• Nutrition Research and Practice
• /
• 제4권6호
• /
• pp.492-498
• /
• 2010

Both metabolic syndrome (MetS) and elevated LDL cholesterol (LDL-C) increase the risk for cardiovascular disease (CVD). We hypothesized that low HDL cholesterol (HDL-C) would further increase CVD risk in women having both conditions. To assess this, we recruited 89 women with MetS (25-72 y) and LDL-C ${\geq}$ 2.6 mmol/L. To determine whether plasma HDL-C concentrations were associated with dietary components, circulating atherogenic particles, and other risk factors for CVD, we divided the subjects into two groups: high HDL-C (H-HDL) (${\geq}$ 1.3 mmol/L, n=32) and low HDL-C (L-HDL) (< 1.3 mmol/L, n=57). Plasma lipids, insulin, adiponectin, apolipoproteins, oxidized LDL, Lipoprotein(a), and lipoprotein size and subfractions were measured, and 3-d dietary records were used to assess macronutrient intake. Women with L-HDL had higher sugar intake and glycemic load (P< 0.05), higher plasma insulin (P< 0.01), lower adiponectin (P< 0.05), and higher numbers of atherogenic lipoproteins such as large VLDL (P < 0.01) and small LDL (P<0.001) than the H-HDL group. Women with L-HDL also had larger VLDL and both smaller LDL and HDL particle diameters (P<0.001). HDL-C was positively correlated with LDL size (r=0.691, P<0.0001) and HDL size (r=0.606, P<0.001), and inversely correlated with VLDL size (r=-0.327, P<0.01). We concluded that L-HDL could be used as a marker for increased numbers of circulating atherogenic lipoproteins as well as increased insulin resistance in women who are already at risk for CVD.

• 한국산학기술학회논문지
• /
• 제20권11호
• /
• pp.157-163
• /
• 2019

본 연구는 노인 인구에서 대조군과 만성폐쇄성폐질환 환자의 빈혈 유병률과 헤모글로빈 농도의 차이를 살펴보고자 시행되었다. 또한, 본 연구는 노인 인구에서 만성폐쇄성폐질환의 중증도에 따른 빈혈 유병률과 헤모글로빈 농도를 조사하였다. 제 7기 국민건강영양조사 1차 년도(2016) 조사에 참여한 8150명의 의무기록을 분석하여 총 694명이 연구에 포함되었다. 대상자를 만성폐쇄성폐질환군과 비질환 대조군으로 분류하였고, 헤모글로빈, 헤마토크리트, 적혈구 농도 및 빈혈 유병 유무를 조사하였다. 만성폐쇄성폐질환군은 중증도에 따라 하위그룹으로 나누어 동일한 분석을 시행하였다. 비질환 대조군과 만성폐쇄성폐질환군의 빈혈 유병률은 그룹 간에 차이가 없었다. 비질환 대조군에 비해 만성폐쇄성폐질환군의 헤모글로빈, 헤마토크리트 및 적혈구 농도가 통계적으로 유의하게 높았다. 통계적으로 유의하진 않았으나, 만성폐쇄성폐질환의 중증도가 심해짐에 따라 빈혈 유병률은 감소하고 헤모글로빈, 헤마토크리트 및 적혈구 농도는 증가하는 경향성을 보였다. 본 연구를 통해 노인 만성폐쇄성폐질환 환자의 빈혈 유병률 및 헤모글로빈 농도에 대한 구체적인 자료를 제시할 수 있었다. 노인 만성폐쇄성폐질환 환자에서 빈혈이 발생한다면 원인에 대한 추가적인 평가를 고려해 봐야 한다.

• 한국의학물리학회:학술대회논문집
• /
• 한국의학물리학회 2004년도 제29회 추계학술대회 발표논문집
• /
• pp.158-161
• /
• 2004

