• Title/Summary/Keyword: Channel effect

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Histopathological studies on the influence of mast cell in the growth of rat mammary carcinoma 3. Effect of xylazine on the course of DMBA-induced rat mammary carcinoma (Rat mammary carcinoma의 발육(發育)에 있어서 비만세포(肥滿細胞)의 영향(影響)에 관한 병리조직학적(病理組織學的) 연구(硏究) 3. 종양발육(腫瘍發育)에 미치는 xylazine의 효과(效果))

  • Kim, Tae-hwan;Lee, Cha-soo
    • Korean Journal of Veterinary Research
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    • v.31 no.3
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    • pp.343-353
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    • 1991
  • In order to investigate the histopathological, mechanism of Rompun-induced shock, the development of mammary carcinoma, the numerical changes and the morphological findings of the mast cells appeared in the carcinoma were microscopically observed in the rat treated with DMBA and each chemical of compound 48/80 and Rompun. Also mast cell degranulation induced by Rompun was observed with electron microscope. The results observed were summarized as follows: Tumor appeared in 100% of the animals. Tumors grew more rapidly to $10{\times}10mm$ in rats depleted of mast cells ($37.7{\pm}4.2$ days) than was observed in the control group ($42.5{\pm}4.7$ days) (p<0.005). The mean number of tumors per rat was $2.8{\pm}1.3$ in the compound 48/80- treated group in contrast to $3.4{\pm}1.3$ in the control group. No significant difference was apparent in the tumor induction time of Rompun treated group compared with the compound 48/80-treated group, but the tumor measuring at least $10{\times}10mm$ appeared more quickly in the Rompun treated group than in the control group (p<0.005). The numbers of mast cells in the control group were inclined to increase significantly according to the mammary tumor development (p<0.005). In contrast, the mast cells were fewer significantly in the compound 48/80-treated group and Rompun-treated group than in the control group (p<0.005). The numbers of mast cells in the compound 48/80-treated group and Rompun-treated group were inclined to reduce significantly according to the stages of the mammary carcinoma growth in contrast to the control group respectively. The ultrastructural morphologies of mast cells at 30 minutes after Rompun injection were appeared many normal granules in the cytoplasm, but many normal and degranulated granules were scattered along the cell membrane. And at 1 hour after Rompun injection mast cell granules were disappeared nearly or rarely seen. many long cytoplasmic projections were folded back to adhere to their own surface membrane. and mast cells resulted in a reduced size of these cells. Otherwise. compound 48/80 caused extensive degranulation of mast cells by disrupting cell membrane. but mast cell degranulation by Rompun was observed exocytosis of granules through a channel. From the above results. it is concluded that the Rompun may give rise to the dealth of animals as a shock caused by mast cell degranulation.

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Surface Modification of Li Metal Electrode with PDMS/GO Composite Thin Film: Controlled Growth of Li Layer and Improved Performance of Lithium Metal Battery (LMB) (PDMS/GO 복합체 박막의 리튬 금속 표면 개질: 리튬전극의 성장 제어 및 리튬금속전지(LMB) 성능 향상)

  • Lee, Sanghyun;Seok, Dohyeong;Jeong, Yohan;Sohn, Hiesang
    • Membrane Journal
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    • v.30 no.1
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    • pp.38-45
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    • 2020
  • Although Lithium metal battery (LMB) has a very large theoretical capacity, it has a critical problem such as formation of dendrite which causes short circuit and short cycle life of the LMB. In this study, PDMS/GO composite with evenly dispersed graphene oxide (GO) nanosheets in poly (dimethylsiloxane) (PDMS) was synthesized and coated into a thin film, resulting in the effect that can physically suppress the formation of dendrite. However, PDMS has low ion conductivity, so that we attained improved ion conductivity of PDMS/GO thin film by etching technic using 5wt% hydrofluoric acid (HF), to facilitate the movement of lithium (Li) ions by forming the channel of Li ions. The morphology of the PDMS/GO thin film was observed to confirm using SEM. When the PDMS/GO thin film was utilized to lithium metal battery system, the columbic efficiency was maintained at 87.4% on average until the 100th cycles. In addition, voltage profiles indicated reduced overpotential in comparison to the electrode without thin film.

