• 동의신경정신과학회지
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• 제20권1호
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• pp.59-73
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• 2009

Objectives : This experiment was designed to investigate the effect of the ODTCMT hot water extract & ultra-fine Powder on Alzheimer's Disease Model Induced by 13A. Methods : The effects of the ODTCMT hot water extract on expression of IL-l${\beta}$, IL-6, TNF-${\alpha}$ in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. The effects of the ODTCMT hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine were investigated. Results : 1. The ODTCMT hot water extract significantly suppressed the production of TNF-${\alpha}$, IL-6 and IL-l${\beta}$ in BV2 microglial cell line treated with LPS. 2. The ODTCMT hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. Conclusions : These results suggest that the ODTCMT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the ODTCMT hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.

• 동의생리병리학회지
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• 제29권1호
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• pp.39-45
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• 2015

This experiment was designed to investigate the effect of Added Chongmyung-tang (ACM) on Alzheimer's disease mouse model. Effects of ACM on learning behavior were investigated using the Morris water maze method. Expression levels of molecular factors related to Alzheimer's disease such as glial fibrillary acidic protein (GFAP), cluster of differentiation antigen 68 (CD68), and tau protein in the hippocampus of APP-SWE Tg2576 mice were analyzed by immunofluorescence staining method. ACM reduced escape latency in the Morris water maze test. ACM decreased the expression level of GFAP and tau protein in the hippocampus. These results suggest that ACM may be involved in regulating molecules that are known to play an important role in the pathogenesis of Alzheimer's disease.

• 대한한의학방제학회지
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• 제10권1호
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• pp.33-39
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• 2002

There are total 33 prescriptions containing Polygala tenuifolia as a principal medicine in Donguibogam. This report describes the studies on therapeutic range, symptom, pathology and composition of 33 Polygala tenuifolia-main blended Prescriptions from Donguibogam. The percentage of Polygala tenuifolia-main blended prescriptions for the therapeutic range are as follows: psychopathy is the most frequent(54.4%) and eczema, purulent inflammation is second(21%) and feebleness is third(15%). The main pathologies of Polygala tenuifolia-main blended prescriptions are associated with heart, kidney and stomach. The main combinations of Polygala tenuifolia-main blended prescriptions in psychopathy are Jeongji-hwan and Chongmyung-tang.