• Title/Summary/Keyword: City Centre

검색결과 117건 처리시간 0.026초

Thyroid Transcription Factor-1 Expression in Advanced Non-Small Cell Lung Cancer: Impact on Survival Outcome

  • Elsamany, Shereef Ahmed;Al-Fayea, Turki M;Alzahrani, Abdullah Said;Abozeed, Waleed Nabeel;Darwish, Waseem;Farooq, Mian Usman;Almadani, Ahmed Salahuddin;Bukhari, Esraa Ahmed
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제16권7호
    • /
    • pp.2987-2991
    • /
    • 2015
  • Background: The prognostic role of thyroid transcription factor-1 (TTF-1) expression in lung cancer has been assessed but with inconsistent results. The present study aimed to evaluate the prognostic value of TTF1 expression in advanced non-squamous non-small cell lung cancer (NSCLC). Materials and Methods: In this retrospective study, patients with stage IIIB-IV non-squamous NSCLC were enrolled. Progression free survival (PFS) and overall survival (OS) were assessed according to TTF1 expression status, age categories (${\leq}60$ vs >60 years), gender, performance status (PS) (0-2 vs 3-4), type of 1st line chemotherapy (pemetrexed containing vs others) and EGFR status. Results: A total of 120 patients were included. In univariate analysis, PFS was improved in patients with PS 0-2 (7.0 vs 2.0 months, p=0.002) and those who received pemetrexed-containing chemotherapy (9.2 vs 5.8 months, p=0.004). OS was improved in female patients (23.0 vs 8.7 months, p<0.0001), PS 0-2 (14.4 vs 2.0 months, p<0.0001), those with pemetrexed-containing chemotherapy (17.0 vs 11.0 months, p=0.019), TTF1-positive (12.8 vs 5.8 months, p=0.011) and EGFR- mutant patients (23.0 vs 11.7 months, p=0.006). In multivariate analysis, male gender (HR=2.34, p=0.025) and non-pemetrexed containing therapy (HR=2.24, p=0.022) were independent predictors of worse PFS. Wild EGFR status (HR=2.49, p=0.015) and male gender (HR=2.78, p=0.008) were predictors of worse OS. Conclusions: Pemetrexed-containing therapy significantly improved PFS while OS was improved in EGFR mutant patients. Female patients had better PFS and OS. TTF1 expression was not a prognostic marker in advanced non-squamous NSCLC.

On the possibility of freak wave forecasting

  • Janssen, Peter A.E.M.;Mori, Nobuhito;Onorato, Miguel
    • 한국해양공학회:학술대회논문집
    • /
    • 한국해양공학회 2006년 창립20주년기념 정기학술대회 및 국제워크샵
    • /
    • pp.121-126
    • /
    • 2006
  • Modern Ocean wave forecasting systems predict the mean sea state, as characterized by the wave spectrum, in a box of size ${\Delta}x{\Delta}y$ surrounding a grid point at location x. It is shown that this approach also allows the determination of deviations from the mean sea state, i.e. the probability distribution function of the surface elevation. Hence, ocean wave forecasting may provide valuable information on extreme sea states.

  • PDF

Recent Progress of Freak Wave Prediction

  • Mori, Nobuhito;Janssen, Peter A.E.M.
    • 한국해양공학회:학술대회논문집
    • /
    • 한국해양공학회 2006년 창립20주년기념 정기학술대회 및 국제워크샵
    • /
    • pp.127-134
    • /
    • 2006
  • Based on a weakly non-Gaussian theory the occurrence probability of freak waves is formulated in terms of the number of waves in a time series and the surface elevation kurtosis. Finite kurtosis gives rise to a significant enhancement of freak wave generation in comparison with the linear narrow banded wave theory. For fixed number of waves, the estimated amplification ratio of freak wave occurrence due to the deviation from the Gaussian theory is 50% - 300%. The results of the theory are compared with laboratory and field data.

