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Isolation and Structure Determination of a Proteasome Inhibitory Metabolite from a Culture of Scytonema hofmanni

  • Shim, Sang-Hee;Chlipala, George;Orjala, Jimmy
    • Journal of Microbiology and Biotechnology
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    • v.18 no.10
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    • pp.1655-1658
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    • 2008

  • Cyanobacteria, blue-green algae, are a rich source of bioactive secondary metabolites with many potential applications. The ubiquitin-proteasome proteolytic system plays an important role in selective protein degradation and regulates cellular events including apoptosis. Cancer cells are more sensitive to the proapoptotic effects of proteasome inhibition than normal cells. Thus, proteasome inhibitors can be potential anticancer agents. Cyanobacteria have been shown to be a rich source of highly effective inhibitors of proteases. A proteasome inhibitor was screened from an extract of the culture of Scytonema hofmanni on the basis of its inhibitory activity, which led to the isolation of nostodione A with an $IC_{50}$ value of 50${\mu}M$. Its structure was determined by spectroscopic methods such as $^{1}H$-NMR and ESI-MS spectral analyses.

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A Comparative Study on the Element and Form of Document Styles for documenting Resources based on Internet (인터넷 기반 전자정보원의 참고서지 기술요소와 형식에 관한 비교분석)

  • 김홍렬
    • Journal of Korean Library and Information Science Society
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    • v.33 no.3
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    • pp.87-108
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    • 2002

  • The objective of this study is to provide the basic data for the elements and form of bibliographic reference for citing internet sources. The analysis study through various styles were conducted for the purpose. In this paper, documentation styles recommended by MLA APA, CBE and Chicago manual, IS0690-2, SIST-02 are introduced. And, elements and forms of documentation styles for documenting information are carefully analyzed. Also, examples of reference for documenting internet resources were followed.

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PVDF interdigitated transducer for generating and detecting Lamb waves in plates

  • Gu, Hua;Lloyd, George M.;Wang, Ming L.
    • Smart Structures and Systems
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    • v.4 no.3
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    • pp.291-304
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    • 2008

  • Piezoelectric materials have been widely used in ultrasonic nondestructive testing (NDT). PZT ceramics can be used to receive and generate surface acoustic waves. It is a common application to attach PZT transducers to the surface of structures for detecting cracks in nondestructive testing. However, not until recently have piezoelectric polymers attracted more and more attention to be the material for interdigitated (IDT) surface and guided-wave transducers. In this paper, an interdigitated gold-on-polyvinylidene fluoride (PVDF) transducer for actuating and sensing Lamb waves has been introduced. A specific etching technology is employed for making the surface electrodes into a certain finger pattern, the spacings of which yield different single mode responses of Lamb waves. Experiments have been performed on steel and carbon fiber composite plates. Results from PVDF IDT sensors have been compared with those from PZT transducers for verification.

  • https://doi.org/10.12989/sss.2008.4.3.291 인용