• Journal of Korean Medicine Rehabilitation
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• v.23 no.3
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• pp.149-157
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• 2013

Objectives This study was designed to: (1) investigate the clinical feature of tongue diagnosis, (2) make an observation of significant changes in tongue diagnosis according to the patient's physical condition and laboratory result and (3) identify clinical efficacy of tongue diagnosis. Methods 300 patients' tongue diagnosis results were analyzed and the patients were divided to each group according to the physical condition and laboratory result. Then, chi-square test was performed to assess statistical significance between tongue diagnosis results of each group. Results As a result of analyzing the spread of tongue diagnosis according to the patient's physical condition and laboratory result, 18 groups had statistical significance related to specific tongue color and tongue coating. Conclusions Even if there would be possible misinterpretations in one-to-one match between the tongue diagnosis and certain diseases, we identified that tongue diagnosis results were changed somewhat related to patient's physical condition with some tendency and tongue diagnosis could be used for meaningful clinical diagnostic tool.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.1781-1787
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• 2015

Background: miRNAs are relatively recently discovered cancer biomarkers which have important implications for cancer early diagnosis, treatment and estimation of prognosis. Here we focussed on expression of mir-196a-5p in gastric cancer tissues and cell lines so as to analyse its significance for clinicopathologic characteristics and generate enriched KEGG pathways clustered by target genes for exploring its potential roles as a biomarker in gastric cancer. Materials and Methods: The expression of mir-196a-5p in poorly, moderate and well differentiated gastric cancer cell lines compared with GES-1 was detected by RT-qPCR, and the expression of mir-196a-5p in gastric cancer tissues comparing with adjacent non cancer tissues of 58 cases were also assessed by RT-qPCR. Subsequently, an analysis of clinical significance of mir-196a-5p in gastric cancer and enriched KEGG pathways was executed based on the miRWalk prediction database combined with bioinformatics tools DAVID 6.7 and Mirfocus 3.0. Results: RT-qPCR showed that mir-196a-5p was up-regulated in 6 poorly and moderate differentiated gastric cancer cell lines SGC-7901, MKN-45, MKN-28, MGC-803, BGC-823, HGC-27 compared with GES-1, but down-regulated in the highly differentiated gastric cancer cell line AGS. Clinical data indicated mir-196a-5p to beup-regulated in gastric cancer tissues (47/58). Overexpression of mir-196a-5p was associated with more extensive degree of lymph node metastasis and clinical stage (P < 0.05; x2 test). Enriched KEGG pathway analyses of predicted and validated targets in miRWalk combined with DAVID 6.7 and Mirfocus 3.0 showed that the targeted genes regulated by mir-196a-5p were involved in malignancy associated biology. Conclusions: Overexpression of mir-196a-5p is associated with lymph node metastasis and clinical stage, and enriched KEGG pathway analyses showed that targeted genes regulated by mir-196a-5p may contribute to tumorgenesis, suggesting roles as an oncogenic miRNA biomarker in gastric cancer.

• Journal of Korean Clinical Health Science
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• v.1 no.1
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• pp.1-7
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• 2013

Purpose. To analysis the prevalence of the myopia and corneal astigmatism in Korea women university students. Methods. From August 2011 to December 2012, one hundreds subjects were performed in refraction test using the Auto-Keratometry. Results. The mean age of the 100 subjects (200 eyes) was $21.23{\pm}2.34$. The mean spherical refractive power was -$1.78{\pm}1.65$(OD) and -$1.83{\pm}1.67$(OS) Diopter. The mean astigmatism power was $1.22{\pm}0.96$ (OD) and $1.27{\pm}0.91$ (OS). The mean corneal astigmatism was $1.44{\pm}0.81$(OD) and $1.55{\pm}0.93$(OS). Corneal astigmatism was between 0.25 D and 1.25 D in 67.7% of eyes, 1.25 D or higher in 27.5% eyes, and less than 0.25 D in 4.8% of eyes. Astigmatism was with the rule in 65%, against the rule in 31.5%, and oblique in 3.5%. There was a statistical significance between right eye and left eye in the spherical equivalent power(p=0.002). Also there was a statistical significance between spherical power and refractive astigmatism in OD(p=0.006) and OS(0.003) and a statistical significance between corneal astigmatism and refractive astigmatism in OS(p=0.0003). However, there was not a statistical significance between spherical power and corneal astigmatism in OD(p=0.08) and OS(0.1) and a statistical significance between corneal astigmatism and refractive astigmatism in OS(p=0.48). Conclusions. In this study, these results suggested that the analysis of the refractive myopia and corneal astigmatism can provide the visual correct and useful diagnosis information for the eyewear dispensing, contact lens fitting and corneal refraction surgery.

