• Journal of Korean Society of Water and Wastewater
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• v.35 no.2
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• pp.113-120
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• 2021

High voltage impulse (HVI) has been gained attention as an alternative technique that could control the CaCO₃ scale problems encountered in water main, pipe, cooling tower and heat exchanger vessels. The aim of this study was to investigate the effect of electric field (E) and contact time (t) of HVI on reduction of Ca²⁺ concentration at two different temperatures of 25℃ and 60℃. A kinetic model on the effect of E and t was investigated too. As the E and t increased, the Ca²⁺ concentration decreased more than that of the control (= no HVI). The Ca²⁺ concentration decreased up to 81% at 15 kV/cm at 60℃, which was nearly 2 times greater than the control. With these experimental data-set of reduction of Ca²⁺ concentration under different E and t, the kinetic model was developed. The relationship between E and t required to reduce the concentration of Ca²⁺ by 30% was modeled at each temperature. The empirical model equations were; E^0.83· t = 60.3 at 25℃ and E^0.08· t = 1.1 at 60℃. These equations state the products of Eⁿ and t is always constant, which means that the required contact time can be reduced in accordance with the increment of E and vice versa.

• Bulletin of the Korean Chemical Society
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• v.32 no.2
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• pp.687-692
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• 2011

$^1H$ and $^{13}C$ NMR spectra of series of (E)-1-aryl-(2- and 3-thienyl)-2-propenones, that are aldol condensation products between 2- and 3-thiophenecarbaldehydes and m- and p-substituted acetophenones, were examined to make complete assignments of the chemical shifts. Long range couplings, $^4J$ and $^5J$, are observed in the $^1H-^1H$ COSY of both 2- and 3-thienyl compounds, which makes the elucidation of the conformation in solution possible. In contrast, the 2-furyl analogue shows the long range coupling phenomena, but the 3-furyl and phenyl analogues do not show similar phenomena.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.1
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• pp.181-189
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• 2007

To examine the effects of HHCP on atopic dermatitis and its various immunopathologic parameters was induced by DNCB in NC/Nga mice and the animals were orally administrated with HHCP. We summarized the results obtained from serum levels of IgE and the numbers of various immune cells as follow. HHCP has no cytotoxic effects at the range of concentration (1-400 ${\mu}g$/ml) on fibroblast isolated from lung of BALB/c mice. HHCP significantly lowered the serum levels of IgE compared with control at 16 and 20 week. HHCP significantly reduced the number of CD19$^+$ cell in spleen and DLN, as well as the number of B220$^+$ /IgE$^+$ cell in DLN compared with control. HHCP significantly reduced the number of ${\alpha}$${\beta}$ TCR$^+$ in spleen and DLN, the number of CD8$^+$ in spleen compared with control, and also significantly reduced the number of CD3$^+$, CCR3, CD3$^+$/CD69$^+$, CD3/ CCR3, CD4$^+$, CD3$^+$/ CD4$^+$/CD45$^+$ cell in DLN. HHCP increased the number of NK$^+$ cells in spleen compared with control, in contrast significantly decreased the number of CD11c$^+$/ Classll$^+$ cell and CD11b$^+$/Gr-1$^+$ cell in DLN. Taken together, these results suggested that HHCP has suppressive effects on atopic dermatitis through the inhibition of IgE production and modulation of immune cell population in NC/Nga mice.

• Journal of Veterinary Clinics
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• v.8 no.1
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• pp.59-63
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• 1991

For the purpose of effective therapy and prevention of post weaning E. coli diarrhea, Enrofloxacin-(Baytril premix) was administered in the feed and a series of investigations were made the occurence of diarrhea, weight gain, feed conversion rate, changes In the counts of faecal E. coli and susceptibility of the isolated E. coli strains to antimicrobials. The results obtained were as follows 1. The weaned piglets which were treated with Baytril premix gained the average body weight of 3.2kg over the control group at the age of 62 days. The result indicates a marked weight gain effect which, by statiscal analysis, showed a significant difference(P<0.01). Administration of Baytril premix also resulted in the improvement of feed conversion rate and provention of post weaning diarrhea. 2. The counts of faecal E. coli in Baytri premx treated piglets showed a marked decrease from 3.14${\times}$10$\^$8/cells/g to 2${\times}$10$\^$7/cells/g at 5days post treatment and 1${\times}$10$\^$5/cells/g at 10 days post treatment. 3. 10 strains of E. coli isolated fred the experimental pig farm were highly susceptible to Bayoil, gentamicin and trimethoprim plus sulfamethoxazole.

• Biomolecules & Therapeutics
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• v.26 no.3
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• pp.274-281
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• 2018

A previous study in humans demonstrated the sustained inhibitory effects of donepezil on acetylcholinesterase (AChE) activity; however, the effective concentration of donepezil in humans and animals is unclear. This study aimed to characterize the effective concentration of donepezil on AChE inhibition and impaired learning and memory in rodents. A pharmacokinetic study of donepezil showed a mean peak plasma concentration of donepezil after oral treatment (3 and 10 mg/kg) of approximately $1.2{\pm}0.4h$ and $1.4{\pm}0.5h$, respectively; absolute bioavailability was calculated as 3.6%. Further, AChE activity was inhibited by increasing plasma concentrations of donepezil, and a maximum inhibition of $31.5{\pm}5.7%$ was observed after donepezil treatment in hairless rats. Plasma AChE activity was negatively correlated with plasma donepezil concentration. The pharmacological effects of donepezil are dependent upon its concentration and AChE activity; therefore, we assessed the effects of donepezil on learning and memory using a Y-maze in mice. Donepezil treatment (3 mg/kg) significantly prevented the progression of scopolamine-induced memory impairment in mice. As the concentration of donepezil in the brain increased, the recovery of spontaneous alternations also improved; maximal improvement was observed at $46.5{\pm}3.5ng/g$ in the brain. In conclusion, our findings suggest that the AChE inhibitory activity and pharmacological effects of donepezil can be predicted by the concentration of donepezil. Further, $46.5{\pm}3.5ng/g$ donepezil is an efficacious target concentration in the brain for treating learning and memory impairment in rodents.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.4 no.2
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• pp.238-242
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• 2001

