• 약학회지
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• 제29권6호
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• pp.362-366
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• 1985

These paper was attempted to investigate the mechanism of increased blood level of sulfisomidine by cimetidine pretreatment pharmacokinetically. Especially, effect of cimetidine pretreatment on both renal clearance and biliary clearance of sulfisomidine was studied in rabbits. The results are as follows. The blood level of sulfisomidine administered intravenously in dose of 25mg/kg was elevated significantly by cimetidine pretreatment. Relative bioavailability and biological half-life were increased significantly by cimetidine pretreatment. Overall elimination rate constant ($betha$) and distribution rate constant ($K_{13}$) of sulfisomidine were decreased significantly by cimetidine pretreatment. The renal and biliary clearance of sulfisomidine were decreased significantly compared with those of control rabbits by cimetidine pretreatment. The results may be also related to the inhibition of sulfisomidine metabolism enzyme activity or reduction of blood flow in the liver.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2009년도 제33회 추계학술대회논문집
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• pp.395-398
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• 2009

Currently, a new generation of ducted fan UAVs (Unmanned Aerial Vehicles) is under development for a wide range of inspection, investigation and combat missions as well as for a variety of civil roles like traffic monitoring, meteorological studies, hazard mitigation etc. The current study presents extensive results obtained experimentally in order to investigate the tip clearance effects on performance characteristics of a ducted fan for small UAV systems. Three ducted fans having different tip clearance gap and with same rotor size were examined under three different yawed conditions of calibrated slanted hot-wire probe. Three dimensional velocity flow fields were measured from hub to tip at outlet of the ducted fan. The analysis of data were done by PLEAT (Phase locked Ensemble Averaging Technique) and three non-linear differential equations were solved simultaneously by using Newton -Rhapson numerical method. Flow field characteristics such as tip vortex and secondary flow were confirmed through axial, radial and tangential velocity contour plots. At the same time, the effects of tip clearance on axial thrust and input power were also investigated by using wind tunnel measurement system. For enhancing the performance of ducted fan, tip clearance level should be as small as possible.

• 대한핵의학회지
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• 제3권2호
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• pp.49-54
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• 1969

The present study has been undertaken to analyze scan manifestations in obstructive jaundice. Scan changes were cprrelated with the duration of jaundice. In addition, clearance rates of trace dose of colloidal radiogold were assessed in each case. The materials were consisted of 19 cases with surgically and/or histopathlogically verified obstructive jaundice from various causes including common duct stone, empyema of the gall bladder and carcinoma of the pancreas head etc. Blood clearance rates of colloidal $^{198}Au$ were determined after the injection of 8 uCi by simple geometrical drawing of recorded strip charts. Scan was performed following additional injection of the same radiogold. In 16 out of 19 cases, the scan revealed rather typical "arborifrom" mottlings around the porta hepatis. The intensity and appearance of such mottlings on the scan was related with the duration of jaundice and level of serum bilirubin and alkaline phosphatase. The blood clearance rates remained to be within normal range in 74 percent of the patients. In the remaining 26 percent, clearance rates ranged between 4.1 and 6 minutes. It is concluded that the association of "arboriform" mottlings and normal or mildly delayed clearance rates in the patients with jaundice is characteristic of obstructive changes in the biliary system.

• Industrial Engineering and Management Systems
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• 제11권1호
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• pp.30-38
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• 2012

This paper discusses a clearance pricing on daily perishable products considering a reference price of consumers. The daily perishable products are sometimes sold at a discount price before closing time to stimulate demand when the number of unsold products is more than initially envisioned. The discount pricing results both in an increase of the revenue of the day and in a decrease of the disposal cost. The discounting, however, also declines a reference price of consumers which is a mental price and serves as an anchor price to judge if a current sales price is loss or gain for the consumers. An excess discounting decreases the demand for the products sold at a regular price in the future and diminishes long-term profit. This study conducts a mathematical analysis on the clearance pricing problem for a single period with stochastic variations both on demand and on the inventory level at clearance time. The expected profit function especially depends on the response of consumers to the clearing price against their reference prices. A procedure is proposed to derive an optimal clearance price when consumers are loss-neutral. A sufficient condition is shown to obtain an optimal price for loss-averse and loss-seeking consumers by an analogous procedure.

