• 무역상무연구
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• 제49권
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• pp.3-41
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• 2011

In this article, the author have studied on main revisions and some recommendations of the Incoterms(R) 2010. Main revisions are as belows. 1. Two new Incoterms rules -DAT and DAP- have replaced the Incoterms 2000 rules DAF, DES, DEQ and DDU. 2. New classification of the Incoterms(R) 2010 are adopted. First class is Rules for any mode or modes of transport(EXW, FCA, CPT, CIP, DAT, DAP and DDP belong to this class.) and second class is rules for sea and inland waterway transport(FAS, FOB, CFR and CIF belong to this class.). 3. Incoterms(R) 2010 rules formally recognizes that they are available for application to both international and domestic sale contracts. 4. The Guidance Notes and Introduction are not part of the actual Incoterms(R) 2010 rules. 5. Under the FOB, CFR and CIF, all mention of the ship's rail as the point of delivery has been omitted in preference for the goods being delivered when they are "on board" the vessel. 6. Incoterms(R) 2010 rules include the obligation to 'procure goods shipped' as an alternative to the obligation to ship goods in the relevant Incoterms rules. 7. Incoterms(R) 2010 rules give electronic means of communication the same effect as paper communication. 8. Incoterms(R) 2010 rules have allocated obligations between the buyer and seller to obtain or to render assistance in obtaining security-related clearances. such as chain-of custody information. Some recommendations are as belows. 1. The parties must incorporate the Incoterms(R) 2010 rules into their contract of sale. 2. The parties must choose the appropriate Incoterms(R) 2010 rules. 3. Specify the place or port as precisely as possible in their contract of sale. 4. Remember that Incoterms(R) 2010 rules do not give the parties a complete contract of sale. 5. Incoterms(R) 2010 rules do not prohibit alteration of Incoterms rule, but there are dangers in so doings. In order to avoid any unwelcome surprises, the parties would need to make the intended effect of such alterations extremely clear in their contract.

• 한국산업보건학회지
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• 제11권1호
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• pp.9-16
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• 2001

Chromium exposure can be in the forms of environmental pollution and occupational exposure. The harmful effects of chromium on the body greatly differ depending on its valence or solubility. Accordingly, the recommended permissible exposure limit for each chromium compound is different. This study investigated the increase or decrease of distribution and excretion of total chromium exposed simultaneously the soluble Cr+6 and Cr+3 compounds. There were no difference of total chromium concentration in plasma, red bloods cells, urine, organs between simultaneously injected and individually injected soluble Cr+6 and Cr+3 compound. The chromium clearances in urine also showed that there were two phases in the two groups. In the first phase, biological half lives of the total chromium of the two groups have been similar within 24 hr., but in the second phase, biological half life of the group injected simultaneously was 62.7 hr. and was less than that of the other group's 188.3 hr. The average concentration of total chromium in plasma was same with the control, and that of RBCs was $0.218nmol/m{\ell}$ and was slightly increased in comparison with $0.121nmol/m{\ell}$ of the control, which was not statistically significant. As a result, there were no differences of distribution and excretion of chromium between the group exposed simultaneously and the other group exposed separately the soluble Cr+6 and Cr+3 compounds. The biological half life of chromium of the former group in urine was less than that of the other group.

• Journal of Pharmaceutical Investigation
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• 제21권1호
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• pp.43-50
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• 1991

The hepatic uptake of an anionic fluorescence probe, l-anilino-8-naphthalene sulfonate (ANS) was characterized using isolated rat hepatocytes. The initial uptake rate of ANS by isolated hepatocytes was determined. The uptake process of ANS was fitted well to the Michaelis-Menten equation with a saturable component. The $V_{max}$ and $K_m$ values were $2.9{\pm}0.1\;nmol/min/mg$ protein and $29.1{\pm}3.2\;{\mu}M$, respectively. The uptake clearance $(CL_{up})$ based on the ratio of $V_{max}$ to $K_m$ was 11.7 ml/min/g liver, revealing the good coincidence with that assessed from the analysis of the plasma disappearance curve in previous report. Furthermore, the effect of serum protein on the hepatic uptake of ANS into isolated hepatocytes was investigated. The permeability clearances $(PS_{inf})$ of ANS uptake were much higher than those predicted based on the unbound fractions in the presence of serum. These suggested that the hepatic uptake of extensively serum protein-bound ANS is mediated not only by the unbound form of ligand but also by the serum protein-mediated uptake mechanism.