A Basic Study on Micro-Electric Potential accompanied with Specimen Failure during Uniaxial Compressive Test (일축 압축에 의한 시료 파괴 시 수반되는 미소 전위에 대한 기초 연구)

  • Kim, Jong-Wook;Park, Sam-Gyu;Song, Young-Soo;Sung, Nak-Hun;Kim, Jung-Ho;Cho, Seong-Jun
    • Geophysics and Geophysical Exploration
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    • v.10 no.3
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    • pp.203-210
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    • 2007
  • As a part of basic studies on monitoring of landslides and slope stability using SP measurements, micro-electric potentials of rock samples were measured accompanied with the rock failure by a uniaxial loading test were measured. The measurement system consists of a 8 channel A/D converter with 24 bit resolution, uniaxial loading tester, strain gages and 4 sets of electrode attached to a rock sample. Rock samples of granite, limestone, and sandstone were tested. Also, mortar samples were tested in order to monitor electric-potentials of a uniform sample. Micro-electric potentials were detected in all saturated samples and the strength of them increased as the loading force increased. Sandstone samples showed the largest strength of micro-electric potential and it followed limestone and granite samples, which indicates a positive relationship with porosity of rocks. The mechanism generating these micro-electric potential can be explained in terms of electro-kinetics. In case of dry samples, micro-electric potential could be observed only in sandstone samples, where piezoelectric effect played main role due to high contents of quartz in sandstone samples. We found that biggest micro-electric potentials were observed at the electrodes near the crack surface of rock samples. This is very encouraging result that SP monitoring can be applied to predicting landsliding or to estimate collapsing position combining with monitoring of acoustic emissions.

New Sidelobe Canceller for 3-D Phased Array Radar in Strong Interference (강한 간섭 신호를 제거하기 위한 3차원 위상배열 레이다용 새로운 부엽제거기)

  • Cho, Myeong-Je;Han, Dogn-Seog;Jung, Jin-Won;Kim, Soo-Joong
    • Journal of the Korean Institute of Telematics and Electronics S
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    • v.35S no.10
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    • pp.144-155
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    • 1998
  • The array weights that will maximize the SNR for any type of noise environment are determined by the function of the antenna design configuration and the directions of receiving target and interference signals. The conventional SLCs(sidelobe cancellers) using the SNR maximization perform worst from the saturation of the receiving system of main channel when the main antenna has pattern with high gain at the arrival angle of strong interference. In this paper, the new SLC is accomplished by using two independent antenna architecture. Main antenna is implemented with adaptive nulling, which is used for rejecting high-power interference primarily. Auxiliary antenna is realized with adaptive array for receiving interference signal to be suppressed completely, which has a characteristics of sufficient gain for every direction. The new SLC is implemented with above both antennas. We show that the new SLC, which consists of the adaptive nulling main antenna and the adaptive array auxiliary antenna, is useful in reducing the effect of strong interference like jammer, because the adaptive nulling at main antenna prevents its receiver and signal processor for saturation by strong interference. The proposed SLC has improved SNR over the conventional SLCs. The improved SNR at sidelobe region is typically more than 7 dB for a given test signal. Moreover, it improves the SNR of about 20 dB under strong interference at mainlobe.

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Laver(Kim) Thickness Measurement and Control System Design (해태(김)두께측정 및 조절 장치 설계)

  • Lee, Bae-Kyu;Choi, Young-Il;Kim, Jung-Hwa
    • Journal of the Institute of Electronics and Information Engineers
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    • v.50 no.11
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    • pp.226-233
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    • 2013
  • In this study, In Laver's automatic drying device, laver thickness measurement and control devices that are associated with. Disconnect the water and steam, after put a certain amount of the mixture(water and laver) in the mold. In process, Laver of the size and thickness (weight) to determine, constant light source to detect and image LED Lamp occur Vision Sensor (Camera) prepare, then the values of these state of the image is transmitted in real time embedded computers. Built-in measurement and control with the purpose of the application of each of the channels separately provided measurements are displayed on a monitor, And servo signals sent to each of the channels and it become so set function should be. In this paper, the laver drying device, prior to the laver thickness measurement and control devices that rely on the experience of existing workers directly laver manually adjust the thickness of the lever, but the lever by each channel relative to the actuator by installing was to improve the quality. In addition, The effect of productivity gains and labor savings are.

