• Journal of Chest Surgery
• /
• 제31권7호
• /
• pp.703-710
• /
• 1998

연세대학교 의과대학 영동세브란스병원에서는 1989년 3월부터 1997년 9월까지 외래와 전화추적이 가능하였던 654명(남자 354명과 여자 300명)의 다한증 환자를 대상으로 흉부교감신경절제술을 시행하였다. 다한증에 대한 흉강 내시경을 이용한 수술기법은 기존의 개흉술보다 선명한 수술시야를 확보할 수 있는 장점이 있다. 단순기관 삽관을 이용한 마취 유도기법으로 마취시간의 단축과 수술시간의 단축, 그리고 입원기간의 단축이 가능하게 되었다. 시간절약뿐만 아니라 수술기법이 쉽고 미용효과를 최대로 살릴수 있는 2 mm주사침 흉강경을 이용한 흉부 교감신경 절제술은 최근 다한증에 가장 확실한 치료법이 되었다. 수술기법의 변화는 수술의 결과를 향상시켰으며, 수술 후 만족도를 95%이상으로 향상시켰다.

• 인터넷정보학회논문지
• /
• 제8권1호
• /
• pp.87-98
• /
• 2007

현재 국내 정보보호산업 통계조사는 조사목적 및 조사기준과 방법이 조사기관마다 서로 달라 신뢰성에 대한 문제가 제기되고 있다. 본 논문에서는 국내 정보보호관련 통계조사 방법의 문제점을 지적하고 보다 효율적으로 다양한 통계조사를 수행할 수 있는 조사시스템을 제안한다. 제안한 시스템은 회원 데이터베이스의 이메일과 싸이트 방문기업을 대상으로 다양한 통계조사(기업경기전망조사, 수요조사, 애로요인조사 등)를 수행할 수 있다. 특히 반복되는 동일 조사의 경우 예측에 매우 유용한 도구로 활용될 수 있을 것이다.

• Journal of Biosystems Engineering
• /
• 제28권1호
• /
• pp.27-34
• /
• 2003

Present combustion engines have reached almost at the limit of development due to the fundamental structural problems. This study was carried out to propose a new concept internal combustion engine which has great potential advantages to the conventional engines. Proposed new concept engine is a kind of rotary engine. A rotor is rotating concentrically in a cylinder which is divided into two partitioning valves. and it makes four compartments in the cylinder. The volumes of each of four compartments are changing continuously with the rotor movement, and performs the functions of intake, compression. expansion and exhaust simultaneously. The results of this study can be summarized as follows. 1. Expected theoretical thermal efficiency is 44.9 percent at the condition of 1000rpm and compression ratio of 8.0. which is almost the same as that of the conventional engines. i.e., piston and Wankel rotary engine. 2. The new concept engine has 2. working strokes in every revolution. Therefore. the new concept engine can reduce the specific weight and volume than four-stroke piston engine. 3. The torque variation is very small. therefore minimal noise and vibration are expectable. 4. The new concept engine can reduce mechanical energy loss than piston engine because neither crank mechanism nor eccentrical motion exists.

• 대한기관식도과학회지
• /
• 제9권2호
• /
• pp.60-64
• /
• 2003

Restenosis frequently develops with granulation and overgrowth of scar following surgical treatment for laryngotracheal stenosis. Various methods such as stenting or CO2 laser application have been used to prevent restenosis, but they were seldom unsatisfactory. Mitomycin is an antineoplastic antibiotics derived from Streptomyces caespitosus; it inhibits fibroblast proliferation and acts as an alkylating agent to inhibit DNA synthesis. This study was desinged to evaluate effectiveness and determine indications of usage of topical mitomycin for laryngotracheal stenosis as a nonsurgical means of reducing postoperative granulation and scar tissue formation. Patients and Method : A retrospective study was performed on eight cases of laryngotracheal stenosis with topical mitomycin application. The author analyzed clinical outcomes of operative treatment with topical mitomycin. Patients underwent laryngotracheal reconstruction, endoscopic granulation removal, or bronchoscopic bougienage followed by topical application of mitomycin (0.4 mg/$m{\ell}$, 4minuntes) on the lesion intraoperatively. Result : Overall success rate of decannulation was 38% ($\frac{3}{8}$). Successful decannulation was possible in 75% ($\frac{3}{4}$) of laryngeal stenosis patients, 75% ($\frac{3}{4}$) of children, 60% ($\frac{3}{5}$) of the patients without previous surgery, and 75% ($\frac{3}{4}$) of bronchoscopic bougienage. Conclusion : The topical application of mitomycin in laryngotracheal stenosis was effective in untreated pediatric laryngeal stenosis which underwent bronchoscopic bougienage. Our results show that the topical mitomycin application for laryngotracheal stenosis could be a effective adjuvant treatment.

