• 대한한방내과학회지
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• 제33권4호
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• pp.485-497
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• 2012

Objectives : The aim of this study was to systematically investigate herbal-drug-associated adverse drug reactions (herbal ADRs) reports submitted by a single oriental hospital and to analyze the general characteristics, causative agents, clinical manifestations, severity and types of herbal medicines which caused herbal ADRs. Methods : This study proceeded with IRB approval. The data on herbal ADR were collected prospectively from January 2008 to February 2012 by EMR of Dongguk University Ilsan Oriental Hospital. The World Health Organization (WHO)-Uppsala Monitoring Center (UMC) criteria was used to determinate causality for each herbal ADR. WHO-Adverse Reaction Terminology (WHO-ART) System Organ Class (SOC) code and WHO severity category were also used in this study. Results : A total of twenty eight cases were reported. Twenty two cases were assessed to have over possible relations with herbal medication. The gender ratio of these cases were 64.6 percent female and 36.4 percent male, demonstrating no statistical significance. Patients aged over 60 were 59.1%. Gastro-intestinal system was reported to be the most frequently affected organ (38.8%), and followed by psychiatric system (22.4%), and integumentary system (22.4%). The most common clinical symptom was headache (12.2%), followed by diarrhea (10.2%), and pruritus (10.2%). The severity of most cases was assessed to be mild (89.8%). The percentage of moderate ones was 10.2%, and there were no severe cases. Conclusions : Progressive study and further analysis on herbal ADRs are warranted for safety in the clinical use of herbal medicines.

• 동의생리병리학회지
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• 제27권5호
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• pp.587-593
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• 2013

Exhaustion syndrome(虛勞) became broadly experienced symptoms in Korean population. In this work, we carried out a systematic literature review on exhaustion syndrome(ES) and chronic fatigue. We searched through the databases Koreanstudies Information Service System, Oriental Medicine Advanced Searching Integrated System, DataBase Periodical Information Academic for the articles published between 1994 and 2013, with the keywords 'exhaustion syndrome(虛勞)', 'consumption(虛損)', 'overexertion syndrome(勞倦)', 'fatigue', 'chronic fatigue' and 'degree of fatigue'. Among the first-run rough-searched 602 articles, we narrowed down the scope within the field of Oriental medicine (126 articles), and finally selected 28 articles appropriate to the intended research field; the selected articles were categorized by literature study(7 papers), clinical treatment (7), clinical diagnosis (5), treatment effects of herbal medicine (2), diagnosis in Sasang medicine and treatment effect of dry cupping therapy (2), and questionnaire-based diagnosis (5). We found that the overall research level on ES remained in the preliminary stages, and more efforts are needed in the field of terminology definition and standardization of diagnosis, and treatment efficacy validation beyond muscle fatigue. Finally, to develop reliable diagnostic devices on ES, we proposed a study design that included the development of objective ES diagnostic indicators and a clinical validation procedure.

• 한국정보과학회논문지:시스템및이론
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• 제35권4호
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• pp.158-165
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• 2008

LOINC(Logical Observation Identifiers Names and Codes)는 Regenstrief Institute에서 제공하는 병원 검사 명칭 및 임상용어를 위한 표준체계이다. 평생전자건강진료정보에서 검사결과의 교류는 매우 중요한 영역 중 하나이며, 이를 위해서는 현재 각 병원의 표준화되지 않은 검사 명칭을 표준화하는 일이 시급하다. 본 논문에서는 병원의 로컬데이타베이스를 Regenstrief에서 제공하는 LOINC 검색 매핑도구인 RELMA(Regenstrief LOINC Mapping Assistant)가 요구하는 LMOF(Local Master Observation File) 포맷으로 미리 전처리 해주는 도구를 개발함으로써, LOINC 매핑작업을 보다 효율적으로 할 수 있는 해결책을 제시한다. 제안한 도구를 이용하여 로컬데이타베이스를 전처리 한 후 RELMA로 검색하였을 때, 인터페이스 측면에서 기존 전처리하지 않고 RELMA를 사용한 방법에 비해서 사용자의 편의성이 향상되었고 검색되는 키워드가 15% 감소하는 검색의 효율성을 가져올 수 있었다.