Effect of Clamping Pressure on Surface Properties of Gas Diffusion Layer in PEFCs (체결압이 고분자연료전지 기체확산층의 표면성질에 미치는 영향)

  • Ahn, Eun-Jin;Park, Gu-Gon;Yoon, Young-Gi;Park, Jin-Soo;Lee, Won-Yong;Kim, Chang-Soo
    • Journal of the Korean Electrochemical Society
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    • v.10 no.4
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    • pp.306-310
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    • 2007
  • Characteristics of GDL (Gas Diffusion Layer) mainly determine the gas diffusion and water removal in a cell, thereby changing the performance and affecting durability of PEFC. To optimize the water management and understand the two phase flow in a GDL, it is important to study the behaviors of GDL micro structure under the real operating condition. In the clamped condition of cell, the GDL beneath the rib is more compressed than beneath the channel. Many researches on physical, electrochemical, mechanical behaviors of gas diffusion layer has been conducted. However, changes in surface properties under clamped condition have rarely studied. In present study, the morphology of broken connections of carbon fibers and detachment of PTFE coatings on the fibers were shown from the microscopic observations. In addition, changes in wetting properties of GDL by compression were investigated by using XPS and liquid uptake methods. The hydrophobic characteristics of GDL surface beneath the rib of the flow field plate are changed due to the deformation of micro structure.

Time-split Mixing Model for Analysis of 2D Advection-Dispersion in Open Channels (개수로에서 2차원 이송-분산 해석을 위한 시간분리 혼합 모형)

  • Jung, Youngjai;Seo, Il Won
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.33 no.2
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    • pp.495-506
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    • 2013
  • This study developed the Time-split Mixing Model (TMM) which can represent the pollutant mixing process on a three-dimensional open channel through constructing the conceptual model based on Taylor's assumption (1954) that the shear flow dispersion is the result of combination of shear advection and diffusion by turbulence. The developed model splits the 2-D mixing process into longitudinal mixing and transverse mixing, and it represents the 2-D advection-dispersion by the repetitive calculation of concentration separation by the vertical non-uniformity of flow velocity and then vertical mixing by turbulent diffusion sequentially. The simulation results indicated that the proposed model explains the effect of concentration overlapping by boundary walls, and the simulated concentration was in good agreement with the analytical solution of the 2-D advection-dispersion equation in Taylor period (Chatwin, 1970). The proposed model could explain the correlation between hydraulic factors and the dispersion coefficient to provide the physical insight about the dispersion behavior. The longitudinal dispersion coefficient calculated by the TMM varied with the mixing time unlike the constant value suggested by Elder (1959), whereas the transverse dispersion coefficient was similar with the coefficient evaluated by experiments of Sayre and Chang (1968), Fischer et al. (1979).

Phosphorylation as a Signal Transduction Pathway Related with N-channel Inactivation in Rat Sympathetic Neurons (N형 칼슘통로 비활성화와 연계된 세포 신호전달 체계로서의 인산화과정)

  • Lim Wonil;Goo Yong Sook
    • Progress in Medical Physics
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    • v.15 no.4
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    • pp.220-227
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    • 2004
  • In N-type $Ca^{2+}$ channels, the mechanism of inactivation - decline of inward current during a depolarizing voltage step- is still controversial between voltage-dependent inactivation and $Ca^{2+}$ -dependent inactivation. In the previous paper we demonstrated that fast component of inactivation of N-type calcium channels does not involve classic $Ca^{2+}$ -dependent mechanism and the slowly inactivating component could result from a $Ca^{2+}$ -dependent process. However, there should be signal transduction pathway which enhances inactivation no matter what the inactivation mechanism is. We have investigated the effect of phosphorylation on calcium channels of rat sympathetic neurons. Intracellular dialysis with the phosphatase inhibitors okadaic acid markedly enhanced the inactivation. The rapidly inactivating component is N-type calcium current, which is blocked by $\omega$-conotoxin GVIA. Staurosporine, a nonselective protein kinase inhibitor, prevented the action of okadaic acid, suggesting that protein phosphorylation is involved. More specifically lavendustin C, inhibitor of CaM kinase II, prevented the action of okadaic acid, suggesting that calmodulin dependent pathway is involved in inactivation process. It is not certain to this point whether phosphorylation process is inactivation itself. Molecular biological research regarding binding site should be followed to address the question of how the divalent cation binding site is related to phoshorylation process.

