• Korean Journal of Clinical Pharmacy
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• v.32 no.4
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• pp.336-351
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• 2022

Background: Prader-Willi Syndrome (PWS) is a rare genetic disorder. To improve the health deterioration of PWS, investigating optimal treatment options for PWS is required. Thus, we aimed to evaluate the efficacy of pharmacotherapies compared with supportive care or placebos in patients with PWS. Methods: PubMed and EMBASE databases were used to search for randomized controlled trials (RCTs) evaluating the efficacy of pharmacotherapy in PWS patients. Only RCTs that evaluating the efficacy of pharmacotherapy in PWS patients were retrieved. Results: A total of 26 studies were included to evaluate body composition, hormones, glucose levels and hyperphagia behavioral status. Pharmacological treatment group showed a significant decrease of body fat (mean difference (MD): -6.32, 95% confidence interval (CI): -10.58 to -2.06, p=0.004), a significant increase of lean body mass (LBM) (MD: 1.86, 95% CI: 1.43 to 2.30, p<0.00001) and insulin-like growth factor 1 (IGF-1) levels (MD: 241.62, 95% CI: 68.59 to 414.64, p=0.006) compared with the control group. Nevertheless, based on other outcomes evaluated by the current systematic review, pharmacological options showed different efficacy in treating PWS. Conclusion: Pharmacological therapies were effective to decrease significantly in body fat and increase significantly on LBM and IGF-1 levels in patients with PWS. However, still, individualized therapies should be considered in real-world practice in PWS treatment.

• Journal of Korean Academy of Nursing
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• v.48 no.3
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• pp.362-374
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• 2018

Purpose: This study aimed to develop a triage competency scale (TCS) for emergency nurses, and to evaluate its validity and reliability. Methods: Preliminary items were derived based on the attributes and indicators elicited from a concept analysis study on triage competency. Ten experts assessed whether the preliminary items belonged to the construct factor and determined the appropriateness of each item. A revised questionnaire was administered to 250 nurses in 18 emergency departments to evaluate the reliability and validity of the scale. Data analysis comprised item analysis, confirmatory factor analysis, contrasted group validity, and criterion-related validity, including criterion-related validity of the problem solving method using video scenarios. Results: The item analysis and confirmatory factor analysis yielded 5 factors with 30 items; the fit index of the derived model was good (${\chi}^2/df=2.46$, Root Mean squared Residual=.04, Root Mean Squared Error of Approximation=.08). Additionally, contrasted group validity was assessed. Participants were classified as novice, advanced beginner, competent, and proficient, and significant differences were observed in the mean score for each group (F=6.02, p=.001). With reference to criterion-related validity, there was a positive correlation between scores on the TCS and the Clinical Decision Making in Nursing Scale (r=.48, p<.001). Further, the total score on the problem solving method using video scenarios was positively correlated with the TCS score (r=.13, p=.04). The Cronbach's ${\alpha}$ of the final model was .91. Conclusion: Our TCS is useful for the objective assessment of triage competency among emergency nurses and the evaluation of triage education programs.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.27 no.2
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• pp.140-150
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• 2005

Maxillary sinus lifting procedure and bone grafting are used to reconstruct atrophic maxillae. These procedure are usually followed by the placement of endosseous dental implants. Different materials and techniques can be used for sinus bone grafting. Platelets are known to contain various growth factors involved in the repair of the vasculature and tissues, and it is known that the specialized platelet secretory granules, the alpha granules, contain platelet derived growth factor(PDGF), transforming growth factor-beta(TGF-beta), insuline like growth factor-I(IGF-I), epidermoid growth factor(EGF), and others. This study was to evaluate the effect of PRP on bone formation in a sinus bone grafting. Twelve rabbits were included in this randomized, blinded, prospective pilot study. In experimental group, sinus bone grafting with autobone and platelet rich plasma. In control group, sinus bone grafting with only autobone. Rabbits were sacrificed at 2nd, 4th, 8th, 12th weeks postoperatively. Clinical and radiographic tests, histological analysis were conducted to compare both sides. In clinical examination, there in no significant difference between experimental group and control group. But, in radiographic examination, a distinct incresed in the radiopaque of the PRP experimental group at 2nd and 4th weeks. The histologic examination revealed that more new bone formation and osteoblast activity were seen in experimental group at 2nd and 4th weeks. In conclusion, PRPs action in sinus bone grafting had a capacity of increased new bone formation in a early bone healing stage.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.3
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• pp.193-203
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• 2021

Sunscreen is a product that blocks and scatters UV rays to protect them from UV rays. Domestic consumers generously invest in sunscreen, ranking first in the world in terms of sun care consumption per capita in 2019. Sunscreens are subject to a variety of factors, including regulations, ingredients, formulations, clinical trials, and product labeling, but are tightly controlled as product demand increases. In this study, various factors affecting the UV protection factor were investigated and analyzed. Preemptive measures such as continuous investigation are required so that various factors such as these do not become obstacles for domestic cosmetics companies to export, and to revitalize the export market with international competitiveness.

