• 제목/요약/키워드: Clinical pharmacology

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EFFECTS OF CYP2D6*10 GENOTYPE AND CYP3A4 INHIBITION ON THE DISPOSITION AND NEUROLOGICAL SIDE EFFECTS OF HALOPERIDOL IN HUMAN SUBJECTS

  • Park, Ji-Young;Shon, Ji-Hong;Yoon, Young-Ran;Kim, Kyung-Ah;Kim, Min-Jung;Shim, Ju-Chul;Cha, In-June;Shin, Jae-Gook
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.149-149
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    • 2001

  • Cytochrome P450 (CYP) 2D6 and CYP3A4 have been reported to be involved in the major metabolic pathways and formations of neurotoxic metabolites (HPP$\^$+/, RHPP$\^$+/) from haloperidol (HAL). However, no in vivo study has been addressed to the involvement of both CYP isoforms on the formation of toxic HAL metabolites.(omitted)

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