• Korean Journal of Veterinary Research
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• v.38 no.4
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• pp.946-956
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• 1998

Fifteen mongrel dogs (14 male and 1 female) were injected intravenously with 30mg of streptozotocin and 50mg of alloxan monohydrate per kilogram of body weight to induce diabetes mellitus. Before treatment with streptozotocin and alloxan fasting serum glucose concentration was determined every other day or thrice a week (Monday, Wednesday, Friday) for 3 months. Among 15 dogs 4 dogs developed diabetes mellitus and survived more than 9 weeks without injection of insulin. After treatment fasting serum glucose and hemoglobin $A_1$ concentrations of the 4 dogs were determined every other day or thrice a week. Fasting serum glucose concentration increased acutely from 24 hours after treatment and then showed severe fluctuation. Hemoglobin $A_1$ concentration increased gradually until 7~9 weeks after treatment and then showed very slow increase afterwards. Correlation of hemoglobin $A_1$ to fasting glucose concentration was relatively weak(r = 0.10~0.80). Hemoglobin $A_1$ and fasting glucose concentration of preceding 7 week showed very high correlation (r = 0.98~0.99). It was indicated that hemoglobin $A_1$ concentration in chemically induced diabetic dogs reflects mean glucose concentration of preceding 7~9 weeks.

• Journal of the Korean Society of Clothing and Textiles
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• v.23 no.7
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• pp.1064-1072
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• 1999

Nylon fabric was grafted for the purpose of the development of detergency against the hemoglobin as a protein soil. By free-radical producing chemical initiator systems the graft using acrylic acid(AA) as a hydrophilic vinyl monomer was performed to change surface energies in the presence of ammonium persulfate(APS) as an initiator and then acrylic acid grafted Nylon was treated with NaOH solution. The surface morphology for Nylon-g-NaAA with changing graft rate were studied by scanning electron microscopy (SEM) The properties of the Nylon such as diameter tenacity elongation contact angle and the hemoglobin removal were also investigated. The diameter of grafted Nylon fiber increased as the graft ratio increased. The tenacity of grafted Nylon also increased with increasing graft ratio up to 15% The elongation however decreased gradually according to graft, The contact angle decreased after graft and alkaline treatment. The amount of hemoglobin on the grafted Nylon increased in proportion to the graft ratio. Hemoglobin was easily removed from grafted Nylon while it was difficult to be removed from ungrafted Nylon. The detergency of hemoglobin for grafted Nylon decreased when the graft ratio exceeded 15% The removal of hemoglobin increased markedly with increasing hemoglobin content and revolution speed. Therefore the removal of hemoglobin was improved due to graft and alkaline treatment.

• Textile Coloration and Finishing
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• v.11 no.3
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• pp.41-48
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• 1999

The removal of hemoglobin from acrylic acid grafted Nylon fabrics has been investigated. In order to change detergency of Nylon 6 fabric, acrylic acid(AA) were graft copolymerized on Nylon fabric using ammonium persulfate(APS) as a initiator, and then acrylic acid grafted Nylon was treated with NaOH solution. The graft ratio increased linearly with increasing acrylic acid concentration. The graft ratio was the highest when the concentration of APS was 0.05%, and it decreased as the concentration of APS increased. The surface of Nylon fabric became rough due to graft. Moisture regain was increased by graft and alkaline treatment, contact angle was also improved compared with the ungrafted. The hemoglobin was easily solubilized and removed from grafted Nylon fabric, while it was difficult to remove hemoglobin from ungrafted Nylon fabric. The effects of graft on removal of hemoglobin was related with increase of moisture regain and transformation of COOH to COONa by alkaline treatment.

• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.208.2-208.2
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• 2016

Many researchers have paid attention to the studies on the interaction between non-thermal plasma and aqueous solutions for biomedical applications. The gas composition in the plasma is very important. Oxygen and nitrogen are the main gases of interest in biological applications. Especially, we focus on the oxygen concentration. In this experiment, we studied the role of oxygen concentration in plasma induced chemical reactions in solution. At first, the amount of ions are measured according to changing the oxygen concentration. And we checked the relationship between these ions and pH value. Secondly, when the oxygen concentration is changed, it identified the type and amount of radical generated by the plasma. In order to confirm the effect of these chemical property change to biological material, hemoglobin and RBCs are chosen. RBCs are one of the common basic biological cells. Thirdly, when plasma treated according to oxygen concentration in nitrogen feeding gas, oxidation of hemoglobin and RBC is checked. Finally, membrane oxidation of RBC is measured to examine the relation between hemoglobin oxidation and membrane damage through relative hemolysis and Young's modulus. Our results suggest that reactive species generated by the plasma differsdepending on the oxygen concentration changes. The pH values are decreased when oxygen concentration increased. OH decrease and NO increase are also observed. These reactive species makes change of chemical properties of solution. We also able to confirm that the difference in these reactive species to affect the oxidation of the Hb and RBCs. The Hb and RBCs are more oxidized with the high oxygen concentration conditions. But membrane is damaged more by plasma treatment with only nitrogen gas. It is shown that red blood cells membrane damage and oxidation of hemoglobin are not directly related.

• The Journal of Korean Medicine
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• v.23 no.1
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• pp.112-119
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• 2002

Objectives : Anemia is the center of interest in every maternity, both during pregnancy and lactation. The oriental postpartum care has one principle : to invigorate Qi and blood greatly. In this study, we seek to confirm that most sufferers of anemia recover under oriental postpartum care. To assure that this study had significance in non-iron supplement, we made a comparative study between oral iron supplement and non-iron supplement groups in oriental postpartum care. Methods : A comparative study was conducted to discern the difference in hemoglobin change between admission and after 2 weeks under the circumstances of 30 oral iron supplemented and 38 non-iron supplemented women who were admitted to the hospital attached to Woosuk University Oriental Medical College from April to August 2001 for postpartum care. Results : The mean hemoglobin level of after 2 weeks was 11.95 mg% (p<0.001). The mean hemoglobin level after 2 weeks was 11.65 mg% and 12.18 mg% in the iron supplemented and non-iron supplemented women respectively. The difference between the two groups was not significant. Conclusions : Oriental postpartum care overcomes anemia significantly in postpartum maternity. This is confirmed significantly under the non-iron supplement.

• Biomolecules & Therapeutics
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• v.2 no.4
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• pp.343-346
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• 1994

In vivo activity of recombinant human erythropoietin (rh-EPO) has been examined using polycythemic model in mice and acute hemorrhage model in rats. The number of reticulocytes in blood stream was increased after a single injection of rh-EPO depending on the dosage of rh-EPO in polycythemy model. It seemed that optimal dose of rh-EPO for polycythemic mice was around 1-10 U/kg. Rh-EPO also showed the effectiveness for increase of reticulocyte numbers both in male and female rats after bleeding. The number of reticulocytes and the change of hemoglobin concentration in the blood stream of normal rats has been examined after injection of rh-EPO. The maximum value of reticulocyte was observed on the 6th day of the injection in these normal rats. In addition, the increase of reticulocyte and the concentration of hemoglobin were dependent on the dosage of rh-EPO. The increase of hemoglobin concentration was continued to the 9th day after injection. In this study, the efficacy of rh-EPO was confirmed in both mice and rats.

• The Journal of Korean Medicine
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• v.20 no.1 s.37
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• pp.75-83
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• 1999

To investigate the effects of negative therapy at back meridian points on blood gas components and immune functions in male college students, this study was conducted on treatment types(abdomen group and back group) at three sampling times (before, post-2 wks and post-4 wks) by using $2{\times}3$ factoral design. Blood gas $components(pH,\;PCO_2,\;PO_2,\;HCO_3^-,\;O_2SAT,\;BE)$, red blood cell, hematocrit, hemoglobin, white blood cell and subsets(neutrophil, basophil, eosinophil. lymphocyte, monocyte), total T cells, helper T cells, suppressor T cells, Th/Ts ratio, total B cells, serum immunoglobulin levels (IgG, IgA, IgM, IgD, IgE), Cytokines(Interlukin$-1{\beta}$, -2, -4, 2 receptor, -6 and ${\gamma}$-interferon), NK cells were measured. Collected with data were analyzed statistically by repealed measured ANOVA. The pattern of change between two groups for hematocrit, hemoglobin, suppressor T cells, interleukin-6, ${\gamma}-interferon$, NK cells at post-2 weeks and BE, lymphocyte, basophil at post-4 weeks was significantly different(p<0.05) And also the pattern of change over time for ${HCO_3}^-$(2 wks vs 4 wks), WBC, neutrophil, lymphocyte(0 wks vs 2 wks and 2 wks vs 4 wks) was significantly different(p<0.05). In summary, these data suggest that negative therapy at back meridian points had an effect on blood gas components and immune functions in male college students because practicing negative therapy at back meridian points was not associated with changes of all blood gas components and immune factors but associated with changes of BE, hematocrit, hemoglobin, WBC. neutrophil, lymphocyte, interleukin-6. ${\gamma}-interferon$, NK cells.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.09a
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• pp.13-18
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• 2001

