• 근관절건강학회지
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• 제8권1호
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• pp.51-64
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• 2001

The purposes of this study were to examine and to predict the affecting factors on exercise participation of Rheumatoid arthritis Patients. The subjects were 161 adult out-patients who visited the hospital for rheumatic disease in H-university. Data were composed of self-reported questionnaire. The conceptual model of this study consisted of that personal characters(age, marriage, education, income), situational characters(pain intensity, fatigue, IADL, depression), behavioral characters(formerly exercise behavior, life-style), and cognitive-perceptional characters(perceived health status, perceived benefit, perceived barrier, perceived self-efficacy) affected directly to exercise participation. Logistic regression analysis was applied for testing model of this study. The results were as follows : 1. Personal characters(education), situational characters(pain intensity), behavioral characters(formerly exercise behavior, life-style), and cognitive characters(perceived barrier, perceived self-efficacy) were significant difference between current exercise participants(127subjects) and non-exercise participants(34). 2. Personal characters(income), situational characters(pain intensity), behavioral characters(life-style), and cognitive-perceptional characters(perceived barrier, perceived self-efficacy) were correlated to exercise participation. 3. Formerly exercise behavior, perceived barrier, and perceived self-efficacy were significant predictor of exercise participation. The logistic equation predicted overall 81.94% of this study subjects 161.

• Journal of Yeungnam Medical Science
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• 제40권3호
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• pp.225-232
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• 2023

Cognitive dysfunction is relatively less considered a complication of hypertension. However, there is sufficient evidence to show that high blood pressure in middle age increases the risk of cognitive decline and dementia in old age. The greatest impact on cognitive function in those with hypertension is on executive or frontal lobe function, similar to the area most damaged in vascular dementia. Possible cognitive disorders associated with hypertension are vascular dementia, Alzheimer disease, and Lewy body dementia, listed in decreasing strength of association. The pathophysiology of cognitive dysfunction in individuals with hypertension includes brain atrophy, microinfarcts, microbleeds, neuronal loss, white matter lesions, network disruption, neurovascular unit damage, reduced cerebral blood flow, blood-brain barrier damage, enlarged perivascular damage, and proteinopathy. Antihypertensive drugs may reduce the risk of cognitive decline and dementia. Given the high prevalence of dementia and its impact on quality of life, treatment of hypertension to reduce cognitive decline may be a clinically relevant intervention.

• The Korean Journal of Physiology and Pharmacology
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• 제26권1호
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• pp.47-57
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• 2022

Stiripentol is an anti-epileptic drug for the treating of refractory status epilepticus. It has been reported that stiripentol can attenuate seizure severity and reduce seizure-induced neuronal damage in animal models of epilepsy. The objective of the present study was to investigate effects of post-treatment with stiripentol on cognitive deficit and neuronal damage in the cornu ammonis 1 (CA1) region of the hippocampus proper following transient ischemia in the forebrain of gerbils. To evaluate ischemia-induced cognitive impairments, passive avoidance test and 8-arm radial maze test were performed. It was found that post-treatment with stiripentol at 20 mg/kg, but not 10 or 15 mg/kg, reduced ischemia-induced memory impairment. Transient ischemia-induced neuronal death in the CA1 region was also significantly attenuated only by 20 mg/kg stiripentol treatment after transient ischemia. In addition, 20 mg/kg stiripentol treatment significantly decreased ischemia-induced astrocyte damage and immunoglobulin G leakage. In brief, stiripentol treatment after transient ischemia ameliorated transient ischemia-induced cognitive impairment in gerbils, showing that pyramidal neurons were protected and astrocyte damage and blood brain barrier leakage were significantly attenuated in the hippocampus. Results of this study suggest stiripentol can be developed as a candidate of therapeutic drug for ischemic stroke.

• 한국도서관정보학회지
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• 제48권1호
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• pp.227-243
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• 2017

본 연구는 노인이 건강정보검색에서 어떠한 어려움과 감정변화를 경험하는지를 살펴보고자 하였다. 이를 위해, 총 10명의 노인들을 대상으로 개별면담을 실시하였고, 그 결과 참여한 노인들이 경험하는 어려움에는 크게 인지적 어려움과 신체적 어려움이 있는 것으로 나타났다. 인지적인 어려움에는 첫째, 어디에서 어떻게 건강정보를 찾는지의 어려움을 나타내었고, 둘째, 정보검색도구의 이용의 어려움을 나타내었고, 셋째, 신뢰할 수 있는 정확한 정보선택의 어려움을 나타내었다. 참여한 노인들의 신체적인 어려움에 대해서는 눈, 손, 다리, 몸 전체에 어려움이 있다고 나타내고 있었다. 감정변화에 대해서는 정보검색 초기에는 '궁금하다'와 '감정이 없었다'가 중간단계에는 여러 감정상태를 보이다가 정보를 찾은 후에는 긍정적인 감정표현과 건강에 대한 경각심이나 두려움이 한편으로 생기기도 하였다. 이러한 연구결과를 도서관의 관점에서 분석하고 논의한 후, 노인들을 위한 도서관의 역할을 제언하였다.

