• Korean Journal of Pharmacognosy
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• v.36 no.1 s.140
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• pp.50-55
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• 2005

Reactive oxygen species (ROS) are continuously produced at a high rate as a by-product obtained in the aerobic metabolism. A major portion of living organisms has defense system as superoxide dismutase or catalase against damage produced by ROS. Several lines of evidence provided that ROS appears to cause to develop aging and various diseases. Spatholobus suberectus Dunn has been known as a Korean folk medicine for promoting blood circulation and relieving blood stasis as anemia. In this study, we have investigated the antioxidant activities of Spatholobus suberectus Dunn in order to find the antioxidant substances from natural products. For various antioxidant experiment, the major antioxidant component was isolated from EtOAc extract of Spatholobus suberectus Dunn. This compound was identified as (-)-epicatechin by chemical and physical analysis.

• Korean Journal of Pharmacognosy
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• v.46 no.1
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• pp.23-30
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• 2015

Processing of medicinal plants is one of the processing methods for reducing of toxicity or improving of effect on medicinal plants. In this study, we studied the changes in the constituents and antioxidant activity in accordance with the processing conditions by the salt water of Citrus unshiu Markovich. Changes in antioxidant activity was measured by the DPPH method and changes in the components were analyzed by high performance liquid chromatography. As a result, the content of the main constituents (narirutin, hesperidin) and total polyphenol were increased by increasing the concentration of salt water. Moreover, antioxidant activity was increased gradually in proportion to the increase of the total polyphenol content.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2011.04a
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• pp.131-135
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• 2011

소방공무원은 한국에서 가장 위험한 직업군중 하나로 분류될 수 있으며, 이들 소방공무원이 현장에서 동료들의 부상이나 사망을 목격하게 되거나, 개인이 견딜 수 없는 조직문화나 불합리한 제도 등 문화적 요인이나 제도적 요인등도 스트레스를 매우 위험한 수준까지 발전시킬 수 있으며, 또한 위험을 유발하는 직간접적인 요인들이 결국 소방공무원의 스트레스를 높이고 조직몰입을 떨어뜨려 조직의 효과성을 저해함으로서 소방공무원의 스트레스는 조직몰입도에 상당한 영향을 미칠 수 있으므로, 보다 효과적으로 소방조직문화를 향상시킬 수 있는 방안에 대해 집중적으로 검토하고 연구하고자 하였다.

• Korean Journal of Pharmacognosy
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• v.35 no.3 s.138
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• pp.184-188
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• 2004

This study was carried out to evaluate glutathione S-transferase (GST) activity and hyaluronidase inhibitory effect of medicinal plants. The EtOH extracts of 20 species plants were tested. As the result, Acorus gramineus and Pueraria lobata exhibited GST activity. On the continuous experiment, the n-BuOH fraction of Acorus gramineus and the $H_2O$ fraction of Pueraria lobata showed the elevation of GST activity. On the experiment of hyaluronidase inhibitory effect, Acorus gramineus exhibited a potent inhibitory activity. These results suggest that the extract of Acorus gramineus can be applicable for the development of a new anti-inflammatory agent.

• Korean Journal of Pharmacognosy
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• v.40 no.2
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• pp.103-108
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• 2009

GCSB-5 preparation is a purified extract from a mixture of 6 medicinal plants(Acanthopanacis Cortex, Achyranthis Radix, Saposhnikoviae Radix, Cibotii Rhizoma, Glycine Semen Nigra, Eucommiae Cortex) that have been widely used for the treatment of various bone disorders. The aim of this study was to investigate HPLC analysis method and screening of standard compound on Saposhnikoviae Radix for quality standardization of a medicinal crude drug GCSB-5. Standard compound of Saposhnikoviae Radix was decided with cimifugin by isolation and instrumental analysis such as NMR. HPLC analysis method for the simultaneous determination of cimifugin was established for the quality control of the medicinal plants of Saposhnikoviae Radix species, GCSB-5 raw material and preparation. And validation of HPLC analysis methods were conformed for verification of HPLC methods by check to specificity, linearity, intra-day precision, inter-day precision and accuracy following ICH guideline.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2011.11a
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• pp.494-497
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• 2011

