• 대한의생명과학회지
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• 제9권4호
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• pp.209-214
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• 2003

To determine the clinical usefulness of Immuno Blot test, 160 samples from the patients with chronic HCV infection were analyzed. And serotyping and line probe assay were performed to evaluate the distribution of hepatitis C virus genotypes in Korean isolates. In this group, as a result of genotyping type 1 band 2a, the serotype I and II were the most common source of HCV infection. There were no significant difference in response to the alpha-interferon HCV infection treatment with the subtype 1 b or 2a. And the serotypes of NS4 peptides were compared with the genotypes to evaluate their clinical usefulness. Among 49 cases studied for genotypes and serotype, genotype 1 b, 1 b/2b, 2a, 2a/2c and 2b were 51.0％, 2.0％, 34.6％, 8.1％ and 4.0％, respectively. The serotypes I and II were 57.1％ and 42.8％, respectively; they were matched with genotypes in 85.7％ and seemed to be easy to perform. To monitor their performing progress or treatment response, serotype test was made before the genotype test. The Result showed that there was no significant difference in response to the alpha-interferon HCV infection treatment with the subtype 1 b or 2a in Korea.

• 대한디지털의료영상학회논문지
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• 제13권2호
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• pp.91-97
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• 2011

This study was conducted to know usefulness of panoramic radiography by comparing clinical evaluation and dental panoramic radiography in case of oral examination. Following results were concluded by analyzing difference between the result of Clinical evaluation and dental panoramic radiography. According to comparison the result of clinical evaluation and panoramic radiography, In Shin's research, dental caries was higher by 23.1%, periodontal disease was 31.9%, in An's research, dental caries was 24.2%. From new point of view from panoramic radiography, impacted tooth was 33.6%, Sinus abnormalities was 11.6%, periapical lesion was 5.4% in Shin's research and periapical lesion was 17.4%, 3rd molar impaction was 15.3% and retained root was 5.3% in An's research. Any kind of caries were not found in oral examination in the 66.7% of patients among patients with dental root caries in An's research. There were misdiagnose in oral examination(even side(59.5%),proximal side(59.5%), seconds caries(44.0%).

• 대한치과의사협회지
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• 제57권11호
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• pp.690-699
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• 2019

Ultrasound sonography(US) is used to evaluate various diseases of maxillofacial region including salivary glands, soft tissue and jaw lesions because of easy accessibility and no hazard of ionizing radiation. Also, US can offer dynamic study showing real-time images during diagnostic or surgical procedure. US images provide accurate information about the internal features of lesions on the jaw prior to surgical treatment. Doppler images are used to visualize the vascular distribution of the lesions and to provide additional information to enhance diagnostic value. Nevertheless, the clinical application of US imaging is limited in the dental field. This is due to the lack of knowledge about the US image and the image characteristics of the anatomical structures. It is necessary to evaluate the diagnostic value of US and evaluate its usefulness by looking at clinical cases using US images. Therefore, US imaging may be recommended as an assistant image in evaluating jaw lesions. US images provided accurate information about the internal structure of lesions on the jaw prior to surgical treatment, and diagnostic value was enhanced by visualizing the vascular distribution of the lesion using doppler imaging.

• Annals of Clinical Neurophysiology
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• 제9권2호
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• pp.63-68
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• 2007

The EEG plays an important diagnostic role in epilepsy and provides supporting evidence of a seizure disorder as well as assisting with classification of seizures and epilepsy syndromes. There are a variety of electroclinical syndromes that are really defined by the EEG such as Lennox-Gastaut syndrome, benign rolandic epilepsy, childhood absence epilepsy, juvenile myoclonic epilepsy and also for localization purposes, it is vitally important especially for temporal lobe epilepsy. The sensitivity of first routine EEG in diagnosis of epilepsy has been known about 20-50%, but this proportion rises to 80-90% if sleep EEG and repetitive recording should be added. Convincing evidences suggest that the EEG may also provide useful prognostic information regarding seizure recurrence after a single unprovoked attack and following antiepileptic drug (AED) withdrawal. Moreover, patterns in the EEG make it possible to disclose an ictal feature of nonconvulsive status epilepticus, separate epileptic from other non-epileptic episodes and clarify the clues predictive of the cause of the encephalopathy (i.e., triphasic waves in metabolic encephalopathy). Therefore, regardless of its low sensitivity and other pitfalls, EEG should be considered not only in the situation of new onset episode such as a newly developed, unprovoked seizure or a condition manifesting decreased mentality from obscure origin, but also as a barometer of the long-term outcome following AED withdrawal.

