• 농업과학연구
• /
• 제31권2호
• /
• pp.77-86
• /
• 2004

본 연구에서는 딸기에 대한 고분자 키토산의 수확 전후 처리가 과실의 품질과 부패에 미치는 영향을 조사하였다. 키토산 처리는 수확한 딸기의 잿빛곰팡이병 억제, 과실의 경도 증진 및 표피의 광택을 유지시키는 효과가 명확하였다. 그러나 0.2% 농도 키토산 4회 누적적인 처리도 식물 자체에 생리적 장해를 일으키지 않으며 내적 품질에 현저한 영향을 미치지 않았다. 키토산 처리의 효과는 물리적 손상이 없을 경우 우수하였으며 손상을 받은 과실에서는 명확한 선도유지효과를 나타내지 않았다. 수확 후 처리의 효과는 명확하지 않았으며 수확 전 처리 효과를 증대시키지 않았다. 이상의 결과로 볼 때 키토산은 화학적 방제를 배제할 수 있는 수단으로 과실의 경도 증진, 부패 억제를 통한 품질 향상의 대안이 될 수 있는 것으로 판단된다.

• Journal of Pharmaceutical Investigation
• /
• 제31권2호
• /
• pp.101-106
• /
• 2001

Alginate-chitosan (anion-cationic polymeric complex) was prepared to control the release rate of silver sulfadiazine (AgSD). Na-alginate (2%) solution containing AgSD was gelled in $CaCl_2$ solution. The gel beads formed were immediately encapsulated with chitosan (CS). The gel matrix and membrane were then reinforced with chondroitin-6-sulfate (Ch6S). Release rate of AgSD from the gel matrix was investigated by placing alginate beads in the sac of cellulose membrane simmered in HEPES-buffer solution. The concentration of AgSD released was analyzed by UV at 264 nm. Incorporation capacity of AgSD in Ca-alginate gel was more than 90%. Alginate-Ch6S-CS could control the release rate of AgSD. The amount of AgSD release was dependent on the AgSD loading dose. Incorporation of tripolyphosphate (polyanionic crosslinker) onto the alginate-Ch6S-CS bead increased the release rate of AgSD. Collagen-coating had no influence on the AgSD release rate. Alginate-Ch6S-CS beads with a sufficiently high AgSD encapsulation were capable of controlling the release of the drug over 10 days. In summary, alginate-Ch6S-CS beads could be used as a sustained delivery for AgSD and provide local targeting with low silver toxicity and patient discomfort.

• 한국자기학회:학술대회 개요집
• /
• 한국자기학회 2008년도 Asian Magnetics Conference
• /
• pp.148.1-148.1
• /
• 2008

• 한국잡초학회지
• /
• 제11권3호
• /
• pp.159-166
• /
• 1991

필자(筆者)들의 전보(前報)에서와 동일(同一)한 Oxyfluorfen 6제형(劑型)을 동일(同一)한 초자실(硝子室)에서 4수준의 관개수심 조건을 부여하여 서로 다른 묘령의 벼와 8종의 주요 논잡초종에 대한 약해 반응 및 약효 차이를 비교 검토하였다. 공시 제형 가운데 Elvan. Coal slag, Chitosan 및 Bentonite B 제형은 비담수 및 천수조건에서, 그리고 Elvan, Coal slag는 심수조건에서 약해가 경미하였고, 제초효과는 Bentonite A 및 B. Chitosan이 전반적으로 높았고, Elvan, Coal slag는 Sand coating과 함께 낮은 경향이었다. 그러나, Oxyfluorfen의 제초대상을 일년생으로 제한하여 판단할 경우에는 제초 효과면에서 제형간 차이가 크지 않았으므로 상대적으로 약해가 경미하였던 Elvan, Coal slag, Chitosan 및 Bentonite B제형을 보완 개발하거나 약해 약효간의 유사관계가 분명하였던 Elvan 및 Bentonite A형의 최초 방출 속도를 보완개발 함이 기대된다.

• 한국식품과학회지
• /
• 제35권3호
• /
• pp.410-416
• /
• 2003

돈육에 칼슘 용액 주입 후 분자량 약 30 kDa의 키토산 1%와 젤라틴 3%의 혼합액을 코팅하여 $1^{\circ}C$에서 18일간 저장한 결과, 키토산/젤라틴을 코팅 처리한 전 실험구에서 저장성 및 지질의 산화도가 낮게 측정되었고, 적색도는 돈육의 내 외부에서 약간 증가하는 경향을 나타내었다. 키토산/젤라틴을 코팅한 돈육의 경우 저장기간 동안 수분함량 및 pH 변화에서도 안정하게 유지되었고, 보수력은 칼슘을 주입한 다음 키토산/젤라틴 혼합액으로 코팅한 돈육에서 비교적 높게 측정되었는데, 전반적으로 큰 차이를 보이지 않았다. 연도는 칼슘 용액을 돈육의 내부에 주입한 경우에 shear force가 가장 낮게 측정되었고, 이러한 결과는 근원섬유의 소편화도에서도 같은 결과를 나타내어 연도를 개선시키는데 효과적이었다. 따라서 돈육에 칼슘 용액을 주입하고, 키토산을 표면 처리하면 저장성의 증진 및 연도의 개선 등으로 돈육의 품질을 향상시키는데 적합한 방법이라 사료된다.

