• Clinical and Experimental Reproductive Medicine
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• 제24권1호
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• pp.135-141
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• 1997

The early studies demonstrated that the relative amount of FSH was important for stimulating normal ovarian activity and demonstrated the existence of a threshold level for FSH, above which follicular growth was activated. It was found that only a modest increase in circulating FSH level above the threshold (between 10 and 30%) was required to stimulate folliculogenesis. In addition, FSH is primary responsible for initiating estradiol production through the activation of the aromatase enzyme system in granulosa cells, follicular secretion and growth. LH on the other hand, plays a supportive role in ovarian steroidogenesis, stimulating the ovarian thecal cells to produce androgen, the precursor for estradiol synthesis. But there is now an increasing number of reports in the literature demonstrating an adverse effect of LH on fertility and miscarriage in infertile and fertile women. So HP-FSH is the drug of a highly purified FSH preparation which has a higher specific activity and far fewer impurities than FSH. This study was performed to evaluate the efficacy and safety of HP-FSH administered (SC; subcutaneous) versus FSH(IM; intramuscular) for ovulation induction. 20 candidates patients for ovulation induction were participated. All patients underwent pituitary desensitizing with a long gonadotropin-releasing hormone (GnRH) agonist protocol and ovulation induction was started with HP-FSH SC (10 patients; group I) or FSH IM (10 patients; group II). After ovulation, outcome of ovulation induction and local reaction of injection site were compared. There were no difference of outcome of ovulation in two groups except pregnancy rate/embryo transfer. Group I had a higher pregnancy rate/ embryo transfer than Group II (44.4% Vs 28.6%). Pain, redness, tenderness, bruising and itching when the injection received on the first 5 days of treated (50 SC and 50 IM injections) were assessed. There were no significant difference (P>0.05) in the incidence of tenderness, bruising and itching between the IM and SC injection. But IM injection (FSH) had a tendency of higher above incidence. The number of reports of pain, redness were significantly increased in IM injection group (P<0.05). These results indicate that SC administration of HP-FSH has been shown to be as effect for superovulation as traditional gonadotropins, with an improved safety profile due to the removal of extaneous proteins.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1845-1849
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• 2014

Background: There is no standard treatment for patients with colorectal cancer (CRC) progressing after irinotecan and oxaliplatin treatment. Here we aimed to retrospectively evaluate the efficacy and tolerability of raltitrexed in combination with oral 5-fluoropyrimidine (uracil tegafur-UFT) or mitomycin C as salvage therapy in mCRC patients. Materials and Methods: A total of 62 patients who had received raltitrexed combined with UFT or mitomycin C were identified between December 2008 and June 2013. They were given raltitrexed 2.6 $mg/m^2$ (max 5 mg) i.v. on day 1 in combination with either oral UFT 500 mg/day on days 1-14 every 3 weeks (group A) or mitomycin C 6 $mg/m^2$ i.v. on day every 3 weeks (group B). Results: Forty-two patients (67.7%) were in group A and 20 (32.2%) in group B. In 15 patients (24%) grade 3/4 toxicity was observed, resulting in dose reduction, and in 13 patients (20.9%) dose delay was necessary. The median progression free survival (PFS) was 3 months (95%CI 2.65-3.34) and median overall survival (OS) was 6 months (95%CI 2.09-9.90) in the whole group. Median PFS was 3 months (95%CI 2.60-3.39) in group A vs 3 months (95%CI 1.64-4.35) in group B (p=0.90). Median OS was 6 months (95%CI 2.47-9.53) in group A vs 12 months (95%CI 2.83-21.1) in group B (p=0.46). Conclusions: The combination of raltitrexed with UFT or mitomycin C seem to be a salvage therapy option due to safety profile and moderate clinical activity in heavily-pretreated mCRC patients.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4353-4358
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• 2013

