• 한국도로학회논문집
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• 제9권3호
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• pp.83-89
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• 2007

보다 안전하고 효율적인 교차로 신호운영을 위해서는 보행자의 횡단시간뿐만 아니라 자전거 이용자 특성에 따른 횡단시간을 고려한 신호운영이 필요하며. 특히 보행자와 물리적으로 분리 운영되는 교차로의 경우에는 자전거 횡단시간을 고려한 최소녹색시간 및 소거손실시간 계획이 이루어져야 할 것이다. 본 연구에서는 보행자와 마찬가지로 자전거 이용자가 교차로를 안전하게 횡단할 수 있는 시간(최소녹색시간. 소거손실시간 등)을 자전거 이용수요가 많은 현장에서 자전거 이용자의 횡단특성에 따라 조사 분석하였으며, 횡단유형은 크게 3가지로 정지한 상태에서 출발하는 형태(Stopping), 주행중인 속도로 횡단하는 형태(Riding), 자전거를 끌고 가는 형태(Pulling) 등으로 구분하였다. 조사 분석결과, 최소 녹색시간 산정시 고려 될 수 있는 횡단유형별 속도는 Stopping의 경우 1.36($15^{th}$ percentile), 1.60m/sec($25^{th}$ percentile), Pulling의 경우에는 0.75($15^{th}$ percentile), 0.87m/sec($25^{th}$ percentile) 라 할 수 있겠으며, 소거손실시간의 경우에는 자전거 이용자 형태 중 Riding의 경우로 2.51($15^{th}$ percentile), 2.79m/sec($25^{th}$ percentile)를 적용할 수 있을 것으로 판단된다.

• 에너지공학
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• 제29권1호
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• pp.63-74
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• 2020

영구정지 후 해체가 계획된 고리 1호기 원자력발전소는 해체 과정에서 다양한 종류의 방사성폐기물이 대량으로 발생할 것으로 예상되고 있다. 이 중 가장 많은 발생량을 차지할 것으로 예상되는 콘크리트 방사성폐기물에 대하여 기존 폐기물의 처분 현황 및 법적 제한사항등을 분석하여 적절하고 효율적인 처분방법을 마련하는 것은 중요한 사안일 것으로 판단된다. 콘크리트 방사성폐기물은 다양한 준위의 폐기물들이며, 이 중 규제해제 준위에 해당되어 자체처분이 가능한 폐기물은 바이오실드 콘크리트이다. 본 논문에서는 방사화 평가 결과를 바탕으로 자체처분이 가능한 폐기물을 자체처분 평가 코드인 RESRAD 코드 프로그램을 이용하여 자체처분 안전성 평가를 수행하였다. 대상 폐기물의 자체처분 시나리오를 선정하고 자체처분시 개인별 피폭선량을 계산하여 국내 원자력안전법에서 규정하는 자체처분 기준 제한치의 만족 여부를 판단하였다. 평가 결과, 전체적으로 상당히 낮은 결과 값을 보이며 기준 제한치를 만족하는 결과를 나타내었다. 이러한 자체처분 안전성 평가 결과를 바탕으로 규제해제 대상으로서 자체처분 가능한 바이오실드 콘크리트 폐기물에 대한 적절한 처분방법을 제시하였다.

• 한국식품영양과학회지
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• 제30권6호
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• pp.1283-1286
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• 2001

마크로파지의 활성을 조사하기 위해 carbon clearance time을 조사한 결과 AEY 처리구가 control이나 CEY 처리구에 비해 짧았다. 특히 AEY 500$\mu\textrm{g}$ 처리에서 carbon clearance 시간이 5분으로 control에서 9.42분, CEY(250$\mu\textrm{g}$ 처리)에서 9.01분보다 유의성 있는 감소를 보였다. AEY 처리에 의해 응집소가와 용혈소가가 다소증가되었다. SRBC처리 1일째와 3일째에 250$\mu\textrm{g}$ 처리구를 비교해 보면, control, CEY, AEY의 응집소가는 각각 5.50, 5.63, 6.00 및 5.25, 5.38, 5.50로 용혈소가는 각각 4.75, 5.38, 5.50 및 4.25, 5.63, 5.63으로 AEY 처리구가 control, CEY 처리구에 비해 면역 활성이 있었지만 유의성은 없었다.

• 한국임상약학회지
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• 제3권1호
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• pp.31-43
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• 1993

The influence of phenobarbital(PB) pretreatment(75mg/kg/day, Lp. for 4 days) on the hepatic clearance of indocyanine green(ICG) as a model compound of organic anionic drugs was investigated in rats in order to elucidate the relative contributions of change in the hepatic blood flow versus increase in the hepatic intrinsic activity to remove ICG due to PB pretreatment. ICG(1mg/kg) was injected single bolus via femoral or portal vein to the control and the PB-pretreated rats. The initial hepatic uptake clearance$(V_{d.c.}K_{12})$ obtained from plasma concentration-time data was increased by $38.4\% in the PB-pretreated rats, which may be due to the increased hepatic blood flow by PB pretreatment. Using a pharmacokinetic approach, hepatic blood flows were estimated of 67.5ml/min/kg in control rats and 91.9ml/min/kg in PB-pretreated rats. They were in good agreement with other's blood flow estimates observed experimentally. It may be concluded that the $38\%$ increased initial hepatic uptake clearance of ICG was due to the $36\%$ increased hepatic blood flow with phenobarbital, and that the increased hepatic blood flow and the activated hepatic intrinsic clearance with phenobarbital contributed to $49\%\;and\;51\%$ of the increased systemic clearance of ICG, respectively.