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Enhancement of the Detection Probability for Distributed Cooperative Spectrum Sensing using UWB as a Common Channel (UWB 신호채널을 사용한 분산협력 스펙트럼 센싱의 검출확률 향상)

  • Islam, A.B.M.Tariqul;Song, Ju-Bin
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.45 no.7
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    • pp.22-31
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    • 2008
  • Cognitive radio should imply a proper sensing technique for detecting the presence of licensed users to identify the unused spectrum holes. Besides this, this information should also be used to opportunistically provide communication among secondary users. At the same time the performance of the primary user should not be declined by the secondary users. The detection of licensed users may be significantly difficult for shadowing effect. To prevail over this problem cooperative spectrum sensing, In which the combined observation information gained by multiple secondary users is employed to achieve higher performance of detection, has been inspected. However, the primary challenge of cooperative sensing lays in its ability to detect the presence of licensed user quickly and accurately. In this paper, we have used UltraWideBand (UWB) to detect the presence of licensed users and transmit the sensing information among the nodes of the network. UWB has the capability of transmitting data at a very high rate. It is unique in co-existence capability with narrow band systems. Here, we have shown that the detection probability of licensed user is improved by means of transmitting the spectrum sensing information via UWB. We also have analyzed the throughput of the proposed technique and compared the result with existing sensing method.

Possible Causes of Paleosecular Variation and Deflection of Geomagnetic Directions Recorded by Lava Flows on the Island of Hawaii

  • Czango Baag
    • Proceedings of the International Union of Geodesy And Geophysics Korea Journal of Geophysical Research Conference
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    • 2003.05a
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    • pp.20-20
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    • 2003
  • In the summers of 1997 and 1998 and in February of 2000 we made 570 measurements of the ambient geomagnetic field 120 cm above the pavement surface of State Route 130, south of Pahoa, the island of Hawaii using a three-component fluxgate magnetometer. We measured at every 15.2 m (50 feet) interval covering a distance of 6, 310 m (20, 704 ft) where both historic and pre-historic highly magnetic basalt flows underlie. We also collected 197 core samples from eight road cuts, 489 specimens of which were subject to AF demagnetizations at 5 - 10 mT level up to a maximum field of 60 mT. We observed significant inclination anomalies ranging from a minimum of $31^{\circ}$ to a maximum $40^{\circ}$ where a uniform inclination value of $36.7^{\circ}$ (International Geomagnetic Reference Field, IGRF) was expected. Since the mean of the observed inclinations is approximately $35^{\circ}$ we assume that the study area is slightly affected by the magnetic terrain effect to a systematically shallower inclinations for being located in the regionally sloping surface of the southern side of the island (Baag, et al., 1995). We observed inclination anomalies showing wider (spacial) wavelength (160 - 600 m) and higher amplitudes in the historic lava flows area than in the northern pre-historic flows. Our observations imply that preexisting inclination anomalies such as those that we observed would have been interpreted as paleosecular variation (PSV). These inclination anomalies can best be attributed to concealed underground highly magnetic dikes, channel type lava flows, on-and-off hydrothermal activities through fissure-like openings, etc. Both the within- and between-site dispersions of natural remanent magnetization (NRM) are largest (up to ${\pm}7^{\circ}$) above the flows of 1955, while the area of pre-historic flows in the northern part of the study area exhibit the smallest dispersion. Nevertheless, mean inclinations of each historic flow of 1955 and 1790 are almost identical to that of the corresponding present field, whereas mean of NRM (after AF demagnetization) inclinations for each of the four pre-historic lava flow units is twelve to thirteen degrees lower than the present field inclination. We observed three cases of very large inclination variations from within a single flow, the best fitting curves of which are linear, second and third order polynomials each from within a single flow, whereas no present field variations are observed. This phenomena can be attributed to the notion that local magnetic anomalies on the surface of an active volcano are not permanent, but are transient. Therefore we believe that local magnetic anomalies of an active volcano may be constantly modified due to on going subsurface injections and circulations of hot material and also due to wide spacial and temporal distribution of highly magnetic basaltic flows that will constantly modify the topography which will in turn modify the local ambient geomagnetic field (Baag, et al., 1995). Our observations bring into question the general reliability of PSV data inferred from volcanic rocks, because on-going various geologic and geophysical activities associated with active volcano would continuously deflect and modify the ambient geomagnetic field.

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