• 원자력산업
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• 제20권6호통권208호
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• pp.55-59
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• 2000

• 한국운동역학회지
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• 제20권4호
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• pp.381-386
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• 2010

This study examined the changes in the walking pattern during level walking under low illumination conditions. Fourteen male subjects ($22.1{\pm}2.21$ years, $174{\pm}3.74\;cm$, $68.86{\pm}10.81\;kg$) with normal vision and no disabilities were enrolled in this study. All experiments were performed on a level walkway with three conditions: normal walking (preferred & low speed) and walking with low illumination. 3D motion capturing system was used for acquisition and analysis of the walking motion data with a sampling frequency of 120Hz. The walking speed, normalized jerk(NJ) at the center of mass(COM), wrist and heel, knee and elbow joint angle, ratio of the knee joint angle to elbow joint angle and the toe clearance on stance phase were used to compare the differences in walking pattern between the two illumination conditions, The results showed that the walking speed and joint angles decreased in low illumination, whereas the NJ and toe minimum clearance increased. In low illumination, most variables were similar to effects of low speed walking, but toe clearance was different from the effects of low speed. These results can be used as primary data for examining the changes in the level walking pattern of young adults under low illumination. Further study will be needed to compare these results in young adults with those in the elderly.

• 방사성폐기물학회지
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• 제2권1호
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• pp.60-67
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• 2004

연구로 1,2호기 해체과정에서 발생되는 많은 양의 철재폐기물 중 자체처분대상 철재폐기물을 대상으로 재활용하는 경우에 대해서 피폭방사선량을 평가하고, 규제해제농도기준(안)을 도출하였다. 평가도구는 RESRAD-RECYCLE ver 3.06을 이용하여 ICRP60에서 제시하고 있는 유효선량 개념에 근거한 내부피폭 선량환산인자를 수정하였고, IAEA Safety Series 111-P-1.1 및 NUREG-1640을 적용하여 예상되는 최대개인선량 및 집단선량을 평가하였다. 0.4 Bq/g의 철재폐기물에 대한 RESRAD-RECYCLE 전산코드의 평가결과 개인최대선량 및 집단선량은 23.9 $\mu$Sv/y, 0.11 man$.$Sv/y이다. 최종적인 핵종별 규제해제농도기준은 일반평가방법과 세부평가결과를 종합하여 가장 보수적인 평가결과를 추출하여 결정하였다. 그 결과 $Co^{60}$, C $s^{137}$ 핵종에 대한 규제해제농도준위는 1.14${\times}$$10^{-1}$ Bq/g미만이 되어야 국내 원자력법에서 정하고 있는 처분제한치(최대개인선량 : 10 $\mu$Sv/y, 집단선량 : 1 man$.$Sv/y)를 만족할 수 있다.

• Tuberculosis and Respiratory Diseases
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• 제45권3호
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• pp.546-552
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• 1998

