• 분석과학
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• 제6권4호
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• pp.375-381
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• 1993

생체시료 중 ${\beta}$-blockers의 동시분석을 위한 시료 전처리 과정에서 고상추출법을 사용하기 위해 4가지 흡착제의 흡착 및 탈착 효율을 조사하였다. 용출 용매로서 methanol을 사용하였을 때 Chromosorb 107이 가장 높은 회수율을 보였다. ${\beta}$-Blockers의 breakthrough 조사를 하여 Chromosorb 107 컬럼의 우수한 흡착 및 탈착 성질을 혈청 중 2~8 ppm 농도 범위의 ${\beta}$-blockers를 동시에 고상추출하는 데 Chromosorb 107/methanol의 유용성을 조사하였다.

• 약학회지
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• 제36권6호
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• pp.563-569
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• 1992

The sorption and desorption properties of four different solid adsorbents were evaluated for the trace enrichment of ibuprofen from biological samples. Chromosorb 107 gave the highest dynamic adsorption coefficient. Among the organic solvents examined, acetone gave the highest desorption coefficient. Using the Chromosorb 107 column, the optimum elution volume of the eluting solvent was evaluated from the breakthrough curve of ibuprofen. The usefulness of Chromosorb 107 as the solid adsorbent and acetone as the eluting solvent was examined for the solid-phase extraction of ibuprofen from serum in the concentration range of $20{\sim}40\;{\mu}g/ml$.

• Archives of Pharmacal Research
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• 제17권3호
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• pp.175-181
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• 1994

The solid-phase extraction (SPF) with subsequent tert-butyldimethylsilyl (TBDMS) derivatization was investigated for the rapid profiling and screening of various carboxylated non-steroidal antiinflammatory drugs (NSAIDs) simultaneously in biological fluid samples. Compared to the conventional SPF in adsorption mode using Chromosorb 102, Chromosorb 107, Carbopak B and Thermosorb, the SPF in partition mode using Chromosorb P as the adsorbent, and ethyl acetate/methylene chloride as the eluting solvents provided hightest overall recovenies of the NSAIDs from aqueous solutions with good precision. The solid-phase extracted NASIDs were silylated with N-methyl-N-(tert-butyldimethylsily)trifuoroacetamide to TBDMS derivatives and directly analyzed by capillary gas chromatography and gs chromatography-mass spectrometry. The usefulness of the present method was examined for the profilling and screening of saliva, serum and urine samples for various NSAIDs simultaneously.