• Title/Summary/Keyword: Circling

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The Mouse Mutations Circling and Spinner are Allelic

  • Kyoung in Cho;Lee, Eun-Ju;Kim, Myoung-Ok;Kim, Sung-Hyun;Pakr, Jun-Hong;Jung, Boo-Kyung;Kim, Hee-Chul;Sol ha Hwang;Suh, Jun-Gyo
    • Proceedings of the KSAR Conference
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    • 2003.06a
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    • pp.90-90
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    • 2003
  • Circling mice were recorded to display profound deafness and a head-tossing and bidirectional circling behavior, showing an autosomal recessive mode of inheritance. In addition, the histological examination of inner ears revealed that the region around organ of Corti, spiral ganglion neurons and outer hair cells showed definite abnormality. On the other hand, a genetic linkage map was constructed in an intraspecific backcross between cir and C57BL/6J mice. The cir gene was mapped to a region between D9Mitl16/D9Mit15 and D9Mit38 on the mouse chromosome 9. Estimated distances between cir and D9Mitl16, and between cir and D9Mit38 are 0.70 $\pm$ 0.40 and 0.23 $\pm$ 0.23 cM, respectively. The markers in order was defined as follows: centromere-D9Mit182- D9Mit51/ D9Mit79/ D9Mit310- D9Mit212/ D9Mit184- D9Mit116/ D9Mit15- cir- D9Mit38- D9Mit20- D9Mit243- D9Mit16- D9Mit55/ D9Mit125- D9Mit281 Based on genetic mapping, we constructed for a YAC contig across cir region. They covered the entire region or cir and cir gene was located on between the lactotransferrin (ltf) and the macrotubule-associated protein (map4). It is known that sr gene is localized in 64cM of mouse chromosome 9. The two mouse were found to be allelic by complementation test. Recently the spinner mouse has been mapped to our cir region, and tmie gene were elucidated. And further study will be needed in circling mouse to prove tmie gene mutaiton.

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Paragon of people circling the pagoda of Woljeongsa Temple and performance of its cultural inheritance (월정사 탑돌이의 전형과 공연문화)

  • Lee, Chang-sik
    • (The) Research of the performance art and culture
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    • no.36
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    • pp.751-781
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    • 2018
  • Task of circling the pagoda of Waljeongsa(Woljeongsa Tabdori) is the major intangible cultural heritage with representativeness and historical meaning as a Buddhism culture, one of the Buddhism folk plays, which was firstly played after the liberation. Woljeongsa Tabdori holds significant designation importance in terms of Buddhism folklore heritage with Korean unique tradition and identity of Gangwon-do province. Temples are demonstrating Tabdori nationwide but Woljeongsa Tabdori is the unique case that systematically inherits the culture based on the designation of being intangible cultural heritage. That is why it is needed to focus on the cultural and internal value of Woljeongsa Tabdori. Tabdori is the integrated symbol of Buddhism respect and worship to the Buddha and pagoda. It is hard to presume the originality of Woljeongsa Tabdori: given the history of Woljeonsa temple, it lies into Goguryeo traditional play and Bokhui(Pagoda circling folk play) in Silla era. It fits into the courtesy of Circumambulating Stupa considering Moon in Goguryo mural, background of Odaesan Hwaeom thought/tripitaka and essence of Octagonal 9-story stone pagoda. At the first stage of Tabdori, Buddhist musical instruments such as Buddhism temple bell, singing bowl, cloud-shaped gong and wooden-fish. However, later, Samhyeon Yukgak has been added and then, Boyeom and Bakpaljeongjinga were singing: it could be interpreted that it was a pure Buddhist ceremony but it has become to have traditional aspect and been spread to the public. The origin of Woljeongsa Tabdori is related to the explanation of Circumambulating Stupa that experiences the glory of the ending ceremony. When a temple has a rite, the Buddhists make an offering to the Buddha. At that time, Buddhist prayer, sermon and chant are followed. After the rite, the Buddhists are circling the pagoda with the monks while praying for Buddhist charity and making their own wishes. It prays not only going after death to Nirvana of the one but also national prosperity and the welfare of the people for peaceful reign. As the temple holds bigger rites, many Buddhists gather and the Tabdori was a success. The scene of circling the pagoda and making own wishes in line with the Buddhist sermon was solemn. The idea on changes and convergence of Woljeongsa Tabdori requires strategic inheritance to promote the transmission while maintaining the paragon and purpose of designating the cultural heritage and reviving its identity. Korean Tabdori was held in Buddha's birthday in April and the mid-autumn day. Tabdori is a memorial service type Buddhist ceremony that once the monk holds the Buddhist rosary, circles the pagoda and sings the great mind and charity of the Buddha, Buddhists follow the step, lighting the lantern, circling the pagoda and praying for the gentle and easy death. Transmission education of the successor, diversified approach of the expert's advice and discourse on the revival of the origin should be reinforced in phases.