• 대한간호학회지
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• 제31권4호
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• pp.681-691
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• 2001

Purpose: The exercise status in patients with rheumatoid arthritis, associations between exercise behavior and personal factors, and associations between exercise behavior and exercise-specific cognitions and their effects were assessed. Method: Four hundred thirty nine outpatients with rheumatoid arthritis were studied. The exercise status was measured by a single item. The intensity was multiplied by the frequency and duration of each exercise. The product of these intensity values for all exercises was defined as exercise behavior. Based on the Pender's revised health promotion model, exercise benefit, barrier, self-efficacy, enjoyment and social support were chosen as exercise specific cognitions and affect variables. Path analysis was used to identify the predictors of exercise behavior. Results: Compared to the duration before being diagnosed, the number of subjects who exercised regularly increased after being diagnosed. However over half of the subjects refrain from any sort of exercise and the type of exercise is very limited. Among the variables, exercise barrier, self-efficacy, and social support were found to be significant predictors of exercise behavior, and only previous exercise experience was found to be significant predictors of all behavior specific cognitions and affect variables. Conclusion: These findings suggest that studies should explore exercise behaviors and strategies to emphasize the cognitive-motivational messages to promote exercise behaviors.

• 한국경영정보학회:학술대회논문집
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• 한국경영정보학회 2007년도 추계학술대회
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• pp.284-293
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• 2007

In the present competitive organizational environment more organizations are implementing knowledge management initiatives to gain strategic advantage. One such initiative is that of implementing electronic knowledge repositories (EKR) which often leads to a rapid increase in the quantity of information employees have to process daily; raising concerns of employees being overloaded. This is especially true for current EKRs using distributive technology, enabling customizable individual workspaces which can result in loose knowledge structures. This paper identifies a new type of information overload (IO), extending the concept as occurring in both knowledge seekers and contributors and uses cognitive dissonance theory to provide evidence that IO can change employees' perception of EKR usage. This research paper provides the first empirical evidence that overload has no sufficient affect on EKR continuance intention directly, but has significant negative affect on the two main success measures; perceived usefulness and satisfaction of the system.

• BMB Reports
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• 제42권8호
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• pp.475-481
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• 2009

Emerging data demonstrate pivotal roles for brain insulin resistance and insulin deficiency as mediators of cognitive impairment and neurodegeneration, particularly Alzheimer's disease (AD). Insulin and insulin-like growth factors (IGFs) regulate neuronal survival, energy metabolism, and plasticity, which are required for learning and memory. Hence, endogenous brain-specific impairments in insulin and IGF signaling account for the majority of AD-associated abnormalities. However, a second major mechanism of cognitive impairment has been linked to obesity and Type 2 diabetes (T2DM). Human and experimental animal studies revealed that neurodegeneration associated with peripheral insulin resistance is likely effectuated via a liver-brain axis whereby toxic lipids, including ceramides, cross the blood brain barrier and cause brain insulin resistance, oxidative stress, neuro-inflammation, and cell death. In essence, there are dual mechanisms of brain insulin resistance leading to AD-type neurodegeneration: one mediated by endogenous, CNS factors; and the other, peripheral insulin resistance with excess cytotoxic ceramide production.

• 대한장애인치과학회지
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• 제15권1호
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• pp.14-22
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• 2019

The aim of this study was to determine the factors contributing to the barrier of dental treatment for special needs patients perceived by the main caregivers of the patients. A questionnaire was developed with three parts: patient-related factors, caregiver-related factors, and factors for treatment barriers. Patient- and caregiver-related factors were analyzed for correlations with the barrier factors. Fisher's exact test and Chi-square test were used at the level of 0.05. A total of 52 caregivers (mean age [SD]=50.2 [11.5] years) for the patients with intellectual and cognitive disabilities (mean age [SD]=38.9 [21.3]) responded to the questionnaires. Oral hygiene status, need for assistance in tooth brushing, and cooperation for tooth brushing were correlated with the level of treatment cooperation of the patients (p<0.05). The above three factors were also correlated with the treatment barrier despite patients presenting oral symptoms (p<0.05). Two thirds of the caregivers felt the treatment cost as severe or a considerable financial burden. For patients, insurance types and need for assistance in tooth brushing, and for caregivers, education levels and financial status were significant factors contributing to financial burden (p<0.05). There were background factors of the patients and their caregivers associated with access to dental treatment for special needs patients. Deficient cooperative skills and financial burdens were the main obstacles to treatment access. Tooth brushing skills and oral hygiene status can be proxy measures to cooperative ability for dental treatment.