Food allergy is a disease caused by an abnormal immunological reaction to specific food proteins. Whole milk and soy beans are the most frequent causes of food allergy, some studies show that 2.2~2.8% of children aged between 1 and 2 year are allergic to milk. It can be classified to acute (urticaria, asthma, anaphylaxis) or chronic (diarrhea, atopic dermatitis) allergy according to clinical symptoms, or to IgE related or non IgE related allergy by an immunological aspect. Generally, allergies invading only the GI tract are mostly due to a non IgE related reaction. These hypersensitive, immunologic reactions of the GI tract, not related to specific IgE for food, present themselves in many ways such as food protein-induced enteropathy, food protein-induced enterocolitis syndrome (FPIES), celiac disease, food induced protocolitis, or allergic eosinophillic gastroenteritis. FPIES is one kind of non IgE related allergic reaction and is manifested as severe vomiting and diarrhea in infants between 1 week and 3 months. We report a case of FPIES in a 40-day old male infant presenting with 3 times of repeated events of watery diarrhea after cow's milk feeding.

• Korean Institute of Interior Design Journal
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• v.22 no.5
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• pp.68-77
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• 2013

'The Third space,' which is the concept that embraces sociological, spatial, and marketing concepts, refers to the place which is other than the home and the workplace and which is a comfortable frequented place where meditation, psychological relaxation, and social needs can be satisfied. 'The Third space' has the characteristics of comfort, openness, interactivity, playfulness, and diversity. In modern times, most of consumption spaces play the role of 'the Third space,' and the typical example is $Caf{\acute{e}}$. $Caf{\acute{e}}$ began from its origin with the characteristics of 'the Third space,' and recently it has become the complex cultural space of urban dwellers. $Caf{\acute{e}}$ as 'the Third space' has the characteristics of a healing space, communication space, personalized space, value-expressive space, culture and consumption space, nomad space. Such characteristics of $Caf{\acute{e}}$ are well represented in the cafes around the regions where 'street culture' has recently been formed. As examined through the examples, $Caf{\acute{e}}$ as 'the Third space' can be more strategically produced by establishing themes through storytelling, giving spatial identity through style creation, diversifying the sequence through complex space organization, and establishing interaction devices through experience elements.

• BMB Reports
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• v.32 no.4
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• pp.399-404
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• 1999

2,3-Dihydroxybiphenyl 1,2-dioxygenase (2,3-DHBD), which catalyzes the ring meta-cleavage of 2,3-dihydroxybiphenyl, is encoded by the phnQ gene of biphenyl- and phenanthrene-degrading Pseudomonas sp. strain DJ77. We determined the nucleotide sequence of a DNA fragment of 1497 base pairs which included the phnQ gene. The fragment lncluded an open reading frame of 903 base pairs to accommodate the enzyme. The predicted amino acid sequence of the enzyme subunit consisted of 300 residues. In front of the gene, a sequence resembling an E. coli promoter was identified, which led to constitutive expression of the cloned gene in E. coli. The deduced amino acid sequence of the PhnQ enzyme exhibited 85.6% identity with that of the corresponding enzyme in Sphingomonas yanoikuyae Q1 (formerly S. paucimobilis Q1) and 22.1% identity with that of catechol 1,2,3-dioxygenase from the same DJ77 strain. PhnQ showed broader substrate preference than previously-cloned PhnE, catechol 2,3-dioxygenase. Ten amino acid residues, considered to be important for the role of extradiol dioxygenases, were conserved.

• Korean journal of applied entomology
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• v.60 no.1
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• pp.91-98
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• 2021

The populations of Riptortus pedestris (Fabricius) cause serious economic damages in local apple orchards. However, there was no study to manage its populations with environment friendly tactics. Thus, this study was conducted to analyze its attraction effects of one of R. pedestris aggregation pheromone compounds, (E)-2-hexenyl (Z)-3hexenoate (E2HZ3H), to its parasitoids, Ooencyrtus nezarae (Ishii) and Gryon japonicum (Ashmead). This compound did not increase the number of these two parasitoids and change its spatial distribution. However, this compound could attract two parasitoids within limited distance. These results indicates that one compound of R. pedestris aggregation pheromone, E2HZ3H, could be a good candidate to manage R. pedestris populations in conditions that its populations locally occurs in apple orchards.

• Composites Research
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• v.21 no.5
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• pp.15-22
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• 2008

This paper describes the results of structural integrity and crashworthiness of Automatic Guideway Transit(AGT) vehicle made of sandwich composites. The applied sandwich composite of vehicle structure was composed of aluminum honeycomb core and WR580/NF4000 glass fabric/epoxy laminate composite facesheet. Material testing was conducted to determine the input parameters for the composite facesheet model, and the effective equivalent damage model fer the orthotropic honeycomb core material. The finite element analysis using ANSYS v11.0 was dont to evaluate structural integrity of AGT vehicle according to JIS E 7105 and ASCE 21-98. Crashworthiness analysis was carried out using explicit finite element code LS-DYNA3D with the lapse of time. The crash condition was frontal accident with speed of 10km/h at rigid wall. The results showed that the structural integrity and crashworthiness of AGT vehicle were proven under the specified loading and crash conditions. Also, the modified Chang-Chang failure criterion was recommended to evaluate the failure modes of composite structures after crashworthiness event.