• 대한암한의학회지
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• 제24권1호
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• pp.19-28
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• 2019

Objective : The purpose of this study is to report and observe effects of Integrative Cancer Treatment (ICT) on metastatic breast cancer patient. Method : A left breast cancer patient diagnosed with recurrence on liver and bones April 2018. The patient had received paclitaxel chemotherapy for two months and discontinued it because of tumor progression and side effects. The patient has been treated with ICT since March 2018 and has been taking capecitabine since October 2018. The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (CEA, CA15-3). The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (CEA, CA15-3), liver function test (AST, ALT), Eastern Cooperative Oncology Group performance status (ECOG PS), and numeric rating scales (NRS). Results : After the ICT, tumor size was partially decreased accompanying by reducing the levels of tumor markers. Major clinical symptoms induced by paclitaxel chemotherapy were improved. There were no severe adverse events induced by ICT based on National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5.0. Conclusion : This case suggests that ICT may have synergistic effect for the treatment of metastatic breast cancer patient in conjunction with capecitabine.

• Hip & pelvis
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• 제34권1호
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• pp.56-61
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• 2022

Purpose: Histopathologic analysis of femoral head specimens following total hip arthroplasty (THA) is a routine practice that represents a significant use of health care resources. However, it occasionally results in discovery of undiagnosed hematopoietic malignancy and other discrepant diagnoses such as avascular necrosis. The purpose of this study was to determine the rate of discordant and discrepant diagnoses discovered from routine histopathological evaluation of femoral heads following THA and perform a cost analysis of this practice. Materials and Methods: A review of patients undergoing primary THA between 2004-2017 was conducted. A comparison of the surgeon's preoperative and postoperative diagnosis, and the histopathologic diagnosis was performed. In cases where the clinical and histopathology differed, a review determined whether this resulted in a change in clinical management. Medicare reimbursement and previously published cost data corrected for inflation were utilized for cost calculations. Results: A review of 2,134 procedures was performed. The pathologic diagnosis matched the postoperative diagnosis in 96.0% of cases. Eighty-three cases (4.0%) had a discrepant diagnosis where treatment was not substantially altered. There was one case of discordant diagnosis where lymphoma was diagnosed and subsequently treated. The cost per discrepant diagnosis was $141,880 and per discordant diagnosis was $1,669 when using 100% Medicare reimbursement and Current Procedural Terminology (CPT) code combination 88304+88311. Conclusion: Histopathologic analysis of femoral head specimens in THAs showed an association with high costs given the rarity of discordant diagnoses. Routine use of the practice should be at the discretion of individual hospitals with consideration for cost and utility thresholds.

• 대한암한의학회지
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• 제16권1호
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• pp.55-61
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• 2011

Objectives : Epidermal growth factor receptor-inhibitors have demonstrated improved overall survival in patients with non-small cell lung cancer, but their use is associated with dermatologic adverse reactions that often require symptomatic treatment. Methods : A 44-year-old woman, who started the chemotherapy of Iressa$^{(R)}$ on August 2010, developed cutaneous symptoms such as papulopustular rash, dry skin, and pruritus on her face and scalp after taking Iressa$^{(R)}$ for four weeks. The patient visited our clinic with such symptoms on March 2011 and underwent herebal remedy targeted to alleviate the skin reactions. The severity of dermatologic symptoms was evaluated with the numeric rating scale and the Common Terminology Criteria for Adverse Events version 4.0. Results : Noticeable changes on the skin lesion were observed after the two months of treatment, without any dose modification of the Iressa$^{(R)}$. The cutaneous symptoms as papulopustular rash, dry skin and pruritus were improved and there was no adverse event induced by the treatment with herbal medicine. Conclusions : This case report suggests that the treatment with a herbal medicine, Samultang-gagambang be considered as a useful treatment to relieve EGFR-inhibitor induced dermatologic adverse reactions.

