• Biomolecules & Therapeutics
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• v.23 no.2
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• pp.165-173
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• 2015

Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects.

• Journal of the Korean Society for Precision Engineering
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• v.18 no.7
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• pp.120-126
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• 2001

The widely used spot welded section members of vehicles are structures which absorb most of the energy in a front-end collision. In front-end collision, sufficiently absorbed in the front parts, the impact energy does not reach the passengers. Simultaneously, the frame gets less damaged. This structures have to be very stiff, but collapse progressively to absorb the kinetic energy as expected. In the view of stiffness, the double-hat shaped section member is stiffer than the hat shaped section member. In progress of collapse, the hat shaped section member is collapsing progressively, but the double-hat shaped section member does not due to stiffness. An analysis on the hat shaped section member was previously completed. This paper concerns the collapse characteristic of the double-hat shaped section member. In the program system presented in this study, an explicit finite element code, LS-DYNA3D is adopted for simulating complicate collapse behavior of double hat shaped section members with respect to spot weld pitches. And comparing with the results from the quasi-static and impact experiment, the simulation has been verified.

• International Journal of Precision Engineering and Manufacturing
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• v.4 no.2
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• pp.23-29
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• 2003

The spot welded sections of automobiles (hat and double hat shaped sections) absorb most of the energy in a front-end collision. The target of this paper is to analyze the energy absorbing capacity of the structure against the front-end collision, and to obtain useful information for designing stage. Changed the spot welded pitches on the flanges, the hat and double hat shaped section members were tested on the axial collapse loads at various impact velocities. It was expected that para-closed sections would show collapse characteristics which be quite different from those of perfectly closed sections. Hat shaped section members were tested at the impact collapse velocities of 4.72m/sec, 6.54m/sec and 7.1m/sec and double hat shaped section members were tested at the impact collapse velocities of 6.54m/sec, 7.1 m/sec and 7.27m/sec.

• Korean Journal of Pharmacognosy
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• v.37 no.2 s.145
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• pp.97-102
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• 2006

Garlic(Allium sativum Linn) is widely used as a common condiment for a variety of foods and beverages. It has been well known that fresh garlic and garlic supplement of commercial preparations have various therapeutic properties including antimicrobial activity, antiplatelet aggregation, antihypertension, and cholesterol-lowering effects, which contribute to its increasing uses for an alternative medicine. Allicin(diallyl thiosulfinate), the major bioactive components of garlic, is formed by alliinase cleavage of the naturally occurring alliin upon crushing or mincing of garlic, and is the progenitor of a number of other products, such as diallyl disulfide. CYP3A4, heme-containing monooxygenase, is a key enzyme responsible for drug metabolism. Therefor, in the present study, we isolated and examined the compounds with CYP3A4-inhibiting activities from garlic. Among EtOAc extracts of garlic, we found that N-p-coumaroyltyramine and N-feruloyltyramine showed remarkable CYP3A4-inhibiting activities, compared to diallyl disulfide. Structures of the isolated active compounds were established by chemical and spectroscopic means.

• Korean Journal of Pharmacognosy
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• v.39 no.4
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• pp.316-323
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• 2008

In this study, we have investigated the HPLC analysis methods and quantitative analysis of standard compounds for quality standardization of a medicinal crude drug GCSB-5, a herbal formulation consisting of 6 medicinal plants (Acanthopanacis Cortex, Achyranthis Radix, Ledebouriellae Radix, Cibotii Rhizoma, Glycine Semen, Eucommiae Cortex) which are used in traditional medicine to treat various bone disorders. HPLC analysis methods of acanthoside D(Acanthopanacis Cortex), 20-hydroxyecdysone(Achyranthis Radix) which were known standard compounds among 6 medicinal plants were developed on crude material and product. And validation of HPLC analysis methods were conformed for verification of HPLC methods by check to specificity, linearity, intra-day precision, inter-day precision and accuracy following ICH guideline. Content of acanthoside D and 20-hydroxyecdysone on raw material of GCSB-5 were decided at 0.577-0.578 mg/g and 0.311-0.312 mg/g. And we confirmed that content of acanthoside D and 20-hydroxyecdysone on GCSB-5 preparation were 0.302-0.303 mg/capsule and 0.113-0.115 mg/capsule.