Introduction: Breast cancer aggressiveness can be correlated with proliferation status of tumor cells, which can be ascertained with tumor grade and Ki67 indexing. However due to lack of reproducibility, the ASCO do not recommend routine use of Ki67 in determining prognosis in newly diagnosed breast cancers. We therefore aimed to determine associations of the Ki67 index with other prognostic markers like tumor size, grade, lymph node metastasis, ER, PR and HER2neu status. Methods: A total of 194 cases of newly diagnosed breast cancer were included in the study. Immunohistochemical staining for ER, PR, HER2neu and Ki67 was performed by the DAKO envision method. Associations of the Ki67 index with other prognostic factors were evaluated both as continuous and categorical variables. Results: Mean age of the patients was 51.7 years (24-90). Mean Ki67 index was 26.9% (1-90). ER, PR, HER2neu positivity was noted in 90/194 cases (46.4%), 74/194 cases (38.1%) and 110/194 cases (56.70%) respectively. Significant association was found between Ki67 and tumor grade, PR, HER2neu positivity and lymph node status, but no link was apparent with ER positivity and tumor size. There wasan inverse relation between Ki67 index and PR positivity, whereas a direct correlation was seen with HER2neu positivity. However, high Ki67 (>30%) was associated with decreased HER2neu positivity as compared to intermediate Ki67 (16-30%). The same trend was established with lymph node metastasis. Conclusion: Our study indicates that with high grade tumors, clinical utility of ki67 is greater in combination with other prognostic markers because we found that tumors with Ki67 higher than 30% have better prognostic profile compared to tumors with intermediate Ki67 level, as reflected by slightly lower frequency of lymph node metastasis and HER2neu expression. Therefore we suggest that Ki67 index should be categorized into high, intermediate and low groups when considering adjuvant chemotherapy and prognostic stratification.

• Radiation Oncology Journal
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• 제6권1호
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• pp.85-91
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• 1988

한국에너지연구소 원자력병원 싸이클로트론에 의해 생산되는 중성자를 임상에 적용시키기 위해, 이의 물리적 특성을 알기 위하여 방사선선량 측정실험을 시행하였다. 여기서 얻은 결과를 외국의 다른 치료기관에서 얻은 데이타와 비교 분석하였다. 중심축 선상의 심부선량백분율, build-up곡선, open과 쐐기등선량 곡선의 값이 4MV와 6MV X-ray값의 중간에 위치하였다. 최대선량의 build-up은 피부아래 1.35cm에 위치했으며 입사 선량은 약 $40\%$였다. 출력인자는 $6\times6cm$의 조사야에서 0.894, $30\times30cm$의 조사야에서는 1.187이었다. 중성자선의 X-ray오염도는 $10\times10cm$ 조사야에서 심부 2cm에서 $4.9\%$였다.

• 한국임상수의학회지
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• 제30권5호
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• pp.387-389
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• 2013

8년령의 중성화하지 않은 암컷 시츄견이 자궁축농증을 치료받기 위해 충남대학교 부속동물병원에 내원하였다. 임상증상으로 질출혈, 외음부출혈, 다식, 다음/다뇨 및 구토 등이 있었다. 혈액검사상으로는 미약한 백혈구감소증이 있었고 혈청화학적으로 ALP 감소 및 GLU 증가가 있었다. 방사선, 초음파 및 복강천자로 이루어졌으며 자궁축농증에 의한 복막염으로 잠정 진단하였다. 수술적 처치로 난소자궁적출술을 실시하였으며 생리식염수로 복강을 세척하였다. 심산 장 괴사가 있었고 자궁축농증에 의한 난소간막에서 농의 복강내로의 유출이 있었다. 이번 보고에서 2차적으로 패혈성 복막염이 발병할 수 있으니 자궁축농증 진단 시 2차성 질병에 대해서도 고려되어야 할 것이다.

• 대한소아치과학회지
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• 제28권3호
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• pp.369-373
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• 2001

하악 제2소구치의 선천결손은 비교적 흔히 나타나는 이상으로, 방사선사진에서 결손으로 확인되는 경우 여러가지 치료방법을 고려할 수 있다. 환자의 연령, 제2유구치 치근의 흡수상태, 총생의 정도, 악골의 성장, 측모의 형태, 절치의 돌출도, 하안 모고경 등을 고려하여 치료방법을 선택하게 된다. 그러나, 선천결손의 진단과 치료방법의 결정에 있어서 주의해야 할 점이 있다. 하악 제2소구치는 분화와 석회화과정에 있어서 가장 많은 변이를 보이는 치아이다. 경조직 형성은 $2\frac{1}{4}\sim2\frac{1}{2}$세에 시작되며, 대부분 적어도 $3\sim3\frac{1}{2}$세에는 시작된다. 그러나, 이 시기는 다른 영구치에 비해 그 범위가 매우 넓어서 $5\sim6$세, 드물게는 그 이후에 발육이 시작되는 경우도 있다. 그러므로 하악 제2소구치의 선천결손을 조기에 진단하기에는 어려움이 있으며, 선천결손으로 진단한 경우라도 오진할 가능성이 있음을 인식하는 것이 중요하다. 저자는 두 가지 증례를 통한 임상연구와 문헌고찰을 통해 다음과 같은 결론을 얻었다. 1. 두 증례 모두에서 하악 제2소구치의 두드러진 발육지연이 관찰되었다. 2. 치배형성 이후의 석회화 속도는 거의 정상적으로 나타난 것을 보아, 발육지연은 석회화 과정보다는 분화과정에 있었던 것으로 판단되었다. 3. 이와 유사한 증례를 접하였을 경우, 치아의 선천결손으로 단정하기 보다는 발육지연의 가능성을 함께 고려 할 필요가 있을 것으로 사료되었다.

