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Response Prediction after Neoadjuvant Chemotherapy for Colon Cancer Using CT Tumor Regression Grade: A Preliminary Study (대장암 환자의 수술 전 항암화학요법의 반응을 CT 종양퇴행등급을 이용한 반응 예측: 예비 연구)

  • Hwan Ju Je;Seung Hyun Cho;Hyun Seok Oh;An Na Seo;Byung Geon Park;So Mi Lee;See Hyung Kim;Gab Chul Kim;Hunkyu Ryeom;Gyu-Seog Choi
    • Journal of the Korean Society of Radiology
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    • v.84 no.5
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    • pp.1094-1109
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    • 2023
  • Purpose To investigate whether CT-based tumor regression grade (ctTRG) can be used to predict the response to neoadjuvant chemotherapy (NAC) in colon cancer. Materials and Methods A total of 53 patients were enrolled. Two radiologists independently assessed the ctTRG using the length, thickness, layer pattern, and luminal and extraluminal appearance of the tumor. Changes in tumor volume were also analyzed using the 3D Slicer software. We evaluated the association between pathologic TRG (pTRG) and ctTRG. Patients with Rödel's TRG of 2, 3, or 4 were classified as responders. In terms of predicting responder and pathologic complete remission (pCR), receiver operating characteristic was compared between ctTRG and tumor volume change. Results There was a moderate correlation between ctTRG and pTRG (ρ = -0.540, p < 0.001), and the interobserver agreement was substantial (weighted κ = 0.672). In the prediction of responder, there was no significant difference between ctTRG and volumetry (Az = 0.749, criterion: ctTRG ≤ 3 for ctTRG, Az = 0.794, criterion: ≤ -27.1% for volume, p = 0.53). Moreover, there was no significant difference between the two methods in predicting pCR (p = 0.447). Conclusion ctTRG might predict the response to NAC in colon cancer. The diagnostic performance of ctTRG was comparable to that of CT volumetry.

Recovery Pattern of Abdominal Eat, Visceral Organs, and Muscle Tissues in Induced Molting Hens (강제환우계에서 복강지방, 장기, 근육조직의 변화)

  • M. Akram;rahman, Zia-ur;Park, J.H.;M.S. Ryu;C.S. Na;K.S. Ryu
    • Korean Journal of Poultry Science
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    • v.29 no.4
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    • pp.237-241
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    • 2002
  • To observe the effect of Induced molting on the recovery patterns of abdominal fat, visceral organs, and muscle tissues in spent laying hens after induced molting, three hundred sixty 77-wk-old, Babcock White hens were divided into 36 experimental units of 10 hens each and subjected to molt induction for seven wk. The post-molt production phase was spread over 84 to 126 wks of age. Thirty-six birds were randomly slaughtered and dressed at the pre-molt, 5% egg production, Peak, and end Phases of e99 Production. The body weight, abdominal fat, relative weight and length of visceral organs were measured. Proximate compositions of breast and thigh muscles were analyzed at each stage. The body weight was found to be minimal at the 5% egg Production stage, but increased as the egg Production increased for the rest of production. The pattern of abdominal fat change was very similar to that of body weight. The relative weight of the liver decreased to the lowest at the start of Post molting stage, but Peaked at the end Phase of egg Production (P<0.05). However, he heart and gizzard were observed to reach their maximum weight at the 5% egg Production (P<0.05), whereas they were, similar to those of the pre-molt phase for the rest of the production stages. Both intestine and reproductive tracts were found o be significantly smaller at 5% egg Production than at the other stages; however, their sizes increased gradually, reaching leak at the end Phase of e99 Production (P<0.05). Fat contents in breast and thigh muscles decreased significantly to the lowest at the start of the Post-molt stage, but increased to the highest at the end Phase of e99 Production (P<0.05). Thus, he Present study indicated that the molting process reduced body weight by decreasing the weights of abdominal fat and other visceral organs. Molting also influenced the breast and thigh muscle composition by decreasing fat content.

