• Title/Summary/Keyword: Cleft lip

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Hypodontia Pattern and Genetic Association in Cleft Lip and Palate Patients (구순구개열 환자의 치아 선천결손 유형과 관련 유전자에 관한 고찰)

  • Ahn, Hyo-Won;Baek, Seung-Hak
    • Korean Journal of Cleft Lip And Palate
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    • v.10 no.2
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    • pp.81-88
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    • 2007

  • Cleft lip and palate (CLP) is one of the most prevalent congenital craniofacial anomalies. It has a significantly greater incidence of dental abnormalities in number, size, shape, and eruption of the teeth. Knout-out mouse model can identify several genes which play an important role in tooth agenesis. Since disruption of these genes has been confirmed to result in tooth agenesis in humans, CLP associated with hypodontia may be the best models for isolated tooth agenesis. According to the studies of dental abnormalities in CLP, the severity of dental defect is known to be influenced by the CLP phenotype. The cumulative data obtained from mouse and human genetic studies indicated that MSX1, PAX9 and AXIN2 are considered as candidate genes in non-syndromic hypodontia, while Shh, Pitx2, Irf6, p63 and EDA pathway genes are involved in syndromic one. We expect that genetic approach of CLP can offer the basis for tooth regeneration and be a new target in hypodontia therapy.

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Quadrilateral Flap Technique Applied for Complete Cleft Lip Patients - Report of cases - (완전구순열 환자에서 사각피판법의 적용 - 증례보고 -)

  • Nam, Il-Woo;Lee, Ju-Hwan;Lee, In-Woo;Seo, Byoung-Moo
    • Korean Journal of Cleft Lip And Palate
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    • v.12 no.2
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    • pp.65-72
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    • 2009

  • Quadrilateral flap technique for primary cheiloplasty in patients with cleft lip was initially developed by Hagedorn in 1884. After Le Mesurier presented this procedure in 1940's, many surgeons adopted this technique for clinical advantage of reconstruction of Cupid's bow and lesser amount of tissue discarding than straight line technique. However, owing to its drawbacks such as sacrifice of Cupid's bow and prominent scar on philtral ridge, other techniques like Tennison's triangular flap and Millard's rotation-advancement flap have gradually taken its place. Nevertheless, some clinicians like Dr. Wang has modified this quadrilateral flap technique for better clinical outcomes. In this report we present 3 cases of unilateral complete cleft lip patients who underwent primary cheiloplasty with favorable outcomes based on Dr. Wang's modified quadrilateral flap technique.

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