• 대한교통학회지
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• 제28권1호
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• pp.97-105
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• 2010

교차로에서 신호시간 변경 시 교차로를 벗어나지 못한 차량과 대향 차량, 교차로 횡단보도의 보행자(자전거)와의 충돌을 피하기 위하여 황색신호와 별도로 전전색신호를 운영하고 있다. 외국은 전적색신호 운영이 교통사고에 미치는 영향을 분석해 오고 있다. 반면 국내의 경우에는 이와 같은 유사한 연구가 미흡한 실정이다. 본 연구에서는 국내에서 운영되는 전적색신호가 교통사고에 어떠한 영향을 미치는 지를 가설검정 통하여 평가하였다. 전적색신호를 도입한 교차로 10개소에 대하여 전 후 사고율을 분석하였다. 95% 유의 수준에서 비모수 검정을 실시한 결과 전적색신호의 도입은 교차로 안전성을 향상시키는 것으로 분석되었다. 이는 전적색신호가 신호변경 중에 교차로에 남아 있는 차량의 정리와 미리 진입하는 차량을 통제함으로써 교차로내의 직각충돌사고를 감소시켰기 때문으로 분석된다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권3호
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• pp.266-275
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• 2020

Purpose: The outcome predictors of Kasai portoenterostomy (KPE) for biliary atresia (BA) are controversial. This study aimed to identify possible short-term outcome predictors of KPE for BA in infants. Methods: This retrospective study included infants with BA who underwent KPE between January 2015 and December 2017 and were followed up for at least 6 months after surgery at the Pediatric Hepatology Unit, Cairo University Pediatric Hospital, Egypt. The short-term outcome was jaundice clearance within 6 months following surgery. All data were compared between the jaundice free group and those with persistent jaundice to identify the predictors of jaundice clearance. Results: The study included 75 infants. The mean age at the time of surgery was 82.43±22.77 days (range, 37-150 days), and 28 (37.3%) infants cleared their jaundice within 6 months postoperative. Age at surgery did not significantly affect the outcome (p=0.518). Infants with persistent jaundice had significantly higher pre-operative levels of aspartate aminotransferase (AST) than those who were jaundice free (p=0.041). Receiver operating characteristic curve analysis showed that preoperative AST ≤180 IU/L was predictive of a successful KPE, with sensitivity 74.5% and specificity 60.7%. Infants with bile plugs in liver biopsy had a 6-fold higher risk of persistent jaundice than those without bile plugs (95% confidence interval: 1.59-20.75, p=0.008). Conclusion: Jaundice clearance after KPE for BA can be predicted using preoperative AST and presence of bile plugs in liver biopsy.

• The Korean Journal of Physiology and Pharmacology
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• 제28권2호
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• pp.121-127
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• 2024

Vancomycin is a frequently used antibiotic in intensive care units, and the patient's renal clearance affects the pharmacokinetic characteristics of vancomycin. Several advantages have been reported for vancomycin continuous intravenous infusion, but studies on continuous dosing regimens based on patients' renal clearance are insufficient. The aim of this study was to develop a vancomycin serum concentration prediction model by factoring in a patient's renal clearance. Children admitted to our institution between July 1, 2021, and July 31, 2022 with records of continuous infusion of vancomycin were included in the study. Sex, age, height, weight, vancomycin dose by weight, interval from the start of vancomycin administration to the time of therapeutic drug monitoring sampling, and vancomycin serum concentrations were analyzed with the linear regression analysis of the mixed effect model. Univariable regression analysis was performed using the vancomycin serum concentration as a dependent variable. It showed that vancomycin dose (p < 0.001) and serum creatinine (p = 0.007) were factors that had the most impact on vancomycin serum concentration. Vancomycin serum concentration was affected by vancomycin dose (p < 0.001) and serum creatinine (p = 0.001) with statistical significance, and a multivariable regression model was obtained as follows: Vancomycin serum concentration (mg/l) = -1.296 + 0.281 × vancomycin dose (mg/kg) + 20.458 × serum creatinine (mg/dl) (adjusted coefficient of determination, R² = 0.66). This prediction model is expected to contribute to establishing an optimal continuous infusion regimen for vancomycin.

• 무역상무연구
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• 제67권
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• pp.97-118
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• 2015

This study reviews the judgements by the Korean Supreme Court on the time of delivery of goods, as it depends on which bonded place the goods are kept for the purpose of the customs clearance. Thereafter, this study analyzes the Ocean Carrier's liability, when the cargoes are mis-delivered without the presentation of bill of lading in relation to the specific bonded place such as an independent bonded warehouse or a self-use bonded warehouse. Furthermore, considering that voyage charter is a kind of marine transport, this study also reviews whether or not the Court's judgements, which has been developed in respect of the carriage of affreightment, could be applied to voyage charter in respect of the time of delivery goods and the Ocean Carrier's liability for mis-delivery. Lastly, in the case that the substantial importer takes the goods from the independent bonded warehouse without the presentation of bill of lading after the customs clearance, it is noted that the Court has made the Ocean Carrier liable for the mis-delivery through the application of theory of double deposit contract. The position of the Court would be understandable in terms of the protection for the bona-fide holder of bill of lading, but this study reviews the limitation of liability as the device for the protection of the Ocean Carrier, considering the situation where the Ocean Carrier is somewhat unreasonably sacrificed under the bonded system provided for the convenience of substantial importer.

