• 동의신경정신과학회지
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• 제24권3호
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• pp.257-262
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• 2013

Objectives : Aripiprazole is unique drug among the SGA (Second generation antipsychotics) in its pharmacology and pharmacokinetics,but is similar in clinical efficacy. Aripiprazole acts as a partial agonist at dopamine D2 receptors, activating the receptor but eliciting a reduced response compared to the natural neurotransmitter. There are some side effects of aripiprazole, the most common side effects of aripiprazole are headache, nausea, vomiting, insomnia, tremor, constipation and EPS. Difficulty in opening eyes is not defined EPS yet, but it is a rare but important side-effect symptom of aripiprazole. Methods : This article is about a case of side-effect symptom of aripiprazole, 26-year-old single female suffering from schizophrenia had difficulty in opening eyes while she was taking antipsychotics. During the hospitalization, the relaxation therapy is helpful not only to reduce tension in the eyelids but also to headache. Results : It is important that early recognition of aripiprazole-induced oculogyric dystonia can prevent life-threatening complications. Education medical staff to this easily treatable reaction will improve overall quality of health care. Conclusions : This case notifies the need for awareness of the risk of acute oculogyric dystonia in adolescent female patients receiving aripiprazole.

• 셀메드
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• 제5권4호
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• pp.26.1-26.3
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• 2015

A new physiotherapy named Ciliary Muscle Training method and one successful case had been reported first for treatment of Posner-Schlossman Syndrome (PSS), also known as Glaucomatocyclitic Crisis. When a person observed a back and forth moving object, the ciliary muscle would involuntarily do sometimes tense and sometimes relaxant exercise which can relieve the tensive state of the ciliary muscle of patients suffering PSS disease. Through this period of continued treatment, this ciliary muscle training method can improve the health status of the ciliary muscle and finally achieve the purpose of curing PSS disease. In this successful case, the patient's feedback result was very good after receiving our suggested ciliary muscle training method as an attempt to treat PSS, ill right eye of this PSS patient showed normal appearance without any differences from the other normal eye, his vision test values of naked eye were both 4.9 under nearly 200 degrees of myopia. High intraocular pressure (IOP) was mitigated, measured IOP value was in the normal (≦ 21 mmHg) and comfortable state without PSS relapse until now. Therefore, ciliary muscle training method could be a potential clinical treatment approach to PSS disease.

• 셀메드
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• 제6권4호
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• pp.27.1-27.4
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• 2016

Anxiety is a common clinical presentation. Primary anxiety poses a significant problem in its management. Many among the current treatment options of anxiety are habit forming causing significant withdrawal symptoms. There are dose dependent responses often associated with drug adversities. Day time sedation is an undesired effect of many drugs used for anxiety management limiting its usage. Ayurveda recommends a bio- physical procedure to manage anxiety. Shirodhara, a dripping procedure is utilized as a front line therapy for anxiety in Ayurveda. Seeing the limitations of conventional biomedical management of anxiety requiring an improvement upon the existing protocols of managements, and also seeing the use of shirodhara for anxiety management in ayurvedic clinics, a pragmatic study to evaluate the effect of shirodhara in generalized anxiety disorder was done. This was a pragmatic study consisting of shirodhara with ksheer bala oil as an intervention upon generalized anxiety disorder patients. The study was conducted upon 13 patients and observations were done for six weeks. The responses observed through the changes in Hamilton Anxiety Scale were evaluated using paired t test to observe the pre-post significance.

• Clinical and Experimental Reproductive Medicine
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• 제45권2호
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• pp.57-66
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• 2018

It has been estimated that approximately 15% of reproductive-age couples suffer from infertility. Male factors contribute to almost half of infertility cases, and in many patients the underlying cause of oligoasthenoteratozoospermia is unknown. Accumulating evidence suggests that oxidative stress plays a role as a contributing factor to male infertility, and reactive oxygen species have been shown to impair sperm function and motility and to damage sperm membrane and DNA. Therefore, this review explored the evidence provided by studies published from 2002 to 2017 on the impact of oral antioxidants (vitamin C, vitamin E, L-carnitine, coenzyme Q10, zinc, selenium, and pentoxifylline) on seminal fluid parameters in men with idiopathic oligoasthenoteratozoospermia. Most of the studies were randomized controlled studies that investigated the effect of single or combined antioxidants and reported improvements in at least one semen parameter. The most noteworthy effect that was found was that the use of multiple antioxidants increased sperm motility and concentration. Nonetheless, there is a lack of agreement on the dose, the duration of treatment, and whether individual or combined oral antioxidants should be used. Therefore, the current review provides evidence supporting the use of oral antioxidants in the treatment of infertile men with idiopathic oligoasthenoteratozoospermia.

• Advances in Traditional Medicine
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• 제8권4호
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• pp.408-415
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• 2008

In the present study, the ethanolic leaf and bark extract of Wrightia tomentosa were tested for comparative in vivo antitumour properties against Ehrlich ascites carcinoma (EAC) tumour bearing mice at 100 and 200 mg/kg body weight doses given orally once daily for 16 days. The EAC mice receiving 100 and 200 mg/kg ethanolic leaf and bark extract showed a dose dependent elevation in tumour, free survival and a highest number of survivors were observed at 200 mg/ kg for leaf extract of ethanol, which was considered as an optimum dose for its anti neoplastic action. The Median survival time for this dose was approximately 44 days when compared with 23 days of non-drug treated controls. The results indicate that the administration of leaf extract not only increased the survival of animals with ascites tumour and reduced packed cell volume and viable tissue cell count, but also altered many hematological parameters changed during tumour progression, indicating the potent antitumour nature of leaf extract than the bark extract. Statistical analysis also reveals that the leaf extract showed highly significant anti tumour potency (p < 0.001) when compared with control.

