injections with D-galactose (150 mg/kg) increased activated hippocampal astrocytes to 1.7 folds (a marker of brain injury and aging), decreased acetylcholine concentration in cerebrospinal fluid by 45-50%, and thereby impaired learning and memory function in passive avoidance and water-maze performances. Oral treatment with SP preparations (50 or 300 mg/kg) for 5 weeks from 1 week prior to D-galactose injection exerted recovering activities on acetylcholine depletion and brain injury/aging as well as cognitive deficit induced by D-galactose. The results indicate that SP preparations restore cognitive functions of facilitated brain aging model rats by increasing the release of acetylcholine, in addition to neuroprotective activity.

• BMB Reports
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• 제46권2호
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• pp.103-106
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• 2013

Phosphoinositide 3-kinases (PI3Ks) play key roles in synaptic plasticity and cognitive functions in the brain. We recently found that genetic deletion of $PI3K{\gamma}$, the only known member of class IB PI3Ks, results in impaired N-methyl-D-aspartate receptor-dependent long-term depression (NMDAR-LTD) in the hippocampus. The activity of RalA, a small GTP-binding protein, increases following NMDAR-LTD inducing stimuli, and this increase in RalA activity is essential for inducing NMDAR-LTD. We found that RalA activity increased significantly in $PI3K{\gamma}$ knockout mice. Furthermore, NMDAR-LTD-inducing stimuli did not increase RalA activity in $PI3K{\gamma}$ knockout mice. These results suggest that constitutively increased RalA activity occludes further increases in RalA activity during induction of LTD, causing impaired NMDAR-LTD. We propose that $PI3K{\gamma}$ regulates the activity of RalA, which is one of the molecular mechanisms inducing NMDAR-dependent LTD.