• Title/Summary/Keyword: Chain Structure

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NMR Studies on the N-terminal Acetylation Domain of Histone H4

  • Bang, Eun Jeong;Lee, Chang Hun;Yun, Jong Bok;Cheong, Ju Hui;Lee, Dae Yun;Lee, Won Tae
    • Bulletin of the Korean Chemical Society
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    • v.22 no.5
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    • pp.507-513
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    • 2001
  • Histones, nuclear proteins that interact with DNA to form nucleosomes, are essential for both the regulation of transcription and the packaging of DNA within chromosomes. The N-terminal domain of histone H4 which contains four acetylation sites at lysines, may play a separate role in chromatin structure from the remainder of the H4 chain. NMR data suggest that H4NTP peptide does have relating disordered structure at physiological pH, however, it has a defined structure at lower pH conditions. The solution structure calculated from NMR data shows a well structured region comprising residues of Val21-Asp24. In addition, our results suggest that the H4NTP prefers an extended backbone conformation at acetylation sites, however, it (especially Lys 12 ) became more defined structures after acetylation for its optimum function.

The Role of Relational Capital in Supply Chain Management for Distribution Service Firms (유통서비스 기업의 공급사슬 운영성과 경로에서 파트너 관계자산의 역할)

  • Cho, Yeon-Sung
    • Journal of Distribution Science
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    • v.13 no.11
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    • pp.111-121
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    • 2015
  • Purpose - This study's purpose is to investigate the impact of supply chain management (SCM) factors among targeted Korean distribution firms. Antecedents are established for supply chain orientation (SCO) for the management and organization of cultural assets. The research sets up SCO corresponding to management cultural assets and to organizational factors in the results. The research model is created to examine the SCO based on a strategic perspective and the operational performance of the SC and SCM. In addition, an integrated model is constructed to analyze the moderating effect by setting partner cooperation as a relational capital factor. The main aim of this study is to analyze the characteristics of the supply chain structure as a source of competitive advantage for distribution service firms participating in the supply chain. In the moderating effects analysis, the role of partner cooperation as relational capital is examined in detail. Research design, data, and methodology - The study examined the existing research related to supply chains, discussing the antecedents of the performance of SCM and SCO. SCM was established with the partner's cooperation as relational capital. Including the moderating effects of the partner cooperation, the research proposed a seven hypotheses path analysis model. The samples were collected from the Korean export enterprises in the distribution service sector, with 185 samples selected for the final analysis. To try and measure the four latent variables presented in the analysis model based on existing studies, 22 measurement items were used. The empirical analysis used the appropriate PLS (partial least squares) method on the path analysis reliability and validity and for common method bias. After testing the seven hypotheses, the research tested the moderating effects to the path analysis. Using PLS as structural equation modeling, the seven hypotheses were tested including the moderating effects of the partner relational capital on the 185 samples. Results - In the results, the SCO had a positive impact on both SCM and the relational capital of partner cooperation. The SCM had a significant impact on the operational performance of the SC. Further, partner cooperation also had a significant impact on SCM and the operational performance of the SC. The moderating effect analysis of the SCM and partner cooperation found a significant impact on the operational performance of the SC. On the other hand, the moderating effect of the SCO and partner cooperation did not affect the SCM. Conclusion - The results of this research show that the existing supply chain-related research can be applied to the operational performance of the SC for a Korean distribution service firm. In view of the fact that SCO is a source of competitive advantage, it should be taken into account when a firm wants to improve the performance of the SCM of the distribution service. This is because it can be assumed that SCO plays a role in supply chain management for the distribution firm.

The Flow Properties and Stability of O/W Emulsion Composed of Various Mixed Nonionic Surfactants(II) The Phase Behavior and Flow Properties of O/W Emulsion According to the Addition of the Long Chain Alcohols (혼합 비이온계면활성제의 조성에 따른 O/W 에멀젼의 유동특성 및 안정성(II) 고급 알코올의 첨가에 따른 O/W 에멀젼의 상거동 및 유동특성)

  • Lee, Ho-Sik;Kim, Jum-Sik
    • Applied Chemistry for Engineering
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    • v.4 no.2
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    • pp.423-431
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    • 1993
  • Long chain alcohols, the mixtures of 1-hexadecanol/1-octadecanol, were used as cosurfactants for O/W emulsion prepared with glycerol monostearate/POE(100) monostearate mixed nonionic surfactants, and the phase behavior and flow properties of O/W emulsions were observed. The transition temperature of long chain alcohol was varied with the composition of 1-hexadecanol/1-octadecanol and had the lowest value when the mixed ratio of 1-hexadecanol/1-octadecanol was 2/1. The liquid crystalline phase was formed as the addition of long chain alcohol and the secondry droplet, the flocculate of the emulsion particles, was made, and thus the viscosity of the emulsion was increased. When the temperature of emulsion system was under the transition temperature of long chain alcohol, the mobility of hydrocarbon group of long chain alcohol was restricted, and thus gel structure was formed and the viscosity of the the O/W emulsion was increased, but along with the time, the liquid crystalline phase was disappeared and the viscosity of emulsion was decreased. Long chain alcohol/nonionic surfactants/water formed the liquid crystalline phase when the long chain alcohol was added above the saturation point of solution(2 wt% in this experoment), and the secondry droplet didn't formed when the long chain alcohol was added more than a certain amount (10 wt% in this experiment).