• Annals of Clinical Neurophysiology
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• 제9권2호
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• pp.69-74
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• 2007

Electroencephalogram (EEG) is a representative diagnostic tool in epilepsy. However, there are several points of debate on the role of EEG in diagnosis and management of epilepsy. We suggest that EEG has some limitations for differential diagnosis from nonepileptic episodic diseases, classification of epilepsy, prediction of recurrence, and evaluation of treatment response. Interictal EEG cannot diagnose or exclude epilepsy because interictal epileptic discharge (IED) is frequently absent in epilepsy and can appear in nonepileptic conditions. Although EEG is helpful in classification of epilepsy, focal spikes in generalized epilepsy and secondary bilateral synchrony in localization related epilepsy cause interrater disagreement. It is controversial whether EEG predicts recurrence after the first seizure in adults. The predictive value of EEG in antiepileptic drug (AED) withdrawal is not absolute. The prognosis after AED withdrawal depends on epilepsy syndrome. Many studies could not confirm the value of EEG in assessing the treatment response. After all, epilepsy is clinically diagnosed and assessed. Interictal EEG alone does not provide decisive information and routine follow-up of EEG is not recommended.

• 임상간호연구
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• 제16권3호
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• pp.157-174
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• 2010

Purpose: This study aims to develop, verify, and suggest outcome indicators for advanced practice nurses (APNs) in order to clarify their usefulness. Methods: To develop outcome indicators, the following methods were applied: reviewing literature intended to identify preliminary outcome indicators; surveying outcome indicators currently used for APNs and collecting the opinions from representatives of the professionals in clinical practice; verifying the content validity of preliminary outcome indicators by professionals and verifying the preliminary outcome indicators with 252 APNs. Results: Suggested outcome indicators are categorized into 84 items in total. Of these, the number of outcome indicators commonly appearing across disciplines was 18, mostly related to satisfaction and education. A majority of other outcome indictors exhibiting high relevance to individual disciplines are associated with care, including critical care (19 items), oncologic care (9 items) and emergency care (10 items). Conclusion: As the outcome indicators identified in this study are available to demonstrate the usefulness of APNs, it is recommended that future studies need to select and use appropriate outcome indicators according to characteristics and conditions of the discipline under examination. In addition, it is necessary to validate whether the suggested outcome indicators reflect adequately the practices of APNs.

• 정신신체의학
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• 제17권2호
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• pp.75-81
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• 2009

연구목적 : 소아정신과의사의 진료가 개설되지 않은 일반정신과 외래 및 소아과 외래에서 아동의 정신과적 장애를 선별 진단하는 목적으로 한국어판 강점 난점설문지(Korean version of Strengths and Difficulties Questionnaire : SDQ-Kr)가 활용될 수 있는지 알아보기 위하여 아동 정신병리의 표준진단도구인 아동행동조사표 (Korean version of Childhood Behavior Checklist : K-CBCL)와 비교 분석하였다. 방법 : 부모용 SDQ-Kr과 K-CBCL을 정신과 외래아동 313명, 정신과로 진료의뢰된 소아과 자문아동 91명, 소아과 외래아동(대조군) 93명의 부모에게 시행하였다. 이들은 모두 4~11세였고, 정신과아동은 ADHD, 정서장애, 또는 품행장애 중 하나로 진단되었다. SDQ-Kr과 K-CBCL의 대응되는 소척도 평균점수에서 세 집단간 차이가 있는지 성별을 나누어 비교하였다. 또한 두 설문지의 대응하는 소척도 점수들간 상관계수를 산출함으로써 SDQ-Kr의 구인타당도를 조사하였다. 정신과아동과 소아과아동에 대한 두 설문지의 집단 판별력을 비교하기 위해 AUC를 산출하고, 또한 정신과아동에 대한 두 설문지의 진단예측도를 비교하였다. 결과 : SDQ-Kr과 K-CBCL의 소척도 모두에서 정신과아동이 가장 높은 점수를 보였고 소아과 자문아동, 소아과 대조아동 순서로 나타났다. 두 설문지의 대응되는 소척도들은 유의하게 상관되었으며, 모두 정신과아동과 소아과아동의 집단 판별력이 우수한 것으로 나타났으나 SDQ-Kr이 더 나은 결과를 보였다. 정신과아동의 진단 예측도에서도 SDQ-Kr이 높은 예측력을 나타냈다. 결론 : 이 연구 결과는 SDQ-Kr이 소아과 외래에서 정신과적 진료가 필요한 아동을 선별하고, 일반정신과에서 소아정신과적 진단을 내리는데 일차적인 진단도구로 활용될 수 있음을 시사한다.

