• The Journal of Korean Physical Therapy
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• 제33권3호
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• pp.136-141
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• 2021

Purpose: Dementia is a disease in which cognitive function declines, leading to deterioration of body functions and activities of daily living. The purpose of this study is to explore the effects of dual-task training, including cognitive tasks, on cognitive and body function and β-amyloid levels in Alzheimer's dementia patients. Methods: 34 inpatients diagnosed with Alzheimer's dementia at a nursing hospital located in South Korea. The patients were randomly divided into a dual-task group (n=16) and a single-task group (n=18). Each group was trained for 30 minutes three times a week for eight weeks. The MMSE-K was used to measure the patients' cognitive function. To assess the patients' static balance ability, their LOS was measured using BioRescue. while dynamic balance was measured using the BBS. The 10MWT were conducted to evaluate the patients' walking ability. Blood analysis was performed to measure levels of β-amyloid. Results: Both groups exhibited statistically significant improvements in gait function after the training (p<0.05). The dual-task group exhibited statistically significant differences in cognitive function, static and dynamic balance function, and β-amyloid levels after training (p<0.05). A significant difference was observed between the two groups (p<0.05). Conclusion: Dual-task training were found to be effective in improving cognitive and bodily functioning and reducing β-amyloid levels in Alzheimer's dementia patients. Thus, this may be suggested as an effective exercise method for the treatment and early prevention of Alzheimer's dementia.

• 대한물리의학회지
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• 제17권3호
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• pp.51-58
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• 2022

PURPOSE: This study aimed to evaluate the correlation between executive function and gait evaluations for the elderly, and validate the obstacle gait evaluation as a cognitive impairment test tool. METHODS: This study was a cross-sectional design. 79 people aged 65 years or older were selected as subjects. The Korean version of the Mini-Mental State Examination (MMSE-KC) to evaluate overall cognitive function and the Trail Making Test (TMT) A, B to measure executive function were performed. The 4-meter walking speed test and the walking speed test while crossing over an obstacle were carried out to evaluate gait. The Spearman's correlation was used to measure the correlation between cognition and gait speed. RESULTS: There was no significant correlation between the 4 m gait speed and executive function( TMT-A (p = .056), TMT-B (p = .115)). However, there was a significant correlation between the 4 m gait speed and MMSE-KC (r = .277, p < .05). There was also a significant correlation between walking speed while crossing over an obstacle and all tests (MMSE-KC (r = .382, p < .01). TMT-A (r = -.327, p < .01), TMT-B (r = -.283, p < .05)). CONCLUSION: It was found that the gait speed while crossing over an obstacle was correlated with all cognitive function tests. Therefore, we suggest the use of the gait speed test while crossing over an obstacle rather than the simple gait test to diagnose cognitive decline.

• 대한간호학회지
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• 제47권1호
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• pp.1-13
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• 2017

Purpose: The purpose of this study was to examine the effects of a cognitive training program on neurocognitive task performance and activities of daily living (ADL) in patients who had a stroke. Methods: The research design for this study was a nonequivalent control group non-synchronized design. Patients were assigned to the experimental (n=21) or control group (n=21). The experimental group received a 4-week cognitive training program and usual care (i.e., rehabilitation service), while the control was received usual care only. Cognitive function was measured with a standardized neurocognitive test battery and ADL was assessed at baseline and one and two months after completion of the intervention. Repeated measures ANOVA was used to determine changes in cognitive function and ADL over 2 months. Results: The interaction of group and time was significant indicating that the experimental group showed improvement in attention, visuospatial function, verbal memory, and executive function compared to the control group which had a sustained or gradual decrease in test performance. A significant group by time interaction in instrumental ADL was also found between the experimental group with gradual improvement and the control group showing no noticeable change. Conclusion: Findings show that the cognitive training program developed in this study is beneficial in restoring cognitive function and improving ADL in patients following a stroke. Further study is needed to investigate the long-term relationship between cognitive training participation and cognitive improvement and effective functioning in daily living.

