• 대한한의학원전학회지
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• 제25권1호
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• pp.69-87
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• 2012

Objective: "Nan Jing Hui Zhu Jian Zheng" published in 1923 is a book that 'Jiang Shan-Lei' wrote. He selected the past footnotes about "Nan Jing(難經)" and developed his own medical ideas on its base. Method : We will try to understand on scholarship paradigm of 'Jiang Shan-Lei' focus on his "Nan Jing Hui Zhu Jian Zheng". Result and Conclusion : He introduced the western medicine system to the Chinese medicine education, and he introduced a viewpoint of the human body of the western medicine to the structure of the human body as well. He judged yes or no of the Chinese medicine theory on the base of his human body viewpoint focused on an anatomy and a physiology. His human body viewpoint like this helped prove actually some of the Chinese medicine theory that was explained ideally. However, it had inappropriate aspects in explaining the Chinese medicine, which has a low alteration of a theory by inferring from the principle, due to a changeability of the western medicine theory itself. Moreover, his rash judgement concerning the Chinese medicine theory on its base brought about even side effects hampering efforts which reveal the Chinese medicine essence.

• Bulletin of the Korean Chemical Society
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• 제34권5호
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• pp.1541-1542
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• 2013

• 대한추나의학회지
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• 제1권1호
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• pp.103-117
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• 2000

The manipulations are the main therapheutic procedure of Chuna. Manipulation is the essential procedure of Chuna theraphy. On the basis of touch parts and motion changes, each elementary manipulation is divided into Stimulating Manipulations (reflexional manipulations) and Mobilizing Manipulations. Objectives: This study were advanced so as to know Chinese Chuna Manipulations especially on Herniated Nucleus Pulposus. Methods We Investigated Chinese medicine paper about Chinese Chuna Manipulations on Herniated Nucleus Pulposus between 1996 and 1999. Results. Chinese Chuna theraphy, Pressing Manipulations and Thrusting-Wrenching Manipulations are mostly used on Herniated Nucleus Pulposus, and Chinese Chuna theraphy carrys out Traction, Injection. Chinese medicine. Acupuncture side by side. Conclusions: Chinese Chuna theraphy uses not only Mobilizing Manipulations, but also Stimulating Manipulations whereas Korean Chuna theraphy chiefly uses Mobilizing Manipulations.

• Journal of Acupuncture Research
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• 제27권4호
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• pp.187-194
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• 2010

Objectives : There has been a need for establishing operational curriculum for chinese characters and chinese writing used by traditional Korean medicine(TKM), but it was not thoroughly recognized so far. Methods : We analysed the usage of unicode chinese characters of acupuncture & moxibustion textbook to recognize the prerequisite chinese characters for TKM studies as clinical perspectives. Results : It was found that 穴, 經, 鍼, 法, 寸, 部, 分, 刺, 下, 上, 中, 位, 氣, 陽, 灸, 脈, 陰, 治, 足, 主 are the most frequently used 20 chinese characters. We also showed that adequate prerequisite chinese character should be designated for the more efficient education of TKM. Conclusions : This study was the first systematic approach to get essential and prerequisite chinese characters for the education of TKM especially for the acupuncture & moxibustion. The prerequisite characters by this study will be used for the development of KEET (Korean Medicine Education Eligibility Test), entrance exam to the Colleges of Oriental Medicine and textbooks, and educational curriculum of premed students.

• 대한한의학회지
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• 제32권1호
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• pp.36-55
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• 2011

Objective: This study was performed to compare knowledge of and expectations for traditional medicine between Korean, Chinese and Taiwanese, to figure out whether these factors influence the intention to use traditional medical treatment in the future. Methods: One-hundred ninety-nine Korean, eighty-five Chinese, and one-hundred seventy-four Taiwanese subjects responded to the survey. A one-way ANOVA was performed to compare experiences of traditional medical treatment, knowledge of both traditional medicine and western medicine, expectations for traditional medicine, and future intention to use traditional medical treatment. Multiple regression analyses were also performed to evaluate a possible correlation between the other factors and the intention to use traditional medical treatment in the future. Results: The experiences of traditional medical treatment were in the order of Taiwanese, Korean, and Chinese, from more frequent to less frequent. Chinese had more knowledge of traditional medicine compared to Taiwanese and Koreans, and the expectations for traditional medicine were in the order of Chinese, Korean and Taiwanese, from higher to lower. The intentions to use traditional medical treatment in the future were in the order of Korean, Chinese and Taiwanese, from more to less. Multiple regression analyses showed that experiences of traditional medical treatment, knowledge of traditional medicine, and expectations for traditional medicine were associated with the intention to use traditional medicine in the future in Korean and Taiwanese, but not in Chinese. Only the expectations for traditional medicine were associated with the future intentions to use traditional medical treatment in Chinese. Conclusions: These findings suggest that Korean and Taiwanese may need to improve their knowledge of traditional medicine whereas Chinese need to link their knowledge of traditional medicine with the intention to use it in the future. Understanding the characteristics of traditional medicine would probably contribute to enhancing the intentions to use it more.

