• Mass Spectrometry Letters
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• 제14권3호
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• pp.91-103
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• 2023

As one of the most common mood disorders, numerous studies have shown depression is the main risk factor for non-suicidal self-harm. The pathogenesis of depression is complex, and a comprehensive and rapid measurement of monoamine neurotransmitters and their metabolites will be very helpful in understanding the pathogenesis of depression. Therefore, a rapid and sensitive underivatized liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous monitoring of the levels of ten neurotransmitters and their metabolites in rat serum and limbic system and successfully applied to quantify the changes of neurotransmitter levels in chronic unpredictable mild stress-induced rats. The analytes studied were mainly involved in tyrosine metabolism, tryptophan metabolism, and glutamate cycling pathways, which are important in the pathogenesis of depression. It had been verified the method was sensitive and effective, with satisfactory linearity, and met the requirements of biological sample determination. Levels of neurotransmitters in rat serum, hippocampus, amygdala, prefrontal cortex, striatum, and hypothalamus were determined via the method. The results showed serotonin, dopamine, norepinephrine, and their metabolites were decreased, glutamine was increased, and glutamate was disturbed in chronic unpredictable mild stress-induced depression rats. This method provides a new approach to studying the pathogenesis of depression and other neurological disorders.

• 한국융합학회논문지
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• 제9권4호
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• pp.341-349
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• 2018

본 연구는 장기요양 재가서비스 이용 노인의 만성통증이 삶의 질에 미치는 영향에서 우울의 매개효과를 검증하는데 목적을 두었다. 이를 위해 장기요양 재가서비스를 이용하고 있는 노인 204을 대상으로 조사를 실시하였다. 본 연구의 주요 분석결과는 변수간의 상관관계에서 만성통증과 우울은 정적관계, 만성통증과 삶의 질과의 관계에서는 부적 상관관계로 분석되었다. 또한, 만성통증과 우울이 삶의 질에 미치는 영향에 있어서 우울은 완전한 매개효과를 보이는 것으로 검증되었다. 이 결과를 통해 장기요양 재가서비스를 이용하는 노인의 다양한 융합적인 정신건강서비스를 위한 프로그램 개발 필요성에 대해 논의하였다.

• 성인간호학회지
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• 제17권3호
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• pp.379-388
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• 2005

Purpose: This study was conducted to explore the degree of depression, perceived health status, chronic disease and quality of life(QOL) among rural elderly and to determine the factors related to their QOL. Method: The design of this study was a correlational study. The subjects were 423 elderly consisted of 157(37.1%) men and 266(62.9%) women dwelling in a rural area of N City. Data were collected from May to December, 2003 using a structured questionnaire. A stepwise multiple regression analysis was performed to identify the factors related to the QOL. Result: It was found that the mean score of QOL was in total with 2.15 out of 5.00 and women elderly's score was significantly lower than men(t=2.20, p=.028). Perceived health status showed statistically significant positive relationship with QOL(r=.608, p<.05), while depression(r=-.751, p<.01) and chronic illness(r=-.336, p<.01) showed statistically significant negative relationship. Depression was found to have the highest correlation with QOL among the subjects. Depression score explained QOL at the most, accounting for 36.8% of the variability, followed by perceived health(8.2%) and the number of chronic illness(.7%). Other factors related to the QOL were economic status and absence of spouse. Conclusion: In order to increase the QOL of rural elderly, it is necessary to decrease the depression, to increase their perceived health status and to decrease the number of chronic illness. We suggest the implementation of a program not only to promote physical health status and self-care ability but to take care of mental health for the rural elderly.

