• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5171-5174
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• 2013

Background: This study aimed to explore potential associations between single nucleotide polymorphisms (SNPs) of the x-ray repair cross-complementing group 1 (XRCC1) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) and non-small cell lung cancer (NSCLC) susceptibility in non-smoker Chinese patients. Methods: A total of 200 NSCLC patients and 200 healthy controls with matched age and gender were recruited for genotyping of XRCC1 SNPs (rs2256507 and rs1001581) and CLPTM1L SNPs (rs401681 and rs4975616). Association of these SNPs with NSCLC risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) from multivariate unconditional logistic regression analyses with adjustment for gender and age. Results: The frequencies of genotype and allele in these four loci (rs2256507, rs1001581, rs401681, and rs4975616) were not significantly different between the cases and controls, or between either of the histological subgroups (adenocarcinoma and squamous cell carcinoma) and controls. Conclusions: Although these SNPs are associated with NSCLC risk in patients with a tobacco-smoking habit, this study demonstrated that XRCC1 and CLPTM1L gene SPNs are not linked with NSCLC risk in non-smoking patients, indicating that molecular mechanisms of NSCLC betwee tobacco smokers and non-smokers may be different. Future studies are needed to uncover the underlying molecular mechanisms for NSCLC in non-smokers.

• Korean Journal of Occupational Health Nursing
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• v.19 no.1
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• pp.28-40
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• 2010

Purpose: The purpose of the study >was to examine the prevalence of work-related musculoskeletal disorders(WMSDs) and to identify the relationship between work-related psychosocial and acculturative factors and WMSDs among Korean-Chinese workers living in Korea. Methods: A cross-sectional survey was conducted with 195 Korean-Chinese workers who have worked full-time for the past 6 months. A structured questionnaire, including measures for musculoskeletal symptoms, physical demand, work-related psychosocial(job demand, job control, interpersonal conflict), acculturative (acculturation strategy and acculturative stress), and personal factors, was used. Descriptive statistics and logistic regression analysis were conducted using the SPSS WIN 17.0. Results: The prevalence of WMSDs was 64.1%. In comparison to Korean workers, job demand of this group was lower while both interpersonal conflict and lack of job control were higher among them. Integration was the most commonly used acculturation strategy and mean scores of acculturative stress were below the median. Acculturative stress was positively correlated with integration and assimilation while negatively correlated with separation and marginalization. Interpersonal conflict and integration appeared to be related to WMSDs among male and female Korean-Chinese workers, respectively. Conclusion: The WMSD interventions need to be planned in consideration of different influences of work-related psychosocial and acculturative factors on WMSDs by gender.

• Clinical and Experimental Reproductive Medicine
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• v.51 no.2
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• pp.142-150
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• 2024

Objective: Diminished ovarian reserve (DOR) is a disorder characterized by impaired ovarian function. Sleep disorders are disruptions of the circadian rhythm, which appears to be closely linked to reproductive systems. This study aimed to investigate the impact of poor sleep quality on the ovarian reserve of childbearing-age women. Methods: A cross-sectional study was conducted in China from June 2021 to March 2023. In total, 102 participants diagnosed with chronic insomnia disorder were included in the study. Questionnaires were administered to assess participants' menstrual patterns, insomnia severity, anxiety, and depression. The anti-Müllerian hormone level and the basal antral follicle count were measured for ovarian reserve evaluation. Correlation analysis and ordinal logistic regression analysis were conducted. Results: The women with insomnia presented high percentages of hypomenorrhea, premenstrual syndrome, and dysmenorrhea (78.4%, 74.5%, and 46.1%, respectively). Severe sleep disorder in the past month was identified as an independent risk factor for hypomenorrhea and premenstrual syndrome (odds ratio [OR], 2.64 and OR, 2.688; p<0.05). The prevalence of DOR among women with insomnia (33.3%) was significantly higher than the average reported in previous studies for young women. Insomnia duration exceeding 1 year was determined to be an independent risk factor for DOR in women aged 36 to 40 years (OR, 4.5; p=0.033). Conclusion: This study highlights the association between sleep disorders and menstrual problems. Prolonged poor sleep quality in women aged 36 to 40 years was identified as a significant risk factor for DOR. We should pay more attention to improving sleep quality in order to maintain normal ovarian function.