• Journal of Korean Clinical Health Science
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• v.6 no.2
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• pp.1126-1135
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• 2018

Purpose. The purpose of this study is to investigate the success model related to the hospital information system accomplishment. It is important to examine the success model of the hospital information system and to analyze the factors affecting the job satisfaction accomplishment. Methods. The method of this study is to 150 copies of the entire survey data were distributed and 135 copies were collected, showing a collection rate of 90%. In order to ensure the reliability of the questionnaire items, Cronbach's Alpha was used to test reliability, and exploratory factor analysis was conducted to determine the convergence of various items. In order to grasp the convergence of various items, exploratory factor analysis was performed. The results of exploratory factor analysis were used to analyze the correlations between variables that were proven to have a single dimensionality before calculating factor loadings and regression analysis by Orthogonal Rotation by Varimax method Results. The results of this study, first, the system quality of the hospital information system has a statistically significant effect on user satisfaction. Second, the information quality of hospital information system is statistically significant for user satisfaction, indicating that information quality improves user satisfaction. Third, service quality of hospital information system was statistically significant in user satisfaction. Finally, the higher the satisfaction of the users who use the hospital information system, the higher the accomplishment of the organization Conclusions. This study is based on the successful model of D & M information system. In addition, the hospital information system, the user satisfaction, and the organizational accomplishment in connection with it can be found significant.

• Clinical and Experimental Pediatrics
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• v.62 no.8
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• pp.307-311
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• 2019

Purpose: Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. Many risk factors can contribute to the development of NEC. The epidermal growth factor (EGF) plays a major role in intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transport. The aim of this study was to assess the role of epidermal growth factor in the development of NEC in preterm neonates. Methods: In this study, 130 preterm neonates were included and divided into 3 groups, as follows: group 1, 40 preterm neonates with NEC; group 2, 50 preterm neonates with sepsis; and group 3, 40 healthy preterm neonates as controls. The NEC group was then subdivided into medical and surgical NEC subgroups. The serum EGF level was measured using enzyme-linked immunosorbent assay. Results: Serum EGF levels (pg/dL) were significantly lower in the NEC group (median [interquartile range, IQR], 9.6 [2-14]) than in the sepsis (10.1 [8-14]) and control groups (11.2 [8-14], P<0.001), with no significant difference between the sepsis and control groups, and were positively correlated with gestational age (r=0.7, P<0.001). A binary logistic regression test revealed that low EGF levels and gestational ages could significantly predict the development of NEC. The receiver-operating characteristic curve for EGF showed an optimal cutoff value of 8 pg/mL, with 73.3% sensitivity, 98% specificity, and an area under the curve of 0.92. Conclusion: The patients with NEC in this study had significantly lower serum EGF levels (P<0.001), which indicated that EGF could be a reliable marker of NEC in preterm neonates.

• The Journal of Korean Academic Society of Nursing Education
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• v.8 no.1
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• pp.51-60
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• 2002