• Journal of Mechanical Science and Technology
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• v.18 no.6
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• pp.924-932
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• 2004

In this study, the axial collapse tests were performed under either static (or quasi-static) or impact loads with several collapse velocities based on the expectation that para-closed sections of the front-end side members (spot welded hat and double hat shaped section members) would show quite different collapse characteristics from those for seamless section. The test results showed that both of the hat and double hat shaped section members failed in the stable sequential collapse mode in the static or quasi-static collapse tests, while the double hat shaped section members underwent the unstable collapse mode especially when the impact velocity is high. The mean collapse loads in the hat shaped section members increase with collapse velocity for all the cases of the static, quasi-static, and impact collapse tests. In the double hat shaped section members, however, the mean collapse loads decrease with increase in collapse velocity in the impact tests.

• Journal of Korean Institute of Industrial Engineers
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• v.27 no.3
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• pp.267-273
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• 2001

While forecasting sales of a new product is very difficult, it is critical to market success. This is especially true when other products have a highly negative influence on the product because of competition effect. In this paper, we develop a choice-based competitive diffusion model and apply to the case where two digital mobile telecommunication services, that is, digital cellular and PCS services, compete. The basic premise is that demand patterns result from choice behavior, where customers choose a product to maximize their utility. In comparison with Bass-type competitive diffusion models, our model provides superior fitting and forecasting performance. The choice-based model is useful in that it enables the description of such competitive environments and provides the flexibility to include marketing mix variables such as price and advertising.

• Microbiology and Biotechnology Letters
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• v.25 no.3
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• pp.293-297
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• 1997

To develope natural food preservatives of pine needle (Pinus densiflora Seib et Zucc.) extract, pine needle sap, ethanol and ether extracts were prepared for investigation of antimicrobial activities against food-related bacteria and yeasts. All extracts exhibited growth inhibiting activities for most of microorganisms tested. However, in general, growth inhibiting activities were higher in ethanol extract than in sap or ether extract. Minimum inhibitory concentrations (MIC) of ethanol extract for Lactobacillus casei, Pseudomonas aeruginosa or Escherchia coli were as low as 0.1 mg/ml, whereas MIC of sap or ether extract for most bacteria and yeasts were 0.25-0.8mg/ml, indicating that the ethanol extract showed the antimicrobial activity by 2.5 $\sim$8 times higher than the sap and ether extract. The antimicrobial activity of the ethanol extract was reduced by heating or alkali treatment. Moreover, growth of Pseudomonas aeruginosa was completely inhibited within 24 hours by the addition of at least 50ppm of ethanol extract. These findings suggest that pine needle, specially the ethanol extrat may play a role for natural food preservatives.

• Journal of Satellite, Information and Communications
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• v.12 no.1
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• pp.107-113
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• 2017

Recently, digital signage is various changes and converging media. It is common to exhibit and guide focusing on information transfer by using the display. Such a method can not express variously changing digital signage. Therefore, we have to find a way to solve the problem of place and structure. In this paper, we experimented the new direction technique. Finally, we are going to propose acoustic direction technique using a microphone to maximize digital signage and intention of delivery by adding an sound reinforcement method to the visual representation.

• Journal of Species Research
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• v.6 no.1
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• pp.25-41
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• 2017

As a subset study for the collection of Korean indigenous prokaryotic species, 62 bacterial strains belonging to the phylum Actinobacteria were isolated from various sources. Each strain showed higher 16S rRNA gene sequence similarity (>98.75%) and formed a robust phylogenetic clade with closest species of the phylum Actinobacteria which were defined with valid names, already. There is no official description on these 62 actinobacterial species in Korea. Consequently, unrecorded 62 species of 25 genera in the 14 families belonging to the order Actinomycetales of the phylum Actinobacteria were found in Korea. Morphological properties, basic biochemical characteristics, isolation source and strain IDs are described in the species descriptions.