• Korean Journal of Acupuncture
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• v.33 no.3
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• pp.102-113
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• 2016

Objectives : This study is aimed at developing and discussing the prediction model of blood stasis pattern of traditional Korean medicine(TKM) using machine learning algorithms: multiple logistic regression and decision tree model. Methods : First, we reviewed the blood stasis(BS) questionnaires of Korean, Chinese, and Japanese version to make a integrated BS questionnaire of patient-reported outcomes. Through a human subject research, patients-reported BS symptoms data were acquired. Next, experts decisions of 5 Korean medicine doctor were also acquired, and supervised learning models were developed using multiple logistic regression and decision tree. Results : Integrated BS questionnaire with 24 items was developed. Multiple logistic regression models with accuracy of 0.92(male) and 0.95(female) validated by 10-folds cross-validation were constructed. By decision tree modeling methods, male model with 8 decision node and female model with 6 decision node were made. In the both models, symptoms of 'recent physical trauma', 'chest pain', 'numbness', and 'menstrual disorder(female only)' were considered as important factors. Conclusions : Because machine learning, especially supervised learning, can reveal and suggest important or essential factors among the very various symptoms making up a pattern identification, it can be a very useful tool in researching diagnostics of TKM. With a proper patient-reported outcomes or well-structured database, it can also be applied to a pre-screening solutions of healthcare system in Mibyoung stage.

• Journal of the Korea Society of Computer and Information
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• v.27 no.11
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• pp.173-179
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• 2022

This study was conducted to provide basic data for the development of oral health education programs by examining oral health knowledge and oral health behaviors, and by identifying factors affecting oral health knowledge and scaling experience of Chinese domestic students. From March to May, a self-reported questionnaire was administered to 194 in the G area. The data were analyzed frequency analysis and independent t-test, multiple regression analysis, logistic regression analysis by using SPSS/WIN 26.0 program. The overall average of oral health knowledge was 13.83 out of 24, and knowledge of periodontal disease and scaling was the highest at 3.75, and knowledge of oral hygiene products was the lowest at 1.38. Oral health knowledge was significantly higher in those who had scaling experience for the past year, brushed teeth for more than 3 minutes at a time, used oral hygiene products, and had oral health education experience. As a result of multiple regression analysis, oral health education experience was the most important factor on oral health knowledge. As a result of logistic regression analysis, oral health knowledge was the most influential factor on scaling experience. It is necessary to expand education on the importance of oral care and actively introduce oral health management program for Chinese domestic students.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.993-996
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• 2013

To evaluate the relation between smoking, alcohol drinking and risk of breast cancer in Chinese women, we conducted a case-control study with 669 cases and 682 population-based controls in Jiangsu Province of China. A structured questionnaire was used to elicit detailed information. Unconditional logistic regression analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs). The results revealed that smoking, whether active or passive through the husband, was related to increased risk of breast cancer. The ORs (adjusted for age, menopausal status, educational levels, occupation, body mass index and income) were 3.55 (95%CI: 1.27-9.91) for active smoking and 1.47 (95%CI: 1.18-1.84) for passive smoking from husbands, respectively. A significant positive relationship was observed between breast cancer risk and the degree of husbands' smoking. There were significant increase trend in ORs with the daily smoked number of cigarettes of husbands, the passive smoking years from husbands and the pack-years of husbands' smoking (trend test: p=0.00003, 0.00013 and 0.0001, respectively). Alcohol consumption was also found to be a risk factor. The findings of this study in particular suggest that husbands' smoking increases risk of breast cancer in Chinese women.

• Korean journal of applied entomology
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• v.47 no.4
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• pp.407-411
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• 2008

This study was conducted to estimate the economic injury level (EIL) and economic threshold (ET) of the green peach aphid, Myzus persicae, on Chinese cabbage (Brassica campestris var). The changes of biomass of Chinese cabbage and M. persicae density were investigated after introduction of M. persicae at different density (0, 2, 5, 10, 15, and 20 per plant; inoculated at 10d after planting). The densities of M. persicae largely increased from the above initial densities to 0, 92.3, 177.4, 406.9, 440.4, and 471.3 aphids per plant at 18d after the initial inoculation, respectively. The biomass of Chinese cabbage significantly decreased with increasing the initial inoculated density of M. persicae: 602.0, 264.2, 262.0, 109.3, 151.0, and 67.3 g in above plots with different initial densities, respectively. The relationship between cumulative aphid days (CAD) and yield loss (%) of Chinese cabbage was well described by a nonlinear logistic equation. Using the estimated equation, EIL of M. persicae on Chinese cabbage was estimated 25 CAD per plant based on the yield loss 13%, which take into account of an empirical gain threshold 5% and marketable rate 92% of spring Chinese cabbage. Also, ET was calculated at 80% of EIL: 20 aphids per plant. Until a more elaborate EIL-model is developed, the present result may be useful for M. persicae management at early growth stage of Chinese cabbage.