• 대한통합의학회지
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• 제10권3호
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• pp.209-219
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• 2022

Purpose : The purpose of this study was two-fold: to investigate the effects of uncertainty and depression on the quality of life (QoL) of elderly people with chronic diseases and to provide basic data on the physical, emotional, and psychological factors affecting their QoL in the field of physical therapy. Methods : A questionnaire covering uncertainty, depression, and QoL was distributed among 320 elderly people. Pearson's correlation analysis was performed to examine the correlation between uncertainty (ambiguity, complexity, inconsistency, and unpredictability), depression, and QoL (physical, psychological, social, and living environment domains) of the respondents; furthermore, multiple regression analysis was performed to identify the factors affecting the QoL of the respondents with a chronic disease. Results : The sub-factors of uncertainty and QoL-"complexity and social domain" (r=-.295, p<.001), "complexity and living environment domain" (r=-.302, p<.001), and "inconsistency and living environment domain" (r=-.360, p<.001)-showed a negative (-) correlation, as did depression and the sub-factors of QoL-"depression and physical domain" (r=-.782, p<.001), "depression and psychological domain" (r=-.876, p<.001), "depression and social domain" (r=-.668, p<.001), and "depression and living environment domain" (r=-.731, p<.001). The factors affecting QoL were complexity (𝛽=-.122, p<.001), inconsistency (𝛽=-.102, p=.002), unpredictability (𝛽=.112, p<.001), and depression (𝛽=-.850, p<.001). The relative influence of the independent variables was in the order of depression, complexity, unpredictability, and inconsistency, and the explanatory power was 77.1 % (F=215.853, p<.001). Conclusion : It is important to help the elderly with chronic diseases reduce the negative impact on their quality of life by helping them gain support from their families and medical professionals and by increasing their understanding through communication so that they can transition from negative emotions to positive emotions of opportunity.

• 대한근관절건강학회:학술대회논문집
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• 대한근관절건강학회 1997년도 제6회 춘계학술대회
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• pp.134-146
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• 1997

Sixty-nine articles were reviewed to understand the depression in patients with rheumatoid arthritis. Among these articles, forty seven were the studies that dealt with depression in rheumatoid disease, nineteen studied the depression in patients with other chronic disease or in normals, and three were the studies that compared the depression in the patients with rheumatic disease and in the other subjects. Specifically, the articles were analyzed (1) to determine whether the patients with rheumatic arthritis were more depressed than normal population or subjects with other chronic diseases ; (2) to test whether the measurement problems exit ; (3) to identify the disease related, personal, psychologic, and demographic variables to affect the depression and (4) to identify the nursing interventions which improve the depression in rheumatoid arthritis. Based upon these results, some suggestion were made for future research and practice.

• 근관절건강학회지
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• 제4권2호
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• pp.249-261
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• 1997

The purpose of this study was to explore the effect of short term selp-help education on pain, depression, self-efficacy, and quality of life in patients having chronic arthritis. This program was carried out 3 hrs per week for 4 weeks by 3 small groups among 10 patients. Research design was a quasi-experimental study of nonequivalent control group pretest-posttest design. The subject of this study were 10 of experimental group and 10 of control group. Before and after 4 weeks program, quality of life, self-efficacy, depression, pain, ADL were measured. As a result, it was confirmed the self-help education was effective to increase quality of life, but self-efficacy, depression, pain, ADL were not improved. This suggests the replicate study to examine the effect of self-help education with the large samples of subjects having chronic arthritis.

• 정신신체의학
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• 제3권2호
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• pp.126-138
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• 1995

For investigating a disease specific psychological mechanism in various dermatological disorders, we tried to explore the difference in correlation among stress perception, locus of control as a coping strategy, depressive symptoms and pruritic symptoms in the patients with psychological pruritis and chronic urticaria. The subjects were composed of 32 patients with psychol-ogical pruritis and 67 patients with chronic urticaria(subject group), and 25 patients with organic pruritis and 59 patient with major depression(control group). Global assesment of recent stress scale(GARS), I-E locus of control scale, Beck Depression Inventory(BDI) and medical college of wisconsin center pain follow up questionnaire were used for assesement. The results were as follows: 1) There were a significant positive correlation between stress perception and depressive symptom in patients with psychological pruritis, chronic urticaria, and major depression but not hi organic pruritis. 2) In relationship between locus of control and depressive symptom, patients with psychological pruritis, organic pruritis, and major depression except chronic ruticaria showed a significant negative correlation. 3) For intensity and pattern of pruritis, there were positive relations with depressive symptom and stress perception only in patients with chronic urticaria. Above results indicate that stress perception and locus of contorl may play a significant role in the formation of psychological and dermatological symptoms in psychological pruitis and chronic urticaria. But the mechanisms of these processes are different in either disorder.