방사선 치료의 핵심 장비인 선형가속기의 10년간 관리 기록을 분석하여 효율적인 관리 지표로 활용하고자한다. 장비의 장애 요인을 다각적으로 분석하기위해 고장 원인을 치료기 부위별로 세분했고 각각이 미치는 영향을 세 단계로 구분하여 조사했다. 또한 장비 사용량이 고장에 미치는 영향을 분석하기 위해 년도별 치료 환자수와 고장건수, 중요 부속의 평균 수명 등을 분석했다. 10년간 전체 고장건수는 587건 이였으며 이중 조사헤드부의 고장이 20%를 자치해 가장 높게 나타났으며 고장이 미치는 영향에 의한 분석에서는 일시적 장애해 당하는 중간 정도의 고장이 41%를 차지해 가장 높게 나타났다. 장애 영향이 가장 큰 조사 불가능 상태의 고장은 가속부에서 49%로 가장 높게 나타났으며 고장과 관련된 지표는 사용연수 및 치료건수와 밀접한 관계를 나타냈다. 중요 부속의 평균 수명은 클라이스트론과 싸이라트론의 경우 치료건수가 증가함에 따라 교체 주기가 빨라져 각각 제조사 권고치의 42%, 83% 수준이였다. 안정적인 치료서비스 제공을 위해서는 사용 연수가 증가함에 따라 장비 관리의 필요성이 더욱 중요시 되어야하며 10년간 장비 관리기록을 통해 얻은 각종 지표가 향후 효율적 관리의 좋은 지침이 될 것으로 사료된다.

• 해양환경안전학회지
• /
• 제23권5호
• /
• pp.497-512
• /
• 2017

2011~2012년 보령연안 수온의 시공간적 변동특성을 장기 연속수온관측 자료를 이용하여 분석하였다. 수온은 반일 또는 일일의 단주기 변동이 전 계절에 탁월하고 그 진폭은 하계와 춘계에 크고 추계에 작다. 수온과 기온의 연변동 진폭은 기온 $12.9^{\circ}C$, 수온 $10.9^{\circ}C$로 기온이 더 크며, 연변동 최고위상은 기온 8월 2일, 수온 8월 22일로 기온이 20일 앞선다. 수온의 연변동 진폭은 원산도와 대천항 연안에서 가장 크다. 수온변동 중 일일주기는 대천항과 무창포항, 반일주기는 원산도 주변 협수로에서 탁월하며, 대천천 하구는 천해조 비율이 높다. 표층수온과 기온은 대체로 풍향 변동에 따라 변동한다. 하천수가 방출되면 수온은 상승 후 하강 또는 하강 후 상승한다. 수온 탁월주기는 0.5일, 1.0일, 15일 주기와 7~10일 전후이다. 수온변동특성에 따라 해역을 분류하면 (1)원산도 남동연안의 혼합수역 (2)삽시도~용도, 장고도~삽시도, 장고도~안면도 남쪽의 서쪽 외해수역 (3)용도~독산의 남쪽 외해수역 (4)송도~대천항~무창포항의 조간대 연안수역으로 구분된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권22호
• /
• pp.9739-9745
• /
• 2014

Purpose: We aimed to evaluate the effects of hormone receptor, HER2, and epidermal growth factor receptor (EGFR) expression on epithelial ovarian cancer (EOC) prognosis and investigate whether or not phenotypic subtypes might exist. Materials and Methods: The medical records of 82 patients who were diagnosed with EOC between 2003 and 2012 and treated by platinum-based chemotherapy were retrospectively evaluated. Expression of EGFR, oestrogen (ER), progesterone (PR), and cerbB2 (HER2) receptors were assessed immunohistochemically on paraffin-embedded tissues of these patients. Three phenotypic subtypes were defined according to ER, PR, and HER2 expression and associations of these with EGFR expression, clinicopathologic features, platinum sensitivity, and survival were investigated. Results: When we classified EOC patients into three subtypes, 63.4% had hormone receptor positive (HR(+)) (considering breast cancer subtypes, luminal A), 18.3% had triple negative, and 18.3% had HER2(+) disease. EGFR positivity was observed in 37 patients (45.1%) and was significantly more frequent with advanced disease (p=0.013). However, no significant association with other clinicopathologic features and platinum sensitivity was observed. HER2(+) patients had significantly poorer outcomes than HER2(-) counterparts (triple negative and HR positive patients) (p=0.019). Multivariate analysis demonstrated that the strongest risk factor for death was residual disease after primary surgery. Conclusions: Triple negative EOC may not be an aggressive phenotype as in breast cancer. The HER2 positive EOC has more aggressive behaviour compared to triple negative and HR(+) phenotypes. EGFR expression is more frequent in advanced tumours, but is not related with poorer outcome. Additional ovarian cancer molecular subtyping using gene expression analysis may provide more reliable data.