• 한국통신학회논문지
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• 제27권4A호
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• pp.310-315
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• 2002

본 논문은 객관적 음질 평가법으로 웨이블렛 변환을 이용한 향상된 바크 코히어런스 함수 (Wavelet based Bark Coherence Function : WBCF)를 제안한다. 바크 코히어런스 함수 (Bark Coherence Function : BCF)는 심리 음향 영역에서 코히어런스 함수를 정의함으로서 음성 통신 시스템의 아날로그 부분에 의하여 발생할 수 있는 선형 왜곡에 강한 객관적 음질 평가법이다. VoIP (Voice over Internet Protocol)와 같은 패킷 기반의 음성 전달 시스템은 가변 지연등이 발생 될 수 있는데, 이것은 원음과 왜곡음의 정확한 시간축 정렬을 불가능하게 하여 기존의 객관적 음질 평가법의 성능을 저하시킨다. 제안된 WBCF는 고주파 영역에서 시간 분해능이 높으며, 저주파 영역에서 주파수 분해능이 높은 웨이블렛 변환을 사용한 후 BCF를 계산하여 VoIP 시스템에서의 객관적 음질을 평가한다. 주/객관적 음질 평가 실험을 통하여 WBCF가 ITU-T 권고안인 Perceptual Speech Quality Measure (PSQM)에 비하여 높은 성능을 가짐을 확인하였다.

• 대한통합의학회지
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• 제8권2호
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• pp.121-130
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• 2020

Purpose : The objective of the current study was to evaluate the impact of the Computer-Based Cognitive Rehabilitation Program (CoTras) on the cognitive function and daily living activities of elderly and adult stroke patients. Methods : Twenty stroke patients were divided into two groups comprising 10 elderly stroke patients and 10 adult stroke patients. The CoTras was applied as the intervention for 30 minutes at a time, three times a week, for nine weeks (i.e., a total of 27 times), to both groups. The Neurobehavioral Cognitive Status Examination was used to assess cognitive function, and the Functional Independence Measure was utilized to evaluate daily living activities, prior to, during, and after the intervention. Results : The CoTras was demonstrated to have a statistically significant and positive effect on the cognitive function and daily living activities of stroke patients. However, the effect of the program on the restoration of weight-shifting capacity, as a component of the daily living activities of stroke patients, was without statistical significance. The program had a greater influence on improving the cognitive function and daily living activities of elderly stroke patients than adult stroke patients. Conclusion : This study makes a meaningful contribution to the literature on the topic as the intervention was demonstrated to lead to a more significant recovery of cognitive function and daily living activities in elderly stroke patients, compared to adult patients. Therefore, it is proposed that the CoTras should be used as a clinical intervention for elderly stroke patients. Future studies that evaluate the application of the CoTras, along with other occupation-based intervention programs, are warranted.

• Journal of Preventive Medicine and Public Health
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• 제40권2호
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• pp.162-168
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• 2007

Objectives : This prospective population-based cohort study was conducted to evaluate the risk factors of cognitive impairment and the degree of cognitive function change through a 5-year follow-up. Methods : The baseline and follow-up surveys were conducted in 1998 and 2003, respectively, Among 176 subjects who had normal cognitive function in the baseline study, 136 were followed up for 5 years. The cognitive function was investigated using the Korean version of the Mini-Mental State Examination (MMSE-K). The collected data were analyzed using SPSS and Stata. Results : Of the 136 subjects analyzed, 25 (18.4%) were cognitively impaired. Old age and low social support in the baseline survey were risk factors for cognitive impairment after 5 years. In the generalized estimating equation for 128 subjects except severe cognitive impairment about the contributing factors of cognitive function change, the interval of 5 years decreased MMSE-K score by 1.02 and the cognitive function was adversely affected with increasing age, decreasing education and decreasing social support. Conclusions : Although the study population was small, it was considered that the study results can be used to develop a community-based prevention system for cognitive impairment.

• 한국보건간호학회지
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• 제36권2호
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• pp.227-239
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• 2022

Purpose: This study aimed to examine the differences in the reciprocal causal relationship between cognitive function and depressive symptoms depending on whether older adults lived with others or alone. Methods: We used panel data retrieved from the sixth (Time 1) and seventh (Time 2) waves of the Korean Longitudinal Study of Aging (KLoSA). The study sample included 2,638 older adults living with others and 628 older adults living alone. We conducted cross-lagged panel analyses (CLPA) to identify the bidirectional causal relationship between cognitive function and depressive symptoms in the groups of older adults living with others and those living alone. Results: In the group of older adults living with others, cognitive function and depressive symptoms showed significant reciprocal relationships. In the group of older adults living alone, although the CLPA confirmed that higher levels of depressive symptoms at Time 1 influenced lower levels of cognitive function at Time 2, cognitive function at Time 1 was not associated with depressive symptoms at Time 2. Conclusion: The results suggest that the strategies for preventing cognitive decline and depressive symptoms should be developed according to whether the older adults live alone. Moreover, further studies should identify factors influencing depressive symptoms among older adults living alone, which will ultimately enable the management of depressive symptoms.

