• Archives of Plastic Surgery
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• v.38 no.4
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• pp.369-375
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• 2011

Purpose: Many hemostatic agents and dressings have been tested with variable degree of success. Chitosan has a positive charge, it attracts red blood cells, which have a negative charge. Our goal is to test the efficacy of new developed chitosan-based hemostatic materials in providing durable hemostasis in a high-flow arterial wound model. Methods: We compared each group with SD rats motality tests and in vitro blood compatibility test by blood clotting index (BCI). We devided the SD rats into 6 groups (N =15) by type of hemostatic agents. A: 100% nonwoven chitosan (degree of the deacetylation: 90%). B: 50% N-acetylation on nonwoven of chitosan gel (degree of the deacetylation: 50%). C: 60% N-acetylation on nonwoven of chitosan ge (degree of the deacetylation: 40%)l. D: Cutanplast$^{(R)}$. E: HemCon$^{(R)}$ F: Gauze. In vivo test, a proximal arterial injury was created in unilateral femoral arteries of 90 anesthetized SD rats. Each materials was made same size and thickness then applied to the injury site for 3 minutes. In vitro test, we compared each group with BCI in human blood. Results: In vivo test, group A showed lower motality rate of 46% than any other groups, Group B and C showed lower motality rate of 60% than group D and E's motality rate of 66%. In vitro test, BCI of group A ($30.6{\pm}1.2$) and B ($29.3{\pm}1.0$) were showed nearly about group D ($29.1{\pm}1.8$) and E ($27.4{\pm}1.6$). Group C ($37.1{\pm}2.0$) showed higher BCI than group A and B, it means group C decreased blood clotting. Conclusion: In conclusion, this study suggests a newly developed chitosan-based hemostatic materials induced durable hemostasis and increased blood clotting, and are considered as effective biologic hemostatic agents.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.44-45
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• 2010

We are currently conducting studies on culturing and biocompatibility assessment of various cells such as neural stem cells and induced pluripotent stem cells(IPS cells) on carbon nanotube (CNT), on nerve regeneration electrodes, and on silicon wafers with a focus on developing nerve integrated CNT based bio devices for interfacing with living organisms, in order to develop brain-machine interfaces (BMI). In addition, we are carried out the chemical modification of carbon nanotube (mainly SWCNTs)-based bio-nanosensors by the plasma ion irradiation (plasma activation) method, and provide a characteristic evaluation of a bio-nanosensor using bovine serum albumin (BSA)/anti-BSA binding and oligonucleotide hybridization. On the other hand, the researches in the case of "novel plasma" have been widely conducted in the fields of chemistry, solid physics, and nanomaterial science. From the above-mentioned background, we are conducting basic experiments on direct irradiation of body tissues and cells using a micro-spot atmospheric pressure plasma source. The device is a coaxial structure having a tungsten wire installed inside a glass capillary, and a grounded ring electrode wrapped on the outside. The conditions of plasma generation are as follows: applied voltage: 5-9 kV, frequency: 1-3 kHz, helium (He) gas flow: 1-1.5 L/min, and plasma irradiation time: 1-300 sec. The experiment was conducted by preparing a culture medium containing mouse fibroblasts (NIH3T3) on a culture dish. A culture dish irradiated with plasma was introduced into a $CO_2$-incubator. The small animals used in the experiment involving plasma irradiation into living tissue were rat, rabbit, and pick and are deeply anesthetized with the gas anesthesia. According to the dependency of cell numbers against the plasma irradiation time, when only He gas was flowed, the growth of cells was inhibited as the floatation of cells caused by gas agitation inside the culture was promoted. On the other hand, there was no floatation of cells and healthy growth was observed when plasma was irradiated. Furthermore, in an experiment testing the effects of plasma irradiation on rats that were artificially given burn wounds, no evidence of electric shock injuries was found in the irradiated areas. In fact, the observed evidence of healing and improvements of the burn wounds suggested the presence of healing effects due to the growth factors in the tissues. Therefore, it appears that the interaction due to ion/radicalcollisions causes a substantial effect on the proliferation of growth factors such as epidermal growth factor (EGF), nerve growth factor (NGF), and transforming growth factor (TGF) that are present in the cells.

