• 소성∙가공
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• 제15권6호
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• pp.428-435
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• 2006

IC leadframe needs precision shape for good efficiency. Friction conditions also have a significant impact on blanking deformation. Therefore, studying the friction produced by the tribology between die and materials becomes necessary. In this study, in order to measure mechanical properties and frictions for leadframe materials such as Ni alloys and coppers, tensile test and straight pulling friction test are executed. In particular, the effect of clearance on the blanking characteristics depending on friction coefficient is examined by finite element simulation. From the finite element simulation, the metal flow, side pressure of punch and crack initiation are evaluated according to the leadframe materials.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1997년도 추계학술대회 논문집
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• pp.19-22
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• 1997

The objective of this research is to use an analytical and experimental approach to develop optimal tool geometry for high speed machining. The tool geometry parameters and cutting process have complex relationships. Until now, numerous cutting tests were needed to acquire optimal design of endmill for the purpose of high speed machining, dut to the insufficient knowledge about process in high speed machining. In order to improve the cutting ability of endmill, a model for optimal cutter shape was developed to minimize resultant cutting force by combing cutting force and wear test and surface roughness test from optimized and conventional cutter with the same cutting condition. Using various tools with different geometry, relationships between the tool geometry parameter, rake angle, clearance angle, lengh of cutter have been stuied.

• Natural Product Sciences
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• 제5권1호
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• pp.54-59
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• 1999

Both ethanol and water extracts of unossified velvet antler were found to exhibit a significant immuno-stimulating activity as measured by carbon clearance test in mice, a remarkable anti-fatigue effect in weight-loaded forced swimming performance in mice, a significant anti-stress effect on immobilization in rats. The antler extracts also showed a weak but significant anti-thrombotic activity. These findings are indicative of adaptogenic properties of antlers and their normalizing effects during stressful condition.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년 영문 학술대회
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• pp.855-861
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• 2008

Micro wave rotor is expected to improve the performance of micro gas turbines drastically. In the present study, a micro wave rotor test rig was designed and built for micro gas turbines of 1-10 kW output range, and its test runs were carried out with cold air flow. In the previous experiments, the leakage loss had large influence on its operating condition. Therefore, abradable coating was applied on the end walls to achieve the operation with zero clearance for leakage reduction and its improvement on the operating condition is discussed in this study.

• 대한약침학회지
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• 제19권1호
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• pp.21-27
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• 2016

Objectives: The present study was undertaken to evaluate the immunomodulatory (IM) activity of IM-133N, a herbal combination in various immunotherapeutic experimental models. Methods: The IM activity of IM-133N was evaluated against three experimental models namely, effect of IM-133N against Escherichia coli (E. coli)-induced abdominal sepsis in mice, and carbon clearance test was performed in Wistar albino rats to evaluated the phagocytic potential of IM-133N, in addition IM-133N was evaluated for its immunoglobulin enhancing potential in rats, where the immunoglobulin levels were measured by zinc sulphate turbity (ZST) test. Further, IM-133N was subjected for detailed liquid chromatography-mass spectrometry (LC-MS)/MS analysis to identify the probable active constituents present in it. Results: The findings of the present study has demonstrated very promising IM property of IM-133N in all the experimental models. Briefly, pretreatment with IM-133N at 125, 250, 500 and 1,000 mg/kg, p.o. doses had protected the mice against E. coli-induced abdominal sepsis and mortality, further the effect of IM-133N was found to be significant and dose-dependent. In support of this, in another study administration of IM-133N showed a significant and dose-dependent increase in serum immunoglobulin levels, estimated by ZST test. In line with the above findings, in the carbon clearance test the low doses (125 and 250 mg/kg, p.o.) of IM-133N increased the rate of carbon clearance, whereas the higher doses (500 and 1,000 mg/kg, p.o.) did not sustain the response, and saturation effect was considered as one of the possible reason for futility of higher doses for IM-133N. In addition, A detailed LC-MS/MS analysis of IM-133N showed 17 bioactive phytochemical constituents: namely, apigenin, chaulmoogric acid, mesquitol, quercetin, symphoxanthone, salireposide, ${\beta}$-sitosterol, nonaeicosanol, ${\beta}$-amyrin, betulic acid, oleanolic acid, symplososide, symponoside, symploveroside, symplocomoside, symconoside A and locoracemoside B. Conclusion: These findings suggest that IM-133N possesses significant IM activity and, hence, could be useful for eradicating opportunistic disease-triggering pathogens via immunotherapeutic mechanisms. The findings also suggest IM-133N may also useful in other immunity disorders.

• Journal of Acupuncture Research
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• 제24권6호
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• pp.75-88
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• 2007

Objectives : We investigated the effects of Hominis placenta Herbal acupuncture on rheumatoid arthritis. Methods : We investigated the Type II collagen-induced arthritis test, vascular permeability test, phenyl benzoquinone-induced writhing test, hot plate test, carbon clearance test, determination of prostaglandin $E_2$ content and cyclooxygenase-2 activity test. Results : Hominis placenta Herbal acupuncture suppressed Type II collagen-induced arthritis in DBA/1J mice and vascular permeability with 10.2% inhibition in ICR mice. We see the phenyl benzoquinone-induced writhing test and the hot plate test in the analgesic activity test. In the phenyl benzoquinone-induced writhing test, Hominis placenta Herbal acupuncture showed that it increased its analgesic effect more than the control(test?) by 85.5%. In the hot plate test, it was also shown that the analgesic effect increased more than the control(test) by 32.1%. In the carbon clearance test, the immuno-stimulatory effect showed more than the control(test) by 8.0%. The formation of prostaglandin $E_2$ was also reduced more than the control(test) by 10.1%. Finally, cyclooxygenase-2 activity was inhibitedwith 36.3%. Conclusions : Hominis placenta Herbal acupuncture may be useful for the treatment of rheumatoid arthritis after injection.

