• YAKHAK HOEJI
• /
• v.46 no.2
• /
• pp.120-123
• /
• 2002

In order to investigate the effects of chitosan on the normal and cyclophosphamide (CY)-suppressed primary humoral immune response in mice, chitosan was orally administered alone (single dose of 62.5, 250 mg/kg) or with CY (20 mg/kg, i.p.) to female ICR mice on the 2nd day before or after immunization with SRBC-antigen. When chitosan alone was administered before antigenic challenge, splenic IgM plaque forming cells (PFC) and splenic cellularity were slightly increased and serum IgM was not changed when compared with control group. However, chitosan significantly enhanced PFC, serum IgM and splenic cellularity when administered after antigenic challenge. The PFC numbers, serum IgM and splenic cellularity were significantly decreased by the treatment of CY, whereas those values were slightly increased by the concomitant treament of CY and chitosan when compared with CY alone-administration. These results indicate that chitosan is able to increase normal humoral immunity (HI) and to slightly inhibit the suppressive effects of CY on HI.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2006.05a
• /
• pp.187-190
• /
• 2006

TETRA system provides the radio authentication service which permits only authorized radio to access network. Radio authentication is the process which checks the sameness of authentication-key(K) by challenge-response protocol between radio and authentication center. This paper analyzes authentication-key generation/delivery/injection model in TETRA authentication system and analyzes the threat of clone radio caused by authentication-key exposure.

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.288.1-288.1
• /
• 2002

Herbal medicines are increasingly being utilized to treat a wide variety of disease processes. The aim of this study was to evaluate the ability of aqueous extract from the roots of Platycodon grandiflorum A. DC (Campanulaceae). Changkil (CK). to affect cellular response in primary cultures of rat hepatocytes to t-butyl hydroperoxide (t-BHP) induced oxidative stress and hepatotoxicity. CK-treated cells showed an increased resistance to oxidative challenge. as revealed by a higher percent of survival capacity in respect to control cells. CK added prior or simultaneously with I-BHP reduced enganced lipid peroxidation measured as production of malondialdehyde and enhnaced intracellular reduced glutathinoe depletion by t-BHP. Furhtermore. CK protected from the t-BHP-induced intracellular generation of reactive oxygen species assessde by montioting dichlorodihydrofluorescein fluorescence. it can be concluded that CK exerts an antioxidant action insice the cell. responsible for the abserved modulation of the cellular response to oxidative challenge. and CK have a marked anitioxdative and hepatoprotective potency.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.13 no.1
• /
• pp.81-86
• /
• 2009

Almost all network systems provide an authentication mechanism based on user ID and password. In such system, it is easy to obtain the user password using a sniffer program with illegal eavesdropping. The one-time password and challenge-response method are useful authentication schemes that protect the user passwords against eavesdropping. In client/server environments, the one-time password scheme using time is especially useful because it solves the synchronization problem. In this paper, we propose a new identification scheme One Pass Identification. The security of Password base System is based on the square root problem, and Password base System is secure against the well known attacks including pre-play attack, off-line dictionary attack and server comprise. A number of pass of Password base System is one, and Password base System processes the password and does not need the key. We think that Password base System is excellent for the consuming time to verify the prover.

• Journal of KIISE:Information Networking
• /
• v.36 no.6
• /
• pp.552-557
• /
• 2009

One-time passwords are used just once and discarded, which makes it more secure than the repeatedly used conventional passwords. This paper proposes a challenge-response based one-time password generator on a user's mobile phone always carried with the user. The generator can provide an additional authentication for a user to issue a money transfer request within his Internet banking session on a PC. A currently used device for Internet banking generates a password that changes every 30 seconds or so, which allows a man-in-the-middle to use it for stealing money within the 30 seconds. Unlike such a device, the proposed generator resists against the man-in-the-middle attack by a novel challenge-response scheme, provides better accessability and protection against stolen devices. As the currently used devices do, it prevents any unauthorized transfer even if the victim's all other credentials are revealed through his PC infected with spyware such as a keyboard logger.

• The Korean Journal of Malacology
• /
• v.29 no.2
• /
• pp.155-161
• /
• 2013

Cathepsins are lysosomal/cysteine proteases belong to papain family (C1 family) that is involved in intracellular protein degradation, antigen processing, hormone maturation, and immune responses. In this study, member of cathepsin family was identified from Manila clam (Mc-Cathepsin D) and investigated the immune response against brown ring disease (BRD) causing Vibrio tapetis challenge. The identified Mc-Cathepsin D gene encodes characteristic features typical for the cathepsin family including eukaryotic and viral aspartyl protease signature domain and two highly conserved active sites ($^{84}VVFDTGSSNLWV^{95}$ and $^{270}IADTGTSLLAG^{281}$). Moreover, MC-Cathepsin D shows higher identity values (-50-70%) and conserved amino acids with known cathepsin D members. Transcriptional results (by quantitative real-time RT-PCR) showed that Mc-Cathepsin D was expressed at higher levels in gills and hemocytes than mantle, adductor muscle, foot, and siphon. After the V. tapetis challenge under laboratory conditions, Mc-Cathepsin D mRNA was up-regulated in gills and hemocytes. Present study indicates that Mc-Cathepsin D is constitutively expressed in different tissues and potentially inducible when infecting BRD by V. tapetis. It is further suggesting that Mc-Cathepsin D may be involved in multiple role including immune response reactions against BRD.