• 대한의생명과학회지
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• 제23권3호
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• pp.201-207
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• 2017

Measuring the pulse wave velocity (PWV) is a non-invasive method for evaluating the stiffness of the vessel wall. While previous studies investigated the association of uric acid level with arterial stiffness, most did not consider smoking status and obesity as covariates. The objective of this study was to investigate the relationship between uric acid levels and arterial stiffness, considering smoking status and obesity. We studied 3390 subjects (1940 males and 1450 females). Abnormal PWV was also defined as the highest quartile of values in the subjects. Data were analyzed using Pearson correlation, t-test, and multiple regression analysis. Approximately 41.9% of men and 3.7% of women were current smokers. Prevalence of hypertension was 11.4% in men and 7.0% in women. In women, hyperuricemia was associated with abnormal PWV (OR 1.58; 95% CI 1.03~2.43). Hyperuricemia was also associated with abnormal PWV (OR 2.37; 95% CI 1.01~5.59) in non- or light male smokers with normal blood pressure. This study suggests that uric acid is associated with arterial stiffness in women and non-smoking men.

• 대한한의학방제학회지
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• 제13권1호
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• pp.71-83
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• 2005

Chelidonii Herba (Baekgulchae in Korean: CHE), a commonly used herb in Korea, Japan and China, is widely used in the treatment of stomach cancer, jaundice, gastric ulcer, edema and pain of stomach. In the present study, we demonstrated that CHE induces apoptosis in AGS cells, human stomach adenocarcinoma cell line. One of the most important recent advances in cancer research is the recognition that apoptosis plays a major role in both tumor formation and treatment response, In this study, CHE caused a decrease of viability in AGC cells. When AGS cells were treated with CHE, cells showed dose-dependent manner apoptotic cell death. Increased apoptotic cell death, exposured to CHE, resulted from induction of Bad translocation to mitochondria, cytochrome-c release from mitochondria to cytosol, activation of caspase-3, 8, 9, and PARP cleavage. These results suggest that CHE may be potential therapeutic approach in the clinical management of stomach adenocarcinoma.

• Biomolecules & Therapeutics
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• 제3권2호
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• pp.116-121
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• 1995

Some multidrug resistance inhibitors have been known to be influenced by the serum concentration. In this study, effect of serum concentration on inhibition of nucleoside transport by BIBW22, a new multidrug resistance inhibitor derived from dipyridamole (DPM), was studied. When 5% or 100% (v/v) of fetal bovine serum (FBS) was contained in the culture, DPM dose for which nucleoside transport was inhibited by 50% (lD$_{50}$) was 0.42 $\mu$M or 1.17 $\mu$M, respectively. BIBW22 also showed the same trend as DPM did in response to increase of FBS concentration. However, ID$_{50}$ value for DPM in the absence or presence of human plasma was 0.007 $\mu$M or 1.02 $\mu$M respectively showing 145 times increase of ID$_{50}$ value. ID$_{50}$ value for BIBW22 in the presence of human plasma was 0.028 $\mu$M showing only 5 times increase in ID$_{50}$ value. This result suggests that potency of BIBW22 was much less affected by the plasma concentration and BIBW22 could be a good candidate for a clinical use in multidrug resistance treatment.treatment.

• Bulletin of the Korean Chemical Society
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• 제28권3호
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• pp.397-402
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• 2007

Restenosis after percutaneous coronary intervention (PCI) continues to be a serious problem in clinical cardiology. To solve this problem, drug eluting stents (DES) with antiproliferative agents have been developed. Variable local drug delivery systems in the context of stenting require the development of stent manufacture, drug pharmacology and coating technology. We have worked on a system that integrates electrophoretic deposition (EPD) technology with the polymeric nanoparticles in DES for local drug delivery and a controlled release system. The surface morphology and drug loading amount of DES by EPD have been investigated under different operational conditions, such as operation time, voltage and the composition of media. We prepared poly-D,L-lactide-co-glycolic acid (PLGA) nanoparticles embedded with curcumin, which was done by a modified spontaneous emulsification method and used polyacrylic acid (PAA) as a surfactant because its carboxylic group contribute negative charge to the surface of CPNPs (?53.5 ± 5.8 mV). In the process of ‘trial and error' endeavors, we found that it is easy to control the drug loading amount deposited onto the stent while keeping uniform surface morphology. Accordingly, stent coating by EPD has a wide application to the modification of DES using various kinds of nanoparticles and drugs.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1987년도 Proceedings of Korea-Japan Panax Ginseng Symposium 1987 Seoul Korea
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• pp.59-66
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• 1987

Psychotropic actions of crude ginseng saponins(CGS), pure ginsenoslue Rbl(GS-bl) and gin- senoside Rgl(GS-gl) isolated from the root of Panax ginseng, were evaluated by determining their effects on agonistic behavior in male(Experiment 1) and female(Experiment 2) mice, using a biologically relevant method. The results of experiment 1 demonstrated that CGS and GS-bl significantly suppressed aggressive episodes (offensive sideways posture and attack bite) in a dose-dependent manner when the resident was drugged, whereas G5-gl was ineffective. However, when the intruder was treated with one of three ginseng saponins, agonistic behavior between resident and intruder males was not altered. In experiment 2, acute administration of CGS and G5-bl significantly suppressed maternal aggression, whereas GS-gl was ineffective. As compared with the vehicle-treated group, chronic treatment with CGS and GS-bl significantly suppressed maternal aggression, while GS-gl showed a tendency to increase the frequency of attack bite by females. These findings clearly indicate that the root of Panax ginseng contains psychoactive ingredient, which can suppress both intermale and maternal aggression in mice. We suggest that the present results have important implications for the clinical usefulness of ginseng saponins in psychiatric medicine.