• Title/Summary/Keyword: Chromosomalanomaly

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Chromosomalanomaly test of Sipjeondaebo-tang extract using the Chiness hamster lung (Chiness hamster lung cell(CHL)에서 십전대보탕 염색체 이상 시험)

  • Ma, Jin-Yeul;Huang, Dae-Sun;Lee, Nam-Hun;Ha, Hye-Kyung;Yu, Young-Beob;Shin, Hyun-Kyoo
    • Herbal Formula Science
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    • v.16 no.2
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    • pp.145-153
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    • 2008
  • Objectives : This study was to assessment the toxicity of Sipjeondaebo-tang(Shiquan dabu-decoction) by Chromosomalanomaly test. Methods : Sipjeondaebo-tang(Shiquan dabu-decoction) water-extract in vivo Chromosomalanomaly test was performed using chiness hamster lung cell line. Results : Sipjeondaebo-tang water extract was negative in Chromosomalanomaly test at the doses of 0, 625, 1250 and $2500{\mu}g/m\ell$ at 6h and 24h.(S9- fraction). Chromosomalanomaly test(S+fraction) was also negative at the doses of 0, 1250, 2500 and $5000{\mu}g/m\ell$. Conclusions : It was concluded that Sipjeondaebo-tang extract did not induce Chromosomalanomaly in the chiness hamster lung cell.

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