• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2935-2937
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• 2014

Studies of the causes of cancer, early detection, prevention or treatment need accurate, comprehensive, and timely cancer data. The clinical laboratory provides important cancer information needed for physicians which influence clinical decisions regarding treatment, diagnosis and patient monitoring. Poor communication between health care providers and clinical laboratory personnel can lead to medical errors and wrong decisions in providing cancer care. Because of the key impact of laboratory information on cancer diagnosis and treatment the quality of the tests, lab reports, and appropriate lab management are very important. A laboratory information management system (LIMS) can have an important role in diagnosis, fast and effective access to cancer data, decrease redundancy and costs, and facilitate the integration and collection of data from different types of instruments and systems. In spite of significant advantages LIMS is limited by factors such as problems in adaption to new instruments that may change existing work processes. Applications of intelligent software simultaneously with existing information systems, in addition to remove these restrictions, have important benefits including adding additional non-laboratory-generated information to the reports, facilitating decision making, and improving quality and productivity of cancer care services. Laboratory systems must have flexibility to change and have the capability to develop and benefit from intelligent devices. Intelligent laboratory information management systems need to benefit from informatics tools and latest technologies like open sources. The aim of this commentary is to survey application, opportunities and necessity of intelligent clinical laboratory as a tool to increase cancer care management productivity.

• Journal of the Korean Wood Science and Technology
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• 제44권2호
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• pp.231-240
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• 2016

The change in chemical compositions of leachate and medium density fiberboard (MDF) from a laboratory-scale simulated landfill which constructed in a plastic container containing alternating layers of soil and MDF was investigated to evaluate decomposing of MDF in soil. Four treatments were conducted: 1) MDF in soil, 2) MDF only, 3) cured UF resin in soil, and 4) soil only. Molecular weight (MW) distribution of compounds in leachate from soil only treatment did not change over time. In UF resin in soil treatment, the MW distribution shifted to a lower MW distribution over time, while the peak shifted to the left indicated changing to higher MW distribution in leachate from treatment 1 and 2 contained MDF. Higher percent nitrogen in leachate was observed in MDF containing treatments due to the UF resin in the MDF. The percent carbon slightly increased in MDF only while that greatly decreased in MDF in soil treatment maybe due to bacterial activity. The percent of extractable materials from the MDF decreased greatly on day 35 compare to day 0, and subsequently did not change much on day 77. In contrast, percent holocellulose and lignin did not change much over time. No structural change of the wood fiber in MDF occurs during the study. Water-soluble materials from MDF in soil contributed the change in chemical composition of leachate.

• ETRI Journal
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• 제29권6호
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• pp.811-813
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• 2007

We report on a ridge waveguide laser diode with laterally tapered waveguides fabricated in a single growing step using a double patterning method. In this structure, nearly constant output power is obtained with the change of the lower tapered waveguide width, and the facet power ratio of 1.4 to 1.5 is observed over the current range. The asymmetric facet power property is also investigated.

• Nuclear Engineering and Technology
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• 제46권2호
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• pp.147-158
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• 2014

In order to investigate how the microstructure of fuel/matrix-interaction (FMI) layers change during irradiation, different U-7Mo dispersion fuel plates have been irradiated to high fission density and then characterized using scanning electron microscopy (SEM). Specifially, samples from irradiated U-7Mo dispersion fuel elements with pure Al, Al-2Si and AA4043 (~4.5 wt.%Si) matrices were SEM characterized using polished samples and samples that were prepared with a focused ion beam (FIB). Features not observable for the polished samples could be captured in SEM images taken of the FIB samples. For the Al matrix sample, a relatively large FMI layer develops, with enrichment of Xe at the FMI layer/Al matrix interface and evidence of debonding. Overall, a significant penetration of Si from the FMI layer into the U-7Mo fuel was observed for samples with Si in the Al matrix, which resulted in a change of the size (larger) and shape (round) of the fission gas bubbles. Additionally, solid fission product phases were observed to nucleate and grow within these bubbles. These changes in the localized regions of the microstructure of the U-7Mo may contribute to changes observed in the macroscopic swelling of fuel plates with Al-Si matrices.

• ETRI Journal
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• 제31권1호
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• pp.62-64
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• 2009

We report on the bias stability characteristics of transparent ZnO thin film transistors (TFTs) under visible light illumination. The transfer curve shows virtually no change under positive gate bias stress with light illumination, while it shows dramatic negative shifts under negative gate bias stress. The major mechanism of the bias stability under visible illumination of our ZnO TFTs is thought to be the charge trapping of photo-generated holes at the gate insulator and/or insulator/channel interface.

