• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.10
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• pp.131-142
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• 2018

Being dealt in Alfred Weber's Theory of the location of Industries, a lot of economic benefits can be obtained through aggregation and clustering of industrial facilities, which derived to the development of industrial complexes in Korea. However, with the IMF economic crisis as well as various institutional changes, the framework of aggregation and clustering of industries is broken, which led to individual developments that took place without any consideration of surrounding industries. For reformation of these condition of industrial complexes, national government-led regeneration projects are being carried out currently. However, national government-led projects mainly focus on profitable projects such as officetel and hotel that are irrelevant to exist composition of industrial complexes which is usually manufacturing base industries and are unable to solve the fundamental problems of industrial complexes. Thus, a necessity of industry clustering is deduced through case analysis of actual private-led manufacturing industry cluster with governance and analysis of benefits on financial, spatial and environmental aspects. In addition, implications on the necessity follow base on factorial analysis on the benefit of clustering development than individual development as well as analysis on the measures taken for successful clustering.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.44 no.1
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• pp.60-70
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• 2021

Recently, with the development of technologies for the fourth industrial revolution, convergence and complex technology are being applied to aircraft, electronic home appliances and mobile devices, and the number of parts used is increasing. Increasing the number of parts and the application of convergence technologies such as HW (hardware) and SW (software) are increasing the No Defect Found (NDF) phenomenon in which the defect is not reproduced or the cause of the defect cannot be identified in the subsequent investigation systems after the discovery of the defect in the product. The NDF phenomenon is a major problem when dealing with complex technical systems, and its consequences may be manifested in decreased safety and dependability and increased life cycle costs. Until now, NDF-related prior studies have been mainly focused on the NDF cost estimation, the cause and impact analysis of NDF in qualitative terms. And there have been no specific methodologies or examples of a working-level perspective to reduce NDF. The purpose of this study is to present a practical methodology for reducing NDF phenomena through data mining methods using quantitative data accumulated in the enterprise. In this study, we performed a cluster analysis using market defects and design-related variables of mobile devices. And then, by analyzing the characteristics of groups with high NDF ratios, we presented improvement directions in terms of design and after service policies. This is significant in solving NDF problems from a practical perspective in the company.

• Journal of Yeungnam Medical Science
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• v.12 no.2
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• pp.366-385
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• 1995

Epidemiological studies are important in both the prevention and treatment of mycobacterial infections. This study was initiated to establish the pulsed-field gel electrophoresis (PFGE) method, which are not yet extensively studied. The most apprpriate restriction endonucleases included DraI, AsnI, and XbaI. The optimal PFGE condition was different according to the enzymes used. Two stage PFGE was performed, in case of DraI first stage was performed with 10 seconds of initial pulse and 15 seconds of final pulse, while the second stage was performed with 60 seconds of initial pulse and 70 seconds of final pulse. The electrophoresis time for DraI-PFGE was 14 hours for each stage. Electrophoresis was performed for 22 hours, in case of XbaI, with 3 seconds of initial pulse and 12 seconds of final pulse. Electrophoresis was performed for 22 hours, in case of AsnI, with 5 seconds of initial pulse and 25 seconds of final pulse. In all cases the voltage of the electrophoresis was maintained constantly at 200 voltage. Standard mycobacterial strains, which included Mycobacterium bovis BCG, M. tuberculosis, and M. fortuitum, could not be differentiated by PFGE analysis. PFGE analysis was performed to differentiate 9 clinically isolated M. fortuitum strains using AsnI. All M. fortuitum strains showed different genotypes except 2 strains. Cluster analysis divided M. fortuitum strains into 2 large groups. PFGE analysis was performed to further differentiate M. fortuitum isolates using XbaI. The undifferentiated 2 M. fortuitum strains showed different PFGE patterns with Xba I. Cluster analysis of the XbaI-PFGE patterns showed more complex grouping than AsnI-PFGE patterns, which showed that XbaI-PFGE analysis was better than AsnI-PFGE in M. fortuitum genotyping. The top dissimilarity values of AsnI-PFGE and XbaI-PFGE were 0.74 and 0.75, respectively. This value was higher than that of arbitrarily primed polymerase chain reaction (AP-PCR) analysis and lower than that of restriction fragment length polymorphism (RFLP) analysis. This suggested that PFGE can be used as a supportive or alternative genotyping method to RFLP analysis.