• 한국추진공학회지
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• 제14권6호
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• pp.60-68
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• 2010

본 연구에서는 팁 형상이 가스터빈 블레이드의 팁 열전달에 미치는 영향을 알아보기 위하여 선형 캐스케이드의 블레이드에 설치된 평면 팁, 스퀼러 팁, Groove 팁들에 대하여 열전달 계수가 측정되었다. 블레이드 팁에서의 열전달 계수는 색상검출방식에 기반을 둔 천이액정법을 이용하여 측정되었으며 각각의 팁 형상에 대하여 팁 간극은 블레이드 스팬의 1.5%와 2.3% 두 조건에서 실험을 수행하였다. 캐스케이드 출구 속도와 블레이드 코드길이에 기초를 둔 Reynolds 수는 $2.48{\times}10^5$ 이다. Groove 팁 표면에서의 열전달 계수는 평면 팁보다 낮게 측정되었으며, 특히 흡입면을 따라 경사진 홈이 파인 팁에서는 스퀼러 팁보다 낮은 열전달 계수가 측정되었다.

• 한국산학기술학회논문지
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• 제14권12호
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• pp.6060-6065
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• 2013

유효 전단면의 크기를 최대가 되도록 하기 위해서는 다이 롤 높이의 최소화가 매우 중요하다. 본 연구에서는 V-링 압입량의 변화와 클리어런스의 변화에 대한 다이 롤 변화를 연구하였다. V-링 거리를 2mm로 고정하고 클리어런스가 다른 다이인서트를 적용할 수 있는 파인블랭킹 금형을 제작하여 전단해석과 실험을 진행하였다. 각 실험으로부터 시편을 채취하여 다이 롤 높이를 분석한 결과 V-링의 압력이 재료의 유동을 효과적으로 억제하고 펀치와 다이 사이의 클리어런스가 재료 두께에 대하여 1%의 경우가 다이 롤 높이가 낮게 됨을 알 수 있었다.

• 약학회지
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• 제41권3호
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• pp.312-320
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• 1997

Pharmacokinetics and tissue distribution of DWP20349 and 20351, new quinolones, were examined in rats after a single intravenous and oral administration. Analyses of DWP20349 an d DWP20351 in plasma, tissue, and urine were determined by both HPLC and bioassay(microbiological assay). The plasma concentrations of the drugs declined biexponentially. The terminal half-lives ($t_{1/2\beta}$) of drugs were about 114 min (DWP20349) and 105 min (DWP20351) after intravenous dosing, and were 77 min (DWP20349) and 79 min (DWP20351) after oral dosing. The volume of distrbution at steady-state ($Vd_{ss}$) and total body clearances ($Cl_t$) of DWP20349 and DWP20351 were 760 ml/kg and 1126 ml/kg, and 5ml/min/kg and 10 ml/min/kg, respectively. The extents of bioavailability if DWP20349 and DWP20351 after oral administration were 29% and 28%, respectively. 24 h urinary recoveries measured by bioassay were 1.8% (DWP20349) and 1.3% (DWP20351) after oral dosing, and 2.4% (DWP20349) and 1.9% (DWP20351) after intravenous dosing. Plasma protein binding ratios ranged from 87%-90% (DWP20349) and 61%-68% (DWP20351). These drugs were highly distrbuted by the order of lung, kidney, liver and plasma (DWP20394), and lung, liver, kidney and plasma (DWP20351) after 1 hour orally administered.

• Nuclear Engineering and Technology
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• 제52권6호
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• pp.1304-1317
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• 2020

The tubes in a heat exchanger, such as a steam generator (SG), are subjected to crossflow, and interaction between tubes and supports can happen, which can cause fretting wear of tubes. Although many experiments and models have been established, some detailed mechanisms are still not sufficiently clear. In this work, more attention is paid to obtain the regulation of impact and sliding in the complex process and many factors, such as excitation forces and clearances. The responses and contact forces were analyzed to obtain clear understanding of the influences of these factors. Room temperature tests in the air were established. The results show that the effect of clearance on the normal work rate is not monotonous and instead has two peaks. The force ratio can influence the normal work rate by changing the distribution of contact angles, which can result in higher sliding in the contact process. Fretting wear tests are conducted, and the wear surfaces are analyzed by a scanning electron microscope (SEM) and energy dispersive X-ray spectrometer (EDX). The results of this work can serve as a reference for impactsliding contact analysis between AVBs and tubes in steam generators.