• Journal of Microbiology
• /
• 제33권4호
• /
• pp.295-301
• /
• 1995

An antifungal Pseudomonas stutzeri YPL-1 produced extracellular chitinase and .betha.-1, 3-glucanase that were key enzymes in the decomposition of fungal hyphal walls. These lytic extracellular enzymes markedly inhibited mycelial growth of the phytopathogenic fungus Fusarium solani. A chitinase from P. stutzeri YPL-1 inhibited fungal mycelial growth by 87%, whereas a .betha.-1, 3-glucanase from the bacterium inhibited growth by 53%. Furthermore, co-operative action of the enzymes synergistically inhibited 95% of the fungal growth. The lytic enzymes caused absnormal swelling and retreating on the fungal hyphal walls in a dual cultures. Scanning electron microscopy clearly showed hyphal degradation of F. solani in the regions interacting with P. stutzeri YPL-1. In an in vivo pot test, P. stutzeri YPL-1 proved to have biocontrol ability as a powerful agent in controlling plant disease. Planting of kidney bean (Phaseolus vulgaris L.) seedlings with the bacterial suspension in F. solani-infested soil significantly suppressed the development of fusarial root-rot. The characteristics of a crude preparation of .betha.-1, 3-glucanase produced from P. stutzeri YPL-1 were investigated. The bacterium detected after 2 hr of incubation. The enzyme had optimum temperature and pH of 40.deg.C and pH 5.5, respectively. The enzyme was stable in the pH range of 4.5 to 7.0 and at temperatures below 40.deg.C, with a half-life of 40 min at 60.deg.C.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제16권1호
• /
• pp.97-115
• /
• 2022

Smart power grid is a user friendly system that transforms the traditional electric grid to the one that operates in a co-operative and reliable manner. Demand Response (DR) is one of the important components of the smart grid. The DR programs enable the end user participation by which they can communicate with the electricity service provider and shape their daily energy consumption patterns and reduce their consumption costs. The increasing demands of electricity owing to growing population stresses the need for optimal usage of electricity and also to look out alternative and cheap renewable sources of electricity. The solar and wind energy are the promising sources of alternative energy at present because of renewable nature and low cost implementation. The proposed work models a smart home with renewable energy units. The random nature of the renewable sources like wind and solar energy brings an uncertainty to the model developed. A stochastic dual descent optimization method is used to bring optimality to the developed model. The proposed work is validated using the simulation results. From the results it is concluded that proposed work brings a balanced usage of the grid power and the renewable energy units. The work also optimizes the daily consumption pattern thereby reducing the consumption cost for the end users of electricity.

• Journal of Ginseng Research
• /
• 제48권1호
• /
• pp.31-39
• /
• 2024

Background: Ginsenoside Rg3, a primary bioactive component of red ginseng, has anti-cancer effects. However, the effects of Rg3-enriched ginseng extract (Rg3RGE) on apoptosis and autophagy in breast cancer have not yet been investigated. In the present study, we explored the anti-tumor effects of Rg3RGE on breast cancer cells stimulated CoCl₂, a mimetic of the chronic hypoxic response, and determined the operative mechanisms of action. Methods: The inhibitory mechanisms of Rg3RGE on breast cancer cells, such as apoptosis, autophagy and ROS levels, were detected both in vitro. To determine the anti-cancer effects of Rg3RGE in vivo, the cancer xenograft model was used. Results: Rg3RGE suppressed CoCl₂-induced spheroid formation and cell viability in 3D culture of breast cancer cells. Rg3RGE promoted apoptosis by increasing cleaved caspase 3 and cleaved PARP and decreasing Bcl2 under the hypoxia mimetic conditions. Further, we identified that Rg3RGE promoted apoptosis by inhibiting lysosomal degradation of autophagosome contents in CoCl₂-induced autophagy. We further identified that Rg3RGE-induced apoptotic cell death and autophagy inhibition was mediated by increased intracellular ROS levels. Similarly, in the in vivo xenograft model, Rg3RGE induced apoptosis and inhibited cell proliferation and autophagy. Conclusion: Rg3RGE-stimulated ROS production promotes apoptosis and inhibits protective autophagy under hypoxic conditions. Autophagosome accumulation is critical to the apoptotic effects of Rg3RGE. The in vivo findings also demonstrate that Rg3RGE inhibits breast cancer cell growth, suggesting that Rg3RGE has potential as potential as a putative breast cancer therapeutic.