• Journal of Genetic Medicine
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• v.16 no.2
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• pp.71-75
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• 2019

Periventricular nodular heterotopia (PNH) is a malformation of cortical development in which normal neurons inappropriately cluster in periventricular areas. Patients with Mowat-Wilson syndrome (MWS) typically present with facial gestalt, complex neurologic problems (e.g., severe developmental delay with marked speech impairment and epilepsy), and multiple anomalies (e.g., Hirschsprung disease, urogenital anomalies, congenital heart defects, eye anomalies, and agenesis of the corpus callosum [CC]). MWS is mostly caused by haploinsufficiency of the gene encoding zinc-finger E-box-binding homeobox 2 (ZEB2) due to premature stops or large deletions. We present a case report of a 9-year-old girl with PNH, drug-responsive epilepsy, severe intellectual disability, and facial dysmorphisms only in whom we performed whole-exome sequencing and found a de novo heterozygous missense mutation (c.3134A>C; p.His1045Pro) of ZEB2 (NM_014795.3; NP_055610.1). This mild case of MWS caused by a rare novel missense mutation of ZEB2 represents the first report of MWS with isolated PNH.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.1
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• pp.47-52
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• 2020

We previously demonstrated that Bordetella bronchiseptica (B. bronchiseptica) antigen (Ag) enhances the Mycoplasma hyopneumoniae Ag-specific immune response. The focus of this study was whether acellular bacterin of B. bronchiseptica could be used as an adjuvant to increase antigen-presenting capability of dendritic cells (DCs) by increasing the level of activation. The metabolic activity of DCs was increased by B. bronchiseptica, similar to lipopolysaccharide (LPS). Flow cytometry analysis revealed that B. bronchiseptica increases the expression of major histocompatibility complex class-2, cluster of differentiation (CD)40, CD54, and CD86 which are closely related to DC-mediated immune responses. B. bronchiseptica enhanced the production of cytokines related to adaptive immune responses. Furthermore, the survival rate of B. bronchiseptica-injected groups was 100% at 15 and 20 mg/kg doses, whereas that of LPS-injected groups was only 20%, 0% at 15 and 20 mg/kg doses respectively, and so B. bronchiseptica is likely to be safer than LPS. Taken together, these results indicate that B. bronchiseptica can be used as an adjuvant to enhance the antigen-presenting capability of DCs. B. bronchiseptica is a candidate for producing vaccines, especially in case of DC-mediating efficacy and safety demands. This study provides researchers and clinicians with valuable information regarding the usage of B. bronchiseptica as a safe bacteria-derived immunostimulating agent for developing efficient vaccines.

• Bulletin of the Korean Chemical Society
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• v.30 no.9
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• pp.2061-2065
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• 2009

Two simple algorithm modifications are made to the THRASH data retrieval program with the aim of improving analysis speed for complex Fourier transform ion cyclotron resonance (FTICR) mass spectra. Instead of calculating the least-squares fit for every charge state in the backup charge state determination algorithm, only some charge states are pre-selected based on the plausibility values obtained from the FT/Patterson analysis. Second, a modification is made to skip figure-of-merit (FOM) calculations in the central m/z region between two neighboring peaks in isotopic cluster distributions, in which signal intensities are negligible. These combined modifications result in a significant improvement in the analysis speed, which reduces analysis time as much as 50% for ubiquitin (8.6 kDa, 76 amino acids) FTICR MS and MS/MS spectra at the reliability (RL) value = 0.90 and five pre-selected charge states with minimal decreases in data analysis quality (Table 3).