The ECMO system, including umbilical cord and membrane type oxygenator was connected with extracorporeal circulation unit, was applied to the fetus growth model of goat. The maximum survival time of goat fetus was 48 hours. Average blood rate for the extracorporeal circulation was $223{\pm}15.2 ml/min.$ The survival time of fetus was deeply related to body temperature, blood circulation and water temperature, anesthetized time, and fetus weights. Extern variables that are composed of anesthetized time, fetus weights, change of hemoglobin, circuit pressure, related to the survival time for fetus corrected the problem of previous ECMO model that is controlled by roller pump. It is directly delivered to heart on load. Applying the results from new ECMO model, further research will provide to the system of ECMO for human.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.61 no.7
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• pp.1049-1055
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• 2012

We measure the hemodynamic responses during the 4 kinds of tasks on the motor cortex in the right and left human brain by using near-infrared spectroscopy. The experimental results show that the change of concentration of oxy-hemoglobin is larger than that of deoxy-hemoglobin and the change of concentration of chromophores induced by finger and arm related task show more activations than that of leg.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.37 no.4
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• pp.272-277
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• 2011

Purpose: The aim of this study was to compare the estimated blood loss and determine the change in hemoglobin depending on the combination of each orthognathic surgery. Subjects and Methods: The subjects of this study were patients who underwent orthognathic surgery among those diagnosed with a dentofaical deformity in Mok-Dong hospital, Ewha Womans University from 2002 to 2009. One hundred patients (men - 36, women - 64, mean age of $24.5{\pm}4.6$) participated in the study and were divided into four groups (group 1 - bilateral sagittal ramus osteotomy [BSSRO], group 2 - BSSRO+Genioplasty, group 3 - Lefort 1+BSSRO+genioplasty, group 4 - anterior segmental osteotomy on maxilla and mandible). A comparative study on the estimated blood loss (EBL), operation time, peri-operative changes in hemoglobin was performed using anesthesia records. The results were analyzed statistically using a Mann-Whitney U-test and Spearman's Rho test - SPSS 12.0 (SPSS Inc. Chicago, IL, USA). Results: In group 1 (BSSRO), the mean EBL, operation time and change in hemoglobin was $394.43{\pm}52.69$ ml, $184{\pm}42.33$ minutes, and 1.43, respectively, In group 2 (BSSRO+genioplasty), it was $556.32{\pm}63.42$ ml, $231{\pm}37.45$ minutes, and 1.80, respectively. In group 3 (Lefort 1+BSSRO+Genioplasty), it was $820.55{\pm}105.54$ ml, $320{\pm}15.41$ minutes, and 2.73, respectively. In group 4 (segmental osteotomy), it was $1025.39{\pm}160.21$ ml, $355{\pm}20.10$ minutes, and 3.33, respectively. In particular, in group 3, significant differences were observed depending on the method of the orthognathic surgery. The mean EBL in a Lefort 1 osteotomy with advancement was only 687 ml, whereas Lefort 1 osteotomy with canting correction (992 ml), even impaction (764 ml), and posterior nasal spine impaction (100 ml) showed a much higher EBL. Conclusion: From these results, the EBL and peri-operation hemoglobin increased as treatment plans became more complicated and increasing operation time. Safe orthognathic surgery should be performed by applying proper autologous transfusion plans based on the average EBL of each orthognathic surgery type.