• Clinical and Experimental Pediatrics
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• 제51권8호
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• pp.856-860
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• 2008

목 적 : 소아에서 진단 목적으로 척수액 검사를 시행한 환아에서 요추 천자 후 발생하는 두통과 요통에 영향을 주는 요인들을 조사하고, 특히 소아에서 불편을 호소하는 요추 천자 후 절대안정이 필요한가를 알아보기 위해 본 연구를 하였다. 방 법 : 2005년 7월부터 2007년 7월까지 건국대학교병원 소아청소년과에 뇌수막염 진단을 위해 요추 천자를 시행한 2세부터 15세의 환아 70명을 대상으로 하였다. 저자들은 그들을 2개의 집단으로 나누었다. 요추 천자 후 절대 안정을 하지 않은 집단은 24명이었고 절대 안정을 4시간 동안 시행한 집단은 46명이었다. 요추 천자 후 발생되는 두통, 요통과 같은 합병증이 나이, 성별, 요추 천자 횟수, 척수액내의 백혈구 세포수 및 압력, PCR enterovirus, 절대 안정여부와 상관 관계가 있는지 분석하였다. 결 과 : 요추 천자 후 발생되는 두통, 요통과 같은 합병증은 나이, 성별, 척수액 압력, 장 바이러스와는 통계학적인 의미가 없었다. 두통은 척수액내의 백혈구 세포수가 높을수록 통계학적인 의미가 있었다(P=0.043). 증상의 빈도는 두 집단 간에 큰 의미는 없었다. 요통의 발생 횟수는 요추 천자 횟수가 많을수록 통계학적으로 의미 있게 증가하였다(P=0.046). 결 론 : 척수액내의 백혈구수와 요추 천자 횟수는 천자 후에 발생하는 두통과 요통에 영향을 주는 인자로 생각된다. 요추 천자 후 예방적으로 시행되는 절대 안정은 천자 후에 발생하는 두통 및 요통의 발생 빈도에 영향을 주지 않기 때문에 시행할 필요가 없다고 생각한다.

• Nutrition Research and Practice
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• 제10권3호
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• pp.313-320
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• 2016

BACKGROUND/OBJECTIVES: This study was conducted to compare the overall changes in dietary intake and metabolic syndrome risk parameters in Vietnamese marriage-based female immigrants over time. SUBJECTS/METHODS: The subjects of this study were 581 Vietnamese marriage-based female immigrants, who were recruited from local clinical centers in Korea. Baseline data were collected from 2006-2011 and the follow-up data were collected from 2012-2014. Dietary food intake was assessed by a 1-day 24-hour recall method. RESULTS: Compared to the baseline, the mean body weight, body mass index, waist circumference, high density lipoprotein (HDL)-cholesterol, systolic blood pressure and diastolic blood pressure increased while the fasting blood sugar, triglycerides and low density lipoprotein-cholesterol decreased at follow-up. The total consumption of foods such as vegetables/fruits/seaweeds/mushrooms, oil and fat, and eggs decreased during the follow-up period, whereas the consumption of sugars, beverages and meats increased. Partial correlation between the rate of change [(Follow-up - Baseline) / Baseline ${\times}100$] in metabolic syndrome risk parameters and food intake after controlling for confounding factors showed that the waist circumference was positively correlated with either the total plant food intake (r = 0.1042, P = 0.0129) or the total food intake (r = 0.0880, P = 0.0359). The plasma levels of total cholesterol (r = -0.1918, P = 0.0289) and HDL-cholesterol (r = -0.1424, P = 0.0007) were negatively correlated with the percentage of total intake from plant food, and HDL-cholesterol levels were positively correlated with the intake of total animal food (r = 0.0980, P = 0.0217). The serum C-reactive protein levels were positively correlated with the total intake of animal food (r = 0.2374, P < 0.0001) or the percentage of total intake from animal food (r = 0.1346, P = 0.0016). CONCLUSIONS: These results suggest that the change rate of dietary intake such as total plant food or animal food is associated with the change rates of metabolic syndrome risk parameters.

