• 제목/요약/키워드: Chang-Won Lee

검색결과 6,345건 처리시간 0.038초

에폭시수지의 경화제 변화량에 따르는 열분해 영향 (The Effect of Thermal Decomposition of Epoxy Resin for a Variation of Hardener)

  • 박근호;이용숙;송주영;이수;김성일
    • 한국응용과학기술학회지
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    • 제24권4호
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    • pp.393-398
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    • 2007

  • We investigated heat stability of epoxy resin products and epoxy resin according to the influence hardener. The heat flow which shows the degree of thermal decomposition of the epoxy resin product and epoxy resin measured by using the differential scanning calorimeter (DSC). As a result, we found that in the case of heat stability for epoxy resin as hardener was added, the ratio of one to one (epoxy resin : hardener) was the most suitable in air condition and nitrogen atmosphere.

  • https://doi.org/10.12925/jkocs.2007.24.4.10 인용 PDF KSCI

팔진탕합화적환(八珍湯合化積丸)과 Adriamycin의 병용처리시 나타나는 synergistic 항종양(抗腫瘍) 효과(效果)에 관(關)한 작용기전 연구(硏究) (Study on Synergistic Anti-tumor Effect of Combination with Adriamycin and Palginhonhapwhajucwhan)

  • 문구;문석재;원진희;조정연;박상구;송봉길;박래길;이병구
    • 대한한방내과학회지
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    • 제21권3호
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    • pp.443-452
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    • 2000

  • Objective : This study was designed to evaluate the synergistic effect on cytotoxicity of combination with adriamycin and Palginhonhapwhajucwhan, a traditional prescription for cancer treatment in oriental medicine, in Chang, HL-60, Hep-3B and Alexander cells. Methods : We observed cell viability in Chang, HL-60, Hep-3B, and Alexander cells by crystal violet staining. Those cells were treated with various concentrations of adriamycin alone, Palginhonhapwhajucwhan alone and combination of two medications for 10 hr. On condition of $0.5{\mu}l/ml$ adriamycin alone, $15.6{\mu}l/ml$ Paljintanghapwhajucwhan alone and combination of two medications, at first, we observed colony forming of Chang and HL-60 cells. Second, we observed DNA fragmentation by agarose electrophoresis in Chang, HL-60, Hep-38 and Alexander cells. Third, we measured the catalytic activation of caspase-1, 2, 3, 6, 8, and 9 protease in Chang cells and caspase-3 protease in Chang, HL-60, Hep-3B and Alexander cells by using fluorogenic substrate. Finally, we isolated mRNA of Fas in Chang, HL-60, Hep-38 and Alexander cells and observed that Fas gene was amplified by RT-PCR Results : 1. The combination of adriamycin and Palginhonhapwhajucwhan synergistically augmented the cytotoxicity of Chang and HL-60 cells whereas did not in Hep-38 and Alexander cells. 2. Cotreatment of two drugs also markedly inhibited the colony forming ability both in Chang and HL-60 cells. 3. The cytotoxicity of these medicatons was revealed as apoptosis characterized by high molecular wight DNA fragmentaton. 4. The apoptotic cytotoxicity was mediated by activation of caspase-3 protease in Chang cells. 5. Synergistic increase in apoptotic cytotoxicity by combination of two medications was dependent on the expression of Fas in cancer cells. Conclusions : Combination of adriamycin and Palginhonhapwhajucwhan significantly augmented apoptotic cytotoxicity of Fas-positive cells such as Chang and HL-60 cells via acticaton of apoptosis signaling pathway.

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하인두(Hypopharynx) 암의 방사선 치료성적

  • 이창걸;류삼열;조관호;서창옥;김귀언;노준규;이원상;김광문;홍원표;김주항;김병수
    • 대한두경부종양학회:학술대회논문집
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    • 대한두경부종양학회 1986년도 제3차 학술대회 연제순서 및 초록집
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    • pp.22.1-22.1
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    • 1986

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