The Construction and Application of Planning Support System for the Sustainable Urban Development (지속가능한 도시개발을 위한 계획지원시스템의 구축과 활용에 관한 연구)

  • Lee, Hee-Yeon
    • Journal of the Korean Geographical Society
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    • v.42 no.1 s.118
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    • pp.133-155
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    • 2007
  • The sustainable urban development has emerged as a new paradigm of urban studies in recent years. A review of the literature of land use and transport policies in relation to sustainable development reveals a consensus that the main objectives of sustainable strategy should decrease the numbers and length of journeys, and change the land use pattern towards mixed use and high density. However, there is a lack of empirical research as to what types of policies might influence effectively the reduction in the energy consumption and emission of $CO_2$. in order to sustain urban development. This paper tries to construct the conceptual structure of the PSS(planning support system), which is designed to the simulation of the probable effects of policies and planning of different kinds in cities, and evaluate the sustainablilty level according to construct the structure of the PSS(planning support system), which is designed to the simulation of the probable effects of policies and planning of different kinds in cities, and evaluate the sustainablilty level according to the alternative scenarios. The PSS is composed of three components (input-modeling-output). The core of PSS is integrating land use-transport-environment modeling. The advantages of integrating land use-transport-environment modeling are well known, but there are very few such integrated modeling packages in practice. So this paper tries to apply TRANUS software, which is an integrated land use and transport model. The TRANUS system was calibrated to city of Yongin for the base year. The purpose of the application of TRANUS to Yongin is to examine the operability of TRANUS system in Korea. From the outputs and results of operating the system, TRANUS may be effectively used to evaluate the effects of alternative sustainable urban development policies, since sustainablilty indicators can be extracted from several aspects such as land use consumption, total trips, distance and cost, energy consumption, ratio of transport split.

Morphometric Characterization of Newly Defined Subspecies Apis cerana koreana (Hymenoptera: Apidae) in the Republic of Korea (국내 토종벌(Apis cerana koreana) 아종의 형태적 특성 분석)

  • Olga, Frunze;Jung-Eun, Kim;Dongwon, Kim;Eun-Jin, Kang;Kyungmun, Kim;Bo-Sun, Park;Yong-Soo, Choi
    • Korean journal of applied entomology
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    • v.61 no.3
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    • pp.399-408
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    • 2022
  • There has been much debate on the morphometric divergence between the recently identified Apis cerana koreana and Apis cerana honey bees. The aim of this study was to obtain phenotypic information that can be used to compare A. c. koreana data with other A. cerana subspecies data from open resources and determine breeding results on the basis of morphometric traits. To differentiate A. c. koreana, we investigated 22 classic morphological characteristics; royal jelly secretion; and the weight of workers, queens, and drones of A. c. koreana bred in Korea. To define the selection results, we used the geometric morphometric method. The artificially selected A. c. koreana secreted significantly more royal jelly (1.18 times) than the naturally selected A. c. koreana, which positively influenced the health of the colonies. These honey bees were identified more clearly with the geometric morphometric method than with the classic morphometric method, which is traditionally used to determine the subspecies. Large trends were noted for A. c. koreana on the basis of our results and literature from the 1980s regarding A. cerana sizes in Korea (tarsal index, length of forewing, and cubital index were measured). The cluster analysis revealed the proximity of A. c. koreana, A. cerana in China, and A. c. indica on the basis of eight classic characters, which, perhaps, relay the origin of the honey bees. The results of this study defined the morphometric responses of A. c. koreana honey bees to geographic isolation, climate change, and selection, which are important to identify, protect, and preserve honey bee stock in Korea.

