• Journal of Physiology & Pathology in Korean Medicine
• /
• v.17 no.6
• /
• pp.1393-1403
• /
• 2003

The genetic effects of restraint stress challenge on HPA axis and the therapeutic effect of Boshimgeonbi-Tang on the stress were studied with cDNA microarray analyses on hypothalamus using an immobilization-stress mouse as stress model. Male CD-1 mice were restrained in a tightly fitted and ventilated vinyl holder for 2hours once a day, and this challenge was repeated for seven consecutive days. The body weights of the immobilization-stress mice were diminished about 25 percent degree as compared to normal ones. Seven days later, total RNA was extracted from the organs of the mouse, body-labeled with CyDye/sup TM/ fluorescence dyes (Amersham Bioscience Co., NJ), and then hybridized to cDNA microarray chip. Scanning and analyzing the array slides were carried out using GenePix 4000 series scanner and GenePix Pro/sup TM/ analyzing program, respectively. The expression profiles of 109 genes out of 6000 genes on the chip were significantly modulated in hypothalamus by the immobilization stress. Energy metabolism-, lipid metabolism-, apoptosis- and signal transduction-related genes were transcriptionally activated whereas DNA repair-, protein biosynthesis-, and structure integrity-related genes were down-regulated in hypothalamus. The 58 genes were up-regulated by the mRNA expression folds of 1.5 to 7.9. and the 51 genes were down-regulated by 1.5 - 3.5 fold. The 20 genes among them were selected to confirm the expression profiles by RT-PCR. The mRNA expression levels of Tnfrsf1a (apoptosis), Calm2 (cell cycle), Bag3 (apoptosis), Hspe1 (protein folding), Aatk (apoptosis), Dffa (apoptosis), Itgb1 (cell adhesion), Vcam1 (cell adhesion), Fkbp5 (protein folding), BDNF (neuron survival) were restored to the normal one by the treatment of Boshimgeonbi-Tang.

• Computers and Concrete
• /
• v.20 no.3
• /
• pp.351-360
• /
• 2017

This paper presents an efficient membrane finite element for the cyclic inelastic response analysis of RC structures under complex plane stress states including shear. The model strikes a balance between accuracy and numerical efficiency to meet the challenge of shear wall simulations in earthquake engineering practice. The concrete material model at the integration points of the finite element is based on damage plasticity with two damage parameters. All reinforcing bars with the same orientation are represented by an embedded orthotropic steel layer based on uniaxial stress-strain relation, so that the dowel and bond-slip effect of the reinforcing steel are presently neglected in the interest of computational efficiency. The model is validated with significant experimental results of the cyclic response of RC panels with uniform stress states.

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 2006.05a
• /
• pp.247-250
• /
• 2006

The growing demand for more fuel-efficient vehicles to reduce energy consumption and air pollution is a challenge for the automotive industry. The characteristic properties of aluminum, high strengrth stiffness to weight ratio, good formability, good corrosion resistence, and recycling potential make it the ideal candidate to replace heavier materials in the car to respond to the weight resuction demand within the automotive industry. In this paper, A series of compression test was carried out to find the flow stress of A6082 at 300, 400 and $500^{\circ}C$, then we tried to estimate weldability, extrusion load and effective stress of die in the aluminum extrusion process through the 3D FE simulation at non-steady state for aluminum automotive parts.

• Proceeding of EDISON Challenge
• /
• 2017.03a
• /
• pp.304-310
• /
• 2017

In this paper, various webs of I-shaped beam used in aircraft spars are examined. Under the assumption that an aircraft spar is a cantilevered beam with a constant cross-section and is subjected to only bending, four kinds of webs are analyzed for three different sizes. To enable comparison, each hole has the same area and are subjected to the same load by using EDISON 2D Continuum analysis. While circular hole is the most often used, elliptic one is obtained with the minimum von-Mises stress by about 40% decreased. To verify the results gathered by EDISON, comparison was made with ANSYS and analytic predictions obtained with the stress intensity factor K. As comparison shows insignificant discrepancies, it is concluded that a well-designed beam with elliptic holes will be the most efficient spar regarding weight to rigidity ratio in terms of the bending stress.

• Proceeding of EDISON Challenge
• /
• 2015.03a
• /
• pp.217-222
• /
• 2015

In this paper, a study was conducted for the optimization through shear web of shape the Edison program in wind power blade. We measured the displacement and stress distribution through two optimization methods to select the model with the smallest displacement and stress values. Before running the analysis, We try to find the inflection point through the shear web of the model and then analyze by introducing the geometric nonlinearity. The first optimization variables are introduced by the pitch angle and three web shapes. Third model such a honeycomb structure is good way to get an advantage for bending test. According to a method of previous optimization, third model is chosen and then the thickness of the web and blade as a variable is introduced, it is extracted as a result of displacement and the maximum stress per mass.