• Archives of Pharmacal Research
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• 제21권4호
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• pp.411-417
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• 1998

In order to investigate the effect of the pretreatment with various doses of diltiazem (DTZ) on the pharmacokinetics of indocyanine green (ICG) at steady state, especially the hepatic blood clearance due to the change of hepatic blood flow, the following experiments were carried out with ICG, a hepatic function test marker, not metabolized in liver and only excreted in bile. The intravenous bolus injection ($3,780\mu\textrm{g}$/kg) and the constant-rate infusion ($10,100\mu\textrm{g}$/kg/hr) of ICG into the left femoral vein were made in order to check the steady-state plasma concentration ($C_{ss} of $10\mu\textrm{g}$/ml) of ICG at 20, 25 and 30 min. Following a 90-min washout period, the intravenous bolus injection (108, 430, 860 and $1,720\mu\textrm{g}$/kg) and the constant-rate infusion (108, 433, 866 and $1,730\mu\textrm{g}$/kg/hr) of DTZ into the right femoral vein were made and the achievement of the steady-state plasma levels ($C_{ss} of 50, 200, 400 and 800 ng/ml) of DTZ were conformed at 60, 70 and 80 min. During the steady state of DTZ, the intravenous bolus injection ($3,780\mu\textrm{g}$/kg) and the constant-rate infusion ($10,200\mu\textrm{g}$/kg/hr) of ICG into the left femoral vein were made and also the steady-state plasma concentration of ICG was checked at 20, 25 and 30 min. The plasma concentrations of DTZ and ICG were determined using a high performance liquid chromatographic technique. At the steady state, the hepatic blood clearance of ICG was obtained from the plasma concentration and blood-to-plasma concentration ratio ($R_B$) of ICG. The pretreatment with various doses of DTZ did not influence the plasma concentrations, $R_B$ and plasma free fraction ($f_p$) of ICG. So the hepatic blood clearance of ICG was independent of concentration of DTZ. The hepatic blood clearance of ICG could be affected by both hepatic bood flow and hepatic intrinsic clearance. But there was no change of the hepatic blood clearance of ICG between the control and the DTZ-pretreated rats in this study. So it may be suggested that DTZ does not influence hepatic blood flow.

• 대한기계학회논문집B
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• 제34권2호
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• pp.179-184
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• 2010

스트레이트 휜 히트 싱크가 장착된 공간에 팁 클리어런스(tip clearance)와 바이패스 유동이 열성능에 미치는 영향을 실험적으로 규명하고자 한다. 수평 및 수직 방향으로의 바이패스 유동에 의한 열성능 평가는 열식 질량 유량계(MFC)와 소형 풍동으로 이루어진다. 팁 클리어런스와 바이패스 유동에 의한 히트 싱크의 열성능은 열저항을 통하여 평가한다. 실험 결과, 스트레이트 휜 히트 싱크의 열저항은 팁 클리어런스가 증가함에 따라 점진적으로 증가하며, 유동 가이드 장치는 바이패스 유동을 감소하는 역할을 한다. 본 연구에서는 동일 유량 조건에서 히트 싱크의 입구에서 유동 가이드 장치까지의 거리에 따라 스트레이트 휜 히트 싱크의 최적값이 존재함을 확인하였다. 히트 싱크로 유입되는 유량이 증가함에 따라 유동 가이드 장치에 의한 열성능 개선 정도는 증가한다.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 1998년도 유체기계 연구개발 발표회 논문집
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• pp.191-197
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• 1998

The recent results of the engine development performed in this you on Turbogreen 1200, the first industrial gas turbine engine developed in Korea, are presented. In order to improve the engine performance and structural stability from the first prototype engine, several variants of the engine and major components such as combustor and rotor assembly have been developed and tested. This paper shows these results especially focused on the engine test and performance analysis, in which test system, instrumentation and data processing are discussed as well. The engine performance and its trend give relatively good coincidence with the design ones. At design power of 1.2MW, the thermal efficiency of the engine is estimated over $25\%$ which is below the design target of $27.2\%$. This gap of efficiency is caused mainly by large tip clearance between turbine blades and casing. Considering high design efficiency superior to those of other competitive engines in this power class, Turbogreen 1200 would have a strong competition in its performance if the design efficiency is achieved by further developments such as tip clearance control, which are very possible and natural in final mass production of the developed gas turbine engine.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2004년도 춘계학술대회 논문집
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• pp.57-61
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• 2004

in order to improve the quality of the sheared surface in cutting of sandwich sheet metals the cut-off operation is mainly investigated which is the typical shearing process in sheet metal forming technology. For experiments the cut-off die is made which can be easily adjusted by die design variables such as blankholding force, pad force, and clearance. The sheet metals chose as specimen are clad304(STS304-Al1050-STS304) and anti-vibration sheet metal. The shearing process is visualized by the computer vision system installed in front of the cut-off die and the sheared surface before and after cut-off operation is measured and quantitatively compared with the help of the optical microscope. From test results the good sheared surface was shown when the clearance gets small with large blankholding force.