• 보건의료생명과학 논문지
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• 제10권2호
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• pp.305-314
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• 2022

본 연구의 목적은 만성질환자들의 일반적 특성, 생활 행태 및 질환 특성 등의 보건행태요인이 우울에 미치는 영향을 확인하는 것이다. 이를 위해 2019~2020년에 진행된 제8기 국민건강영양조사에 참여한 7,359명 중, 만 19세 이상 만성질환자로서 기본 조사 항목들에 결측치가 없는 1,980명에 대한 보건행태요인과 우울 간의 카이제곱 검정 분석을 수행한 후, 유의적이었던 요인들을 독립변수로 이분 로지스틱회귀분석을 수행하였다. 분석 결과, 남성보다는 여성에서 우울이 1.49배(CI: 1.086~2.044) 높았고 비흡연자보다는 흡연자에서 1.828 높았으며(CI: 1.285~2.561), 소득수준이 높을수록 우울에 대한 영향력이 감소하였다. 특히 '스트레스가 없음' 대비 '대단히 많음'에서 교차비가 28.034(CI: 13.132~59.849)로서 스트레스를 느끼는 강도가 높은 경우 우울에 가장 큰 영향을 미쳤고, 다음으로 주관적인 건강 인지와 수면시간의 영향력이 높았다. 본 연구에서는 만성질환자 집단에서 우울을 개선하기 위해 실천해야 할 중요한 생활습관 및 보건행태요인의 우선순위를 확인하였다는 것에 의의가 있다. 그리고 동반 이환의 수는 우울 발생에 유의적이지 않았기 때문에, 향후 만성질환 종류별로 우울에 영향을 미치는 정도를 파악하고 환자별 맞춤형 정책 대안을 제시하는 것이 필요할 것이다.

• The Korean Journal of Pain
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• 제31권3호
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• pp.199-205
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• 2018

Background: Sleep disturbance and depression are becoming more recognized as important symptoms among individuals with chronic low back pain. This study evaluated the effect of stabilization exercise on pain-related disability, sleep disturbance and the psychological status of patients with non-specific chronic low back pain (NSCLBP). Methods: A total of 26 patients (M/F = 17/9) with NSCLBP with a mean age of $50.0{\pm}15.5$ took part in this study. Participants were recruited from selected hospitals in Lagos state. Ethical approval was sought and obtained from the health research and ethics committee of Lagos University Teaching Hospital Idi-araba, Lagos, Nigeria. Participants performed stabilization exercise for eight weeks consecutively and were assessed for pain-related disability, anxiety, depression, and sleep disturbance using the pain-disability index, hospital anxiety and depression scale, and the insomnia severity index at baseline, the 4th week, and the 8th week, postintervention. Results: The participants studied recorded significant reduction in pain-related disability (P = 0.001). There was also improvement in the sleep quality (P = 0.001), depression level (P = 0.001), and anxiety level (P = 0.001), post intervention. Conclusions: This study revealed that stabilization exercise is very useful in the management of sleep disturbance, pain-related disability, depression, and anxiety in NSCLBP patients.

• 지역사회간호학회지
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• 제22권4호
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• pp.399-408
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• 2011

Purpose: This study was conducted to evaluate the effects of an education program on the knowledge of medication and prevention of depression in the elderly at a local community. Methods: This study utilized the nonequivalent control group pretest-posttest design. Thirty consecutive people were included in this study for the experimental group, and another 30 people were allocated to the control group. The program was performed once a week for 3 weeks. Data were collected from March 15 to April 30, 2010 and statistical analyses were performed by ${\chi}^2$-test and independent t-test using the SPSS/WIN 12.0 program. Results: There were statistically significant differences in the knowledge of medication, depression and medication compliance between the experimental and control groups. Conclusion: This study demonstrated that an education program for the knowledge of medication and prevention of depression in the elderly with chronic disease could improve their knowledge of medication and their medication compliance, and decrease their depression. These results suggest that education of knowledge with social psychology can be an effective and practical method of management to the elderly with chronic disease at local communities.