• 수면정신생리
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• 제3권2호
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• pp.1-17
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• 1996

To demonstrate the clinical usefulness of electroencephalography (EEG) and factors increasing the usefulness of EEG, the authors evaluated each relationship between EEG related factors and clinical variables, and neuroimaging studies (CT and MRI)-related factors, and factors which are related with routine neurological examination for 207 patients who had been evaluated with both of EEG and neuroimaging study(CT or/and MRI). The results were as follows: 1) Abnormality of EEG findings had significant relationships with chief complaints, diagnosis, medication use, seizure attack, pathological reflex, and level of consciousness. However there were no significant correlations between abnormality of EEG findings and neuroimaging studies (CT and MRI)- related factors. 2) Laterality of EEG findings had significant relationships with abnormality, laterality, and focality of CT findings, and also with abnormality of MRI findings. But there were no significant correlations between laterality of EEG findings and clinical variables, and neurological examination-related factors. 3) Anterior-posterior distribution of EEG findings was significantly related with medication use. 4) Focality of EEG findings had significant relationships with sex, sensory dysfunction sign, and cerebellar dysfunction sign. But there were no significant correlations between focality of EEG findings and neuroimaging studies(CT and MRI) related factors. 5) Abnormal EEG pattern had significant correlations with various factors, such as age, chief complaints, duration from onset of symptom to taking MRI, seizure attack, abnormality and nature of lesion in CT findings, cortical atrophy in MRI findings, motor dysfunction sign, sensory dysfunction sign, and pathological reflex. 6) With abnormality on sleep activation, age, age of onset, seizure attack, ventricular enlargement in CT findings, and abnormality of MRI findings were significantly correlated. 7) With abnormality on hyperventilation activation, duration of illness and laterality of MRI findings were significantly correlated. Above results may suggest that abnormality of EEG findings is more closely related with functional change of the brain than structural changes of the brain and laterality of EEG findings is vice versa. And also that medication use has an influence on anterior versus posterior distribution of EEG findings and focality of EEG findings is not related with structural changes of the brain. Activation with sleep may be effective to show age differences and provocation of seizure activity and hyperventilation may be effective to detect the abnormal EEG findings by cerebrovascular insufficiency.

• 한국산학기술학회논문지
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• 제16권8호
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• pp.5476-5484
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• 2015

본 연구의 목적은 산학연 공동기술개발사업으로 개발한 가상현실재활시스템이 뇌졸중 환자에게 긍정적인 영향을 주는지 임상 실험으로 알아보고 이를 통해 개발제품의 임상적 사용 가능성을 검증하기 위함이다. 임상실험을 통해 검증하고자 가상현실재활시스템을 재활병원에 입원하고 있는 뇌졸중 24명(뇌출혈 13명, 뇌경색 11명)에게 제공하였다. 실험군(13명)에는 가상현실재활시스템 위주의 훈련을 실시하였고, 대조군(11명)에는 재활치료의 유형인 보편적 기능훈련으로 일상생활활동 훈련, 지필물과 테이블 탑 위주의 인지재활 훈련, 운동조절 훈련을 실시하였다. 실험군과 대조군 모두 주 3회 하루 2회씩 총 8주간 실시하였다. 두 집단 모두 사전사후 기능적 독립 측정(Functional Independent Measure; FIM), 한국형 간이정신상태 검사(Mini-Mental State Examination for Korean; MMSE-K), 자아존중감척도 평가를 실시하였다. 실험결과 가상현실재활시스템을 제공한 집단과 보편적 재활치료를 받은 집단이 일상생활활동, 기초인지, 자아존중감척도에서 유사한 결과를 보였다. 중재 전후를 비교해 본 결과 가상현실재활시스템을 제공한 집단이 중재 전보다 중재 후에 일상생활활동, 기초인지, 자아존중감에서 모두 의미 있는 향상이 있었다(P<.05). 산학공동으로 개발한 가상현실재활시스템이 뇌졸중 환자의 일상생활 기능과 기초 인지능력을 회복시키고, 삶의 만족과 인간행동의 원인이 되는 자아존중감에 긍정적인 영향을 보여 주었기 때문에 가상현실재활시스템의 임상 적용 가능성을 긍정적으로 확인하였다. 추후 연구에서는 가상현실재활시스템을 뇌손상 환자와 치매 환자의 다양한 기능 회복에 대한 임상적 유용성을 검증할 필요가 있다.

• Annals of Clinical Neurophysiology
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• 제20권2호
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• pp.71-78
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• 2018

Nerve conduction study (NCS) is an electrophysiological tool to assess the overall function of cranial and peripheral nervous system, therefore NCS has been diagnostically helpful in the identification and characterization of disorders involving nerve roots, peripheral nerves, muscle and neuromuscular junction, and are frequently accompanied by a needle Electromyography. Furthermore, NCS could provide valuable quantitative and qualitative results into neuromuscular function. Usually, motor, sensory, or mixed nerve studies can be performed with using NCS, stimulating the nerves with the recording electrodes placed over a distal muscle, a cutaneous sensory nerve, or the entire mixed nerve, respectively. And these findings of motor, sensory, and mixed nerve studies often show different and distinct patterns of specific abnormalities indicating the neuromuscular disorders. The purpose of this special article is to review the neurophysiologic usefulness of NCS, to outline the technical factors associated with the performance of NCS, and to demonstrate characteristic NCS changes in the setting of various neuromuscular conditions.