Clinical Outcome of Multicystic Dysplastic Kidney in 46 Children (다낭성 이형성 신 환아 46명의 예후와 관련한 임상적 고찰)

  • Jeong Il-Cheon;Hwang You-Sik;Ahn Sun-Young;Han Sang-Won;Lee Jae-Seung
    • Childhood Kidney Diseases
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    • v.10 no.1
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    • pp.27-32
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    • 2006
  • Purpose : Conservative management of multicystic dysplastic kidney(MCDK) without nephrectomy has recently been advocated. The purpose of this study was to determine the clinical course of conservatively managed MCDK and to find out possible predictive factors for involution of MCDK by ultrasonography(US). Methods : A retrospective analysis was made on 45 patients(26 boys and 20 girls) in whom MCDK was detected and had been traced by US between Dec. 1993 and Aug. 2005 at Severance Hospital. Results : Median follow-up time was 30 months(range 2-102 months). All patients under-went radionuclide scans and voiding eystourethrograms. The serial follow-up US showed complete involution in 11(24%), partial involution in 19(41%), and no interval change or increased in cyst size in 13(28%) patients. Nephrectomy was done in 3 patients(7%) due to relapsing urinary tract infection(UTI) and severe abdominal distension. The mean age of complete involution of MCDK was 37 months(range 12-84 months). Episodes of UTI were present in 17 patients(37%) and additional genitourinary(GU) abnormalities were found in 22 patients(44%). Hypertension and renal insufficiency was complicated in one patient. No child developed malignant tumor. Univariate analysis showed that five variables were associated with complete involution of the MCDK; gender, site, UTI episode, additional GU abnormalities, and renal length on initial US. After adjusting using the Pearson model, the presence of additional GU abnormalities was exclusively associated with complete involution among the 5 variables(P=0.034). Conclusion : In our review of 46 cases of MCDK, non-surgical approach for patients with MCDK was advisable and we could predict poor prognosis when MCDK is associated with other GU anomalies.

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A study on the simulation method for the flushing flowrate and velocity in the watermain using a hydrant and a drain valve (소화전과 이토변을 이용한 플러싱 적용 시 관 내 세척유량과 유속 모의 방안에 관한 연구)

  • Gim, ARin;Lee, Eunhwan;Lee, SongI;Kim, kwang hyun;Jun, Hwandon
    • Journal of Korea Water Resources Association
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    • v.55 no.spc1
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    • pp.1251-1260
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    • 2022
  • Recently, due to the deterioration of watermains and the detachment of scale which is accumulated on the watermain surface, water quality accidents in a water supply network occur frequently. As scale accumulated on watermains is stabilized, it may not cause water quality accidents under the normal operating condition. However, due to water hammer or transient flow caused by the abrupt velocity and/or direction of flow change, it can be detached from the watermain surface resulting in water quality accidents. To prevent these kinds of water quality accidents, it is required to remove scale by watermain cleaning regularly. Many researches about flushing which is the most popular water cleaning method are focused on the desirable velocity criteria and the cleaning condition to accomplish the effect of flushing whereas less amount of research effort is given to develop a method to consider whether the desirable velocity for flushing can be obtained before flushing is performed. During flushing, the major and minor headloss is occurred when flushing water flows through a hydrant or drain valve. These headloss may slow down the velocity of flushing water so that it can reduce the flushing effect. Thus, in this study, we suggest a method to simulate the flow velocity of flushing water using "MinorLoss Coefficient" and "Emitter Coefficient" in EPANET. The suggested method is applied to a sample network and the water supply network of "A" city in Korea to compare the flushing effect between "flushing through a hydrant" and "flushing through a drain valve". In case of "flushing through a hydrant", if the hydraulic condition ocurring from a watermain pipe connecting to the inlet pipe of a hydrant to the outlet of a hydrant is not considered, the actual flowrate and velocity of a flow is less than the simulated flowrate and velocity of a flow. In case of "flushing through a drain valve", the flushing velocity and flowrate can be easily simulated and the difference between the simulated and the actual velocity and flowrate is not significant. Also, "flushing through a drain valve" is very effective to flushing a long-length pipe section because of its efficiency to obtain the flushing velocity. However, the number and location of a drain valve is limited compared to a hydrant so that "flushing through a drain valve" has a limited application in the field. For this reason, the engineer should consider various field conditions to come up with a proper flushing plan.