• 한국재난정보학회 논문집
• /
• 제3권1호
• /
• pp.55-68
• /
• 2007

Recently, people in cities of developed countries are exposed to unfortified damages of crime and disaster due to urbanization, industrialization and information-oriented era caused by congestion of population in terms of hardware and various social pathology phenomena and frequent and large scale of disaster caused by crime and disorder, which occur in the course of going through nuclear family, a gap between rich and poor and aging society in terms of software. In this regard, demand for security upon individual life and property has been increased but the police that are responsible for the public security does not effectively reduce damage in life and property because their activities are mainly oriented in coping with security accidents more than prevention. Shortage of manpower and budget, retarded equipment, and heavy overwork are the reasons. In order to confront with this kind of situation, we should utilize CCTV system with the purpose of declining possible chances of crime, not for eliminating cause of crime as crime prevention activities to predict danger in advance as a way of prevention and we may expect a role of damage prevention by installing CCTV in places where security accident may possibly happen. In conclusion, there are invasion of privacy, misuse of the system, insufficiency of overall monitoring office management, lack of citizens' understanding and economical allotment of the system installation costs in installation of CCTV system. However. it is necessary to install the CCTV system for effective prevention of crime and prevention activities of security accidents and accurate PR of purposes of installing CCTV to local residents, establishing relevant laws about system misuse, allotment of equipment costs and fees by R&D of the system machinery, cost reduction method of storage, management and replacement, saving costs from co-operative attitude of government, and local autonomous entities and local residents should be involved.

• Journal of International Society for Simulation Surgery
• /
• 제1권1호
• /
• pp.13-15
• /
• 2014

Nowadays, with advanced 3D printing techniques, the custom-made implant can be manufactured for the patient. Especially in skull reconstruction, it is difficult to design the implant due to complicated geometry. In large defect, an autograft is inappropriate to cover the defect due to donor morbidity. We present the process of manufacturing the 3D custom-made implant for skull reconstruction. There was one patient with skull defect repaired using custom-made 3D titanium implant in the plastic and reconstructive surgery department. The patient had defect of the left parieto-temporal area after craniectomy due to traumatic subdural hematoma. Custom-made 3D titanium implants were manufactured by Medyssey Co., Ltd. using 3D CT data, Mimics software and an EBM (Electron Beam Melting) machine. The engineer and surgeon reviewed several different designs and simulated a mock surgery on 3D skull model. During the operation, the custom-made implant was fit to the defect properly without dead space. The operative site healed without any specific complications. In skull reconstruction, autograft has been the treatment of choice. However, it is not always available and depends on the size of defect and donor morbidity. As 3D printing technique has been advanced, it is useful to manufacture custom-made implant for skull reconstruction.

• 한국산림과학회지
• /
• 제66권1호
• /
• pp.8-15
• /
• 1984

인구(人口)의 도시집중(都市集中)에 의(依)해 급격히 증가(增加)하고 있는 아파트단지(團地)의 조경수목(造景樹木)에 대(對)한 관리(管理)는 쾌적(快適)한 주거환경(住居環境)의 제공(提供)이라는 면(面)에서 중요(重要)한 의미(意味)를 지니고 있다. 주거환경(住居環境)의 질(質)을 높이는 데 중요(重要)한 역할(役割)을 담당하고 있는 조경수목(造景樹木)은 그동안 관리부실(管理不實)로 인(因)해 생육(生育)이 불량(不良)하고, 높은 하자율(瑕疵率)을 나타내었다. 이러한 현실(現實)에 대(對)한 개선방법(改善方法)으로는 식재공사(植栽工事)의 하자발생(瑕疵發生)을 최소(最少)로 하기 위한 시공기술(施工技術)의 향상(向上)과 이론적(理論的) 연구(硏究)가 필요(必要)하며, 조경부문관리인(造景尃門管理人)을 두어 관리기능(管理機能)을 강화(强化)함과 동시(同時)에 제도상(制度上) 적정수준(適正水準)의 관리비(管理費) 항목(項目)이 설정(設定)되어야 하며, 높은 주민(住民)의 관리의식(管理意識)을 바탕으로 관리(管理)에 대한 자발적(自發的)인 참여(參與)를 유도(誘導)할 수 있는 분위기(雰圍氣)를 조성(造成)하는 것이라 하겠다.