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Design of Electroluminescent Polymer for Polymer Light Emitting Diode

  • Chen, Show-An
    • Proceedings of the Polymer Society of Korea Conference
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    • 2006.10a
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    • pp.19-20
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    • 2006
  • We report the design of electroluminescent conjugated polymers for high efficiency, turn-on voltage, color Tuning, and easy processing. Three approaches for the design are reported, being: (1) single chain consideration, (2) supramolecular structure consideration, and (3) conformation manipulation. Two polymer systems are to be reported, being fluorene-based and carbazole-based conjugated polymers.

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Synthesis and Photovoltaic Properties of Conjugated Polymers Having Push-pull Structure according to the Type of Side-chain in the N-Substituted Phenothiazine (Push-pull 구조의 공액 고분자 합성 및 Phenothiazine의 질소 원자에 치환된 Side-chain에 따른 유기박막태양전지로의 특성 연구)

  • Seong, Ki-Ho;Yun, Dae-Hee;Woo, Je-Wan
    • Applied Chemistry for Engineering
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    • v.25 no.6
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    • pp.624-631
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    • 2014
  • In this study, a new series of conjugated polymer 3-(5-(5,6-bis(octyloxy)-7-(thiophen-2-yl)benzo[c][1,2,5]thiadiazol-4-yl)thiophen-2-yl)-10-(4-(octyloxy)phenyl)-10H-phenothiazine (P1) and 3-(5-(5,6-bis(octyloxy)-7-(thiophen-2-yl)benzo[c][1,2,5]thiadiazol-4-yl)thiophen-2-yl)-10-(4-((2-ethylhexyl)oxy)phenyl)-10H-phenothiazine (P2) were synthesised and organic photovoltaics (OPVs) properties were characterized. The push-pull structure polymer consisted of phenothiazine derivative as an electron donor and benzothiadiazole derivative as an electron acceptor. The aliphatic chain substituted aromatic ring was substituted at the position of N in phenothiazine for the electron-rich and improved solubility. Excellent thermal stabilities of P1 and P2 were confirmed by measured Td values as 321.9 and $323.7^{\circ}C$, respectively and the degrees of polymerization were 4,911 (P1) and 5,294 (P2). The maximum absorption wavelength of P1 and P2 were 549 and 566 nm, respectively. The device was fabricated and the OPVs property was measured. As a result, the power efficiency of conversion for P1 and P2 were 0.96 and 0.90%, respectively.

Antitumor Toxic Protein Abrin and Abrus Agglutinin

  • Liu, Chao-Lin;Lin, Jung-Yaw
    • Toxicological Research
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    • v.17
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    • pp.109-115
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    • 2001
  • Abrus agglutinin was purified from the kernels of Abrus precatorius by Sepharose 4B affinity column chromatography followed by Sephadex G-100 gel filtration column chromatography. About 1.25 g of abrus agglutinin was obtained from 1 kg of the kernels. The LD$_{50}$ of abrus agglutinin is 5 mg/kg of body weight, which is less toxic than that of abrin, 20$\mu\textrm{g}$/kg body weight. The amino acid sequence of abrus agglutinin was determined by protein sequencing techniques and deduced from the nucleotide sequence of a cDNA clone encoding full length of abrus agglutinin. There are 258 residues, 2 residues and 267 residues in the A-chain, the linker peptide and the B-chain of abrus agglutinin, respectively. Abrus agglutinin had high homology to abrin-a (77.8%). The 13 amino acid residues involved in catalytic function, which are highly conserved among abrin and ricin, were also conserved within abrus agglutinin. The protein synthesis inhibitory activity of abrus agglutinin ($IC_{50}$/ = 3.5 nM) was weaker than that of abrin-a (0.05 nM). By molecular modeling followed by site-directed mutagenesis showed that Pro199 of abrus agglutinin A-chain located in amphipathic helix H and corresponding to Asn200 of abrin A-chain, can induce bending of helix H. This bending would presumably affect the binding of abrus agglutinin A-chain to its target sequence GpApGpAp, in the tetraloop structure of 285 r-RNA subunit and this could be one of major factors contributing to the relatively weak protein synthesis inhibitory activity and toxicity of abrus agglutinin.n.

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Application of Coordination Policies for Fuzzy Newsvendor Model

  • Ryu Kwang-Yeol;Choi Hon-Zong;Lee Seok-Woo;Jung Moo-Young;Cha Young-Pil
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 2006.05a
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    • pp.187-192
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    • 2006
  • In the absence of a clear command and control structure, a key challenge in supply chain management is the coordination and alignment of the supply chain members who pursue divergent and often conflicting goals. The newsvendor model is typically used as a framework to quantify the cost of misalignment and to assess the impact of coordination initiatives. This paper considers a fuzzy approach for the newsvendor problem which includes a single manufacturer and a single retailer. We use several fuzzy parameters in the model such as the demand, the wholesale price, and the market sales price. We apply a coordination policy, referred to as buyback, to solve the fuzzy newsvendor problem. Based on the buyback policy, the optimal order quantity of the retailer can be computed, and the possible profits of the members in the supply chain can be calculated with minimum sharing of private information. Focusing on the fuzzy model with buyback policy for the newsvendor problem, we illustrate exemplary fuzzy models. We also illustrate an integration model, which extends a single-manufacturer-single-retailer model to the single-manufacturer-multiple-retailer setting. In the extended model, we consider three coordination policies including quantity discount, profit sharing, and buyback, as well as non-coordination case.

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