• The Journal of Industrial Distribution & Business
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• v.9 no.8
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• pp.27-34
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• 2018

Purpose - This paper discussed and illustrated the most efficient method to calculate the distribution centers for a national project in China. Through demonstration of implementing the GIS, spatial analysis, and location calculation model, this paper mainly dealt with the construction distribution problem and inconvenient supply of materials problems. Research design, data, and methodology - In this paper, the research design structure based on three steps: implementing the Geographic Information System to locate the points coordination data, calculating the distribution centers of the project, and optimizing the most efficient and effective coordination. The data of the calculation is from an actual project. The methodology of this paper is summarizing the spatial analysis capabilities and digital graphic data calculation to locate logistics distribution centers, and since the illustration of the calculation is useful for locating the coordination, the result of this paper has certain reference values for the project construction. Results - This paper illustrates the steel and cement resource of every distribution point to confirm the most efficient distribution center location coordination. Conclusions - The integrated logistical management models are used to ensure the results for the purposes of our calculation. The result of the calculation is also a useful example for future Chinese national projects.

• Journal of Preventive Medicine and Public Health
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• v.31 no.4 s.63
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• pp.828-843
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• 1998

To find the association of perception of health status with lifestyle of different ethnic groups living in north-eastern part of China, a cross-sectional questionnaire survey was done by 10 local health workers for 375 Korean immigrants and 217 Chinese whose age was 30 years old or more. Because Korean immigrants showed higher mortality than Chinese, we expected to find significant lifestyle related with perception of health status which was known to be a predictor of mortality by different ethnic groups. The results were as follows : 1. We found that 59.7% of Yanbian Koreans and 42.9% of Yanbian Chinese felt unhealthy (p=0.000). 2. For Yanbian Koreans, significant variables associated with perception of health status were selected through logistic regression analysis and they were sex; female to male with an OR=2.45 (95% confidence interval[CI] 1.06, 5.64), prevalence of chronic illness with an OR=5.48 (95% CI: 4.62, 15.56), mont of meal; small or moderate to full with an OR=2.67 (95% CI : 1.40, 5.09), preference of spicy food with an OR=1.78 (95% CI : 1.04, 3.04), and less amount intake of vitamin $B_2$, with an OR=2.29 (95% CI : 1.33, 3.93). 3. For Yanbian Chinese, significant variables associated with perception of health status were prevalence of chronic illness with an OR=4.97 (95% CI : 2.11, 11.68), history of taking ginseng with an OR=3.72 (95% CI : 1.33, 10.43), and less intake of vitamin C with an OR=0.18 (95% CI : 0.07, 0.46). In conclusion, sex, presence of chronic illness, dietary habit, and amount of $vitamin-B_1$ intake were associated with perception of health status in Yanbian Koreans. Presence of chronic illness, experience of ginseng intake, and amount of vitamin C intake were associated with perception of health status in Yanbian Chinese. To prove cause-effect relation between perception of health status and lifestyle, further study is needed for these different ethnic groups.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.85-91
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• 2014

Background: Genome-wide association studies (GWAS) have identified various genetic susceptibility loci for breast cancer based mainly on European-ancestry populations. Differing linkage disequilibrium patterns exist between European and Asian populations. Methods: Ten SNPs (rs2075555 in COL1A1, rs12652447 in FBXL17, rs10941679 in 5p12/MRPS30, rs11878583 in ZNF577, rs7166081 in SMAD3, rs16917302 in ZNF365, rs311499 in 20q13.3, rs1045485 in CASP8, rs12964873 in CDH1 and rs8170 in 19p13.1) were here genotyped in 1009 Chinese females (487 patients with breast cancer and 522 control subjects) using the Sequenom MassARRAY iPLEX platform. Association analysis based on unconditional logistic regression was carried out to determine the odds ratio (OR) and 95% confidence interval (95% CI) for each SNP. Stratification analyses were carried out based on the estrogen receptor (ER) and progesterone receptor (PR) status. Results: Among the 10 SNPs, rs10941679 showed significant association with breast cancer when differences between the case and control groups in this Han Chinese population were compared (30.09% GG, 45.4% GA and 23.7% AA; P = 0.012). Four SNPs (rs311499, rs1045485, rs12964873 and rs8170) showed no polymorphisms in our study. The remaining five SNPs showed no association with breast cancer in the present population. Immunohistochemical tests showed that rs2075555 was associated with ER status; the AA genotype showed greater association with ER negative than ER positive (OR = 0.54, 95% CI, 0.29-0.99; P = 0.046). AA of rs7166081 was also associated with ER status, but showed a greater association with ER positive than negative (OR = 1.59, 95% CI = 1.04-2.44; P = 0.031). However, no significant associations were found among the SNPs and PR status. Conclusion: In this study using a Han Chinese population, rs10941679 was the only SNP associated with breast cancer risk, indicating a difference between European and Chinese populations in susceptibility loci. Therefore, confirmation studies are necessary before utilization of these loci in Chinese.