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.37.2-37.2
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• 2013

Recently it turns out that simple-looking elliptical galaxies and lenticular galaxies are more complex and intriguing than expected. One of the most surprising and intriguing findings in extragalactic studies during the last two decades is a discovery that color distribution of the globular clusters in these galaxies is bimodal, suggesting that there are two subpopulations: blue and red globular clusters. We present a determination of the two-dimensional shape parameters of the blue and red globular cluster systems (GCSs) in a large number of bright elliptical galaxies and lenticular galaxies. The position angles of both and red GCSs show a correlation with those of the stellar light distribution, showing that the major axes of the GCSs are well aligned with those of their host galaxies. However, the shapes of the red GCSs show a tight correlation with the stellar light distribution as with the rotation property of their host galaxies, while the shapes of the blue GCSs do much less. These provide clear geometric evidence that the origins of the blue and red globular clusters are distinct and that these galaxies may have dual halos: a blue (metal-poor) halo and a red (metal-rich) halo. These two halos show significant differences in metallicity, structure, and kinematics, indicating that they are formed in two distinguishable ways. The red halos might have formed via dissipational processes with rotation, while the blue halos are through accretion.

• Journal of the Korean Data and Information Science Society
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• v.20 no.6
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• pp.1155-1167
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• 2009

We made a new sample design for life and consciousness survey of Kyungpook people in 2007. We used the 10% sample survey data of 2005 population and housing census as a survey population. After stratification, we allocate proportionally samples within strata after examining various characteristics in previous survey, which includes economic activity state, an income level per year, and housing possession. And we calculated weight in a new sample design and derived estimators and a formula of standard error using the weights.

• BMB Reports
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• v.44 no.10
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• pp.674-679
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• 2011

Bacillus sphaericus produces mosquito-larvicidal binary toxin composed of BinA and BinB. While BinB is expected to bind to a specific receptor on the cell membrane, BinA interacts to BinB or BinB receptor complex and translocates into the cytosol to exert its activity via unknown mechanism. To investigate functional roles of aromatic cluster in BinA, amino acids at positions Y213, Y214, Y215, W222 and W226 were substituted by leucine. All mutant proteins were highly produced and their secondary structures were not affected by these substitutions. All mutants are able to insert into lipid monolayers as observed by Langmuir-Blodgett trough and could permeabilize the liposomes in a similar manner as the wild type. However, mosquito-larvicidal activity was abolished for W222L and W226L mutants suggesting that tryptophan residues at both positions play an important role in the toxicity of BinA, possibly involved in the cytopathological process after toxin entry into the cells.

• Journal of computational fluids engineering
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• v.13 no.1
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• pp.35-40
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• 2008

Generally flight vehicles have many cavities such as wheel wells, bomb bays and windows on their external surfaces and the flow around these cavities makes separation, vortex, shock and expansion waves, reattachment and other complex flow phenomenon. The flow around the cavity makes abnormal and three-dimensional noise and vibration even thought the aspect ratio (L/D) is small. The cavity giving large effects to the flow might make large noise, cause structural damage or breakage, harm the aerodynamic performance and stability, or damage the sensitive devices. In this study, numerical analysis was performed for cavity flows by the unsteady compressible three dimensional Reynolds-Averaged Navier-Stokes (RANS) equations with Wilcox's $\kappa-\omega$ turbulence model. The MPI(Message Passing Interface) parallelized code was used for calculations by PC-cluster. The cavity has the aspect ratios of 2.5, 3.5 and 4.5 with the W/D ratio of 2 for three-dimensional cavities. The Sound Pressure Level (SPL) analysis was done with FFT to check the dominant frequency of the cavity flow. The dominant frequencies were analyzed and compared with the results of Rossiter's formula and Ahuja& Mendoza's experimental datum.