Comparison on Physicochemical and Cooking Properties of Milled Kernel in Waxy Corn Hybrids (찰옥수수쌀의 품종별 이화학특성 및 취반특성)

  • Lee, Yu Young;Lee, Choon-Ki;Lee, Jin-Suk;Kim, Mi-Jung;Kim, Sun-Lim;Kim, Yul-Ho;Park, Hyang Mi;Kim, Wook-Han;Kwon, Young-Up;Kim, Sung Kook
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.58 no.4
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    • pp.424-431
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    • 2013
  • Consumption of waxy corn is steadily increasing due to consumer preference for natural food. However, availability of waxy corn is limited because most of them are used for steamed waxy corn. It is therefore important to create new demands of waxy corn using food processing technology. There is little prior research about characteristics of milled kernel in waxy corn. This study examined the physicochemical and cooking properties of milled kernel using nine waxy corn hybrids. Colored hybrids (Heukjinju, Miheukchal, and Eolrukchal1) showed high milling yield and low change of grain length after milling process compared to other hybrids. The total starch content ranged from 62.1 to 68.4% and the gelatinization temperature of starch was lowest in Yeonnong1 ($69.9^{\circ}C$). The breakdown viscosity of Yeonnong1, Miheukchal and Heukjinju was higher than those of tested hybrids, whereas setback viscosity of those hybrids was lower. In cooking properties of milled waxy corn, water absorption and volume expansion rate were high in Yeonnong2 (84.9, 219.3%), Miheukchal (85.9, 211.4%), and Heukjinju (80.9, 203.7%). In the sensory test, the overall preference was significantly higher in Heukjinju and Miheukchal. Thus, Heukjinju, Yeonnong2, and Miheukchal showed good scores in milling yield, cooking properties, and the preference of sensory test. These results will provide fundamental information to extend milled waxy corns usage.

Mapping Precise Two-dimensional Surface Deformation on Kilauea Volcano, Hawaii using ALOS2 PALSAR2 Spotlight SAR Interferometry (ALOS-2 PALSAR-2 Spotlight 영상의 위성레이더 간섭기법을 활용한 킬라우에아 화산의 정밀 2차원 지표변위 매핑)

  • Hong, Seong-Jae;Baek, Won-Kyung;Jung, Hyung-Sup
    • Korean Journal of Remote Sensing
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    • v.35 no.6_3
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    • pp.1235-1249
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    • 2019
  • Kilauea Volcano is one of the most active volcano in the world. In this study, we used the ALOS-2 PALSAR-2 satellite imagery to measure the surface deformation occurring near the summit of the Kilauea volcano from 2015 to 2017. In order to measure two-dimensional surface deformation, interferometric synthetic aperture radar (InSAR) and multiple aperture SAR interferometry (MAI) methods were performed using two interferometric pairs. To improve the precision of 2D measurement, we compared root-mean-squared deviation (RMSD) of the difference of measurement value as we change the effective antenna length and normalized squint value, which are factors that can affect the measurement performance of the MAI method. Through the compare, the values of the factors, which can measure deformation most precisely, were selected. After select optimal values of the factors, the RMSD values of the difference of the MAI measurement were decreased from 4.07 cm to 2.05 cm. In each interferograms, the maximum deformation in line-of-sight direction is -28.6 cm and -27.3 cm, respectively, and the maximum deformation in the along-track direction is 20.2 cm and 20.8 cm, in the opposite direction is -24.9 cm and -24.3 cm, respectively. After stacking the two interferograms, two-dimensional surface deformation mapping was performed, and a maximum surface deformation of approximately 30.4 cm was measured in the northwest direction. In addition, large deformation of more than 20 cm were measured in all directions. The measurement results show that the risk of eruption activity is increasing in Kilauea Volcano. The measurements of the surface deformation of Kilauea volcano from 2015 to 2017 are expected to be helpful for the study of the eruption activity of Kilauea volcano in the future.