• Journal of Ginseng Research
• /
• 제45권2호
• /
• pp.236-245
• /
• 2021

Background: Red ginseng (RG) extract, especially ginsenoside Rg1 and Rb1 fractions has been reported to have antithrombotic activities. However, gastric instability and low intestinal permeability are considered to be obstacles to its oral administration. We hypothesized that stability, permeability, and activities of RG might be improved by encapsulation within nanoparticles (NPs) prepared with antithrombotic coating materials. Methods: RG-loaded chitosan (CS) NPs (PF-NPs) were prepared by complex ionic gelation with the antithrombotic wall materials, polyglutamic acid (PGA), and fucoidan (Fu). The concentrations of PGA (mg/mL, X₁) and Fu (mg/mL, X₂) were optimized for the smallest particle size by response surface methodology. Antithrombotic activities of RG and PF-NPs were analyzed using ex vivo and in vivo antiplatelet activities, in vivo carrageenan-induced mouse tail, and arteriovenous shunt rat thrombosis models. Results: In accordance with a quadratic regression model, the smallest PF-NPs (286 ± 36.6 nm) were fabricated at 0.628 mg/mL PGA and 0.081 mg/mL Fu. The inhibitory activities of RG on ex vivo and in vivo platelet aggregation and thrombosis in in vivo arteriovenous shunt significantly (p < 0.05) increased to approximately 66.82%, 35.42%, and 38.95%, respectively, by encapsulation within PF-NPs. For an in vivo carrageenan-induced mouse tail thrombosis model, though RG had a weaker inhibitory effect, PF-NPs reduced thrombus significantly due to the presence of PGA and Fu. Conclusion: PF-NPs contributed to improve the activities of RG not only by nanoencapsulation but also by antithrombotic coating materials. Therefore, PG-NPs can be suggested as an efficient delivery system for oral administration of RG.

• Applied Biological Chemistry
• /
• 제47권3호
• /
• pp.361-365
• /
• 2004

키틴, 키토산 및 그 유도체의 토양처리와 종자 피복 등이 토마토 생육에 미치는 효과를 조사하고 분석하였다. 키틴과 그 유도체의 토양 처리는 토마토 초기 생육을 촉진하였으며, 키틴과 키토산을 토양에 혼화 처리한 경우 그 효과가 가장 탁월하였다. 이들의 처리는 토마토 근부의 생육을 촉진하였다. 토마토 식물체 중의 무기성분을 분석하여 이들의 처리효과를 분석하였던 바, 키틴 키토산의 처리는 질소와 칼륨의 흡수를 촉진하였으며 칼슘의 흡수를 억제하였다. 그러므로 이들은 식물의 무기양분 흡수의 조절을 통하여 생육을 촉진하는 것으로 판단하였다.

• Journal of Pharmaceutical Investigation
• /
• 제37권1호
• /
• pp.15-22
• /
• 2007

An oil-in-water solvent evaporation method was used to prepare the cyclosporin A (CyA)-loaded nanoparticles varying in poly (D,L-lactide-co-glycolide) (PLGA) polymer (RG 502H, RG 503H) and the amount of additive ethyl myristate (EM) or chitosan (CS). The particles were characterized for drug loading and entrapment efficiency by HPLC, surface morphology by scanning electron microscopy, particle size by dynamic light scattering and surface charge by Zetapotential. The results showed drug loadings ranging from 10.9% to 15.8% with high encapsulation efficiency (82.0-97.8%). SEM and DLS studies showed discrete and spherical particles with smooth surfaces and mean size ranging 257.6-721.7 nm. The additive EM or CS did not change the mean sizes of the nanoparticles, whereas by the coating effect of CS, the Zetapotential values of the CS-added nanoparticles were moved to the more positive direction as the amount of CS was increased. From the pharmacokinetic analysis, the nanoparticles formulations showed the higher bioavailability and MRT than $Neoral^{\circledR}$ While little adding effect of EM or CS was detected in pharmacokinetic profile when RG 503H was used as polymer carrier, more noticeable different pharmacokinetic behaviors could be observed in case of RC 502H. EM incorporation was found to elevate the $K_{el}$, whereas CS coating resulted in the decrease of F and $K_{el}$, which seems to be due to the function of CS as a barrier and a mucoadhesive coating.

• Journal of the Korean Wood Science and Technology
• /
• 제49권6호
• /
• pp.658-666
• /
• 2021

A novel flame retardant and antibacterial composite membrane coating for wood surfaces was prepared by adding POSS-based phosphorous nitrogen flame retardant (later referred to as NH₂-POSS) and silver nanoparticles (Ag NPs) to chitosan (CS). The effects of NH₂-POSS content (mass fractions of CS 0%, 0.5%, 1%, 3%, 5%, and 7%) on the structure and properties of the composite membrane coating on wood were investigated. The composite film was prepared by the method of blending and ducting. Contact angle, tensile property and antibacterial effects of the composite film were measured, and infrared spectroscopy was used. The results show that the addition of NH₂-POSS can not only improve the toughness of the membrane, but also the flame retardancy of the membrane, which improves the application of the membrane in wood products. However, with the addition of NH₂-POSS, the transparency of the composite membrane was weakened. The inhibitory effect of the composite membrane on the growth of Escherichia coli was enhanced with the increase in Ag NPs. This research provides a foundation for the application of functional wood.

• 대한치주과학회:학술대회논문집
• /
• 대한치주과학회 2005년도 제45회 종합학술대회 연제초록
• /
• pp.163-164
• /
• 2005