• 한국산학기술학회논문지
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• 제11권9호
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• pp.3330-3335
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• 2010

의료정보화의 가속화로 기관 간 교환되는 의료정보의 의미적 호환성 보장이 주요 과제로 떠오르고 있다. 진단검사결과는 의료정보 중에서 교환이 가장 필요한 영역으로 알려져 있다. 본 연구의 목적은 진단검사결과의 교환을 위한 임상콘텐츠모형을 개발하는 것이다. 연구 기간은 '08년 3월부터' 08년 9월까지였다. 연구 방법은 첫째, Health Level 7의 참조정보모델과 진단검사 분야 표준용어체계인 LOINC로부터 각각 속성과 코드를 도출하였다. 둘째, 진단 검사 처방 및 검사결과보고의 업무 과정별 속성을 분석하였다. 분석된 속성이 HL7의 참조정보모델에서 제공하는 속성으로 표현이 가능한가를 검토하였다. 셋째, 확정된 속성과 임상콘텐츠모형의 구조를 이용하여 헤모글로빈 원형을 개발하였다. 넷째, 진단검사의학과 전문의를 포함한 5명의 전문의가 원형에 대한 안면 타당도평가를 실시하였으며, 평가 내용은 본 모형이 진단검사결과를 정확하게 표현하고 교환을 지원할 수 있는가에 관한 것이었다. 평가 결과 본 모형은 개발목적에 부합하는 것으로 평가되었다. 본 모형은 향후 진단검사영역의 정보교류에 기여할 수 있을 것으로 기대한다.

• 대한한의학원전학회지
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• 제22권4호
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• pp.117-128
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• 2009

This study is purposed to list the full translation of "The secret method of tumor treatment(治瘇方)" and to report the results to the academic world. The results are described as follows. 1. It seems to be difficult to accept the current "The secret method of tumor treatment(治瘇秘方)" as the original script of "The method of tumor treatment(治瘇方)". It seemed that the Imeonguk(任彦國)'s 'Important and Valuable Method(遺方)' at the era of Joseon was copied by handwriting among the private sector. 2. There are contents which are overlapped with "Experience Method of Acupuncture(針灸經驗方)". A further study is required whether the "Experience Method of Acupuncture" was added later on. Because resolution for the before and after of these two books may be acted as an important matter to conjecture the related schools with acupuncture science. 3. The Korean style unique method and terminology were introduced frequently in "The method of tumor treatment". Besides that, materials for the medicine were filled with the things of easy-to-contact in our daily life. It is regarded as one of the excellent materials to confirm the superiority of oriental medical science through the clinical experiments today.

• 대한암한의학회지
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• 제22권1호
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• pp.13-22
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• 2017

Objective: The purpose of this study is to report the effect of Nobongsangki-Jeong on skin rash caused by Olmutinib. Methods: A female Non-Small cell lung carcinoma patient (Adenocarcinoma, Stage IV, Epidermal Growth Factor Receptor positive) suffered from skin rash due to the side effect of Olmutinib administration. She was treated with Nobongsangki-Jeong for the symptom management for 14 days. The clinical outcomes were measured by numeric rating scale (NRS) and National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 4.03. Results: After treatment, skin rash was improved from NRS 5 to 1. Pruritus and pain of skin were improved from NCI-CTCAE grade 2 to 1. Conclusion: This case study suggests that Nobongsangki-Jeong may have the efficacy for the treatment of skin rash caused by Olmutinib.

• Clinical and Experimental Pediatrics
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• 제49권8호
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• pp.895-897
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• 2006

폐 격리증이 없는 정상적인 폐에 체 혈관이 이상 기시하는 것은 매우 드문 질환이다. 저자들은 반복적인 하기도 감염을 보이는 영아에서 선천성 심장질환의 상태가 본 하기도 감염을 나타낼 정도로 심하지 않음을 이상히 여겨 컴퓨터 단층 촬영을 시행하였다. 그 결과 폐 격리증이 없는 폐의 이상 체 동맥 기시가 우측 폐하 엽에 존재함과 동시에 우측 하엽 폐동맥이 없는 사실을 확인하게 되었다. 어린 나이에 이 같은 선천성 질환의 조합은 이전에 보고 된 바가 없는 매우 드문 질환으로 생각된다.