• Journal of Nutrition and Health
• /
• 제51권2호
• /
• pp.132-139
• /
• 2018

본 연구는 일반병동에 입원하여 3일 이상 경장영양을 시행한 성인 환자 95명을 대상으로 영양집중지원팀의 중재 효과를 평가하기 위해 영양중재를 받은 중재군과 받지 못한 군으로 분류하여 열량 및 단백질 지원율과 생화학적 지표를 비교 분석 하였다. 연구결과를 통해 환자의 입원초기부터 적절한 영양관리를 계획하고, 영양집중지원팀의 영양중재로 체계적인 관리를 실시하면 환자의 영양상태가 개선되는 것을 확인할 수 있었다. 결론적으로 영양불량 문제가 있는 환자에게 영양집중지원팀의 중재를 받아 문제를 개선할 수 있도록 절차를 마련한다면, 이는 환자의 임상적 치료에 긍정적인 영향을 줄 것으로 생각된다. 본 연구는 국내에서 경장영양을 시행한 일반병동 환자를 대상으로 영양집중 지원팀의 중재 효과에 대한 초기 연구이며, 집중영양치료료 수가 신설 이후 진행된 연구다. 추후 일반병동 환자를 대상으로 영양집중지원팀의 중재효과에 대한 연구가 다양하게 시행된다면 의료진의 관심이 증대 될 것이고, 나아가 영양집중지원팀의 중재를 통해 진료의 질을 높일 수 있을 것이다.

• 대한치과의사협회지
• /
• 제48권2호
• /
• pp.119-126
• /
• 2010

Introduction. In this study, we applied the immediate loading to implant using temporary prosthesis, and compared the treatment results by each placement site, amongst pre-loading period. The study was intended to search for occurrence of complications and the amount of marginal bone resorption. Materials and Methods. We retrospectively reviewed the medical records of 99 cases of implants from 29 patients who were treated at Seoul National University Bundang Hospital from September 2003 to September 2008. We grouped all the cases by placement arches and pre-loading periods, and subdivided each group by placement site(anterior/posterior), type of prosthesis(full-mouth cross splinting/Partial multiple splinting, Single). Results. In the cases of anterior maxilla, the average amounts of marginal bone resorption showed $1.71{\pm}0.71mm$ in group 1, and $1.44{\pm}0.69mm$ in group 2, which means they revealed no statistically significant difference between group 1 and group 2(p=0.646). In the cases of posterior maxilla, the average amounts of marginal bone resorption showed $1.25{\pm}0.72mm$ in group 1, and $1.14{\pm}1.15mm$ in group 2, which means they were not statistically significant. In the cases of anterior mandible, there was no cases classified as group 4, but the average amounts of marginal bone resorption in group 3 showed $1.38{\pm}0.79mm$. In the cases of posterior mandible, Group 3 showed $1.39{\pm}0.64mm$, and group 4 showed $1.84{\pm}1.19mm$ as amounts of marginal bone resorption, which means they revealed no statistically significant difference between group 3 and group 4(P=0.210). The survival rate of group1 was 97.14%, 92.1% of group3, and 100% of group 2 and group4. According to each type of prosthesis, each average amount of marginal bone resorption revealed no statistically significant difference in maxi11a(p=0.575) in mandible(p=0.206). Conclusion. It is concluded that the marginal bone resorption and the rate of complications might not be affected by placement sites and pre-loading periods. The marginal bone resorption and the rate of complications might vary as different bone quality of placement site and implant system, diameter, length, etc. It is suggested that the proper placement of immediate loading implants decreases the whole treatment period and any inconvenience occurred to patients.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제37권6호
• /
• pp.470-476
• /
• 2011

Introduction: The incidence of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has increased gradually in patients who have undergone surgical treatment for osteomyelitis. In this study, a retrospective analysis of BRONJ patients was carried out using the data of osteomyelitis patients treated surgically. Materials and Methods: Osteomyelitis patients, who underwent curettage, sequestrectomy, saucerization or decortications, and partial mandibulectomy at Seoul National University Dental Hospital from 2004 to 2010 were enrolled in this study. The patients were classified and categorized into two groups based on the surgical records and progress notes. One group comprised of patients with osteomyelitis and osteoporosis, and the other group included patients with osteomyelitis only. The epidemiological data of the BRONJ patients was analyzed to identify any trend in the incidence of BRONJ in osteomyelitis patients. Results: Among 200 patients who underwent surgical intervention for osteomyelitis, 64 (32.0%) were identified as having osteoporosis as the underlying disease. In these 64 patients, more than 81.3% had been prescribed bisphosphonates. Females were far more affected by BRONJ than males. The incidence of BRONJ also increased with age. The posterior part of the mandible was affected more frequently by BRONJ. Conclusion: Although the availability of potent antibiotics and increased oral hygiene care can reduce the overall incidence of osteomyelitis, BRONJ can increase the total incidence. To prevent BRONJ, it is recommended that an oral examination be performed before prescribing bisphosphonates. Moreover, the patients should be educated about the potential risks of dental procedures that might be causal factors for BRONJ. Furthermore, patient swho take bisphosphonates for the treatment of osteoporosis should undergo periodic follow up oral examinations to prevent BRONJ.