• 약학회지
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• 제32권4호
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• pp.258-273
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• 1988

In this study attempts were made to observe the effects of guanabenz on renal function in dog, which manifests the antihypertensive action by inhibition of sympathetic tone through stimulating the presynaptic adrenoceptor (${\alpha}_2-adrenoceptor$). Guanabenz, when injected at a dose of $30.0{\mu}g/kg$, or infused at a dose of $3.0{\mu}g/kg/min$ intravenously, produced diuretic action with increased amounts of $Na^+\;and\;K^+$ in urine, and with decreased reabsorption rates of $Na^+\;and\;K^+$ in renal tubules. It was also observed that the rates of osmolar and free water clearances were increased, but the glomerular filtration rate and renal plasma flow were not changed. Guanabenz injected at a dose of $3.0{\mu}g/kg$ into a carotid artery or infused intravenously at a dose of $3.0{\mu}g/kg/min$ in a state of water diuresis elicited the diuretic action of the similar aspect as a case of guanabenz given intravenously. The diuretic action produced by guanabenz was completly blocked by pretreatment of i.v. prazosin, ${\alpha}_1-adrenoblocking$ agent, or of i.v. yohimbine, ${\alpha}_2-adrenergic$ blocking agent. Prazosin, when given into a renal artery, inhibited the diuretic action by i.v. guanabenz in only injected kidney, whereas in case of yohimbine the action was inhibited in both kidney. Guanabenz infused at a dose of $1.0{\mu}g/kg/min$ into a renal artery exhibited no significant changes of renal function in both kidney. In denervation experiments, guanabenz given intravenously produced typical diuretic action in innervated kidney, whereas in denervated kidney, it did not affect the action at initial period but exhibited the action with increase of only free water clearance at later period. These results suggest that guanabenz produced diuretic action in dog by inhibition of electrolyte reabsorption rates in renal tabules, mainly proximal tubule and of ADH release, which is mediated by stimulating of central sympathetic ${\alpha}_2-receptor$.

• 태양에너지
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• 제17권1호
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• pp.47-58
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• 1997

본 연구는 2차원 충돌공기분류계의 포텐셜코어 영역에서 열전달증진을 목적으로 노즐출구와 전열면사이에 메쉬를 설치한후 노즐출구 속도, 메쉬와 전열면사이의 간극, 노즐출구와 전열면사이의 거리를 변화시킬 때의 열전달특성을 메쉬를 설치하지 않은 경우와 비교 검토한 것으로 메쉬를 설치했을 때에는 분류가 전열면에 충돌하면서 소분류로 분할되어 발생하는 난류에 의해 충돌영역에서 열전달성능이 좋아지며, 또한 벽면분류영역으로 진행하면서 홀과 홀사이의 밑부분에서 일어나는 가속으로 인해 열전달성능이 향상된다. 특히 메쉬와 전열면사이의 간극을 변화시켰을 경우 정체점부근에서는 간극이 클수록, 벽면분류영역에서는 간극이 작을수록 전달성능은 향상되며 U=18m/s, H/B=2, C=1인 경우에는 메쉬를 설치하지 않은 평판보다 평균 약 44%의 열전달증진 효과과 있었다. 그리고 본 실험결과를 기존의 난류촉진체를 이용한 연구결과와도 비교 검토하였다.

• 한국소음진동공학회논문집
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• 제21권6호
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• pp.562-569
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• 2011

In this study linear and nonlinear dynamic stability characteristics of a medium-size high-speed turbocharger, whose rotor is supported by two 3-lobe journal bearings, are analyzed to evaluate and identify the effects of its bearing design variables. The rotor has the rated speed of 40,500 rpm and maximum continuous speed of 45,000 rpm. At first, utilizing the linear stability analysis method, bearing designs of yielding stable or unstable LogDecs as small as possible are searched by manipulating with machined bearing clearances and preloads. As next, utilizing the nonlinear analysis method, limit cycles of the rotor responses at the rated and maximum continuous speeds are simulated to check their acceptances. Results have shown that for the turbocharger rotor-bearing system considered, the 3-lobe journal bearing design with a smaller machined clearance and a larger preload are preferred for the stable rotor responses. More importantly, since there exists a good correlation between the linear and nonlinear stability analysis results, it is concluded that firstly the linear stability analysis method may be applied to screen quickly the ranges of bearing designs for stable or least unstable solutions and then, lastly the nonlinear stability analysis method may be deployed to check an absolute motion stability in terms of the limit cycle.