• Fire Science and Engineering
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• v.31 no.5
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• pp.63-69
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• 2017

This study describes the development of a long-distance hose for ultra-high pressure operation, which can be used in conjunction with an ultra-high pressure pump and can be effectively applied to the fire suppression of high-rise buildings and a long, large tunnels. Also, it has phosphorescent properties, which can help to secure the withdrawal route of the fire-fighters when they are threatened by the fire. We developed an ultra-high pressure hose aiming at a pressure of 3 MPa and a flow rate of 2000 lpm and developed an ultra-high pressure fire hose that can withstand this very high pressure by using a double jacket, triple polyurethane coating and warf (Wp) of 52. In order to ensure the performance of the developed ultra-high pressure hose, its structure, appearance, leakage at high pressure, length and elongation were inspected by a certified certification agency, who also subjected it to a peeling test, friction test, breaking pressure test and free fall test. Also, it was studied in addition to the luminescent high-pressure hose for fire-fighting. In the phosphorescence test, the luminance measurement value was more than the reference value of the luminance test after 40 minutes, which confirmed that its performance was satisfactory for fire-fighting products. In the future, if such an ultra-high pressure fire hose were commercialized and applied in the field, it could contribute to securing improved fire suppression and safer exit from fires, as compared to the fire hoses currently used in the suppression of fires in skyscraper buildings and long tunnels.

• Polymer(Korea)
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• v.38 no.2
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• pp.193-198
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• 2014

Lens and DVD require high quality of optical property. Conventional injection molded products contain high residual stress and this invokes birefringence since high cavity pressure and high temperature variation are involved in a molding process. Thus these products are often molded by injection compression molding in order to minimize the residual stress through reducing cavity pressure and uniform cavity pressure. In this study, molding parameters affecting molding quality such as property uniformity in injection compression molding were investigated through experiment. Molding quality deviations among the cavities in multi-cavity mold were also studied. Transparent resins, PC and PS were used in this study. Compression gap, compression speed, compression force, and compression delay time for processing variables in injection compression molding were applied in experiment. Compression force, compression delay time, and compression gap significantly affected the optical property of product. The degree of influence of process variable on the product quality was different in different resins. This implies that the optimal operational conditions in injection compression molding existed for each resin according to flow property.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.11
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• pp.1776-1788
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• 2019

Objective: The demands for measures to improve disease resistance and productivity of livestock are increasing, as most countries prohibit the addition of antibiotics to feed. This study therefore aimed to uncover functional feed additives to help enhance livestock immunity and disease resistance, using Acanthopanax sessiliflorus fruit extract (ASF). Methods: ASF was extracted with 70% EtOH, and total polyphenolic and catechin contents were measured by the Folin-Ciocalteu and vanillin assay, respectively. The 3D4/31 porcine macrophage cells ($M{\Phi}$) were activated by phorbol 12-myristate 13-acetate (PMA), and cell survival and growth rate were measured with or without ASF treatment. Flow-cytometric analysis determined the lysosomal activity, reactive oxygen species levels (ROS), and cell cycle distribution. Nuclear factor kappa B ($NF-{\kappa}B$) and superoxide dismutase (SOD) protein expression levels were quantified by western blotting and densitometry analysis. Quantitative polymerase chain reaction was applied to measure the lipid metabolism-related genes expression level. Lastly, the antibacterial activity of 3D4/31 $M{\Phi}$ cells was evaluated by the colony forming unit assay. Results: ASF upregulated the cell viability and growth rate of 3D4/31 $M{\Phi}$, with or without PMA activation. Moreover, lysosomal activity and intracellular ROS levels were increased after ASF exposure. In addition, the antioxidant enzyme SOD2 expression levels were proportionately increased with ROS levels. Both ASF and PMA treatment resulted in upregulation of $NF-{\kappa}B$ protein, tumor necrosis factor $(TNF){\alpha}$ mRNA expression levels, lipid synthesis, and fatty acid oxidation metabolism. Interestingly, co-treatment of ASF with PMA resulted in recovery of $NF-{\kappa}B$, $TNF{\alpha}$, and lipid metabolism levels. Finally, ASF pretreatment enhanced the in vitro bactericidal activity of 3D4/31 $M{\Phi}$ against Escherichia coli. Conclusion: This study provides a novel insight into the regulation of $NF-{\kappa}B$ activity and lipid metabolism in $M{\Phi}$, and we anticipate that ASF has the potential to be effective as a feed additive to enhance livestock immunity.

• Journal of Digital Convergence
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• v.19 no.9
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• pp.189-199
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• 2021

In order to increase the self-reliance rate of new and renewable energy in order to respond to the mandatory domestic zero-energy buildings, the taller the building, the more limited the site area, and installing PV modules on the roof is not enough. Therefore, BIPV (Building integrated photovoltaic, hereinafter BIPV) is the industry receiving the most attention as a core energy source that can realize zero-energy buildings. Therefore, this study conducted a survey on the problems of the BIPV industry in a self-discussing method for experts with more than 10 years of experience of designers, builders, product manufacturers, and maintainers in order to suggest the right direction and revitalize the BIPV industry. Industrial problems of BIPV adjustment are drawn extention range of standard and certification for products, range improvement for current small condition of various kind productions, need to revise standards for capable of accomodating roof-type, color-module and louver-module, necessary of barrier in flow of foreign modules into korea through domestic certification mandatory, difficulty in obtaining BIPV information, request to prevent confusion among participants by exact guidelime about architectural application part of BIPV, and lack of the BIPV definition clearness, support policy, etc. Based on the improvements needed for the elements, giving change and competitiveness impacts aims to present and propose counter measures and direction.