  • PDF

순환식 하지 훈련이 뇌졸중 환자의 보행능력에 미치는 영향 (The effects of a task-oriented circuit training program of lower limb on walking ability after stroke)

  • 공선웅;김지선;문성장;진원화;윤태원;한미란;조영환
    • PNF and Movement
    • /
    • 제8권2호
    • /
    • pp.47-55
    • /
    • 2010
  • Purpose : The purpose of present study was to determine effects of a task-oriented circuit training(TOCT) for lower limb on walking ability after stroke. Methods : Twenty one chronic stroke patients participated. Participants were randomly divided into either TOCT group or control group(11 experimental, 10 control). All of participants were in-patients at local rehabilitation centre and had been receiving a traditional rehabilitation program, five days a week. TOCT group have additionally undergone for four weeks, three days a week, the TOCT program but control group was not received any additional program except the traditional rehabilitation program. The 10 m walking test (10MWT), the 2 min walking test (2MWT), the step test (ST) and the figure-8 walking test (F8WT) to measure a walking ability were carried out twice before and after training. Results : After participation in the program, subjects of TOCT demonstrated a significant improvement in the scores of the 10MWT, 2MWT, the ST, the F8WT. The control group had no change on the any tests. After the training, the results to improve significantly in TOCT group compared to post-test of control group were the time of 10MWT and the time and the step of curved walking of F8WT. Conclusion : The present study suggests that the TOCT program may become a useful strategy for enhancing walking ability in the rehabilitation of stroke patients.

  • PDF

고유수용성 감각 증진 운동이 뇌졸중 환자의 균형 능력에 미치는 영향 (The effects of proprioceptive exercises on balance ability after stroke)

  • 송현승;박혜령;배시절;박지성;조형태;장하희;김수진
    • PNF and Movement
    • /
    • 제8권2호
    • /
    • pp.1-8
    • /
    • 2010
  • Purpose : The purpose of this study was to investigate the effects of proprioceptive exercise (PE) using a trampoline and a balance board on a balance ability after stroke. Method : Sixteen chronic stroke patients participated. Participants were randomly assigned to the PE group or control group (8 experimental, 8 control). All of participants were in-patients at local rehabilitation centre and had been receiving a traditional rehabilitation program, five days a week. The PE group have additionally undergone for four weeks, three days a week, the PE using a trampoline and a balance board under supervision by a physical therapist but control group was not received any additional program except the traditional rehabilitation program. The position sense test used to assess a proprioceptive sense at a knee joint. The Berg Balance Scale (BBS) and the Timed Up & Go (TUG) test to measure the balance ability were carried out before and after the training. Result : After the training the error of position sense at knee joint of PE group significantly decreased compared to the control group. The PE group demonstrated a significant improvement in the scores of the BBS and TUG. Conclusion : The present study suggests that the PE program using a trampoline and balance board may become a useful tool for enhancing a balance ability in chronic stroke patients through the ennced proprioceptive position senses.

  • PDF

Advances in Imaging of Subsurface Archaeology using GPR

  • Goodman Dean;Nishimur Yasushi;Schneider Kent;Piro Salvadore;Hongo Hiromichi;Higashi Noriaki
    • 한국지구물리탐사학회:학술대회논문집
    • /
    • 한국지구물리탐사학회 2004년도 정기총회 및 제6최 특별 심포지움
    • /
    • pp.8-21
    • /
    • 2004
  • Examples of GPR survey results at a variety of archaeological sites are presented. Several new analyses which include static corrections for the tilt of the GPR antenna are shown for imaging of burial mounds with significant topography. Example archaeological site plans developed from GPR remote sensing of Roman and Japanese sites are given. The first completely automated GPR survey, using only Global Positioning Satellite navigation to create 3D data volumes, is employed for a site in Louisiana to detect lost graves of the Choctaw Indian Tribe.