• IMMUNE NETWORK
• /
• v.15 no.1
• /
• pp.27-36
• /
• 2015

In the present study, we investigated the protection conferred by a live attenuated Salmonella enterica serovar Typhimurium (ST) strain against Salmonella Typhimurium, Salmonella Gallinarum (SG), and Salmonella Enteritidis (SE) infection in layer chickens. Birds were orally primed with the attenuated ST strain at 7 days of age and then boosted at 4 weeks post prime immunization (PPI). Sequential monitoring of plasma IgG and mucosal secretory IgA (sIgA) levels revealed that inoculation with ST induced a significant antibody response to antigens against ST, SE, and SG. Moreover, significant lymphoproliferative responses to the 3 Salmonella serovars were observed in the immunized group. We also investigated protection against virulent ST, SE, and SG strain challenge. Upon virulent SG challenge, the immunized group showed significantly reduced mortality compared to the non-immunized group. The reduced persistence of the virulent ST and SE challenge strains in the liver, spleen, and cecal tissues of the immunized group suggests that immunization with the attenuated ST strain may not only protect against ST infection but can also confer cross protection against SE and SG infection.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.39B no.12
• /
• pp.831-841
• /
• 2014

The attacker can access the RFID systems illegally because authentication operation on the RFID systems are performed in wireless communication. Authentication methods based on the PUF were presented to defend attacks. Because of Hash and AES, the cost is expensive for the low-cost RFID tag. In this paper, the PUF-based encryption processor and the mutual authentication protocol are proposed for low-cost RFID authentication. The challenge-response pairs (PUF's input and output) are utilized as the authentication key and encrypted by the PUF's characteristics. The encryption method is changed each session and XOR operation with random number is utilized. Therefore, it is difficult for the attacker to analyze challenge-response pairs and attack the systems. In addition, the proposed method with PUF is strong against physical attacks. And the method protects the tag cloning attack by physical attacks because there is no authentication data in the tag. Proposed processor is implemented at low cost with small footprint and low power.

• Journal of Animal Science and Technology
• /
• v.62 no.5
• /
• pp.605-613
• /
• 2020

This study was conducted to evaluate the effects of dietary supplementation of plant flavonoid (quercetin) on immune parameters, growth performance, and nutrient digestibility in growing pigs challenged with Escherichia coli lipopolysaccharide (LPS). A total of 40 crossbred ([Landrace × Yorkshire] × Duroc) growing pigs; initial body weight (BW) of 26.95 ± 1.26 kg were used in a six-week experimental trial. Pigs were randomly allocated into one of four treatment groups in a 2 × 2 factorial arrangement with the following factors; without LPS challenge and with LPS challenge (day 21) supplemented with or without 0.1% flavonoid according to BW (2 replicate pens per treatment with 2 gilts and 3 barrows per pen). The single-dose LPS (100 ug / kg BW) injection showed trends tended to be increased in interleukin-6 (IL-6) after 2 h and 6 h of challenge compared with unchallenged pigs. However, other measured immune indices (white blood cell, immunoglobulin G, lymphocyte, and tumor necrosis factor), growth performance, and nutrient digestibility were not significantly different between challenged and non-challenged animals. The supplementation of flavonoid significantly increased (p < 0.05) average daily gain (ADG) during day 0-21, tended to increase dry matter and nitrogen digestibility, significantly reduced IL-6, increased Ig-G and WBC concentrations and increased lymphocytes percentage regardless of LPS challenge.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.20 no.5
• /
• pp.1149-1154
• /
• 2006

Repeated administration of all addictive drugs, including nicotine, can produce sensitization of extracellular dopamine levels in the nucleus accumbens and behavioral sensitization in rat, as evidenced by an enhanced locomotor response and increased dopamine release in brain to a subsequent injection of the drug. In order to investigate the effect of Zizyphus jujuba extract on repeated nicotin-induced sensitization, rats were given repeated injection of saline or nicotine (0.4 mg/kg s.c., twice a day for 7 d), followed by one challenge injection on the 4th day after the last daily injection. Systemic challenge with nicotine (0.4 mg/kg s.c.) and a direct local challenge of 3 mM a larger increase in locomotor activity and extracellular dopamine release in the nucleus accumbens in nicotine-pretreated rats than in saline-pretreated rats, respectively. Zizyphus jujuba extract significantly decreases locomotor activitiy and dopamine release in the nucleus accumbens induced by a nicotine challenge. These results suggest that Zizyphus jujuba extract may attenuate nicotine-induced neurochemical and behavioral sensitization and may be effective in suppressing compulsive nicotine-seeking behavior.