Development of Loader Equipped with 4Wd and 4WS (II) (4WS System and Construction of Loader) (4WD 및 4WS이 가능한 로더 개발 (II) (4륜 조향장치 및 로더 구성))

  • 조현덕
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.8 no.1
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    • pp.150-157
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    • 1999
  • In this study, the loader was completed that has 4-wheel gear driven drivetrain of study (Ⅰ), the 4-wheel steering with power wheel type, all-wheel traction system, and joy-stick type lever for hydraulic control valve. From driving test of the developed 4WD and 4WS type loader, we obtained that the minimum circling radius and the necessary width in circling motion reduced about 40% and 33% compared with 2WS type loader. Also, all-wheel traction system could keep the tires glued to the ground with greater stability, the power steering allowed a smoother operation, and the joy-stick type lever offered easily to control. Thus, the developed loader having these functions was very fit in a small cattle shed or rugged ground.

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Flow Analysis for the Sludge Pneumatic Dehydrator with Cyclone Type (사이클론형 슬러지 공기건조기의 유동해석)

  • Kim, Bong-Hwan;Jung, Dae-Sik
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.8 no.4
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    • pp.1-6
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    • 2009
  • Air drying technology was developed as an equipment for reducing of moisture content from wastewater treatment and waterworks sludge cake and reproducing it by reusable matter. Advantage of cyclone type pneumatic dehydrator is simple and excellent drying performance. The air drying equipment was composed to the air ejector which made high-speed fluid field, and cyclone which made circling fluid field. Dewatered cake was crushed at the high-speed zone as first step, and formed with dried powder of sphere shape by the collision between particles at the circling fluid zone. In this study, a CFD analysis has been performed to predict air-sludge particles flow in cyclone and ejector of pneumatic dehydrator. The computational results showed typical Rankine vortex structure which was frequently found in swirling flow phenomena. And the conical type wedge in lower part of a cyclone prevented accumulation of the sludge particles in the cyclone. Therefore, this technology was effective in drying of dehydrated cake of waterworks sludge.

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Development of Non-precision Approach Procedures Checklist (비정밀접근절차 체크리스트 개발연구)

  • Gil, Ho-Seong;Jeon, Je-Hyung;Kim, Hyun-Soo;Son, Byung-Heum
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.24 no.3
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    • pp.37-47
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    • 2016
  • After a thorough investigation of aviation accidents involving Korean national carriers both inside and outside of Korea and also after reviewing catastrophic events involving foreign carriers in Korea, we found numerous accidents that caused fatalities and serious personal injuries. Although the aircrafts involved were found to have no specific defects, many of the accidents were caused by the pilot's misjudgement according to previous studies. Our research is to find an new procedure to help the prevention of similar accidents by focusing particularly on CFIT accidents during the procedural operations of Non Precision Approach, Circling Approach and Visual Approach. Therefore, we emphasize the significance of this research on the development of the new checklist that will help achieve a safe and effective procedural operation for non precision approaches.

Inhibition of K+ outward currents by linopirdine in the cochlear outer hair cells of circling mice within the first postnatal week

  • Kang, Shin Wook;Ahn, Ji Woong;Ahn, Seung Cheol
    • The Korean Journal of Physiology and Pharmacology
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    • v.21 no.2
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    • pp.251-257
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    • 2017
  • Inhibition of $K^+$ outward currents by linopirdine in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), was investigated using a whole cell patch clamp technique. Littermate heterozygous (+/cir) and ICR mice of the same age (postnatal day (P) 0 -P6) were used as controls. Voltage steps from -100 mV to 40 mV elicited small inward currents (-100 mV~-70 mV) and slow rising $K^+$ outward currents (-60 mV~40 mV) which activated near -50 mV in all OHCs tested. Linopirdine, a known blocker of $K^+$ currents activated at negative potentials ($I_{K,n}$), did cause inhibition at varying degree (severe, moderate, mild) in $K^+$ outward currents of heterozygous (+/cir) or homozygous (cir/cir) mice OHCs in the concentration range between 1 and $100{\mu}m$, while it was apparent only in one ICR mice OHC out of nine OHCs at $100{\mu}m$. Although the half inhibition concentrations in heterozygous (+/cir) or homozygous (cir/cir) mice OHCs were close to those reported in $I_{K,n}$, biophysical and pharmacological properties of $K^+$ outward currents, such as the activation close to -50 mV, small inward currents evoked by hyperpolarizing steps and TEA sensitivity, were not in line with $I_{K,n}$ reported in other tissues. Our results show that the delayed rectifier type $K^+$ outward currents, which are not similar to $I_{K,n}$ with respect to biophysical and pharmacological properties, are inhibited by linopirdine in the developing (P0~P6) homozygous (cir/cir) or heterozygous (+/cir) mice OHCs.