연구배경: Macrolide란 구조식에 14-number macrocyclic lactone ring을 갖는 항생제를 총칭한다. 최근 개발된 clarythromycin, azythromycin, roxithromycin 등은 기존의 erythromycin에 비하여 소화관 흡수가 용이하고, 반감기가 길며, 위장관 부작용은 덜하면서 몇몇 세균속에 대해서는 더욱 강력한 항균 효과가 있다고 알려져 있다. Erythromycin은 간장의 cytochrome P-450 효소계에 의해 불활성화 되기 때문에, 특히 호흡기 질환 환자에서 사용되는 theophylline의 혈중농도를 증가시켜 theophylline toxicity를 초래할 수 있다고 알려져 있다. 그러나 현재까지 new macrolide에 있어서는 이러한 효과에 대해서는 임상 연구가 미미한 실정이다. 방 법: 기관지 천식환자에서 erythromycin (1000mg/day), clarithromycin(500mg/day), azithromycin(500mg/day), roxithromycin(300mg/day) 등을 theophylline(400mg/day)과 경구 복합 투여하여, 투여전, 투여 후 1주 및 4주(azythyromycin은 1주)에 각각 theophylline 혈중 농도와 청소율을 측정하여 혈중 theophylline 농도 및 청소율에 대한 erythromycin과 new macrolides 항생제의 영향을 평가하고자 하였다. 결 과: Erythromycin과 roxithromycin 투여군에서는 투여 1주 후부터 유의한 theophylline 혈중농도의 상승을 보였으며 특히, erythromycin 투여군에서는 2예에서 병합 투여를 중지하였다. 이러한 소견은 theophylline 청소율에서도 유사하였으나 1주 및 4주간에는 유의한 상승소견을 보이지 않았다. Clarithromycin, azithromycin 투여군에서는 병합 투여중 유의한 혈중 농도의 상승이나 청소율의 감소 소견은 관찰되지 않았다. 결 론: 이상의 결과로 erythromycin 혹은 roxithromycin 투여 환자에 대하여 theophylline을 동시에 복합 투여하는 경우 혈중 theophylline 농도가 예상보다 증가될 수 있으므로 적절한 주기적 관리가 요할 것으로 사료된다.

• 방사성폐기물학회지
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• 제8권2호
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• pp.123-133
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• 2010

방사성핵종의 분포유형에 관한 정보에 기초하여 극저준위폐기물의 자체처분 적합성을 통계학적으로 해석할 수 있는 방법론을 개발하였다. 방사성핵종의 분포에 관한 정보를 알 수 없는 경우에 대해서는 널리 알려진 마코프 부등식과 체비셰프 부등식을 적용하여 방사능농도의 산술평균과 허용되는 최대 표준편차의 상관관계식을 제시하였고, 방사성핵종의 농도가 정규분포 또는 로그정규분포를 갖는 경우에 대해서는 확률밀도함수, 누적확률밀도함수 등의 통계학적 관계식을 이용하여 방사능농도의 산술평균과 허용되는 최대 표준편차의 상관관계식을 새롭게 유도하였다. 또한, 자체처분기준 100 Bq/g 및 신뢰수준 95%인 조건에 대한 사례 적용연구를 통하여 방사능농도의 산술평균과 허용되는 표준편차의 범위를 방사성핵종의 분포유형에 따라 정량적으로 비교 제시하고, 자체처분 대상 폐기물의 방사성핵종 분포유형에 관한 정보가 확보될 경우 동일한 신뢰수준에서 자체처분이 허용될 수 있는 범위가 확장될 수 있음을 통계학적으로 입증하였다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년도 제31회 추계학술대회논문집
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• pp.145-148
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• 2008

현재 항우연에서 개발 중인 우주발사체 터보펌프에 사용되는 터빈은 단단 충동터빈을 적용하고 있다. 우주발사체의 안정성을 위해 팁 간극을 비교적 많이 허용하고 있는데, 효율적인 면에서는 반동터빈 보다 다소 뒤지지만, 높은 출력비를 가지는 충동터빈이 팁 간극이 커질 때 어떤 효율경향을 나타내는지 알아보는 일은 의미 있는 일이다. 실험은 아음속 조건에서 실험하였고, 팁 간극을 각각 코드기준 1%$\sim$20%일 경우 충동과 반동 각각의 경우에 대하여 하류 전압손실을 측정하였다. 측정결과 팁 간극이 10%보다 더 커지면, 충동터빈이 오히려 전압손실량이 반동터빈보다 더 작아진다. 이것은 팁 간극이 비교적 큰 조건에서 충동터빈이 반동터빈보다 효율이나 출력비 면에서 더 나은 성능을 나타냄을 의미한다.