The purpose of this study was to identify the relationship between self-esteem, self- efficacy and clinical practice performance, academic achievement, decision making of major field in clinical practice . The study subjects consisted with 244 students from G. junior nursing college that will adapt a new majoring program of clinical nursing practice funded by Ministry of human and resources development. Data were analyzed using descriptive statistics, and t-test, Pearson correlation, and multiple regression. The results of this study were summarized as follows: 1. The students were relatively performed well in clinical practice setting (total M :3.78). The item of student's personal relationship between patients, patient's family, and professional staff showed high score (M=3.96). However students did not feel comfortable to communicate with patients, patient's family and professional staffs in clinical setting(mean=3.56). 2. Students who had experiences of temporal absence from school showed significant difference in the variable of academic achievement and decision making of major field in clinical practice Students who entered to nursing school with self-motive revealed statistically significant difference in the variable of clinical practice performance, academic achievement, self-esteem, self-efficacy, and decision making of major field in clinical practice. 3. There was a significant correlation between self-esteem and clinical practice performance, (r=.512, p<.000). And the relation between self-esteem and decision making of major field in clinical practice was significantly correlated(r=.377, p<.000). Self-efficacy and clinical practice performance(r=.567, p<.000), and decision making of major field in clinical practice (r=.441, p<.000) showed significant correlations. Also relation between academic achievement and self-esteem reveled a significant correlation(r=.129, p<.05) but correlation between self-efficacy and academic achievement was not significant. 4. Correlation between clinical practice performance and decision making of major field in clinical practice also identified a significant relation(r=.498, p<.000). 5. Self-esteem and self-efficacy variables predicted clinical practice performance and explained 37.7% of clinical practice performance. 6. Aptitude and personal interests(m=4.07) reveled important factor affecting to select majoring area in clinical practice, and advice from parents reflected low percentage on selecting places(m=2.42). In conclusion, the variables of self-esteem and self-efficacy showed significant correlations with the variables of student's clinical practice performance, academic achievement, and decision making of major field in clinical practice. Thus it is recommended that student's affective domain of self-esteem and self-efficacy should be developed by nursing intervention before clinical nursing education.

• The Journal of Korean Academic Society of Nursing Education
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• v.4 no.2
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• pp.172-186
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• 1998

This study is intended to develop a reliable and approproate instrument of the clinical nursing education. This research consisted of 4 step. First step is contruction of the content for evaluation. Second step have the research of the content validity by 10 professors in Department of Nursing, H University, the pilot study for the content validity by 20 professors and clinical preceptors, and the survey with four point Likert Scale, which includes from the point of 'strongly valid' to the point of 'strongly non-valid' by 250 professor and clinical preceptor. The data were collected form March 1998 to July 1998. This study was analyzed by Cronbach's for the reliability and the factor analyisis for the validity of the collected data. The third step showed the final evaluation instrument of clinical nursing education which consists a couple of tool. One is the evaluation instrument of clinical nursing which includes the 20 items, the other is the evaluation instrument for case study which includes the 15 items. The fourth step is the test of reliability and validity of the final evaluation too. The results from these step's study showed the higher reliability and validity. Respectly, Cronbach's revealed the evaluation instrument of clinical nursing and case study is Cronbach's $\alpha$=.92413, Cronbach's $\alpha$=.95602. For further research, it needs to develop a reliable and variable instrument of the students self-evaluation and community based instrument.

• Journal of radiological science and technology
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• v.36 no.3
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• pp.201-208
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• 2013

This study aimed at analyzing stress factors of radiography students may experience during their clinical training, and thus at providing assistance in improving efficiency and quality of clinical training. As for the method of study, a questionnaire survey was conducted targeting radiography students from five universities in Busan and Gyeongsangnam-do regions who had clinical training experiences. The result of the survey showed that, among five stress factors, environmental factor was the highest source of stress, followed by ideals, values, roles and activity. In addition, it was found that the level of stress experienced during clinical training was higher than the level of stress in daily life. If the stress of clinical training can be reduced based on the results of this study, it will not only contribute to improving students' level of satisfaction with clinical training, but also enhance the quality of clinical training.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5433-5438
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• 2015

Background: Systemic chemotherapy for patients with metastatic gastric cancer (MGC) is generally palliative, although some patients experience long-term survival after treatment. Thus, we identified clinical characteristics that are associated with long-term survival of patients with MGC after palliative chemotherapy. Materials and Methods: We retrospectively reviewed 514 MGC patients who received systemic chemotherapy at our institution from 2001 to 2008. To identify clinical predictors of survival beyond 2 years, multivariate logistic regression analyses were performed, and 5-year survival rates were estimated among MGC patients following chemotherapy. Results: Among 514 patients, 96 (19%) and 16 (3%) survived beyond 2 and 5 years, respectively, and performance status of 0 or 1 (odds ratio [OR]=3.39; p=0.01), previous gastrectomy (OR=1.86; p=0.01), single metastatic site (OR=1.80; p=0.03), and normal alkaline phosphatase levels (OR=2.81; p<0.01) were identified as independent predictors of long-term survival. Of the 16 5-year survivors, six were alive at the end of the study and showed no evidence of disease despite cessation of chemotherapy. Conclusions: The present data demonstrate distinct clinical characteristics that are associated with long-term survival of MGC patients, and indicated that palliative chemotherapy can be curative in highly selected patients.