• 약학회지
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• 제30권5호
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• pp.208-213
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• 1986

Rifampicin suspension was administered orally at a does of 34mg/kg to six rabbits after 5, 10 and 20mg/kg pretreatment of isoniazid twice daily for 9 days. The blood level of rifampicin was decreased significantly by isoniazid 10mg/kg 20mg/kg pretraetment. The renal clearance(CLr) of rifampicin was increased by isoniazid 20mg/kg and the biliary clearance(CLb) was incresed by isoniazid 10mg/kg and 20mg/kg pretreatmetn. Elimination rate constant(K) and time to reach maximum concentration(tmax) were increased by isoniazicl pretreatment. But half-life and maximum concentration(C max) were decreased. Relative bioavailability was decreased significantly by isoniazid 10mg/kg and 20mg/kg pretreatment.

• International Journal of Fluid Machinery and Systems
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• 제9권2호
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• pp.119-128
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• 2016

This work presents the numerical investigation of an unsteady cavitating flow around a balancing drum of a multistage pump. The main attention is focused on the cavitation phenomena, which occur in the rear part of the drum clearance, cause the erosion of the drum material and influence the pressure losses and the flow rate through the clearance. The one-way coupling of the URANS equations and the full Rayleigh-Plesset equation is employed to analyse the flow field as well as the dynamics of cavitating bubbles. The numerical simulations show that the erosion processes are highly influenced by shaft vibrations, namely by periodic deformations of the annular clearance in time. The calculated results are verified by erosion tests on a real pump.

• 대한기계학회논문집B
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• 제28권12호
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• pp.1501-1510
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• 2004

The pumping characteristics of a single-stage disk-type drag pump (DTDP) are calculated for the variation of the vertical clearance between a rotor and stator by the three-dimensional direct simulation Monte Carlo (DSMC) method. The gas flow mainly belongs to the molecular transition flow region. Spiral channels of a DTDP are cut on the both the upper and lower sides of a rotating disk, but a stationary disk is planar. The interaction between molecules is described by the variable hard-sphere model. The no time counter method is used as a collision sampling technique. The vertical clearance has a significant effect on the pumping performance. Experiments are performed under the outlet pressure range of 0.4∼533 Pa. When the numerical results are compared with the experimental data, the numerical results agree well quantitatively

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 춘계학술대회
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• pp.358-363
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• 2003

Spot welded structure is operated in diverse situation because of temperature, humidity and precipitation. In addition factors of environmental pollution such as acid rain, that courses corrosion, have the tendency to increase, But spot welded structure strength is affected by dampness and environment temperatures. Therefore, it is important to evaluate effect of temperature of spot welded part, In this study, the strength distribution of spot welded plates is evaluated about the environmental temperature of zine coated steel plates and test is conducted with welded part immersed in distilled and synthetic sea water. Specimens are immersed into water for 10, 100, 500 and 1000hours to evaluate the effects of water immersion time on tensile-shear strength under the conditions of -40, 0, 20 and $50^{\circ}C$. Strength is evaluated by tensile-shear test. The conditions of spot welding are 240kgf electrode force, 10KA welding current with 0 and 5mm clearance. From this study, spot welded specimens with clearance have lower tensile-shear strength in the distilled water or synthetic sea water comparing with spot welded specimens without clearance. And they have lower tensile-shear strength under $-40^{\circ}C$ and over $50^{\circ}C$.

• Archives of Pharmacal Research
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• 제13권3호
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• pp.233-239
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• 1990

The efect of acute renal failure (ARF) on the pharmacokinetics o sulfobromophthalein (BSP) was investigated in order to elucidate if renal failure modifies the hepatic metabolism of drugs. ARF was induced by intravenous (iv) injection of uranyl nitrate (UN) to rats (5 mg/kg) five days before the experiment. Area under the plasma concentration-time curve (AUC)of BSP after portal vein (pv) injection increased by 2-fold and total body clearance ($CL_1$) decreased one half (p <0.01) in UN-induced ARF (UN-ARF) rate compared to the control rats. But the plasma disappearance of BSP after iv injection did not differ significantly between control and UN-ARF rats. Since BSP is excreted via the liver, $CL_1$ represented the approximate hepatic clearance of BSP. Therefore, the decrease in $CL_1$ represented the approximate hepatic clearance of BSP. Therefore, the decrease in $CL_1$ represents a decrease in hepatic intrinsic clearance ($CL_{int}$) for BSP since plasma free fraction ($f_p$) of BSP was not affected by UN-ARF. The content of hepatic cytoplasmic Y-protein, which catalyzes BSP-glutathione conjugation and limits the trasfer of BSP from blood to bile, increased significantly (p < 0.01), however its binding activity (BA) for BSP was decreased significantly (p <0.01) by UN-ARF. The decrease in $CL_{int}$might have some correlation with the changed characteristics of hepatic Y-protein, specifically its decreased BA for BSP.

• 대한핵의학회지
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• 제3권1호
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• pp.59-67
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• 1969

Correlation between the blood clearance half time and findings of liver scan using the colloidal radiogold in patients of liver cirrhosis is observed through the scoring system, in which the more changes in size, shape and density in the liver scan, the more points are given (table 1). Results: 1) Within the increase in severity of hepatocellular dysfunction in liver cirrhosis, the degree and frequency of following changes in liver scan (done with colloidal radiogold) were increased in order. a) generalized hepatomegaly b) enlargement of the left lobe & reduction of the right lobe c) relatively increased radiodensity in the left lobe and 4) visualization of spleen. 2) Frequency of the normal scan in liver cirrhosis was $12{\pm}3.56%$, frequency of normal value in blood clearance half time of the radiogold was $5.0{\pm}2.34%$ and frequency of normal scan & normal blood clearance rate in liver cirrhosis was $3.6{\pm}2.06%$.