• The Journal of the Korean dental association
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• v.50 no.12
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• pp.720-726
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• 2012

Oral mucosal lesions with a papillary or verrucous surface are a heterogenous group of conditions with widely varying clinical behaviour. The etiology is variable and includes infective, traumatic or neoplastic processes. The majority of these lesions are precanceous lesion. Therefore, a biopsy is required to establish a diagnosis and the microscopic examination must be coordinated with the clinical findings. This paper reviews the clinical features and significance of papillary or verrucous lesions.

• The Journal of the Korean dental association
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• v.41 no.1 s.404
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• pp.42-47
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• 2003

Dental professions recommend that mandibular impacted third molar be extracted for the prevention of osteomyelities crneoplasm or for the treatment of halitosis. Even the possibility of emergence of unexpected halitosis after the preventive extraction exists, there are few studies describing the unexpected halitosis. This study intended to measure the emergence of halitosis after extraction of mandibular impacted third molar. Thirty-eight patients who visited Daejin Medical Center participated in this study. Halitosis was objectively measured using Halimeter in 3 intervals-before, after I day, after 7 days. Third factors, scaling and gender, which may influence the halitosis were analyzed with stratification. This study finds that in general halitosis decreased after 1 day but increased after 7 days. Scaling was helpful in decreasing halitosis and women have less severe halitosis than men. The effects of time interval(p<0.05), gender(p=0.836), and scaling(p=0.7929) on the severity of halitosis were not statistically significant. However, since this study's patients are neither a representative sample nor a random sample, all data interpretation was focused on clinical significance instead of conventional statistical significance. Clinical significance of this study's findings are: 1) scaling should be conducted in advance, 2) men should be notified of the higher possibility of halitosis.

• Annals of Clinical Neurophysiology
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• v.6 no.1
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• pp.48-51
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• 2004

The occurrence of polyneuropathy in association with monoclonal gammopathy of undetermined significance (MGUS) is quite common. However, reports of MGUS associated cranial neuropathies are rare. A 63 year-old women was presented with diplopia and swallowing difficulty. Neurological examination showed limitation of abduction of right eye, right peripheral facial palsy, decreased hearing and gag reflex, left side deviation of uvula, and decreased DTR. Sensorimotor polyneuropathy were observed with elctrophysiological studies. Protein and immunoelectrophoresis revealed IgG ${\kappa}$monoclonal gammopathy. She was treated with intravenous immunoglobulin and steroid, and her symptoms and signs were improved. This case suggested that she had sensorimotor polyneuropathy and multiple cranial neuropathies associated with IgG ${\kappa}$MGUS.

• Journal of Korean Clinical Health Science
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• v.2 no.3
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• pp.203-208
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• 2014

Purpose. To analysis the refractive error in 7-9 year-old Korea children. Methods. From July 2013 to June 2014, two hundred eighty two subjects were performed in refraction test using the Auto-Refractometry. Results. The refractive error by spherical equivalent among all subjects was myopia 47.58%, emmetropia 42.35%, astigmatism 32.33%, and hyperopia 8.76%. Myopia was more common in female than males although the difference was not statically significant. The axis of astigmatism was with the rule in 65%, against the rule in 31.5%, and oblique in 3.5% There was a statistical significance between 7 year and 9 year of male in the spherical equivalent power(p=0.010). Also there was a statistical significance between 7 years and 9 years of female in the spherical equivalent power(p=0.036). However, there was not a statistical significance between male and female in spherical equivalent power(p>0.5). Conclusions. In this study, myopia was the most common refractive error. On the other hand, The prevalence of the axis of astigmatism was the with- the- rule. The spherical equivalent of refractive error was similar results between male and female. However The refractive error was different style with aging. these data suggested that the analysis of the refractive error at young children can provide the information of useful diagnosis for the correction of visual acuity.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1995-1998
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• 2013

Objective: To study the expression of the mismatch repair proteins hMSH2 and nm23 in sporadic colorectal cancer, determine any inter-relationship, and further investigate any clinical significance. Methods: Expression of hMSH2 and nm23 proteins was assessed in 87 colorectal cancer tissues by SP immunohistochemistry, with analysis of survival using follow-up data. Results: In the sporadic colorectal cancer tissues, nm23 protein expression appeared independent of the histological type (P>0.05), but correlated with the invasion depth and lymphatic metastasis (P<0.05). In contrast, hMSH2 protein expression was not significantly correlated with these clinicopathologic features (P>0.05), although it positively correlated with that of nm23 protein in the sporadic colorectal cancers (rs=0.635, P<0.05). Combined expression of the two was found to be related with invasion depth, lymphatic metastasis and prognosis of sporadic colorectal cancer (P<0.05). Conclusion: nm23 protein level was related with the degree of malignancy, and could be used as an index to predict the invasion and metastasis potential. The expression of hMSH2 protein is positively correlated that of nm23 protein, and the combined expression of the two has certain guiding significance for the prognosis of sporadic colorectal cancer.

• Proceedings of the Korean Nutrition Society Conference
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• 2006.05a
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• pp.21-21
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• 2006

• Journal of The Korean Society of Inherited Metabolic disease
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• v.4 no.1
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• pp.61-63
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• 2004