• 한국입자에어로졸학회지
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• 제12권4호
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• pp.161-168
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• 2016

The purpose of this study is to determine the performance characteristics of the paint particulate and volatile organic compounds(VOCs) simultaneous removal from the spraying paint booth in the laboratory and real site by sticky paint particulate and VOCs simultaneous removal demonstration unit. The sticky paint particulate and VOCs simultaneous removal unit is composed of the horizontal type pleated filter modules and the zig-zag type granular activated carbon packing modules. The test conditions at the laboratory are $50.15g/m^3$ of average paint aerosol concentration and 300 ppm of VOCs concentration which were same as the working conditions of spraying paint booth in the real site. But, the demonstration conditions at the real site are varied according to the working condition of spraying paint booth for the kind of passenger car bodies. The test results at the laboratory obtained that 99% of total particulate collection efficiency at 0.62 m/min of filtration velocity and 84% at 1.77 m/min of filtration velocity. The VOCs removal efficiencies are 97% at $3500hr^{-1}$ of gas hour space velocity and 59% at $10,000hr^{-1}$ of gas hour space velocity. In the real site test, the average removal efficiency of PM10 was measured to be 99.65%, the average removal efficiency of PM2.5 was 99.38%, the average removal efficiency of PM1 was 98.52%, and the average removal efficiency of VOCs was 89%.

• 한국해양학회지:바다
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• 제5권3호
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• pp.208-215
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• 2000

한국 남해대륙붕에서의 물질순환을 이해하기 위해 남해연안의 보길도와 제주도를 잇는 제주해협에서 1997년부터 1999년까지 3년간 화학물질 플럭스에 대한 조사를 실시하였다. 제주해협의 입자성부유물질, 용존무기영양염류, 입자성유기탄소 및 질소는 전계절에 걸쳐 90% 이상이 동향류에 의해 황해 및 동중국해로부터 제주해협을 통해 남해로 유입된다. 제주해협을 통해 남해로 유입되는 화학물질들의 연간 플럭스는 부유물질이 22.9${\times}$10$^6$ ton yr$^{-1}$, 암모니움 이온은 0.52${\times}$10$^{10}$ mol yr$^{-1}$, 질산이온은 6.05${\times}$10$^{10}$ mol yr$^{-1}$, 인산이온은 0.36${\times}$10$^{10}$ mol yr$^{-1}$, 규산은 10.27${\times}$10$^{10}$ mol yr$^{-1}$이다. 해수수송량(Sv)당 입자성부유물질 연간 플럭스는 제주해협(44.48${\times}$10$^6$ ton yr$^{-1}$ Sv$^{-1}$)이 대한해협 (26.08${\times}$10$^6$ ton yr$^{-1}$ Sv$^{-1}$)보다 약 1.7배 크다. 또한 제주해협 통과 질산이온 연간 플럭스(11.60${\times}$10$^{10}$ mol yr$^{-1}$ Sv$^{-1}$)는 대한해협 (9.72${\times}$10$^{10}$ mol yr$^{-1}$ Sv$^{-1}$)보다 약 1.2배, 동중국해에서 쿠로시오에 의한 수송량(18.55${\times}$10$^{10}$ ton yr$^{-1}$ Sv$^{-1}$)에 비해서는 2/3 수준으로 높다. 결론적으로 풍부한 화학물질들을 함유한 제주해류는 남해 및 동해의 생지화학적 과정들에 있어 상당히 중요함을 시사한다.

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2003년도 추계학술대회
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• pp.163-163
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• 2003

• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 추계학술대회
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• pp.163-163
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• 2003

Difficulties of long-tenn survival of lung cancer patients treated with conventional therapies require the need for novel approaches and gene therapy holds promise in this area. Several genes are known to have anti-tumor activities and have been used as a gene of delivery, however, a number of problems such as efficiency, specificity of the gene delivery hinder the application of gene therapy.(omitted)

• BMB Reports
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• 제40권5호
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• pp.649-655
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• 2007

The nsp14 protein is an exoribonuclease that is encoded by severe acute respiratory syndrome coronavirus (SARS-CoV). We have cloned and expressed the nsp14 protein in Escherichia coli, and characterized the nature and the role(s) of the metal ions in the reaction chemistry. The purified recombinant nsp14 protein digested a 5'-labeled RNA molecule, but failed to digest the RNA substrate that is modified with fluorescein group at the 3'-hydroxyl group, suggesting a 3'-to-5' exoribonuclease activity. The exoribonuclease activity requires $Mg^{2+}$ as a cofactor. Isothermal titration calorimetry (ITC) analysis indicated a two-metal binding mode for divalent cations by nsp14. Endogenous tryptophan fluorescence and circular dichroism (CD) spectra measurements showed that there was a structural change of nsp14 when binding with metal ions. We propose that the conformational change induced by metal ions may be a prerequisite for catalytic activity by correctly positioning the side chains of the residues located in the active site of the enzyme.