• Journal of Preventive Medicine and Public Health
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• 제55권1호
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• pp.106-113
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• 2022

Objectives: Previous studies have found that the oral health of seniors can affect their physical nutrition and quality of life (QoL). Additionally, poor oral health can lead to the development of dementia, which is associated with decreased cognitive function. This study aimed to examine the impact of geriatric oral health (GOH) on the QoL of Korean seniors and the mediating effects of cognitive function. Methods: We used data from the seventh Korean Longitudinal Study of Aging conducted in 2018. In total, 4049 seniors were included in our study. We analyzed the impact of GOH on QoL according to 5 mediating domains of cognitive function and control variables. To examine each path of mediating effects, bootstrapping with 5000 iterations was performed with 95% confidence intervals. Results: Our findings revealed that good GOH had a positive effect on the QoL of seniors. Also, better GOH corresponded to a higher degree of cognitive function within all 5 domains: orientation, memory registration, attention/calculation, memory recall, and language and visuospatial ability. In addition, 3 domains of the 5 domains (attention/calculation, memory recall, and language and visuospatial ability) had significant mediating effects on the relationship between GOH and QoL. Conclusions: This study suggests that adequate management of GOH is crucial for promoting a better QoL and a high degree of cognitive function among seniors. To prevent cognitive impairment, such as dementia, future studies should take a more targeted approach by examining data according to each cognitive domain and various socio-demographic factors.

• 동의신경정신과학회지
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• 제24권4호
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• pp.419-434
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• 2013

Objectives: The object of this study is to observe the cognition and motor function recovery effects of Joojakwhan (JJW), a traditional Korean poly-herbal formula for treating various neuropsychiatric diseases such as dementia, for the mildly stroke rats, with 60 minutes of reperfusion transient middle cerebral artery occlusion (tMCAO). Methods: In the present study, 125, 250 and 500 mg/kg of JJW were orally administered, once per day for 10 continuous days 2 hours after the tMCAO. The body weight changes, infarct sizes under 2% 2, 3, 5-triphenyl tetrazolium chloride (TTC) stain, sensorimotor functions and cognitive motor behavior tests were serially monitored with cerebral caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP)-immunoreactivities and histopathological changes. The effects of tMCAO on sensorimotor functions were evaluated by using of limb placing and body-swing tests, and the cognitive motor behaviors were also observed with water maze tests. Results: From the results of tMCAO, with marked decreases of body weights, disorders of sensorimotor functions increases the limb placing test scores, and decrease the numbers and percentages of body swings to the ipsilateral sides. The cognitive motor behaviors increases the distances and time to reach the escape platform which included the inhibitions of the decreases with repeated trials that were observed with focal cerebral cortex infarct volumes. In addition, the marked increases of the atrophy, numbers of degeneration, caspase-3- and PARP-immunoreactive cells around peri-infarct ipsilateral cerebral cortex were also observed in tMCAO controls when compared with the sham control rats, respectively. Conclusions: The results obtained from this study suggest that oral administrations of JJW indicate obvious cognitions and motor function recoveries of the rats with tMCAO, mild strokes, which are mediated by neuro-protective effects through known antioxidant effects of components.

• 감성과학
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• 제20권4호
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• pp.41-54
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• 2017

신체활동은 노화로 의한 인지기능 저하에 긍정적 영향을 미친다. 하지만 신체활동 참여가 정서인지기능에 미치는 영향을 과학적으로 밝혀 낸 연구는 드물다. 따라서 본 연구의 목적은 청년기와 노년기 성인의 정서인지 기능에 신체활동 참여가 어떠한 영향을 미치는지를 뇌 과학적으로 연구하는 것이다. 연구의 피험자는 D 광역시 성인 남성 60명으로 선정하였으며, 청년 운동 집단(25~35살), 청년 비 운동 집단(26~35살), 노년 운동 집단(60~70살), 노년 비 운동집단(60~70살) 4개의 집단으로 구성하였다. 실험도구는 EEG 측정 장비와 국제정서사진체계(International Affective Picture System: IAPS)를 사용하였다. 본 연구의 실험과제는 사진으로 제시하는 세 가지 정서자극(긍정적, 중립, 부정적)에 적합한 버튼을 눌러 정서적인지 검사를 실시하였다. EEG 측정은 8개(Fp1, Fp2, Fz, C3, C4, Cz, T3, T4)의 영역을 측정하였다. 통계처리는 4(집단)${\times}$3(자극)${\times}$8(영역)에 대한 삼원분산분석을 실시하였다. 결과: 본 연구 결과, 반응시간과 반응정확률 그리고 P3 잠재기는 집단간 주효과가 나타났다. 그리고 P3 진폭은 집단과 자극간 상호작용이 나타났다. 결론: 신체활동은 청년층과 노년층의 정서적 인지기능에 긍정적인 영향을 미치는 것으로 나타났다.