• The KIPS Transactions:PartC
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• v.13C no.5 s.108
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• pp.583-594
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• 2006

The reliability concept of wireless sensor network is essential to get exactly actual data from the ubiquitous environment. A rollback technique for the self-healing helps to increase it. However, a fault can occur in wireless sensor network when to use a previous rollback technique because it is designed just for the local system. So, checkpoint protocols are suggested in order to use a rollback technique in the network without the fault. However, there is trade-off among performance overhead, power consumption, and memory overhead for each of protocols. Hence, we suggest a novel global checkpoint protocol, so called address log based protocol(ALBP), based on an asynchronous protocol. It is a platform based protocol to reduce power consumption, performance overhead, and memory overhead which are the most of consideration in wireless sensor network.

• Journal of KIISE:Computer Systems and Theory
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• v.29 no.6
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• pp.331-339
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• 2002

This paper presents a garbage collection protocol for checkpoints and message logs which are staved on the stable storage or volatile storage for fault tolerancy. The previous works of garbage collections in coordinated checkpointing protocol delete all the checkpoints except for the last checkpoints on earth processes. But implemented in top of reliable communication protocol like as TCP/IP, rollback recovery protocol based on only last checkpoints makes sympathetic rollback. We show that the old checkpoints or message logs except for the last checkpoints have to be preserved in order to replay the lost message. And we define the conditions for garbage collection of checkpoints and message logs for lost messages and present the garbage collection algorithm for checkpoints and message logs in coordinated checkpointing protocol. Since the proposed algorithm uses process information for lost message piggybacked with messages, the additional messages for garbage collection is not required The proposed garbage collection algorithm makes 'the lazy garbage collectioneffect', because relying on the piggybacked checked checkpoint information in send/receive message. But 'the lazy garbage collection effect'does not break the consistency of the whole systems.

• The Transactions of the Korea Information Processing Society
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• v.3 no.2
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• pp.327-338
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• 1996

In this paper, we present a new checkpointing algorithm to preserve the consistency of resources in distributed transaction processing systems, and the error recovery algorithms to recover form the failure. In comparison with the existed algorithms, the checkpointing algorithm proposed in this paper can minimize the interference of the distributed transaction and the stroage cost during checkpointing, and does not need the extra message to make th checkpoint. Also we show that the error recovery algorithms prevent the distributed transaction with a partial fault from spreading the fault, which calls domnio-effect and prevent them from restarting cyclically. And we describe the correctness and the performane of the proposed algorithms.

• Journal of KIISE:Computer Systems and Theory
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• v.31 no.3_4
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• pp.204-212
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• 2004

Existing distributed systems have higher probability of failures occurrence than stand-alone system, so many fault tolerant techniques have been developed. Because of insufficient storage resulting from the increased fault tolerance information stored, the performance of system has been degraded. To avoid performance degradation, it needs delete useless fault tolerance information. In this paper, we propose a garbage collection algorithm for fault tolerance information. And we define and design the garbage collection agent for garbage collection of fault tolerance information, the information agent for management of fault tolerant data, and the facilitator agent for communication between agents. Also, we propose the garbage collection algorithm using the garbage collection agent. For rollback recovery, we use independent checkpointing protocol and sender based pessimistic message logging protocol. In our proposed garbage collection algorithm, the garbage collection, information, and facilitator agent is created with process, and the information agent constructs domain knowledge with its checkpoints and non-determistic events. And the garbage collection agent decides garbage collection time, and it deletes useless fault tolerance information in cooperation with the information and facilitator agent. For propriety of proposed garbage collection technique using agents, we compare domain knowledge of system that performs garbage collection after rollback recovery and domain knowledge of system that doesn't perform garbage collection.

• Korean Journal of Clinical Pharmacy
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• v.28 no.2
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• pp.88-94
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• 2018

Background: We strived to evaluate the status of nivolumab use and associated factors on the clinical efficacy of the drug. Methods: The study was retrospectively conducted in patients who had been administered nivolumab at least once at the cancer center of Seoul National University Hospital from June 2015 to April 2017. Data were collected from electronic medical records. A medication-use evaluation was performed based on the American Society of Health-System Pharmacists mediation-use guidelines. Results: Sixty-six of the 74 patients (89.2%) showed indications approved for nivolumab use by the Korean Ministry of Food and Drug Safety (MFDS; n=55) or the US Food and Drug Administration (FDA; n=11). Approximately 73.0% of the patients were administered the approved dose of 3 mg/kg but 25.7% were administered an unapproved fixed dose of 100 mg. The overall response rate was 21.7%, and the response rate of non-small cell lung cancer patients, who accounted for the largest number of indications, was 18.8%. Adverse reactions were found in 90.1% of the patients and were mostly mild (86%). The expression of programmed death-ligand 1 (PD-L1) was analyzed as a factor affecting treatment response (p=0.028, odds ratio [OR]=11.331). Conclusion: PD-L1 expression was found to affect treatment response. However, caution is required while using an unapproved dosage and in the absence of monitoring for effectiveness and safety. Therefore, an effective protocol or instruction manual for the proper use of nivolumab should be considered.