소방공무원은 가장 위험한 직업중 하나로 과로사부터 훈련이나 화재진압 현장에서의 사망에 이르기까지 생명의 위험에 노출되어 있다. 이러한 위험성은 소방공무원을 기타 다른 분야의 공무원들과 근본적으로 차이를 가지게 하는 특성으로 작용한다. 소방공무원을 둘러싼 위험을 유발하는 요소들은 치명적 사고로 이어질 수 있을 뿐만 아니라, 스트레스를 증가시키고 있다. 위험 유발 요소들은 제도적 요인, 문화적 요인, 그리고 개인적 경험으로 분류될 수 있고 다시 하위 항목으로 나뉠 수 있다. 본 연구에서는 소방공무원과 관련한 위험유발요인들이 스트레스라는 매개변수를 통해 소방공무원들의 조직몰입에 주는 영향을 고찰하였다.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.119.1-119.1
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• 2011

한국천문연구원에서는 2009년부터 외계행성 탐색시스템(KMTNet) 개발 사업을 진행하고 있다. 이 사업에서는 중력렌즈 방법이나 별표면 통과(Transit) 방법으로 외계행성을 탐색하기 위하여, 1.6m 광학 망원경과 3.4억 화소의 모자이크 CCD 카메라로 구성된 2도${\times}$2도의 광시야 관측시스템을 제작하고 있다. 이 시스템은 2014년까지 남반구의 칠레 CTIO(1호기), 남아공화국 SAAO(2호기), 호주 SSO(3호기)에 설치될 예정이다. 광시야 망원경은 최종 설계가 완료되어 제작 중이며, 1호기 주경 가공도 성공적으로 마무리되었다. 모자이크 카메라는 2011년 6월에 미국 오하이오 주립대학교 천문학과와 제작 계약을 체결하였으며, 현재 최종 설계가 진행 중이다. 이번 발표에서는 망원경과 카메라 등 탐색 관측 시스템 제작 현황과 향후 일정을 제시할 것이다.

• Archives of Pharmacal Research
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• v.23 no.2
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• pp.116-120
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• 2000

Aspirin has been widely used as analgesic and anti-inflammatory drug. Recently, it was elucidated that aspirin have anti-coaggregatory effect in low dose. This study was carried out to investigate the synthesis of aspirin derivatives from aspirin and aromatic compound of antioxidant and its biological activities. Synthesis of aspirin derivatives was prepared by esterification in the presence of 1, 1-carbonyldiimidazole. Biological activities was examined using effect of anti-coagulant on bleeding time, effect of antioxidant and effect of anti-platelet aggregation. As a result, SJ-101 showed strong antioxidative activity and anti-coagulant activity among four compounds. Anti-platelet aggregation of SJ-101 was examined by collagen, ADP, PAF method. SJ-101 exhibited more stronger activity to aspirin at collagen aggregation reaction. These finding demonstrates that SJ-101 is usefull as care drug of aging and old-disease because of its has antioxidant activity, anti-coagulant activity and anti-platelet activity.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2004.10a
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• pp.289-303
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• 2004

As needs for telecommunications services diversify, an increasingly wide range of telecommunications services is becoming available in the market. Any subscriber can find a service to satisfy his/her telecommunication requirements and competition between providers to retain heavy users is increasing. Service price reductions are one retention strategy, although price reductions for one service can affect the individual-level usage for other services. Price reductions can also be imposed on a service provider by regulation. For these reasons, understanding how price reductions affect service usage is of growing importance to the telecommunications industry for purposes of pricing and tariff development. In this paper, we develop an individual-level usage model for telecommunications services and analyze the effects on usage of a price reduction. We apply the model to age-stratified aggregate traffic data for a Korean mobile telecommunication service provider. Finally, we develop a model to support a market segmentation and price reduction strategy.

• YAKHAK HOEJI
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• v.52 no.2
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• pp.131-136
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• 2008

Sesamol, one of constituents isolated from sesame seed (Sesamum indicum L.) has been known to have natural antioxidant property. Nicotinic acid and clofibric acid have been used for treatment of hyperlipidemia. Sesamol derivatives prepared by conjugation with nicotinic acid (SJ-301) and clofibric acid (SJ-302) were expected to have various biological activity caused by synergistic effect of sesamol. Thus, this study were carried out to investigate the synthesis of sesamol derivatives from seasamol and antihyperlipidemia drugs and their biological activities. As a result, SJ-301 showed a stronger antihyperlipidemia activity in vivo and inhibitory effect on $TNF-{\alpha}$ release in vitro compared to the original agents such as sesamol, nicotinic acid and clofibric acid.