• Journal of Ginseng Research
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• 제48권3호
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• pp.298-309
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• 2024

Background: 20(S)-ginsenoside Rh2(GRh2), an effective natural histone deacetylase inhibitor, can inhibit acute myeloid leukemia (AML) cell proliferation. Lactate regulated histone lactylation, which has different temporal dynamics from acetylation. However, whether the high level of lactylation modification that we first detected in acute promyelocytic leukemia (APL) is associated with all-trans retinoic acid (ATRA) resistance has not been reported. Furthermore, Whether GRh2 can regulate lactylation modification in ATRA-resistant APL remains unknown. Methods: Lactylation and METTL3 expression levels in ATRA-sensitive and ATRA-resistant APL cells were detected by Western blot analysis, qRT-PCR and CO-IP. Flow cytometry (FCM) and APL xenograft mouse models were used to determine the effect of METTL3 and GRh2 on ATRA-resistance. Results: Histone lactylation and METTL3 expression levels were considerably upregulated in ATRA-resistant APL cells. METTL3 was regulated by histone lactylation and direct lactylation modification. Overexpression of METTL3 promoted ATRA-resistance. GRh2 ameliorated ATRA-resistance by downregulated lactylation level and directly inhibiting METTL3. Conclusions: This study suggests that lactylation-modified METTL3 could provide a promising strategy for ameliorating ATRA-resistance in APL, and GRh2 could act as a potential lactylation-modified METTL3 inhibitor to ameliorate ATRA-resistance in APL.

• 척추신경추나의학회지
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• 제7권1호
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• pp.15-20
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• 2012

Objectives : The aims of this study were to introduce the theory of traditional Chinese orthopedic theory(整脊理論) and to analyze the guideline of diagnosis and treatment of common spinal disorders by treating Chinese spinal manipulation technique(常見病中醫整脊指南). Methods : We have searched the web sites of traditional Chinese orthopedics association (整脊學會), a branch of the China academy of traditional Chinese medicine (TCM), and related articles. Additionally, we analyzed the guideline of diagnosis and treatment of common spinal disorders by treating Chinese spinal manipulation technique which was introduced by that association at 7th academic conference in China in 2011. Results : The guideline was prepared by 2 year project leaded by professor Yi-zhong Wei who was a person in charge of the spinal manipulation guideline of national standardization committee of TCM in China. It was a summary of the whole theory of China spinal manipulation therapy in TCM and contained 22 common spinal disorders by the treatment of traditional Chinese Tuina methods. Spinal manipulation theory was summarized by one doctrine, two theories, and two important view points. The treatment method was abstracted as 8 major Tuina techniques. Conclusions : The guideline will be a way of advance of Chinese spinal manipulation technique. This will be a good reference to Korea Chuna manipulation for improving their techniques.

• 한국한의학연구원논문집
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• 제18권3호
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• pp.133-139
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• 2012

Objective : UMLS is 'Ontology' which establishes the database for medical terminology by gathering various medical vocabularies representing same fundamental concepts. Method : Although Chinese character are represented in the Chinese part of Korean Unicode system in a computer, writing of Chinese characters is vary depending on Chinese input systems and Chinese writers' levels of knowledge. As the result of this, representation of Chinese writing in a computer will be considerably different from an old Chinese document. Therefore, a meaningful relationship between digital Chinese terminology and translated Korean is necessary in order to build Ontology for Chinese medical terms from Oriental medical prescription in a computer system. Result : This research will present 1:1 mapping information among the Chinese characters used in the Oriental medical prescription with analysis of 'same character different sound' and 'same meaning different shape' in Chinese part of Unicode systems. Conclusions : Furthermore, the research will provide top-down menu of relationship between Chinese term and Korean term in medical prescription with assumption of that the Oriental medical prescription has its own unique meaning.

• 대한한의진단학회지
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• 제12권1호
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• pp.1-12
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• 2008

Object: The purpose of this study is to the review recent 20 years chinese achievements on the use of impedance cardiography for chinese medicine. Methods: From the China Journal Full Text Database we searched papers on the use of impedance cardiography for chinese medicine by the keyword "심조항도(心阻抗圖)". Results: The researches are summarized into 3 parts. (1) the researches on the relationship between the parameters of impedance cardiography and the chinese medical diagnoses; pulse diagnosis and tongue inspection. (2) the researches on the objective assessment using impedance cardiography for the effects of chinese medical therapy. (3) the researches on the objective evaluation index of Heart Deficiency Syndrome using impedance cardiography. Conclusion: The parameters of impedance cardiography has been established for its usefulness in various chinese medical researches.

• The Korean Journal of Physiology and Pharmacology
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• 제18권5호
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• pp.371-376
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• 2014

Amino-acid neurotransmitter system dysfunction plays a major role in the pathophysiology of depression. Several studies have demonstrated the potential of amino acids as a source of neuro-specific biomarkers could be used in future diagnosis of depression. Only partial amino acids such as glycine and asparagine were determined from certain parts of rats' brain included hippocampi and cerebral cortex in previous studies. However, according to systematic biology, amino acids in different area of brain are interacted and interrelated. Hence, the determination of 34 amino acids through entire rats' brain was conducted in this study in order to demonstrate more possibilities for biomarkers of depression by discovering other potential amino acids in more areas of rats' brain. As a result, 4 amino acids (L-aspartic acid, L-glutamine, taurine and ${\gamma}$-amino-n-butyric acid) among 34 were typically identified as potentially primary biomarkers of depression by data statistics. Meanwhile, an antidepressant called Fluoxetine was employed to verify other potential amino acids which were not identified by data statistics. Eventually, we found L-${\alpha}$-amino-adipic acid could also become a new potentially secondary biomarker of depression after drug validation. In conclusion, we suggested that L-aspartic acid, L-glutamine, taurine, ${\gamma}$-amino-n-butyric acid and L-${\alpha}$-amino-adipic acid might become potential biomarkers for future diagnosis of depression and development of antidepressant.