• 한국안광학회지
• /
• 제21권3호
• /
• pp.275-280
• /
• 2016

목적: 본 연구는 성인 한국인에게 많이 발생하는 성인병인 녹내장, 고혈압, 당뇨가 백내장에 어느 정도 영향을 미치는 위험 요인을 분석하여 수술 효과에 따른 차이를 밝히는데 목적을 갖는다. 방법: 분석방법은 전남 지역 소재 병원에서 백내장 수술을 받은 환자를 대상으로 수술 전 후 진료 결과에 영향을 미칠 수 있는 변수로 진료의 투입적 변수인 환자 특성과 의료 특성을 진료의 과정적 변수로 기능적 상태, 일반적 상태, 임상적 결과를 분석방법에 반영하였다. 결과: 성인병 중 녹내장, 고혈압, 당뇨가 있는 환자들은 기본적으로 백내장 수술 전부터 성인병이 없는 환자보다 시력이 약 10%정도 낮은 것으로 나타났으며 수술효과 또한 상대적으로 수술 후 시력과 굴절력에서 약 16%정도의 차이가 나는 것으로 나타났다. 결론: 이상의 연구 결과를 통해 성인병 환자의 녹내장, 당뇨, 고혈압이 백내장과 밀접한 상관성을 가짐을 확인하였으며 이들 성인병의 유병 정도에 따라 백내장 또한 수술 전 후 시력 및 안구 굴절력이 기존 일반 성인 대조군과 비교할 때 낮고 큰 차이를 나타내는 것을 확인할 수 있었다.

• 복식
• /
• 제52권2호
• /
• pp.103-113
• /
• 2002

Heungdukwang'(興德王) costume ordinance(834A.D.) is a very important written historical record because it reveals Tongil Shills's(統一新羅) costume. But among the clothing pieces that appeared in Heundukwang'(興德王) costume ordinance, classification of Naeoe(內衣) and Danoe(短衣) is not clear. This study focuses on the categorization of Naeoe(內衣) and Danoe(短衣). Upper garments included among costume ordinance were Pyooe(表衣), Naeoe(內衣) and Danoe(短衣), Pyooe(表衣) and aeoe(內衣) were unisex, while Danoe(短衣) was worn only by women excluding the lower class. Pyooe(表衣) is applicable to Po(袍), Naeoe(內衣) is aplicable to Yu(유). Shilla'(新羅) upper garments appearing in visual records are as follows: -With the exception of Pyooe(表衣), the length of men's upper garments were between hip and knee length. These upper garments featured V-neck and round neck styles with the left side of the garments folded over the right side. -Again excluding Pyooe(表衣), women's upper garments were similar to men's upper garments having V-neck and round necklines. We know this to be true from the relics found during the excavations of Hwangsungdong and Yonggangdong, as well as from the women in the stone reliefs of Sangju. Although we know the shape of necklines. the length of upper garments remained a mystery because women of that tome tucked in their upper garments into the skirts and/or wore an over garment. However a clay doll found around Bulguksa(佛國寺) wearing a knee length garment with V-neck. The upper garment was opened in the front and was worn over another garment with same length and round neckline. At that time, The upper garments found in China and Japan. were not much different than those found in Shilla (新羅). They also included garments that were waist length, had peach-shaped necklines, or were worn over head. Shilla's(新羅) traditional upper garment was between hip and knee length, but with the introduction and influence of Chinese costume. upper garments with a length coming down to the high waist line began to appear. In addition to Chinese influence, because Shilla's(新羅) women wore the upper garment first and then the lower garment, a long upper garment was not necessary. These shorter upper garments came to be known as 'Danoe(短衣)'When we perceive clothing. we look at silhouette first and then the details. Silhouette is much determined by length and neckline or the front of the garment determines the details, So we need to attention to the basis of ancient dress classifications. These classifications were according to first length [Po(袍), Yu(유)] and then neckline [Danryoung(團領), Jingryoung(首領)]. As a result. Naeoe(內衣) and Danoe(短衣) are classified by the length. The length (內衣) was between hip and knee length while Daneoe(短衣) was waist length. Danoe(短衣) was worn by putting the bottom of it inside skirt naeoe(內衣) was worn over a skirt or plant. But both had V-neck and round neck styles, and styles with the left side of the garments folded over the right side.