• Proceeding of EDISON Challenge
• /
• 2015.03a
• /
• pp.263-265
• /
• 2015

In this paper, a coil spring of the suspension components of the car is calculated through FEM(Finite Element Method) when a portion of the one is applied by an external load. we analyze the situation by using 'Large Deformation Analysis SW' in the EDISON structural dynamics server. Results of the analysis are about a displacement of the upper spring after deformation and total mass, and we use them to calculate the spring constant and maximum von-Mises stress by using Hooke's law and von-Mises stress equation. Finally, we visualize the relationship between the calculated spring constant and the mass through graphs and this data are beneficial for industries related to the spring.

• Proceeding of EDISON Challenge
• /
• 2016.03a
• /
• pp.256-261
• /
• 2016

In this paper, Shape optimal design for a chair with 4 legs and 2 stretchers consisting of stainless steel was conducted. The shape was transformed by identifying stress and deformation for the part of leg and stretcher. In addition, load condition and mesh was designed using Hypermesh. The stress analysis was carried out using CSD_Elast that is one of EDISON program. In seat test, Maximum equivalent stress was showed at the contact part between seat and legs. As a result, a leg cross-section with rectangular and arch was designed. And optimal height of stretcher was found to reduce a deformation. Also, maximum deformation was reduced by designing a stretcher with ellipse cross-section. So, Optimal chair having 4 legs with rectangular cross section and 2 stretchers with ellipse cross section was shown to satisfy the safety ratio.

• Animal Bioscience
• /
• v.36 no.4
• /
• pp.540-554
• /
• 2023

Heat stress is a major challenge to animal production in tropical and subtropical climates. Rabbits suffer from heat stress more than farm animals because they have few sweat glands, and their bodies are covered with thick fur. Intensive farming relies on antibiotics as antimicrobials or growth promoters to increase animals' productivity and health. However, the European Union and many countries have banned or restricted the use of antibiotics in animal feed for human health concerns. Several studies have found that replacing antibiotics in rabbit feed with natural plants or feed additives increases productivity and improves immune capacity, especially under heat stress conditions. Growth performance, immune response, gut microflora, and carcass yield may be increased in rabbits fed a diet supplemented with some natural plants and/or propolis. In this review article, we discuss and summarize the effects of some herbs and plant extracts as alternative feed additives on rabbit productivity, especially for those raised under hot ambient temperatures.

• Development and Reproduction
• /
• v.20 no.2
• /
• pp.91-99
• /
• 2016

Lipopolysaccharide (LPS), an endotoxin, elicits strong immune responses in mammals. Several lines of evidence demonstrate that LPS challenge profoundly affects female reproductive function. For example, LPS exposure affects steroidogenesis and folliculogenesis, resulting in delayed puberty onset. The present study was conducted to clarify the mechanism underlying the adverse effect of LPS on the delayed puberty in female rats. LPS was daily injected for 5 days ($50{\mu}g/kg$, PND 25-29) to treated animals and the date at VO was evaluated through daily visual examination. At PND 39, animals were sacrificed, and the tissues were immediately removed and weighed. Among the reproductive organs, the weights of the ovaries and oviduct from LPS-treated animals were significantly lower than those of control animals. There were no changes in the weights of uterus and vagina between the LPS-treated and their control animals. immunological challenge by LPS delayed VO. Multiple corpora lutea were found in the control ovaries, indicating ovulations were occurred. However, none of corpus luteum was present in the LPS-treated ovary. The transcription level of steroidogenic acute regulatory protein (StAR), CYP11A1, CYP17A1 and CYP19 were significantly increased by LPS treatment. On the other hand, the levels of $3{\beta}$-HSD, $17{\beta}$-HSD and LH receptor were not changed by LPS challenge. In conclusion, the present study demonstrated that the repeated LPS exposure during the prepubertal period could induce multiple alterations in the steroidogenic machinery in ovary, and in turn, delayed puberty onset. The prepubertal LPS challenge model used in our study is useful to understand the reciprocal regulation of immune (stress) - reproductive function in early life.

• Child Health Nursing Research
• /
• v.7 no.4
• /
• pp.451-460
• /
• 2001

Congenital heart disease is now estimated to be the most prevalent chronic illness in children. The overall purpose of study is to enhance our understanding of mother's perception of family stress, perceived social support, and coping who has a child newly diagnosed with congenital heart disease. In this investigation, the relationship between family stress, perceived social support, and coping within the context of a acute, non life- threatening chronic illness in the situation of newly diagnosed as Rolland's typology of chronic illness. The study employed data from a subset of a large longitudinal study, children's chronic illness: parents and family adaptation conducted by M. McCubbin (5 R29 NR02563) which was funded by the NIH. The subject for this study were 92 mothers who have a child under age 12 who was newly diagnosed with congenital heart disease within the last 3-4 months. Results form correlational and regression analysis revealed that perceived social support operated as a resiliency factor between family stress and coping of mothers. Child and family characteristics appeared to be important predictors of perceived social support and mother's coping. Therefore, the findings provide an incremental contribution to the explanation of effects for perceived social support and may challenge resiliency model in previous literature. Further, these findings suggest that perceived social support and coping are both influencing in the resiliency of relatively high risk groups of families who has a child with congenital heart disease.