Characteristics of K+ Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week

  • Ahn, Ji Woong;Kang, Shin Wook;Ahn, Seung Cheol
    • The Korean Journal of Physiology and Pharmacology
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    • v.19 no.4
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    • pp.383-388
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    • 2015
  • $K^+$ outward currents in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), were investigated using a whole cell patch clamp technique. Littermate heterozygous (+/cir) mice of the same age (postnatal day (P) 0-P6) were used as controls. Similar slow rising $K^+$ currents were observed in both genotypes, but their biophysical and pharmacological properties were quite different. The values of Vhalf for activation were significantly different in the heterozygous (+/cir) and homozygous (cir/cir) mice ($-8.1{\pm}2.2mV$, heterozygous (+/cir) mice (n=7) and $-17.2{\pm}4.2mV$, homozygous (cir/cir) mice (n=5)). The inactivation curve was expressed by a single first order Boltzmann equation in the homozygous (cir/cir) mice, while it was expressed by a sum of two first order Boltzmann equations in the heterozygous (+/cir) mice. The $K^+$ current of homozygous (cir/cir) mice was more sensitive to TEA in the 1 to 10 mM range, while the 4-AP sensitivities were not different between the two genotypes. Removal of external $Ca^{2+}$ did not affect the $K^+$ currents in either genotype, indicating that the higher sensitivity of $K^+$ current to TEA in the homozygous (cir/cir) mice was not due to an early expression of $Ca^{2+}$ activated $K^+$ channels. Our results suggest that the $K^+$ outward current of developing homozygous (cir/cir) mice OHCs is different in both biophysical and pharmacological aspects than that of heterozygous (+/cir) mice.

A Warning System Using Marker Beacon to Avoid Hazardous Area in VFR Mode (마커를 이용한 시계비행 항공기의 비행 위험지역 회피용 경보장치)

  • Seo, B.S.;Kim, Y.M.;Kang, J.Y.;Yun, T.W.;Hwang, B.W.
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.12 no.3
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    • pp.1-12
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    • 2004
  • When a straight-in landing from an instrument approach using ILS or VOR/DME is not possible or desirable because of topographical reason or bad weather, a circling approach maneuver is initiated by the pilot to align the aircraft with a runway for landing. Visual contact with the runway is necessary while conducting a circle to land maneuver. This research is to develop a new warning system based on a conventional marker system which alerts pilots to watch out for exceeding the circling approach area. The airborne system also uses the same receiver unit without any new installations. The objective of this research is to design and develop a Yagi antenna in a special form. The research includes computer simulations to determine the size of antenna radiation pattern and to compute an expected flight path in case of alarm to validate effectiveness of the system.

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A Study on Countermeasures to Prevent Unstable Approach to Improve Aviation Safety (항공안전도 향상을 위한 불안정 접근 방지대책)

  • Jeon, Je-hyung;Song, Jehwan;Jung, Chang-jae;Lim, se-hoon;Song, Byung-Heum
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.26 no.3
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    • pp.1-8
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    • 2018
  • Aviation industry is growing rapidly, and this growth is expected to continue. However, aircraft accident rate is still high, and 65 percent of accidents occur during landing phase due to unstable approach. Therefore, this research analyzed causes and countermeasures of unstable approach. In order to derive countermeasures, this study selected P International Airport as an example case. In addition, this research analyzed A airline's FOQA data, regional Standard Operating Procedures, and 5 years of environmental factors to identified correlation of those contributing factors. In conclusion, his research concluded following results. First of all, because of P International Airport's geological features, pilots are required to conduct Circling Approach, and this advanced maneuver increases workload at the final stage of flight. Secondarily, meteorological factors such as crosswind, seasonal rain front, local visibility contributes unstable approach. Lastly, these geological and meteorological factors are interrelated, and this uncommon environment can decrease circumstantial judgement ability of pilots and jeopardize aviation safety. As a consequence, it is recommended to reinforce the Crew Resource Management and Threat & Error Management systems so that pilots can perceive identical safety target.

A Study on the Landscape Analysis of Rode Using GIS (G.I.S를 이용한 노선주위의 경관해석에 관한 연구)

  • Jung, Young-Dong;Ko, Jae-Woong
    • Journal of Korean Society for Geospatial Information Science
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    • v.4 no.1 s.6
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    • pp.83-91
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    • 1996
  • With the growth of cities, there is a nero today for construction of outer road of cities but there are many problems in executing the scheme. In this study 5 kilos' distance, a part of the first section from East Kwangju I.C. in 36kilos' distance, the road circling Other Kwangju city is determined as the object of this study and illustrated by GIS. Besides that, the landscape which is varied according to survey location is illustrated each section by using data such as plans and 1he planed height. and the area for this study which is circling around Mt. Mudeung, a noted in Kwangju city is represented by GIS.

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