• 대한지역사회영양학회지
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• 제10권4호
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• pp.493-500
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• 2005

There is some evidence that soy isoflavone has beneficial effects on the concentration of blood lipids. In this study, we investigated habitual isoflavone intake levels and the relation among dietary isoflavone intake, blood pressure, and blood lipids of adult men (n = 149) and women (n = 205). Anthropometric measurements including blood pressure, dietary in-take assessment using 24-hour recall method, and biochemical assessment using blood were conducted. The average age, height, weight, and BMI were 54.7 years, 168.5 cm, 67.3 kg, and 24.5 $kg/m^2$ for men and 53.9 years, 153.8 cm, 59.2 kg, and 25.0 $kg/m^2$ for women, respectively. The mean daily intakes of total food and energy were 1219.1 g and 1740.9 kcal for men and 1071.3 g and 1432.6 kcal for women, respectively. The mean daily isoflavones (daidzein + genistein) intake of men and women were 20.0 mg and 14.2 mg, respectively. Blood pressure of the subjects was 128.3/75.5 mmHg for men and 124.1/73.7 mmHg for women. Serum lipids of men and women were 180.2 and 184.9 mg/dL for total cholesterol, 160.8 and 137.6 mg/dL for triglyceride, 41.5 and 44.7 mg/dL for HDL-cholesterol, 106.6 and 112.7 mg/dL for LDL-cholesterol, and 3.5 and 3.3 for atherogenic index, respectively. Serum triglyceride and atherogenic index of men were significantly higher than those of women. In men, isoflavone intake and the level of total serum cholesterol were negatively (p < 0.05) correlated, after adjusted age. In women, there were significant correlations between isoflavone intake and blood pressure (systolic and diastolic), after adjusted age (p < 0.05). Based on these results, we concluded that higher isoflavone intake seemed to be related to a better lipid profile in men and lower blood pressure in women. But more epidemiological studies and controlled clinical trials would help to confirm the optimal amount required for the prevention and treatment of cardiovascular disease.

• 대한미생물학회지
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• 제21권1호
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• pp.1-16
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• 1986

Fifty-one strains of Pseudomonas aeruginosa were isolated from various clinical specimens. Among them, 26 (51%) strains were gentamicin-resistant (Gm') and 25 (49%) were susceptible to gentamicin (Gm'). The frequencies of resistant strains to piperacillin (Pi), cefotaxime, moxalactam, cefoperazone (Cz), and amikacin (Ak) ranged from 21.6 to 31.4%, and $MIC_{50}$ of these drugs were lower than the critical concentrations of susceptibility and resistance. Thirty (58.8%) strains were multiply resistant to 12 or more drugs. All Gm' strains were multiply resistant to 12 or more drugs and one was resistant to all 18 drugs tested, while only four Gm' strains were multiply resistant to 12 drugs and the multiplicity of resistance of the other Gm' strains were less than 10 drugs. Resistance to Gm appeared to have a significant correlation with the resistance to tobramycin (Tb), Ak, Pi, and Cz. All Gm' strains were resistant to Tb and about 38.4 to 46.1% of them were resistant to Ak, Pi, and Cz. The incorporation of $Ca^{++}$ and $Mg^{++}$ ions in Mueller-Hinton agar (MHA) did not influence the MICs of Gm, Tb, carbenicillin (Cb), Pi, and Cz as compared with the results obtained in MHA without these ions. Gm strains were studied on the combined effect of beta-lactam antibiotics and aminoglycosides by the methods of checkerboard and modified paper strip diffusion. Most Gm' strains showed significant synergistic effects by the FIC index between Ak and three beta-lactam antibiotics; Cb, Pi, and Cz, but these results did not in agreement the results obtained through the method of modified paper strip diffusion test. In order to know the nature of the drug resistance of P. aernginosa, the plasmid profile analysis was studied. Agarose gel electrophoresis of lysates processed by the method of Kado and Liu showed one or more plasmids in 22 (43.1%) strains. A group of 19 strains showed at least one band of plasmid and three strains two bands. The range of the molecular weight of plasmids was 3.8 to 243 Mdal. All strains carrying large plasmids larger than 200 Mdal were isolated from wound specimens. Three Gm' strains also harboured the plasm ids of 13 to 203 Mdal.