• The Journal of Engineering Geology
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• v.31 no.3
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• pp.395-432
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• 2021

Groundwater recharge rates vary widely by location and with time. They are difficult to measure directly and are thus often estimated using simulations. This study employed frequency and regression analysis and a classification and regression tree (CART) algorithm in a machine learning method to estimate groundwater recharge. CART algorithms are considered for the distribution of precipitation by subbasin (PCP), geomorphological data, indices of the relationship between vegetation and landuse, and soil type. The considered geomorphological data were digital elevaion model (DEM), surface slope (SLOP), surface aspect (ASPT), and indices were the perpendicular vegetation index (PVI), normalized difference vegetation index (NDVI), normalized difference tillage index (NDTI), normalized difference residue index (NDRI). The spatio-temperal distribution of groundwater recharge in the SWAT-MOD-FLOW program, was classified as group 4, run in R, sampled for random and a model trained its groundwater recharge was predicted by CART condidering modified PVI, NDVI, NDTI, NDRI, PCP, and geomorphological data. To assess inter-rater reliability for group 4 groundwater recharge, the Kappa coefficient and overall accuracy and confusion matrix using K-fold cross-validation were calculated. The model obtained a Kappa coefficient of 0.3-0.6 and an overall accuracy of 0.5-0.7, indicating that the proposed model for estimating groundwater recharge with respect to soil type and vegetation cover is quite reliable.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.30 no.2
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• pp.189-209
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• 2019

Main Path Analysis (MPA) is one of the text mining techniques that extracts the core literature that contributes knowledge transfer based on citation information in the literature. This study applied various text mining techniques to abstract of the paper related with sense-of-place, which is published at Korea and abroad from 1990 to 2018 so that could discuss in a macro perspective. The main path analysis results showed that from 1990, overseas research on sense-of-place has been carried out in the order of personal identity, public land management, environmental education and urban development-related areas. Also, by using the network analysis, this study found that sense-of-place was discussed at various levels in Korea, including urban development, culture, literature, and history. On the other hand, it has been found that there are few topic changes in international studies, and that discussions on health, identity, landscape and urban development have been going on steadily since the 1990s. This study has implications that it presents a new perspective of grasping the overall flow of relevant research.

• Ecology and Resilient Infrastructure
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• v.5 no.4
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• pp.246-256
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• 2018

In order to analyze hydraulic characteristics of discharge coefficient, hydraulic jump height, and hydraulic jump length, accompanied sediment transport, in the under-flow type vertical lift gate, the hydraulic model experiment and dimensional analysis were performed. The correlations between Froude number and hydraulic characteristics were schematized according to the presence and absence of sediment transport; the correlation of hydraulic characteristics and non-dimensional parameters was analyzed and multiple regression formulae were developed. In the hydraulic characteristics accompanied the sediment transport, by identifying the aspect different from the case that the sediment transport is absent, we verified that it is necessary to introduce variables that can express the characteristics of sediment transport. The multiple regression equations were suggested and each determination coefficient appeared high as 0.749 for discharge coefficient, 0.896 for hydraulic jump height, and 0.955 for hydraulic jump length. In order to evaluate the applicability of the developed hydraulic characteristic equations, 95% prediction interval analysis was conducted on the measured and the calculated by regression equations, and it was determined that NSE (Nash-Sutcliffe Efficiency), RMSE (root mean square), and MAPE (mean absolute percentage error) are appropriate, for the accuracy analysis related to the prediction on hydraulic characteristics of discharge coefficient, hydraulic jump height and length.

• Plant Journal
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• v.14 no.4
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• pp.39-47
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• 2018

In this research, when the output of the standard coal-fired thermal power plant operating continuously at the rated output of 500 MW is changed to operate at 300 to 500 MW, the amount of sulfur oxide produced and the amount of sulfur oxide in the absorption tower of desulfurization equipment and proposed an extra liquid to gas ratio improvement inversely proportional to the output. In order to calibrate the combustion efficiency at low power, the ratio of sulfur oxides relative to the amount of combustion gas is increased as the excess air ratio is increased. When the concentration of sulfur oxide at the inlet of the desulfurization absorber was changed from 300 to 500 ppm along with the output fluctuation. The liquid to gas ratio of limestone slurry and combustion gas was changed from 10.99 to 16.27. Therefore, if the concentration of sulfur oxides with output of 300 MW is x, The following correlation equation is recommended for the minimum required flow rate of slurry for the reduction of surplus energy due to the increase of the liquid weight at low load. $y1[m^3/sec]=0.11x+3.74$