• Title/Summary/Keyword: Chung-Seo

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KPNA3 promotes epithelial-mesenchymal transition by regulating TGF-β and AKT signaling pathways in MDA-MB-231, a triple-negative breast cancer cell line

  • Jaesung Choi;Jee-Hye Choi;Ho Woon Lee;Dongbeom Seo;Gavaachimed Lkhagvasuren;Jung-Woong Kim;Sang-Beom Seo;Kangseok Lee;Kwang-Ho Lee
    • BMB Reports
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    • v.56 no.2
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    • pp.120-125
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    • 2023

  • Karyopherin-α3 (KPNA3), a karyopherin-α isoform, is intimately associated with metastatic progression via epithelial-mesenchymal transition (EMT). However, the molecular mechanism underlying how KPNA3 acts as an EMT inducer remains to be elucidated. In this report, we identified that KPNA3 was significantly upregulated in cancer cells, particularly in triple-negative breast cancer, and its knockdown resulted in the suppression of cell proliferation and metastasis. The comprehensive transcriptome analysis from KPNA3 knockdown cells indicated that KPNA3 is involved in the regulation of numerous EMT-related genes, including the downregulation of GATA3 and E-cadherin and the up-regulation of HAS2. Moreover, it was found that KPNA3 EMT-mediated metastasis can be achieved by TGF-β or AKT signaling pathways; this suggests that the novel independent signaling pathways KPNA3-TGF-β-GATA3-HAS2/E-cadherin and KPNA3-AKT-HAS2/E-cadherin are involved in the EMT-mediated progress of TNBC MDA-MB-231 cells. These findings provide new insights into the divergent EMT inducibility of KPNA3 according to cell and cancer type.

  • https://doi.org/10.5483/BMBRep.2022-0180 인용 PDF

The Usefulness of Quadriceps Exercise for Improvement of Knee Extensor Muscular Function after Cruciate Ligament Reconstruction (십자인대 재건술 후 슬관절 신전근의 근기능 향상을 위한 대퇴사두근 운동의 유용성)

  • Jang, Kyung-Mo;Seo, Dong-Ick;Seo, Kyung-Mook;Kim, Don-Kyu
    • Journal of Korean Physical Therapy Science
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    • v.16 no.3
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    • pp.29-34
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    • 2009

  • Background: The purpose of this study was to investigate the usefulness of quadriceps exercise for improvement of knee extensor muscular function after cruciate ligament reconstruction. Methods: Participate in 18 of patients with cruciate ligament reconstruction, ACL & PCL reconstruction was 9 of patients, respectively. All subjects instructed that quadriceps exercise repeated daily, composed to QSE(quadriceps femoris setting exercise) and SLR(straight leg raises). Knee extensor muscular function was measured before and after quadriceps exercise. Initial test was measured before cruciate ligament reconstruction, and retest was measured 6month after cruciate ligament reconstruction. Results: Knee extensor muscular function significantly increased in both ACL and PCL reconstruction(P<0.05). Conclusion: The results of this study indicated that quadriceps exercise useful for improve knee extensor muscular function in patients with cruciate ligament reconstruction.

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