• 대한기계학회논문집A
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• 제28권12호
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• pp.1864-1870
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• 2004

A spot welded structures have an influence on a diverse climatic situation, for instance temperature, humidity and precipitation. In addition factors of environmental pollution such as acid rain, that courses corrosion, have the tendency to increase. But spot welded structures strength is affected by humidity and environment temperature. Therefore, it is important to evaluate effect of temperature and water immersion on strength properties of spot welded part. In this study, the strength distribution of spot welded plates is evaluated the environmental temperature of zinc coated steel plates. Test is conducted with welded part immersed in distilled and synthetic sea water. Specimens are immersed into water for 10, 100, 500 and 1000 hours to evaluate the offsets of water immersion time on tensile-shear strength under the conditions of -40, 0, 20 and 5$0^{\circ}C$. From this result, spot welded specimens with 5 mm clearance have lower tensile-shear strength in the distilled water or synthetic sea water than without clearance. And they have lower tensile-shear strength under -4$0^{\circ}C$ and over 5$0^{\circ}C$.

• 대한기계학회논문집
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• 제15권1호
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• pp.120-126
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• 1991

본 연구에서는 Kawabata가 제안한 직접수치해법(direct numerical solution method)을 확대하여 윤활표면으 국부 회소가스 효과(local rarefaction effect)로 인 한 공기분자의 벽면 미끄름 현상을 고려한 지배방정식을 Navier-Stokes방정식으로 부 터 유도하고 이를 2차원 유동의 경우까지 확대하여 극소틈새와 높은 압축성 계수를 갖 는 경우에 적용하고 그 결과를 기존의 수정된 레이노래즈 방정식의 해석결과와 비교하 고자 한다.

• Tribology and Lubricants
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• 제25권5호
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• pp.324-329
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• 2009

In this study a complex design fitness analysis of journal bearings is carried out for the LPLi rotary-vane fuel pump application, as an external and horizontal installation, in LPG vehicles. Bearings considered in the analyses are plain and 3-axial groove journal bearings. Upon reflecting the fact that the primary failure mode of bearings in the application is a premature friction and wear failure of bearing metal due to a very low viscosity of liquid fuel LPG as a bearing lubricant, the performance factors of bearings used in an evaluation process of design fitness are a load carrying capacity and vibration suppression ability relative to a rated speed. At this time the design variables of bearings are a radial clearance and length. Results show that, in terms of both of the load carrying capacity and vibration suppression ability, the plain journal bearings are superior to the 3-axial groove journal bearings and among the plain bearings the smaller the bearing clearance (5>10>$15\;{\mu}m$) is and the longer the bearing length (6<8<10<12<14 mm) is, the better the bearing performance is.

• 한국항공우주학회지
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• 제43권4호
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• pp.341-348
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• 2015

본 논문에서는 일반적인 발사체의 형상에 대하여 몬테카를로 시뮬레이션을 적용하여 분리 유격 분석을 수행하였다. 단 분리는 매우 짧은 시간동안 이루어지며, 매우 많은 운동 변수가 관계되고 충돌 발생시 발사 실패가 나타나는 매우 중요한 비행 이벤트이다. 다양한 오차요인이 무작위(random)로 발생하는 경우에도 설정된 유격조건 내에서 분리가 됨을 확인하기 위해 일반적인 발사체 형상에 대한 단 분리 분석을 수행하였다. 몬테카를로 분석 기법을 발사체 단 분리 분석에 적용함으로서 단 분리 운동시 확률적인 결과들을 제시하였다.

• 항공우주시스템공학회지
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• 제14권1호
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• pp.1-7
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• 2020

본 논문은 국내 최초로 독자기술로 개발된 항공기용 연료이송펌프의 기어부를 설계하는 일련의 절차 및 그 결과에 대한 것이다, 기어펌프 방식이 베인펌프 방식에 비하여 전반적 성능이 우월하고, 내부 누설이 소량으로, 연료이송펌프의 설계에 필요사항에 부합하여 이 방식이 선정되었다. 기어 하우징은 흐름을 결정하는 중요한 변수인데, 기어의 외경을 고려하여 적절한 여유공간을 갖도록 설계하였다. 아울러, 모터가 연료이송펌프를 구동하기 위해 필요한 공압 및 축동력 등도 계산하였다.

• 한국임상약학회지
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• 제20권3호
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• pp.200-204
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• 2010

The purpose of this study was to investigate the effect of ticlopidine on the pharmacokinetics of nimodipine in rats. Pharmacokinetic parameters of nimodipine were determined in rats after oral administration of nimodipine (16 mg/kg) with or without ticlopidine (3 or 10 mg/kg). Ticlopidine inhibited cytochrome P450 (CYP)3A4 activity. Ticlopidine significantly (p<0.05, 10 mg/kg) increased the area under the plasma concentration-time curve (AUC) of nimodipine and ticlopidine significantly (p<0.05, 10 mg/kg) prolonged the terminal half-life ($t_{1/2}$) of nimodipine. Ticlopidine significantly (p<0.05, 10 mg/kg) decreased the total body clearance ($CL_t$). The absolute bioavailability (AB%) and relative bioavailability (RB%) of nimodipine by presence of ticlopidine were increased by 14% and by 42%, respectively, compared to the control. Based on these results, the increased bioavailability of nimodipine might be due to inhibition of the metabolizing enzyme cytochrome P450 (CYP)3A4 in the liver or intestinal mucosa and/or reducing total body clearance by ticlopidine.