• 재활치료과학
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• 제9권4호
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• pp.69-81
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• 2020

목적 : 본 연구의 목적은 인지기능저하 노인을 선별할 수 있는 이중과제를 활용한 노인인지기능 선별검사를 개발하는 것이다. 연구방법 : 2019년 5월부터 8월까지 경기도 및 충청도에 있는 지역사회 기관에서 60세 이상 노인 229명을 대상으로 개발된 Y-DuCog(Yonsei Dual Task Cognitive Screening Test)의 신뢰도 및 타당도 검증과 인지기능저하 노인의 분류 기준점을 확인하였다. 결과 : MMSE-K, MoCA-K와 Y-DuCog와의 상관분석을 실시한 결과 Y-DuCog의 이중과제 효과와 이중과제 초당 정답 수에서 상관관계를 보였다. 내적 일치도 분석 결과 이중과제 효과와 이중과제 초당 정답 수의 Cronbach's-α 값은 각각 .848(p<.01), .916(p<.01)의 신뢰도를 보였고, 검사-재검사 신뢰도는 ICCs가 .969~.996으로 높게 나타났다. 선별기준점은 총 수행시간 DTE에서 31.76초를 기준으로 88.7%의 민감도와 83.5%의 특이도를, 총 이중과제 CRR에서 0.38개를 기준으로 84.5%의 민감도와 76.6%의 특이도를 보였다. 결론 : 본 연구를 통해 Y-DuCog의 신뢰도 및 타당도가 검증되었다. Y-DuCog는 기존 지필 평가의 제한점인 교육수준과 문자에 영향을 받지 않으며 간편하고 빠르게 검사를 시행할 수 있어 노인의 인지기능 평가 및 중재 방법에 대한 효과성 검증 시 사용될 수 있을 것으로 기대한다.

• 근관절건강학회지
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• 제8권1호
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• pp.5-26
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• 2001

Many studies have reported that regular aquatic exercise can lead to improvement of health for patients suffering from arthritis. In spite of these benefits, the adherence rate has shown as few as 26% of patients with arthritis who had completed the aquatic exercise education program. Moreover, when patients with arthritis begin an aquatic exercise, 47% withdraw within the first 6 month. No study has been found that constructs model to explain aquatic exercise adherence of patients with arthritis. The purpose of this study were to identify the factors influencing exercise adherence and to construct and test a structural model to explain aquatic exercise adherence of patients with arthritis. Hypothesized model was constructed on the basis of Bandura's social cognitive theory and literature review. Exogenous latent variables included in this model are group cohesion and barrier, endogenous latent variables are self-efficacy, outcome expectancy and self-evaluation. Empirical data used was collected through individual interviews with the structural questionnaire on 249 patients with arthritis who had completed the 6-week aquatic exercise education program of Korean Rheumatology Health Professionals Academy. The interviews were performed from September 6, 1999 through October 8, 1999. A model tested by the covariance structural analysis with LISREL 8.12a program and by descriptive statistics and correlation with SAS 6.12 program. The results are summarized as follows: First, hypothesized model showed a good fit to the empirical data. In the modified model added one new path showed a much better fit. Second, group cohesion had a direct, indirect positive effects, self-efficacy and self evaluation had a direct positive effects on exercise adherence. Barrier had a direct, indirect negative effects on exercise adherence. Outcome expectancy had a direct negative effect, indirect positive effects through self-evaluation on exercise adherence, but total effects was not significant. Total effect size of the variables were group cohesion, self-efficacy, barrier and self evaluation in order. All variables accounted for 54% of the total variance of exercise adherence in the model. In conclusion, this model confirmed to be proper in explaining of aquatic exercise adherence. Group cohesion, self-efficacy, outcome expectancy, self-evaluation, barrier contributed to the aquatic exercise adherence of patients with arthritis. The results of this study suggested that improvement of group cohesion, self-efficacy and self-evaluation, motivation of outcome expectancy through self-evaluation, and reduction of the barrier should be included in the strategy of nursing intervention for the aquatic exercise adherence of patients with arthritis.