  • PDF

Urban Density and the Porous High-Rise: The Integration of the Tall Building in the City - from China to New York

  • Klemperer, James von
    • 국제초고층학회논문집
    • /
    • 제4권2호
    • /
    • pp.135-142
    • /
    • 2015
  • As the skyscraper matures as a building type, its role in actively connecting to, and reinforcing, major threads of urban fabric becomes increasingly more important. The creation of public spaces inside of and adjacent to tall buildings allows for significant additions to the public realm, facilitating better connections between varied uses, providing needed access to critical transportation functions. In this more integrated version of the tall building type, the density afforded by a vertical structure is complemented by strategically devised porosity of plan and section. This paper examines three major tower projects which exemplify a progressive approach to permeable design: the recently completed Jingan Kerry Centre in Shanghai, the Lotte Supertower in Seoul, now half completed, and the One Vanderbilt tower being proposed next to Grand Central Terminal in New York City. These projects suggest possibilities for innovative approaches to private development strategies, public planning processes, and architectural design.

Collaboration and Confucian Reflexivity in Local Energy Governance: The Case of Seoul's One Less Nuclear Power Plant Initiatives

  • Lee, Youhyun;Bae, Suho
    • Journal of Contemporary Eastern Asia
    • /
    • 제18권1호
    • /
    • pp.153-174
    • /
    • 2019
  • South Korea's energy policy has been historically established through an energy production structure that relies on thermal and nuclear power generation in relation to a centralized 'Hard Energy System'. However, climate change issues are forcing the transition to renewable energy, and it is crucial for local governments to enable this. This study analyses Seoul city's local energy governance, which is known as One Less Nuclear Power Plant Initiative, by applying the collaborative governance framework inspired by Ansell and Gash (2008) and the Reflexivity framework of Confucianism. It is considered that the local energy governance model of Seoul city can be used as a model by other local governments, and it will eventually lead to a decentralized energy system in this era of energy transition.

21세기 유럽 해항도시의 롤 모델로서의 하펜시티 함부르크

  • 정진성;조현천
    • 한국항해항만학회:학술대회논문집
    • /
    • 한국항해항만학회 2011년도 춘계학술대회
    • /
    • pp.376-378
    • /
    • 2011
  • 현재 독일 함부르크에서 공사 중에 있는 하펜시티는 수변공간 개발을 통한 도시재생 사업 중 모범적인 사례로 평가받고 있다. 본 발표는 하펜시티가 21세기형 도시를 지향하고 있음을 밝힐 것이다. 이는 도시인구의 교외이동으로 인한 도심의 공동화 현상을 치유하고 극복하는 방안으로서의 재도시화 현상과 맞물려 있다. 따라서 하펜시티 프로젝트의 현황과 특징을 살펴보기에 앞서 유럽의 해항도시에서 도시공동화를 불러일으킨 원인과 그 극복방안으로서의 재도시화 현상에 대해 먼저 살펴볼 것이다. 함부르크 하펜시티가 지향하는 새로운 도시성, 그리고 전통과 창조의 결합을 통한 문화적 가치들이 하펜시티 프로젝트에 어떻게 구체적으로 추구되고 있는지를 살펴보고 소개함으로써 북항 재개발 사업이 개선되어 올바른 방향으로 나아가길 바라기 때문이다.

  • PDF

Human Tracking Based On Context Awareness In Outdoor Environment

  • Binh, Nguyen Thanh;Khare, Ashish;Thanh, Nguyen Chi
    • KSII Transactions on Internet and Information Systems (TIIS)
    • /
    • 제11권6호
    • /
    • pp.3104-3120
    • /
    • 2017
  • The intelligent monitoring system has been successfully applied in many fields such as: monitoring of production lines, transportation, etc. Smart surveillance systems have been developed and proven effective in some specific areas such as monitoring of human activity, traffic, etc. Most of critical application monitoring systems involve object tracking as one of the key steps. However, task of tracking of moving object is not easy. In this paper, the authors propose a method to implement human object tracking in outdoor environment based on human features in shearlet domain. The proposed method uses shearlet transform which combines the human features with context-sensitiveness in order to improve the accuracy of human tracking. The proposed algorithm not only improves the edge accuracy, but also reduces wrong positions of the object between the frames. The authors validated the proposed method by calculating Euclidean distance and Mahalanobis distance values between centre of actual object and centre of tracked object, and it has been found that the proposed method gives better result than the other recent available methods.