Effects of Exogenous Thyroid Hormone $(T_3)$ on Skeletal Development and Physiological Conditions of Juvenile Black Seabream (Acanthopagrus schlegeli) (감성돔(Acanthopagrus schlegeli) 치어의 골격발달 및 생리적 조건에 미치는 외인성 갑상선호르몬$(T_3)$의 영향)

  • KANG Duk-Young;CHANG Young Jin
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.30 no.2
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    • pp.305-312
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    • 1997
  • Juveniles of black seabream, Acanthopagrus schlegeli were fed with the diets containing 0, 10, 20, 50 and 100 ppm of 3,5,3'-triiodo-1-thyronine $(T_3)$ respectively to assess the effect of this hormone on skeletal development and the change of physiological conditions for 50 days. $(T_3)$ treatment lasted for initial 40 days. Fish were fed the prescribed diet by hand to satiation in $2\~4$ times per day. After an initial 40 days period, skeletal development and abnormality were examined, and after a 50 days period, food intake, hepatosomatic index (HSI), thyroid cell height (TCH) and body proximate composition were also examined. Although toed intake was not different among 0, 10 and 20 ppm, the food intake of black seabream fed with the diets containing 50 and 100 ppm of $T_3$was significantly lower than those of 10 ppm. After the initial 40 days of $T_3$ administration, $T_3$ increased the relative growth of operculum, head, caudal fin and pectoral fin to body length, resulting in severe morphological abnormalities at the highest dose. Black seabream treated with 50 and 100 ppm of $T_3$ had abnormal shapes such as lordosis and opercular curl. The HSI parameters were reversely correlation with the dietary concentration of $T_3$. After the initial 40 days of this experiment, atrophy of thyroid gland was observed in fish administered with 50 and 100 ppm of $T_3$. On the 50th day of this experiment, atrophy of thyroid gland was observed only in the group administered with 100 ppm of $T_3$, and no difference was observed on TCH among the rest fours of experimental groups. At the end of the experiment the whore body proximate analyses indicated that there were significant effects of $T_3$ level on moisture, protein, lipid and ash contents.

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Airway size in malocclusions with hyperdivergent skeletal pattern (개방교합성 골격헝태를 갖는 부정교합자의 기도크기)

  • Kwak, So-Yeong;Kim, Hyo-Young;Jeon, Young-MI;Kim, Jong-Ghee
    • The korean journal of orthodontics
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    • v.33 no.4 s.99
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    • pp.293-305
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    • 2003
  • The pharynx have significant locations and functions because it forms a part of the unit in which respiration and deglutition are carried out. Because of the closed relationship between the pharynx and the dentofacial and craniofacial structure, many studies are carried out on this subjects. The purpose of this study were to compare the airway size including pharynx, soft palate, tongue and hyoid bone between normal and hyperdivergent skeletal pattern and to evaluate the change of those size in different age. The sample of this study were consisted of 51 subjects in normal group, 52 subjects in hyperdivergent group. Each was divided into two subgroups by age , child group(9-l2yr old) and adult group(18yr old over). The lateral cephalometric radiographs were taken and the distance, angle and ratio of the facial skeleton, pharynx, soft palate, tongue and hyoid bone were measured and evaluated statistically. The result obtained were summarized as follows : 1 SN-Mn angle, FMA, and Pal-Mn angle were significantly larger in child group than adult group, but the lower anterior facial height(LAFH) and facial height ratio(FHR) were significantly smaller in child group than adult group. Occlu-Mn angle was significantly steep in hyperdivergent group than normal, but not significantly different between child group and adult group. 2. Hyperdivergent group and child group had the stronger correlation between SN-Mn angle, FMA, Pal-Mn angle, LAFH and FHR and airway size than normal group and adult group. Hyperdivevgent child group had significant negative correlation between SN-Mn angle, FMA, Pal-Mn angle and sagittal skeletal dimension of nasopharynx and sagittal depth of nasopharyngeal lumen. Significant positive correlation were seen between LAFH and vertical measurement of airway. 3. There was no difference of the linear measurement of airway size between hyperdivergent group and normal group. 4. Adult group had smaller posterior pharyngeal wall, target nasopharyngeal depth longer nasopharyngeal height and longer pharyngeal length than child group. 5. The sagittal measurement of hyoid bone had no difference between child group and adult group. But adult group had larger vertical measurement of hyoid bone than child group.